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Identifier: 15678924

GI number: 15678924

Start: 821162

End: 822499

Strand: Direct

Name: Not Available

Synonym: MTH904

Alternate gene names: 15678924

Gene position: 821162-822499 (Clockwise)

Preceding gene: 15678923

Following gene: 15678925

Centisome position: 46.89

GC content: 51.42

Gene sequence:

>1338_bases
ATGATACATGCTGAAAGGATAAGAAACCTCAACGGTGAGGAGCCAGATCTTCGCGGCAGTTACGTTGTGTACTGGATGCA
GGCATCTGTGAGGAGCCACTGGAACCATGCCCTTGAATACGCCATTGAAACCGCCAACAGTCTCAAAAAGCCCCTTATAG
TGGTTTTTGGTCTTACAGATGATTTCCCTAATGCCAATTCCCGCCATTACCGTTTCCTCATTGAGGGTCTCAGGGATGTG
AGGTCAAATCTCAGGGAAAGGGGGATTCAGCTTGTGGTTGAAAGGGACTCTCCACCATCCGTTCTTCTCAAATATGCTGA
TGATGCCGCTGCAGCTGTGACAGACAGGGGATACCTTGACATACAGAAGGAATGGGTGGATGAGGCTGCAGGTGCACTTC
ACATCCCCCTCACACAGGTTGAGTCCAACGTCATAGTACCTGTCGAAACGGCCTCAGATAAGGAGGAGTACTCCGCAGGG
ACCTTCAAACCAAAGATAAAAAGGCACCTGAAGAGATTCATGGTCCCCCTGAGGATGAGGACCCTGAAGATGGATTCCCT
GGACCTTGAACCGGGACCTGAATTTGAGGATGCTGTGAGGGACTTCAGGGCCCCTGAGGATCTTGAACCGTCAGTATTCC
GGGGCGGAACATCCACCGCCCTTTCCATCTTCAGTGAGTTTCTGAGGGAAAAACTTGAATGCTTTGAGAGGTACCGGAAC
GATCCTGTGAAGAACTGCCTCTCCAATATGAGCCCCTACCTGCATTTTGGACAGATATCCCCCCTCTACCTTGCACTGAG
GGCTTCAGAGGCCGGTGAATGTCCCGAGTTCCTGGAGGAGCTAATTGTGAGGAGGGAGCTCAGCATGAACTTTGTCCACT
ACAGTGACAGTTACTCAAGCATCAGTTGCCTCCCTGAATGGGCCCAAAGAACCCTCATGGACCATGTGGCTGATCCCAGG
GAGTATGAGTACAGCCTCAGGGAACTTGAATCCGCCAGTACCCATGATCCCTACTGGAACGCTGCGCAGCAGGAGATGGT
CATCACAGGGAAGATGCACGGCTATATGAGGATGTACTGGGGTAAGAAGATACTTGAATGGACCGATCACCCTGCAAGGG
CCTACGACATTGCCCTTTACCTCAATGACAGGTATGAAATTGATGGCAGGGACCCCAACGGATTCGCGGGAGTTGCATGG
TGCTTCGGCAAACATGACCGTGCCTGGGCTGAAAGGGAGATCTTCGGTAAGGTCAGGTACATGAATGACCGCGGACTTAA
GAGGAAGTTCAGGATAGATGAATACGTCGATAGAATCAGGGGCCTCATGGATGAGTAG

Upstream 100 bases:

>100_bases
GTTGTGAGGTTCGGAGGATATCTACCTCGAGAAACAGACACTATTCGAGCCCTACCCACGGGAGCTCGTGCCGGTAACCC
TCATCATCTGAGGGATCAGG

Downstream 100 bases:

>100_bases
AGACCACACAGCAGATGAAGAACTTTATCCTCAGGTCCAGTCACCTGGGGTCCACATAAGGATACAAAACTTTTTATCTT
CAGGTGACCAACTATCTAGG

Product: DNA deoxyribodipyrimidine photolyase (photoreactivation)

