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Identifier: 15679125

GI number: 15679125

Start: 1026754

End: 1027401

Strand: Direct

Name: upp

Synonym: MTH1114

Alternate gene names: 15679125

Gene position: 1026754-1027401 (Clockwise)

Preceding gene: 15679124

Following gene: 15679131

Centisome position: 58.63

GC content: 54.48

Gene sequence:

>648_bases
GTGGATGGAGAGAGGATGATGCTGAGGGTGATTGATAACCTGATAGTCAGGGAGAAGCTCACCACCATAAGGTGCAGGGG
GATAGACCCGGCCAGCTTCAGACGGGGAGTGACTGATATAGGTCGCTACATGGCCTACGAATTTGCAGACACCCTTAAAT
GGCGTGAGGTTGAGGTTGAAACCCCCCTGGGCACGGCCAGTGGTGTTGAGATAACCGACAGGGACAGGATAGTTCTTCTG
AGCATCCTCAGGGCTTCACTGCCCTTCACAGAGGGTGTGATGAAGGTCTTCCCTGAGGCAGAACACGGTATTATCGGTGC
GAGGAGGTCAGATGAGCCCCCATTCAGGGTCTCAATCGACTACATCAGGGTCCCTGAACTTGATGATAAGATACTGGTGA
TAGCGGACCCCATGCTAGCAACAGGGAACACCATGATAGGTATCCTGGAGGCCCTTGAGGCCCATGGCTCCCCTGCGAGG
ACGGTGGTCTTCAATATCATATCCTCCAGGATGGGCCTTGACAGGGTCCTTCAGAGGGGTATAGATGTCTACACATGCGG
TGTTGAGGAGGAGGTTAACGATATGGGCTACATAGTCCCTGGACTCGGGGACGCAGGGGATCTGGCCTTCGGGAGGCCAT
CAGATTAG

Upstream 100 bases:

>100_bases
AATTCGACCTTAAATTTGAGGATGCCAGGATAGAGGTCATCCCCCAGGCCAGGGGTAAAATGCTCAGGGAGATCGATGAT
GGCGATTAACATGATAAGCT

Downstream 100 bases:

>100_bases
TCCGATCCGGGTTGCCGTTTGAGCCATACCCTTTAAAATCAGAGAAAAACCAGTTACTGGTGTTCACGACAGGGTCTGCT
AGGGTGAAGGCAGGGATCAG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MDGERMMLRVIDNLIVREKLTTIRCRGIDPASFRRGVTDIGRYMAYEFADTLKWREVEVETPLGTASGVEITDRDRIVLL
SILRASLPFTEGVMKVFPEAEHGIIGARRSDEPPFRVSIDYIRVPELDDKILVIADPMLATGNTMIGILEALEAHGSPAR
TVVFNIISSRMGLDRVLQRGIDVYTCGVEEEVNDMGYIVPGLGDAGDLAFGRPSD

Sequences:

>Translated_215_residues
MDGERMMLRVIDNLIVREKLTTIRCRGIDPASFRRGVTDIGRYMAYEFADTLKWREVEVETPLGTASGVEITDRDRIVLL
SILRASLPFTEGVMKVFPEAEHGIIGARRSDEPPFRVSIDYIRVPELDDKILVIADPMLATGNTMIGILEALEAHGSPAR
TVVFNIISSRMGLDRVLQRGIDVYTCGVEEEVNDMGYIVPGLGDAGDLAFGRPSD
>Mature_215_residues
MDGERMMLRVIDNLIVREKLTTIRCRGIDPASFRRGVTDIGRYMAYEFADTLKWREVEVETPLGTASGVEITDRDRIVLL
SILRASLPFTEGVMKVFPEAEHGIIGARRSDEPPFRVSIDYIRVPELDDKILVIADPMLATGNTMIGILEALEAHGSPAR
TVVFNIISSRMGLDRVLQRGIDVYTCGVEEEVNDMGYIVPGLGDAGDLAFGRPSD

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=30.2884615384615, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_METTH (O27186)

Other databases:

- EMBL:   AE000666
- PIR:   C69015
- RefSeq:   NP_276242.1
- ProteinModelPortal:   O27186
- SMR:   O27186
- STRING:   O27186
- GeneID:   1471522
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1114
- NMPDR:   fig|187420.1.peg.1097
- eggNOG:   arNOG08389
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- ProtClustDB:   PRK00129
- BioCyc:   MTHE187420:MTH1114-MONOMER
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_A
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 23828; Mature: 23828

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: BINDING 84-84 BINDING 109-109 BINDING 198-198 BINDING 204-204

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGERMMLRVIDNLIVREKLTTIRCRGIDPASFRRGVTDIGRYMAYEFADTLKWREVEVE
CCCHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHCCHHHHHHHHHHHHHHHCCEEEEEEE
TPLGTASGVEITDRDRIVLLSILRASLPFTEGVMKVFPEAEHGIIGARRSDEPPFRVSID
CCCCCCCCCEECCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEECCCCCCCCEEEEEE
YIRVPELDDKILVIADPMLATGNTMIGILEALEAHGSPARTVVFNIISSRMGLDRVLQRG
EEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHCC
IDVYTCGVEEEVNDMGYIVPGLGDAGDLAFGRPSD
CCEEECCCHHHHCCCCEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDGERMMLRVIDNLIVREKLTTIRCRGIDPASFRRGVTDIGRYMAYEFADTLKWREVEVE
CCCHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHCCHHHHHHHHHHHHHHHCCEEEEEEE
TPLGTASGVEITDRDRIVLLSILRASLPFTEGVMKVFPEAEHGIIGARRSDEPPFRVSID
CCCCCCCCCEECCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEECCCCCCCCEEEEEE
YIRVPELDDKILVIADPMLATGNTMIGILEALEAHGSPARTVVFNIISSRMGLDRVLQRG
EEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHCC
IDVYTCGVEEEVNDMGYIVPGLGDAGDLAFGRPSD
CCEEECCCHHHHCCCCEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463