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Identifier: 15679065

GI number: 15679065

Start: 960874

End: 962229

Strand: Direct

Name: Not Available

Synonym: MTH1052

Alternate gene names: 15679065

Gene position: 960874-962229 (Clockwise)

Preceding gene: 15679064

Following gene: 15679066

Centisome position: 54.86

GC content: 49.56

Gene sequence:

>1356_bases
GTGCAGGACATTATAGGGAAGATAGAGGATTACTCCTCAAAGAACGGGATCCTTCTCCCGGATCCCGTGGTGGAATATGT
GGCCCGGATTGCCGATGAGGAGAAGCTGAAGGAGCCTGAACTCCAGGAGATGGTGAGGCTCTTCAGCAGAATAGCCGAAA
GAAACCAGGGCCTTGATGACGATGAACTCCTGGATGCGGTGGAGGATGACTACCAGCGGATACTCAAGGTTCAGGAGCTT
GTCAAACGGAAGAGGGCCAGGTTCCCCCCGAAACTCATTGAGGACATAGCTGAGGTCATGAAGAAGCATGAACTCAGTGA
CGATGAACTGGATGAGCTCATAAGAAGGGTCAGGAGAGCCTATGACCGGGCCCGGGTTGAGGCCGGTGAGGCCGTTGGGA
CGGTGGCAGCCCAGTCAGTGGGTGAACCAGGTACCCAGATGACAATGCGTACCTTCCACTATGCAGGTGTGGCAGAGCTC
AACGTTACACTGGGTCTTCCAAGGCTCATAGAGATCGTTGACGCCCGGAAGAAGATATCCACGCCAACCATGAGCATCTA
CTTCGAGGGGGACCTCAGGTACGATGAGGAATTCGTGCGAAGGAAGGCCAACAAGATAGGTAAGAGCACTCTGAACGATG
TGCTTAAAAATTTCAGCATCCAGTACGCTGACATGTCAGTTGTTGCTGAACTGGATGAGGAGAAGATCCAGGAGAAGCAC
CTTGAATATGATGAGATACTGGCCAAGGTGGAAAAAACTTTTAAGAAAGTAGAAATAGATAACAACATACTGAGATTTGA
ACCCCCGAAGCCCACCATAAGGGAGCTCAGGTTACTCGCAGATAAGGTGAGGAAACTCCAGATAAGCGGGGTTAAAAACA
TAGGAAAGGTGGTTATCCGTAAAGAGGATGATGAATGGGTAATCCATACTGAGGGTTCAAACCTTGGAGCTGTTCTTAAA
GAAGAGGGTGTGGATAAGGTCCGGACCACGACCAACGATATACATGAGATAGAGACAGTTCTGGGCATAGAGGCTGCCAG
AAACGCAATAATACACGAAGCAAAGAGGACCATGGAGGAACAGGGGCTCACAGTTGACATAAGGCACATAATGCTCGTTG
CAGATATGATGACTGCTGATGGCTCTGTCAAGTCCATTGGAAGGCACGGTATCAGTGGTGAAAAGGCCAGTGTTCTTGCA
AGGGCTTCTTTTGAGGAAACCGGTAAGCACCTTCTGAGAGCAAGTATCAGGGGCGAGGTGGACCACCTCACCGGTATCAT
AGAGAACATTATTATAGGGCAACCTATACCCCTGGGTACAGGTTCCGTTAGTGTTGTGATGAAAGAAAGAAAATAG

Upstream 100 bases:

>100_bases
AGACGGCGTTGATCCGGCCAAGAGTGACTACGGAAAGATAGTGGACCTTGATAAACTCGTAGAGGAGATAAGGCTCAAGT
CAAAGGGGTAAGGTGATTCT

Downstream 100 bases:

>100_bases
GAGGCAGTAGATGGACATAGATAGAGGAATACGAGTCGCTGTAGATACTGGTAATGTTATCCTTGGATCAAAGAGGACGA
TTCAGAGCCTCAAACTGGGT

Product: DNA-directed RNA polymerase subunit A''

