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Identifier: 15678878

GI number: 15678878

Start: 780991

End: 782001

Strand: Direct

Name: Not Available

Synonym: MTH858

Alternate gene names: 15678878

Gene position: 780991-782001 (Clockwise)

Preceding gene: 15678877

Following gene: 15678879

Centisome position: 44.59

GC content: 47.48

Gene sequence:

>1011_bases
ATGATCATACCCACAGTTCCAACAACAGATGAACTTCTTGATAAGGGATTCCGGAGGGCCAGGAAGGCCGCGTCCCTTAA
ACGGAGTTCAAAGATTCCTGGCCAGAAGAAGGCCAAGGTTATTGAGTCAACACGTGTCCAGACAGCATGTCAGGTCATAA
GGGACCGGTTGAAGATGATAATCCAGAGAATACCTGATATAGAGTCCCTTCCAGAGTTCTACCAGGACTATATAGACGTG
ACCGTGGGGGTCGATGAACTCAAAAAATCCCTCGGGGCACTTAACTGGGCTGTTGGAATACTTAACCAGCTGGAATCTGA
TTACATGGCCCGTATAAAACGTTCAAAACCGTCTGATGCATCCCATCTGAGGCGGGAGGCCTTCGGCAGGATATCATCAG
TGATAAAGAGGATCGAGGGCGACCTTGATTTTCTTGACTTTGCAAAGAATAAGTTGAGAAACATGCCCACAGTGGACCTT
GACGCCTTCACGGTCGTTATAGCAGGCTTCCCCAACGTTGGAAAATCCACACTCCTCAGGACCCTCACCGGTGCAGAGCC
TGAGGTGGCAGATTACCCCTTCACCACCAAGGGGATCCAGATAGGTCACCTTGAGCGGAAATGGAAGAGGATACAGGTTA
TAGACACACCGGGGCTCCTGGACAGACCGGTTGAGGATATGAACAACATAGAACTCCAGGCCATGGTTGCCCTTGAGAAC
ATAGCAGATGTGATAATGTTCATCTTTGACGCCTCTGAAACATGTGGATACACCCTTGAAAGCCAGTACAGCCTTTACCT
CGGCATAAGGAGCGTCTTTGACATCCCTGTGGTCACGGTCTTCAACAAGATGGATCTTGCAGAAAATGTTAAGTATCTGG
AAGAATATATTAATATGGTTGAAGATCCACTGAAAGTTTCTGCATTCGAGGGCAGAGGGGTCTCCAAGATAATAAAAAAA
CTGGAGGGGTTATATGAAAAAGAAACTCGAGAAGCCCATGACAATGTTTGA

Upstream 100 bases:

>100_bases
GTTCATGCTGAAGCTAACTGCTCATGAGGGGATTAAAGATATCTCCGCACATCAAGATAAATAGATCCACAGAAGTTACA
GGTTTAATGAGAGTGATTTT

Downstream 100 bases:

>100_bases
GAAAAGAAGGCTGATGGCTGAGAAGATGATGGAAGACATGATAAAGAACATGAGGGAGATGCAGAAAGAGTTCGAGAAGA
AAATCGCAGAGTACGCAGAG

Product: GTP1/OBG family GTP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MIIPTVPTTDELLDKGFRRARKAASLKRSSKIPGQKKAKVIESTRVQTACQVIRDRLKMIIQRIPDIESLPEFYQDYIDV
TVGVDELKKSLGALNWAVGILNQLESDYMARIKRSKPSDASHLRREAFGRISSVIKRIEGDLDFLDFAKNKLRNMPTVDL
DAFTVVIAGFPNVGKSTLLRTLTGAEPEVADYPFTTKGIQIGHLERKWKRIQVIDTPGLLDRPVEDMNNIELQAMVALEN
IADVIMFIFDASETCGYTLESQYSLYLGIRSVFDIPVVTVFNKMDLAENVKYLEEYINMVEDPLKVSAFEGRGVSKIIKK
LEGLYEKETREAHDNV