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MIHAERIRNLNGEEPDLRGSYVVYWMQASVRSHWNHALEYAIETANSLKKPLIVVFGLTDDFPNANSRHYRFLIEGLRDV
RSNLRERGIQLVVERDSPPSVLLKYADDAAAAVTDRGYLDIQKEWVDEAAGALHIPLTQVESNVIVPVETASDKEEYSAG
TFKPKIKRHLKRFMVPLRMRTLKMDSLDLEPGPEFEDAVRDFRAPEDLEPSVFRGGTSTALSIFSEFLREKLECFERYRN
DPVKNCLSNMSPYLHFGQISPLYLALRASEAGECPEFLEELIVRRELSMNFVHYSDSYSSISCLPEWAQRTLMDHVADPR
EYEYSLRELESASTHDPYWNAAQQEMVITGKMHGYMRMYWGKKILEWTDHPARAYDIALYLNDRYEIDGRDPNGFAGVAW
CFGKHDRAWAEREIFGKVRYMNDRGLKRKFRIDEYVDRIRGLMDE

Sequences:

>Translated_445_residues
MIHAERIRNLNGEEPDLRGSYVVYWMQASVRSHWNHALEYAIETANSLKKPLIVVFGLTDDFPNANSRHYRFLIEGLRDV
RSNLRERGIQLVVERDSPPSVLLKYADDAAAAVTDRGYLDIQKEWVDEAAGALHIPLTQVESNVIVPVETASDKEEYSAG
TFKPKIKRHLKRFMVPLRMRTLKMDSLDLEPGPEFEDAVRDFRAPEDLEPSVFRGGTSTALSIFSEFLREKLECFERYRN
DPVKNCLSNMSPYLHFGQISPLYLALRASEAGECPEFLEELIVRRELSMNFVHYSDSYSSISCLPEWAQRTLMDHVADPR
EYEYSLRELESASTHDPYWNAAQQEMVITGKMHGYMRMYWGKKILEWTDHPARAYDIALYLNDRYEIDGRDPNGFAGVAW
CFGKHDRAWAEREIFGKVRYMNDRGLKRKFRIDEYVDRIRGLMDE
>Mature_445_residues
MIHAERIRNLNGEEPDLRGSYVVYWMQASVRSHWNHALEYAIETANSLKKPLIVVFGLTDDFPNANSRHYRFLIEGLRDV
RSNLRERGIQLVVERDSPPSVLLKYADDAAAAVTDRGYLDIQKEWVDEAAGALHIPLTQVESNVIVPVETASDKEEYSAG
TFKPKIKRHLKRFMVPLRMRTLKMDSLDLEPGPEFEDAVRDFRAPEDLEPSVFRGGTSTALSIFSEFLREKLECFERYRN
DPVKNCLSNMSPYLHFGQISPLYLALRASEAGECPEFLEELIVRRELSMNFVHYSDSYSSISCLPEWAQRTLMDHVADPR
EYEYSLRELESASTHDPYWNAAQQEMVITGKMHGYMRMYWGKKILEWTDHPARAYDIALYLNDRYEIDGRDPNGFAGVAW
CFGKHDRAWAEREIFGKVRYMNDRGLKRKFRIDEYVDRIRGLMDE

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain

Homologues:

Organism=Drosophila melanogaster, GI24586398, Length=453, Percent_Identity=39.7350993377483, Blast_Score=298, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24586396, Length=453, Percent_Identity=39.7350993377483, Blast_Score=298, Evalue=4e-81,
Organism=Drosophila melanogaster, GI24586404, Length=153, Percent_Identity=52.2875816993464, Blast_Score=169, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PHR_METTH (P12769)

Other databases:

- EMBL:   D30752
- EMBL:   AE000666
- PIR:   A69221
- RefSeq:   NP_276041.1
- ProteinModelPortal:   P12769
- STRING:   P12769
- GeneID:   1471312
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH904
- NMPDR:   fig|187420.1.peg.896
- eggNOG:   arNOG05055
- HOGENOM:   HBG286981
- OMA:   RLNNRYF
- ProtClustDB:   CLSK878495
- BioCyc:   MTHE187420:MTH904-MONOMER
- BRENDA:   4.1.99.3
- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10211
- TIGRFAMs:   TIGR00591

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7; SSF52425 DNA_photolyase_N; SSF48173 Photolyase_FAD-bd/Cryptochr_C

EC number: =4.1.99.3

Molecular weight: Translated: 51762; Mature: 51762

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS01083 DNA_PHOTOLYASES_2_1; PS01084 DNA_PHOTOLYASES_2_2

Important sites: BINDING 239-239

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHAERIRNLNGEEPDLRGSYVVYWMQASVRSHWNHALEYAIETANSLKKPLIVVFGLTD
CCCHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
DFPNANSRHYRFLIEGLRDVRSNLRERGIQLVVERDSPPSVLLKYADDAAAAVTDRGYLD
CCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHEEEECCCHHHHHCCCCCCH
IQKEWVDEAAGALHIPLTQVESNVIVPVETASDKEEYSAGTFKPKIKRHLKRFMVPLRMR
HHHHHHHHHCCEEEEEHHHCCCCEEEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHHHHH
TLKMDSLDLEPGPEFEDAVRDFRAPEDLEPSVFRGGTSTALSIFSEFLREKLECFERYRN
HEECCCCCCCCCCCHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
DPVKNCLSNMSPYLHFGQISPLYLALRASEAGECPEFLEELIVRRELSMNFVHYSDSYSS
CHHHHHHHCCCCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCEEEEECCCCCH
ISCLPEWAQRTLMDHVADPREYEYSLRELESASTHDPYWNAAQQEMVITGKMHGYMRMYW
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECHHHHHHHHH
GKKILEWTDHPARAYDIALYLNDRYEIDGRDPNGFAGVAWCFGKHDRAWAEREIFGKVRY
CCHHHHCCCCCCCEEEEEEEECCEEEECCCCCCCCEEHHHEECCCCHHHHHHHHHHHHEE
MNDRGLKRKFRIDEYVDRIRGLMDE
ECCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIHAERIRNLNGEEPDLRGSYVVYWMQASVRSHWNHALEYAIETANSLKKPLIVVFGLTD
CCCHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
DFPNANSRHYRFLIEGLRDVRSNLRERGIQLVVERDSPPSVLLKYADDAAAAVTDRGYLD
CCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHEEEECCCHHHHHCCCCCCH
IQKEWVDEAAGALHIPLTQVESNVIVPVETASDKEEYSAGTFKPKIKRHLKRFMVPLRMR
HHHHHHHHHCCEEEEEHHHCCCCEEEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHHHHH
TLKMDSLDLEPGPEFEDAVRDFRAPEDLEPSVFRGGTSTALSIFSEFLREKLECFERYRN
HEECCCCCCCCCCCHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
DPVKNCLSNMSPYLHFGQISPLYLALRASEAGECPEFLEELIVRRELSMNFVHYSDSYSS
CHHHHHHHCCCCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCEEEEECCCCCH
ISCLPEWAQRTLMDHVADPREYEYSLRELESASTHDPYWNAAQQEMVITGKMHGYMRMYW
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECHHHHHHHHH
GKKILEWTDHPARAYDIALYLNDRYEIDGRDPNGFAGVAWCFGKHDRAWAEREIFGKVRY
CCHHHHCCCCCCCEEEEEEEECCEEEECCCCCCCCEEHHHEECCCCHHHHHHHHHHHHEE
MNDRGLKRKFRIDEYVDRIRGLMDE
ECCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7813451; 9371463