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MQDIIGKIEDYSSKNGILLPDPVVEYVARIADEEKLKEPELQEMVRLFSRIAERNQGLDDDELLDAVEDDYQRILKVQEL
VKRKRARFPPKLIEDIAEVMKKHELSDDELDELIRRVRRAYDRARVEAGEAVGTVAAQSVGEPGTQMTMRTFHYAGVAEL
NVTLGLPRLIEIVDARKKISTPTMSIYFEGDLRYDEEFVRRKANKIGKSTLNDVLKNFSIQYADMSVVAELDEEKIQEKH
LEYDEILAKVEKTFKKVEIDNNILRFEPPKPTIRELRLLADKVRKLQISGVKNIGKVVIRKEDDEWVIHTEGSNLGAVLK
EEGVDKVRTTTNDIHEIETVLGIEAARNAIIHEAKRTMEEQGLTVDIRHIMLVADMMTADGSVKSIGRHGISGEKASVLA
RASFEETGKHLLRASIRGEVDHLTGIIENIIIGQPIPLGTGSVSVVMKERK

Sequences:

>Translated_451_residues
MQDIIGKIEDYSSKNGILLPDPVVEYVARIADEEKLKEPELQEMVRLFSRIAERNQGLDDDELLDAVEDDYQRILKVQEL
VKRKRARFPPKLIEDIAEVMKKHELSDDELDELIRRVRRAYDRARVEAGEAVGTVAAQSVGEPGTQMTMRTFHYAGVAEL
NVTLGLPRLIEIVDARKKISTPTMSIYFEGDLRYDEEFVRRKANKIGKSTLNDVLKNFSIQYADMSVVAELDEEKIQEKH
LEYDEILAKVEKTFKKVEIDNNILRFEPPKPTIRELRLLADKVRKLQISGVKNIGKVVIRKEDDEWVIHTEGSNLGAVLK
EEGVDKVRTTTNDIHEIETVLGIEAARNAIIHEAKRTMEEQGLTVDIRHIMLVADMMTADGSVKSIGRHGISGEKASVLA
RASFEETGKHLLRASIRGEVDHLTGIIENIIIGQPIPLGTGSVSVVMKERK
>Mature_451_residues
MQDIIGKIEDYSSKNGILLPDPVVEYVARIADEEKLKEPELQEMVRLFSRIAERNQGLDDDELLDAVEDDYQRILKVQEL
VKRKRARFPPKLIEDIAEVMKKHELSDDELDELIRRVRRAYDRARVEAGEAVGTVAAQSVGEPGTQMTMRTFHYAGVAEL
NVTLGLPRLIEIVDARKKISTPTMSIYFEGDLRYDEEFVRRKANKIGKSTLNDVLKNFSIQYADMSVVAELDEEKIQEKH
LEYDEILAKVEKTFKKVEIDNNILRFEPPKPTIRELRLLADKVRKLQISGVKNIGKVVIRKEDDEWVIHTEGSNLGAVLK
EEGVDKVRTTTNDIHEIETVLGIEAARNAIIHEAKRTMEEQGLTVDIRHIMLVADMMTADGSVKSIGRHGISGEKASVLA
RASFEETGKHLLRASIRGEVDHLTGIIENIIIGQPIPLGTGSVSVVMKERK

Specific function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

COG id: COG0086

COG function: function code K; DNA-directed RNA polymerase, beta' subunit/160 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNA polymerase beta' chain family

Homologues:

Organism=Homo sapiens, GI39725938, Length=362, Percent_Identity=35.0828729281768, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI4505939, Length=421, Percent_Identity=32.3040380047506, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI103471997, Length=195, Percent_Identity=36.4102564102564, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI25145495, Length=366, Percent_Identity=34.9726775956284, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI71987878, Length=421, Percent_Identity=32.0665083135392, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI71998295, Length=148, Percent_Identity=37.1621621621622, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320061, Length=417, Percent_Identity=31.1750599520384, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324690, Length=358, Percent_Identity=37.9888268156425, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6324917, Length=188, Percent_Identity=30.8510638297872, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281360912, Length=356, Percent_Identity=37.3595505617978, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI17530899, Length=426, Percent_Identity=30.5164319248826, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI17647875, Length=192, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPOA2_METTH (O27126)

Other databases:

- EMBL:   AE000666
- PIR:   H69006
- RefSeq:   NP_276182.1
- ProteinModelPortal:   O27126
- SMR:   O27126
- STRING:   O27126
- GeneID:   1471460
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1052
- NMPDR:   fig|187420.1.peg.1037
- eggNOG:   arNOG04558
- HOGENOM:   HBG297327
- OMA:   LVADMMT
- ProtClustDB:   PRK14897
- BioCyc:   MTHE187420:MTH1052-MONOMER
- BRENDA:   2.7.7.6
- HAMAP:   MF_00411
- InterPro:   IPR007081
- InterPro:   IPR012757
- PANTHER:   PTHR19376:SF13
- TIGRFAMs:   TIGR02389

Pfam domain/function: PF04998 RNA_pol_Rpb1_5

EC number: =2.7.7.6

Molecular weight: Translated: 51004; Mature: 51004

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDIIGKIEDYSSKNGILLPDPVVEYVARIADEEKLKEPELQEMVRLFSRIAERNQGLDD
CCHHHHHHHHCCCCCCEECCCHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHCCCCCH
DELLDAVEDDYQRILKVQELVKRKRARFPPKLIEDIAEVMKKHELSDDELDELIRRVRRA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
YDRARVEAGEAVGTVAAQSVGEPGTQMTMRTFHYAGVAELNVTLGLPRLIEIVDARKKIS
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCC
TPTMSIYFEGDLRYDEEFVRRKANKIGKSTLNDVLKNFSIQYADMSVVAELDEEKIQEKH
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHC
LEYDEILAKVEKTFKKVEIDNNILRFEPPKPTIRELRLLADKVRKLQISGVKNIGKVVIR
CCHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHCCEEEE
KEDDEWVIHTEGSNLGAVLKEEGVDKVRTTTNDIHEIETVLGIEAARNAIIHEAKRTMEE
ECCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLTVDIRHIMLVADMMTADGSVKSIGRHGISGEKASVLARASFEETGKHLLRASIRGEV
CCCEEEHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCH
DHLTGIIENIIIGQPIPLGTGSVSVVMKERK
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MQDIIGKIEDYSSKNGILLPDPVVEYVARIADEEKLKEPELQEMVRLFSRIAERNQGLDD
CCHHHHHHHHCCCCCCEECCCHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHCCCCCH
DELLDAVEDDYQRILKVQELVKRKRARFPPKLIEDIAEVMKKHELSDDELDELIRRVRRA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
YDRARVEAGEAVGTVAAQSVGEPGTQMTMRTFHYAGVAELNVTLGLPRLIEIVDARKKIS
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCC
TPTMSIYFEGDLRYDEEFVRRKANKIGKSTLNDVLKNFSIQYADMSVVAELDEEKIQEKH
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHC
LEYDEILAKVEKTFKKVEIDNNILRFEPPKPTIRELRLLADKVRKLQISGVKNIGKVVIR
CCHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHCCEEEE
KEDDEWVIHTEGSNLGAVLKEEGVDKVRTTTNDIHEIETVLGIEAARNAIIHEAKRTMEE
ECCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLTVDIRHIMLVADMMTADGSVKSIGRHGISGEKASVLARASFEETGKHLLRASIRGEV
CCCEEEHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCH
DHLTGIIENIIIGQPIPLGTGSVSVVMKERK
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463