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Identifier: 15678920

GI number: 15678920

Start: 816459

End: 817556

Strand: Direct

Name: Not Available

Synonym: MTH900

Alternate gene names: 15678920

Gene position: 816459-817556 (Clockwise)

Preceding gene: 15678919

Following gene: 15678923

Centisome position: 46.62

GC content: 46.17

Gene sequence:

>1098_bases
TTGACCGGTGATTCCTGCAGTTTAGATGGTGATATCTGTCCATCAAGGCTCGGATTTCTCGATAAATATCTGACACTCTG
GATTTTCCTTGCAATGGCGGCAGGTGTTTCAATCGGATACTTCTTTCCTGAATCCCGTCAGTTCATAAACATGTTCCAGG
TGGATACAACAAGCCTCCCCATTGCCATTGGACTCATACTGATGATGTATCCTCCCCTTGCAAAGGTTCATTATGAGGAC
CTCCCTGATGTCTTCAGAAACTTCAGGATACTTGGACTTTCACTGTTGCAGAACTGGATCATTGGCCCTGTACTGATGTT
CATCCTTGCCATTGTCTTCCTGATGGACCATCCAGAATACATGATCGGTCTCATACTAATAGGACTCGCAAGGTGCATTG
CGATGGTGATAGTCTGGAATGAACTTGCCATGGGCGACAGGGAGTATGCAGCGGGGCTTGTGGCATTCAACAGCCTCTTC
CAGGTTTTCTTCTACAGCATATATGCATGGGTCTTTATAACCCTCTTACCGCCACTCTTCGGGGTTCAGGGGACTGCTAT
CGATGTCAGTATATTTGAGATAGCAAAGAGCGTCTTTATCTACCTGGGAATACCCTTCATTGCAGGATTTTTGACCAGGT
ATATCCTCCGGAGAAGGAAGGGTTCTGAGTGGTACGATACAAGGTTTATCCCCAGAATAAGTCCCCTGACACTAATGGCG
CTCCTCTTCACCATCGTGGTGATGTTCAGCCTGAAGGGAGACTATATAGTGCAGATACCCTTTGATGTGCTTCTAATCGC
CATACCCCTCATCATCTACTTCGTGTTCATGTTCCTAATATCCTTCATCCTGGCATACAGTGTGGGGGCTGATTACTCGA
AGTCATGCGCCATTTCATTTACAGCTGCAAGCAACAACTTTGAACTTGCAATAGCTGTCGCAGTGGCCGTCTTTGGTATA
GATTCGGGTGTGGCATTCGCAGCCGTTGTGGGACCGCTCATCGAAGTGCCTGTACTCATAAGCCTTGTAAATGTAGCACT
GTACTTCCAGAGGAGATTATACAAGAGGGTTAAACCAGAAAATTCTCTTTTTCATTAA

Upstream 100 bases:

>100_bases
GGAGAAACGCGGTGTATGGGTCCACTACAGTCTGGCCAGTGATGACCTCCCATCAATGATAAAGCAAGTGATTGAAGCAA
GTGATTACTAAGGTGGTATC

Downstream 100 bases:

>100_bases
AGCGGAGGATTTTGAAGGGAATCCTCCACCAGATTTATTTTTGTTTAGATCATCTGCGGTAGGACTGGGGAATCCAGACA
AGACAATCATCACGTTATTC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MTGDSCSLDGDICPSRLGFLDKYLTLWIFLAMAAGVSIGYFFPESRQFINMFQVDTTSLPIAIGLILMMYPPLAKVHYED
LPDVFRNFRILGLSLLQNWIIGPVLMFILAIVFLMDHPEYMIGLILIGLARCIAMVIVWNELAMGDREYAAGLVAFNSLF
QVFFYSIYAWVFITLLPPLFGVQGTAIDVSIFEIAKSVFIYLGIPFIAGFLTRYILRRRKGSEWYDTRFIPRISPLTLMA
LLFTIVVMFSLKGDYIVQIPFDVLLIAIPLIIYFVFMFLISFILAYSVGADYSKSCAISFTAASNNFELAIAVAVAVFGI
DSGVAFAAVVGPLIEVPVLISLVNVALYFQRRLYKRVKPENSLFH

