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Identifier: 15679054

GI number: 15679054

Start: 946171

End: 947268

Strand: Direct

Name: Not Available

Synonym: MTH1036

Alternate gene names: 15679054

Gene position: 946171-947268 (Clockwise)

Preceding gene: 15679053

Following gene: 15679058

Centisome position: 54.02

GC content: 54.28

Gene sequence:

>1098_bases
ATGAAGTTCTATGAGTACAGCGCCAAGGAGATATTCCGGGCTGAGGGTATAAGCACCCCCCGTGGAGGTGTTGCAGAGAC
CCCTGAAGAAGCTGAAAGGATAGCTGCGGAACTGGGGTGTGATGTTGCAGTTAAATCCCAGGTCCTTACAGGTGGAAGGG
GAAAGGCCGGTGGTATAAGGTTCGCATCCCCCTCAGGTGTCGCTGAAGTTACCGGGGACCTCCTTTCCTCAGAGGTCCGT
GGTGAAACCGTTGAGAAGGTCCTCATAGAGGAGAAGATACCCATAGACCGGGAGCTCTACGTGAGTGCTGTCATTGACCG
GACAGCGAAGATGCCCCTCATAATGGCCAGTGCCGAGGGAGGGGTTGATATAGAGGAACTGGCAGCCAGATCCCCCGAAA
AGATCGTGCGCTACCACATCAACCCCCTCGATGAGTTTCTTCCCTATGAGGCCAGGGAGATTGCAAGGAAGATGGGTCTT
GAAAGTGAACTGATACCCTCTGTCGGTGGAGTGATCTGGAAGTTATATCAGCTCTTCAGGAAGTACGATGCCAGGCTTGC
AGAGATAAACCCCCTGGTCATCTCAGGGGACAGTGTCATCGCAGCAGACGCAAAGCTTGAGGTGGATGACGACTCCATTT
ACCGCCACAGGGAATTTATGGAAATGGAGGAGTATGAACCCGAGGAGTTTGCCTTTGTGAAGCTCGACGGAGATATTGCG
GTTATAGGTAACGGTGCCGGGTTAACCCTCACCGCAATGGACCTCATAAAACTGAACGGGGAACCCGCCACATTCCTCGA
CATCGGTGGCGGTGCCTCAGAGGACGTCATAAGGAGGGCCCTTGACCTCGTCATATCCCATCCCTCAGTCCGGGTTGTAT
TCCTCAACGTCCTTGGCGGTATAACCAGGGCCGATGATGTTGCCAGGGGTGTTGTGAACGCCCTGAGGGATGCCAGAAGA
GACGTGCCCCTTGTGATACGCCTTACCGGAACCAATGAGGAGGAGGGTCAGAGGATCCTGCGGGAGGCAGGAATCCCCTT
TGAGACGTCCCTTGAGAGGGCTGCTGAGAAGGCCGTTGAGATAGCAAAAAACCTCTAA

Upstream 100 bases:

>100_bases
CCGCTGAGGAGGCCATAAAGGACAGCGTACCCCCAGGTACAGAGGAGAAGAACCTCATGGCATTCCAGGCCGGTCGCGAA
CTTATAATGGAGGGAAGCAG

Downstream 100 bases:

>100_bases
ACCTCCAGCTCCCCTTCTCTTTTTTCTGGAAATAGAAAAAACCTCCAGCCAGCTTCCCTTTTTCTGTTTCCTTATAACAA
ACCCTGAAACGTCGGGTTAA

Product: succinyl-CoA synthetase, beta subunit

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MKFYEYSAKEIFRAEGISTPRGGVAETPEEAERIAAELGCDVAVKSQVLTGGRGKAGGIRFASPSGVAEVTGDLLSSEVR
GETVEKVLIEEKIPIDRELYVSAVIDRTAKMPLIMASAEGGVDIEELAARSPEKIVRYHINPLDEFLPYEAREIARKMGL
ESELIPSVGGVIWKLYQLFRKYDARLAEINPLVISGDSVIAADAKLEVDDDSIYRHREFMEMEEYEPEEFAFVKLDGDIA
VIGNGAGLTLTAMDLIKLNGEPATFLDIGGGASEDVIRRALDLVISHPSVRVVFLNVLGGITRADDVARGVVNALRDARR
DVPLVIRLTGTNEEEGQRILREAGIPFETSLERAAEKAVEIAKNL

Sequences:

>Translated_365_residues
MKFYEYSAKEIFRAEGISTPRGGVAETPEEAERIAAELGCDVAVKSQVLTGGRGKAGGIRFASPSGVAEVTGDLLSSEVR
GETVEKVLIEEKIPIDRELYVSAVIDRTAKMPLIMASAEGGVDIEELAARSPEKIVRYHINPLDEFLPYEAREIARKMGL
ESELIPSVGGVIWKLYQLFRKYDARLAEINPLVISGDSVIAADAKLEVDDDSIYRHREFMEMEEYEPEEFAFVKLDGDIA
VIGNGAGLTLTAMDLIKLNGEPATFLDIGGGASEDVIRRALDLVISHPSVRVVFLNVLGGITRADDVARGVVNALRDARR
DVPLVIRLTGTNEEEGQRILREAGIPFETSLERAAEKAVEIAKNL
>Mature_365_residues
MKFYEYSAKEIFRAEGISTPRGGVAETPEEAERIAAELGCDVAVKSQVLTGGRGKAGGIRFASPSGVAEVTGDLLSSEVR
GETVEKVLIEEKIPIDRELYVSAVIDRTAKMPLIMASAEGGVDIEELAARSPEKIVRYHINPLDEFLPYEAREIARKMGL
ESELIPSVGGVIWKLYQLFRKYDARLAEINPLVISGDSVIAADAKLEVDDDSIYRHREFMEMEEYEPEEFAFVKLDGDIA
VIGNGAGLTLTAMDLIKLNGEPATFLDIGGGASEDVIRRALDLVISHPSVRVVFLNVLGGITRADDVARGVVNALRDARR
DVPLVIRLTGTNEEEGQRILREAGIPFETSLERAAEKAVEIAKNL

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Homo sapiens, GI11321583, Length=392, Percent_Identity=34.1836734693878, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI157779135, Length=380, Percent_Identity=33.9473684210526, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI294862256, Length=359, Percent_Identity=33.983286908078, Blast_Score=204, Evalue=1e-52,
Organism=Escherichia coli, GI1786948, Length=367, Percent_Identity=37.6021798365123, Blast_Score=235, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17539378, Length=391, Percent_Identity=36.0613810741688, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI17567829, Length=399, Percent_Identity=33.0827067669173, Blast_Score=210, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6321683, Length=397, Percent_Identity=35.5163727959698, Blast_Score=239, Evalue=5e-64,
Organism=Drosophila melanogaster, GI281361397, Length=395, Percent_Identity=34.1772151898734, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI281361395, Length=395, Percent_Identity=34.1772151898734, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI161078106, Length=395, Percent_Identity=34.1772151898734, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24645208, Length=395, Percent_Identity=34.1772151898734, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI21356231, Length=393, Percent_Identity=34.3511450381679, Blast_Score=216, Evalue=1e-56,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SUCC_METTH (O27115)

Other databases:

- EMBL:   AE000666
- PIR:   C69005
- RefSeq:   NP_276171.1
- ProteinModelPortal:   O27115
- SMR:   O27115
- STRING:   O27115
- GeneID:   1471444
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1036
- NMPDR:   fig|187420.1.peg.1026
- eggNOG:   arNOG04790
- HOGENOM:   HBG315432
- OMA:   DAGTEYY
- ProtClustDB:   CLSK798073
- BioCyc:   MTHE187420:MTH1036-MONOMER
- BRENDA:   6.2.1.5
- HAMAP:   MF_00558
- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.261
- PANTHER:   PTHR11815
- TIGRFAMs:   TIGR01016

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 39855; Mature: 39855

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS50975 ATP_GRASP; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFYEYSAKEIFRAEGISTPRGGVAETPEEAERIAAELGCDVAVKSQVLTGGRGKAGGIR
CCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEE
FASPSGVAEVTGDLLSSEVRGETVEKVLIEEKIPIDRELYVSAVIDRTAKMPLIMASAEG
ECCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCC
GVDIEELAARSPEKIVRYHINPLDEFLPYEAREIARKMGLESELIPSVGGVIWKLYQLFR
CCCHHHHHCCCHHHHHHHCCCCHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
KYDARLAEINPLVISGDSVIAADAKLEVDDDSIYRHREFMEMEEYEPEEFAFVKLDGDIA
HHCCHHHHCCCEEEECCCEEEECCEEEECCHHHHHHHHHHHHHHCCCCCEEEEEECCCEE
VIGNGAGLTLTAMDLIKLNGEPATFLDIGGGASEDVIRRALDLVISHPSVRVVFLNVLGG
EEECCCCCEEEEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEHHHHHCC
ITRADDVARGVVNALRDARRDVPLVIRLTGTNEEEGQRILREAGIPFETSLERAAEKAVE
CCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IAKNL
HHHCC
>Mature Secondary Structure
MKFYEYSAKEIFRAEGISTPRGGVAETPEEAERIAAELGCDVAVKSQVLTGGRGKAGGIR
CCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEE
FASPSGVAEVTGDLLSSEVRGETVEKVLIEEKIPIDRELYVSAVIDRTAKMPLIMASAEG
ECCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCC
GVDIEELAARSPEKIVRYHINPLDEFLPYEAREIARKMGLESELIPSVGGVIWKLYQLFR
CCCHHHHHCCCHHHHHHHCCCCHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
KYDARLAEINPLVISGDSVIAADAKLEVDDDSIYRHREFMEMEEYEPEEFAFVKLDGDIA
HHCCHHHHCCCEEEECCCEEEECCEEEECCHHHHHHHHHHHHHHCCCCCEEEEEECCCEE
VIGNGAGLTLTAMDLIKLNGEPATFLDIGGGASEDVIRRALDLVISHPSVRVVFLNVLGG
EEECCCCCEEEEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEHHHHHCC
ITRADDVARGVVNALRDARRDVPLVIRLTGTNEEEGQRILREAGIPFETSLERAAEKAVE
CCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IAKNL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463