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Identifier: 15679020

GI number: 15679020

Start: 915420

End: 916328

Strand: Direct

Name: Not Available

Synonym: MTH1002

Alternate gene names: 15679020

Gene position: 915420-916328 (Clockwise)

Preceding gene: 15679019

Following gene: 15679022

Centisome position: 52.27

GC content: 54.79

Gene sequence:

>909_bases
GTGCAAACCCCTGAGATAAAGGAGGGAACAGAACAGTACCTCTGGAGAAGAAAAACAATGAACCCTGGAGATAAAGGAGT
GAAGAGAAAGGGAAGTGACCGGCAGAGAGAAAAAATGTCTGTCATCGTTATGGCCGGGACAGAGGATGCCAGGAGGATAA
TCTCGAGGCTCTCAGGGATGCCATGGGTCGAGGTGACAGCCACTGCGACAACAGAGCATGGATCTGACCTTGCAGAGAAG
TCTGGAGCCTCAAGGACAGTTACAGGAGCTCTGGACAGTGATGGGCTCCGTGAACTCATGGCAGACCTTGATGCCTGCAT
CCTGATTGACGCCACCCACCCCTTCGCAGCCCAGGCAACAGAAAATGCTCTCAGGGCCTGCAGGGAAACCGGAACCATTT
ATGTGAGGTTTGAAAGGCCGGAAGTTATCCCTGATGGAGTTATAAGGGTCGGTTCATTCAGGGAGGCCGGTGAAGTCGCC
TCATCCCTCATAGGGGATGGGGAGGTTGTGATGCACCTTGCTGGTGTATCCACCCTGGGTGATGTCCTCAGATCCCTTGA
ACCTGAGAGGGTTGCTGTCCGCGTACTCCCCTCCACCTCATCCATCGAGAAATGCCTCCAGCTGGGGGTCCCGCCCAGCC
ATATCATCGCCATGCAGGGCAGATTCTCGGCTGAAATGAACCTCGCCCTCCTCCGGGAATACCGTGCAGGTGCTGTTATA
ACCAAGGAGAGCGGTGAAACAGGTGGGCTCCCTGAGAAGGTTGAGGCGGCATCAGAACTCGGCATACCGGTTATACTCGT
GGAGAGACCGGAGGTTAACCTTGAGGGTGAGGCTGTCTTCGGTAACATCAACGACCTCATGGACCATGTGCTGAAGATCC
TCAGGGATATGGGACAGCCAGGTGACTGA

Upstream 100 bases:

>100_bases
GTGGTGGACTGGGTGCTGATAGTCCTGGTGGCATCACTGATACTCATCCTCGAGGCTGTCCTGAGATTCTCTGATGGGAG
AAATAAAGTAAAGGAGAACC

Downstream 100 bases:

>100_bases
AGTGATACCCTGGACCTCGCACCGACCCTCTAACTGCTGATTTTCTACCCCATACTACCGATTTTCGAAGAGGACAACTT
CAACTTCCTCTCCCTCATTG

Product: cobalamin biosynthesis protein J

Products: Precorrin 6A; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MQTPEIKEGTEQYLWRRKTMNPGDKGVKRKGSDRQREKMSVIVMAGTEDARRIISRLSGMPWVEVTATATTEHGSDLAEK
SGASRTVTGALDSDGLRELMADLDACILIDATHPFAAQATENALRACRETGTIYVRFERPEVIPDGVIRVGSFREAGEVA
SSLIGDGEVVMHLAGVSTLGDVLRSLEPERVAVRVLPSTSSIEKCLQLGVPPSHIIAMQGRFSAEMNLALLREYRAGAVI
TKESGETGGLPEKVEAASELGIPVILVERPEVNLEGEAVFGNINDLMDHVLKILRDMGQPGD

Sequences:

>Translated_302_residues
MQTPEIKEGTEQYLWRRKTMNPGDKGVKRKGSDRQREKMSVIVMAGTEDARRIISRLSGMPWVEVTATATTEHGSDLAEK
SGASRTVTGALDSDGLRELMADLDACILIDATHPFAAQATENALRACRETGTIYVRFERPEVIPDGVIRVGSFREAGEVA
SSLIGDGEVVMHLAGVSTLGDVLRSLEPERVAVRVLPSTSSIEKCLQLGVPPSHIIAMQGRFSAEMNLALLREYRAGAVI
TKESGETGGLPEKVEAASELGIPVILVERPEVNLEGEAVFGNINDLMDHVLKILRDMGQPGD
>Mature_302_residues
MQTPEIKEGTEQYLWRRKTMNPGDKGVKRKGSDRQREKMSVIVMAGTEDARRIISRLSGMPWVEVTATATTEHGSDLAEK
SGASRTVTGALDSDGLRELMADLDACILIDATHPFAAQATENALRACRETGTIYVRFERPEVIPDGVIRVGSFREAGEVA
SSLIGDGEVVMHLAGVSTLGDVLRSLEPERVAVRVLPSTSSIEKCLQLGVPPSHIIAMQGRFSAEMNLALLREYRAGAVI
TKESGETGGLPEKVEAASELGIPVILVERPEVNLEGEAVFGNINDLMDHVLKILRDMGQPGD

Specific function: Catalyzes the reduction of the macrocycle of cobalt- precorrin-6X into cobalt-precorrin-6Y

COG id: COG2099

COG function: function code H; Precorrin-6x reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin-6x reductase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CBIJ_METTH (O27083)

Other databases:

- EMBL:   AE000666
- PIR:   F69000
- RefSeq:   NP_276137.1
- STRING:   O27083
- GeneID:   1471410
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1002
- NMPDR:   fig|187420.1.peg.992
- eggNOG:   arNOG08036
- HOGENOM:   HBG711334
- OMA:   GNINDLM
- ProtClustDB:   CLSK342378
- BioCyc:   MTHE187420:MTH1002-MONOMER
- InterPro:   IPR003723
- TIGRFAMs:   TIGR00715

Pfam domain/function: PF02571 CbiJ

EC number: 1.3.1.54

Molecular weight: Translated: 32674; Mature: 32674

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS51014 COBK_CBIJ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTPEIKEGTEQYLWRRKTMNPGDKGVKRKGSDRQREKMSVIVMAGTEDARRIISRLSGM
CCCCCCCCHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHEEEEEEECCHHHHHHHHHHCCC
PWVEVTATATTEHGSDLAEKSGASRTVTGALDSDGLRELMADLDACILIDATHPFAAQAT
CEEEEEEEECCCCCCHHHHHCCCCEEEECCCCCHHHHHHHHCCCEEEEEECCCCCHHHHH
ENALRACRETGTIYVRFERPEVIPDGVIRVGSFREAGEVASSLIGDGEVVMHLAGVSTLG
HHHHHHHHHCCEEEEEECCCCCCCCCCEEECCCHHHHHHHHHHCCCCHHEEEHHHHHHHH
DVLRSLEPERVAVRVLPSTSSIEKCLQLGVPPSHIIAMQGRFSAEMNLALLREYRAGAVI
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCHHHEEEECCCCCCHHHHHHHHHHHCCEEE
TKESGETGGLPEKVEAASELGIPVILVERPEVNLEGEAVFGNINDLMDHVLKILRDMGQP
ECCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCEEECCHHHHHHHHHHHHHHCCCC
GD
CC
>Mature Secondary Structure
MQTPEIKEGTEQYLWRRKTMNPGDKGVKRKGSDRQREKMSVIVMAGTEDARRIISRLSGM
CCCCCCCCHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHEEEEEEECCHHHHHHHHHHCCC
PWVEVTATATTEHGSDLAEKSGASRTVTGALDSDGLRELMADLDACILIDATHPFAAQAT
CEEEEEEEECCCCCCHHHHHCCCCEEEECCCCCHHHHHHHHCCCEEEEEECCCCCHHHHH
ENALRACRETGTIYVRFERPEVIPDGVIRVGSFREAGEVASSLIGDGEVVMHLAGVSTLG
HHHHHHHHHCCEEEEEECCCCCCCCCCEEECCCHHHHHHHHHHCCCCHHEEEHHHHHHHH
DVLRSLEPERVAVRVLPSTSSIEKCLQLGVPPSHIIAMQGRFSAEMNLALLREYRAGAVI
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCHHHEEEECCCCCCHHHHHHHHHHHCCEEE
TKESGETGGLPEKVEAASELGIPVILVERPEVNLEGEAVFGNINDLMDHVLKILRDMGQP
ECCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCEEECCHHHHHHHHHHHHHHCCCC
GD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 6B; NADP+

Specific reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463