Sequences:

>Translated_365_residues
MTGDSCSLDGDICPSRLGFLDKYLTLWIFLAMAAGVSIGYFFPESRQFINMFQVDTTSLPIAIGLILMMYPPLAKVHYED
LPDVFRNFRILGLSLLQNWIIGPVLMFILAIVFLMDHPEYMIGLILIGLARCIAMVIVWNELAMGDREYAAGLVAFNSLF
QVFFYSIYAWVFITLLPPLFGVQGTAIDVSIFEIAKSVFIYLGIPFIAGFLTRYILRRRKGSEWYDTRFIPRISPLTLMA
LLFTIVVMFSLKGDYIVQIPFDVLLIAIPLIIYFVFMFLISFILAYSVGADYSKSCAISFTAASNNFELAIAVAVAVFGI
DSGVAFAAVVGPLIEVPVLISLVNVALYFQRRLYKRVKPENSLFH
>Mature_364_residues
TGDSCSLDGDICPSRLGFLDKYLTLWIFLAMAAGVSIGYFFPESRQFINMFQVDTTSLPIAIGLILMMYPPLAKVHYEDL
PDVFRNFRILGLSLLQNWIIGPVLMFILAIVFLMDHPEYMIGLILIGLARCIAMVIVWNELAMGDREYAAGLVAFNSLFQ
VFFYSIYAWVFITLLPPLFGVQGTAIDVSIFEIAKSVFIYLGIPFIAGFLTRYILRRRKGSEWYDTRFIPRISPLTLMAL
LFTIVVMFSLKGDYIVQIPFDVLLIAIPLIIYFVFMFLISFILAYSVGADYSKSCAISFTAASNNFELAIAVAVAVFGID
SGVAFAAVVGPLIEVPVLISLVNVALYFQRRLYKRVKPENSLFH

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6325459, Length=320, Percent_Identity=35.3125, Blast_Score=159, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 41033; Mature: 40901

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGDSCSLDGDICPSRLGFLDKYLTLWIFLAMAAGVSIGYFFPESRQFINMFQVDTTSLP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCCHH
IAIGLILMMYPPLAKVHYEDLPDVFRNFRILGLSLLQNWIIGPVLMFILAIVFLMDHPEY
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
MIGLILIGLARCIAMVIVWNELAMGDREYAAGLVAFNSLFQVFFYSIYAWVFITLLPPLF
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVQGTAIDVSIFEIAKSVFIYLGIPFIAGFLTRYILRRRKGSEWYDTRFIPRISPLTLMA
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
LLFTIVVMFSLKGDYIVQIPFDVLLIAIPLIIYFVFMFLISFILAYSVGADYSKSCAISF
HHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
TAASNNFELAIAVAVAVFGIDSGVAFAAVVGPLIEVPVLISLVNVALYFQRRLYKRVKPE
EECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NSLFH
CCCCC
>Mature Secondary Structure 
TGDSCSLDGDICPSRLGFLDKYLTLWIFLAMAAGVSIGYFFPESRQFINMFQVDTTSLP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCCHH
IAIGLILMMYPPLAKVHYEDLPDVFRNFRILGLSLLQNWIIGPVLMFILAIVFLMDHPEY
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
MIGLILIGLARCIAMVIVWNELAMGDREYAAGLVAFNSLFQVFFYSIYAWVFITLLPPLF
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVQGTAIDVSIFEIAKSVFIYLGIPFIAGFLTRYILRRRKGSEWYDTRFIPRISPLTLMA
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
LLFTIVVMFSLKGDYIVQIPFDVLLIAIPLIIYFVFMFLISFILAYSVGADYSKSCAISF
HHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
TAASNNFELAIAVAVAVFGIDSGVAFAAVVGPLIEVPVLISLVNVALYFQRRLYKRVKPE
EECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NSLFH
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]