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Identifier: 15679059

GI number: 15679059

Start: 951977

End: 952666

Strand: Direct

Name: Not Available

Synonym: MTH1041

Alternate gene names: 15679059

Gene position: 951977-952666 (Clockwise)

Preceding gene: 15679058

Following gene: 15679060

Centisome position: 54.36

GC content: 53.77

Gene sequence:

>690_bases
ATGCTGGAGGATTTGGAGTTGAAGGACACACCCATTGTCATACTGAATTTTAAAACATACCTCGAATCAACAGGTGAGAG
AGCCCTCGAACTTGCATCAATATGCGGGGATGTCGCAGATGAGACCGGTGTTAACATGGCTGTGGCACCGCAGCACATGG
ACCTCCACCGGGTGAGTGATGCTGTAGAAATACCGGTGCTGGCACAGCACATTGACGCCGTTGATGCTGGTGGACACACA
GGGAGCATCCTTGCAGAGTGCGCCAGGGACGCAGGTGCAGCAGGAACCCTCATAAACCATTCAGAAAAGCGGATGCAACT
TGCAGACATCGAATGGGTGATATCAAGGATGAAGGAACTTGAGATGATGTCCGTGGTATGCACGAACAACGTCATGACCA
CTGCTGCTGCCGCCGCCCTGGGACCGGACTTCGTGGCGGTTGAACCCCCTGAACTCATAGGATCCGGAATACCTGTGTCA
AGGGCCGAACCTGAGGTTATAACGGGAAGTGTTGATGCTGTGAAGAAGGTGAACCCTGAGGTCAGTGTGCTCTGTGGCGC
CGGAATATCCACAGGAGACGACATGAAGGCTGCTGTTGACCTGGGGGCCGAGGGTGTTCTTCTTGCATCAGGCATCATCC
TGGCTGACAGCCCACGGGACGCCCTTCTGGATCTTGTAAGTAAGGTTTGA

Upstream 100 bases:

>100_bases
CAGGCAAATTCATTCATGAACCCCTTCAACAACTCCCGCACGGATGTCACAGCATATTTTATAATACACCTCAACCATAC
TATGAGATATCCCATTAATC

Downstream 100 bases:

>100_bases
TGGTGATCCCGGTGTCCTTTAAATTTAAAACCATGGATGACATTGAAGTCACAGGAAAGACAGTCCTTGTCCGCGTGGAC
ATAAATTCGCCTGTGGACCC

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MLEDLELKDTPIVILNFKTYLESTGERALELASICGDVADETGVNMAVAPQHMDLHRVSDAVEIPVLAQHIDAVDAGGHT
GSILAECARDAGAAGTLINHSEKRMQLADIEWVISRMKELEMMSVVCTNNVMTTAAAAALGPDFVAVEPPELIGSGIPVS
RAEPEVITGSVDAVKKVNPEVSVLCGAGISTGDDMKAAVDLGAEGVLLASGIILADSPRDALLDLVSKV

Sequences:

>Translated_229_residues
MLEDLELKDTPIVILNFKTYLESTGERALELASICGDVADETGVNMAVAPQHMDLHRVSDAVEIPVLAQHIDAVDAGGHT
GSILAECARDAGAAGTLINHSEKRMQLADIEWVISRMKELEMMSVVCTNNVMTTAAAAALGPDFVAVEPPELIGSGIPVS
RAEPEVITGSVDAVKKVNPEVSVLCGAGISTGDDMKAAVDLGAEGVLLASGIILADSPRDALLDLVSKV
>Mature_229_residues
MLEDLELKDTPIVILNFKTYLESTGERALELASICGDVADETGVNMAVAPQHMDLHRVSDAVEIPVLAQHIDAVDAGGHT
GSILAECARDAGAAGTLINHSEKRMQLADIEWVISRMKELEMMSVVCTNNVMTTAAAAALGPDFVAVEPPELIGSGIPVS
RAEPEVITGSVDAVKKVNPEVSVLCGAGISTGDDMKAAVDLGAEGVLLASGIILADSPRDALLDLVSKV

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family

Homologues:

None

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): TPIS_METTH (O27120)

Other databases:

- EMBL:   AE000666
- PIR:   A69006
- RefSeq:   NP_276176.1
- ProteinModelPortal:   O27120
- SMR:   O27120
- STRING:   O27120
- GeneID:   1471449
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1041
- NMPDR:   fig|187420.1.peg.1031
- eggNOG:   arNOG04711
- HOGENOM:   HBG297256
- OMA:   VEPPELI
- ProtClustDB:   PRK04302
- BioCyc:   MetaCyc:MONOMER-14534
- BioCyc:   MTHE187420:MTH1041-MONOMER
- BRENDA:   5.3.1.1
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00147_A
- InterPro:   IPR013785
- InterPro:   IPR000652
- InterPro:   IPR022891
- InterPro:   IPR020861
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00419

Pfam domain/function: PF00121 TIM; SSF51351 Triophos_ismrse

EC number: =5.3.1.1

Molecular weight: Translated: 23852; Mature: 23852

Theoretical pI: Translated: 4.11; Mature: 4.11

Prosite motif: PS00171 TIM_1; PS51440 TIM_2

Important sites: ACT_SITE 100-100 ACT_SITE 148-148 BINDING 16-16 BINDING 18-18

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEDLELKDTPIVILNFKTYLESTGERALELASICGDVADETGVNMAVAPQHMDLHRVSD
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHH
AVEIPVLAQHIDAVDAGGHTGSILAECARDAGAAGTLINHSEKRMQLADIEWVISRMKEL
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHH
EMMSVVCTNNVMTTAAAAALGPDFVAVEPPELIGSGIPVSRAEPEVITGSVDAVKKVNPE
HHHHHHHCCCHHHHHHHHHCCCCCEEECCHHHHCCCCCCCCCCCCEEECCHHHHHHCCCC
VSVLCGAGISTGDDMKAAVDLGAEGVLLASGIILADSPRDALLDLVSKV
EEEEECCCCCCCCCHHHHHHCCCCCEEEECCEEEECCCHHHHHHHHHCC
>Mature Secondary Structure
MLEDLELKDTPIVILNFKTYLESTGERALELASICGDVADETGVNMAVAPQHMDLHRVSD
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHH
AVEIPVLAQHIDAVDAGGHTGSILAECARDAGAAGTLINHSEKRMQLADIEWVISRMKEL
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHH
EMMSVVCTNNVMTTAAAAALGPDFVAVEPPELIGSGIPVSRAEPEVITGSVDAVKKVNPE
HHHHHHHCCCHHHHHHHHHCCCCCEEECCHHHHCCCCCCCCCCCCEEECCHHHHHHCCCC
VSVLCGAGISTGDDMKAAVDLGAEGVLLASGIILADSPRDALLDLVSKV
EEEEECCCCCCCCCHHHHHHCCCCCEEEECCEEEECCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463