Sequences:

>Translated_336_residues
MIIPTVPTTDELLDKGFRRARKAASLKRSSKIPGQKKAKVIESTRVQTACQVIRDRLKMIIQRIPDIESLPEFYQDYIDV
TVGVDELKKSLGALNWAVGILNQLESDYMARIKRSKPSDASHLRREAFGRISSVIKRIEGDLDFLDFAKNKLRNMPTVDL
DAFTVVIAGFPNVGKSTLLRTLTGAEPEVADYPFTTKGIQIGHLERKWKRIQVIDTPGLLDRPVEDMNNIELQAMVALEN
IADVIMFIFDASETCGYTLESQYSLYLGIRSVFDIPVVTVFNKMDLAENVKYLEEYINMVEDPLKVSAFEGRGVSKIIKK
LEGLYEKETREAHDNV
>Mature_336_residues
MIIPTVPTTDELLDKGFRRARKAASLKRSSKIPGQKKAKVIESTRVQTACQVIRDRLKMIIQRIPDIESLPEFYQDYIDV
TVGVDELKKSLGALNWAVGILNQLESDYMARIKRSKPSDASHLRREAFGRISSVIKRIEGDLDFLDFAKNKLRNMPTVDL
DAFTVVIAGFPNVGKSTLLRTLTGAEPEVADYPFTTKGIQIGHLERKWKRIQVIDTPGLLDRPVEDMNNIELQAMVALEN
IADVIMFIFDASETCGYTLESQYSLYLGIRSVFDIPVVTVFNKMDLAENVKYLEEYINMVEDPLKVSAFEGRGVSKIIKK
LEGLYEKETREAHDNV

Specific function: Unknown

COG id: COG1084

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP1/OBG family. NOG subfamily [H]

Homologues:

Organism=Homo sapiens, GI55953087, Length=244, Percent_Identity=36.0655737704918, Blast_Score=182, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI25145602, Length=287, Percent_Identity=33.4494773519164, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25145600, Length=287, Percent_Identity=33.4494773519164, Blast_Score=176, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6325164, Length=313, Percent_Identity=32.2683706070287, Blast_Score=183, Evalue=3e-47,
Organism=Drosophila melanogaster, GI19921908, Length=246, Percent_Identity=36.9918699186992, Blast_Score=184, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006073
- InterPro:   IPR010674
- InterPro:   IPR005225 [H]

Pfam domain/function: PF06858 NOG1 [H]

EC number: NA

Molecular weight: Translated: 38034; Mature: 38034

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIPTVPTTDELLDKGFRRARKAASLKRSSKIPGQKKAKVIESTRVQTACQVIRDRLKMI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IQRIPDIESLPEFYQDYIDVTVGVDELKKSLGALNWAVGILNQLESDYMARIKRSKPSDA
HHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
SHLRREAFGRISSVIKRIEGDLDFLDFAKNKLRNMPTVDLDAFTVVIAGFPNVGKSTLLR
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHEECCCCCCHHHHHH
TLTGAEPEVADYPFTTKGIQIGHLERKWKRIQVIDTPGLLDRPVEDMNNIELQAMVALEN
HHCCCCCCCCCCCCCCCCEEECHHHHHHCEEEEECCCCCCCCCHHHHCCCHHHHHHHHHH
IADVIMFIFDASETCGYTLESQYSLYLGIRSVFDIPVVTVFNKMDLAENVKYLEEYINMV
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDPLKVSAFEGRGVSKIIKKLEGLYEKETREAHDNV
CCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIIPTVPTTDELLDKGFRRARKAASLKRSSKIPGQKKAKVIESTRVQTACQVIRDRLKMI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IQRIPDIESLPEFYQDYIDVTVGVDELKKSLGALNWAVGILNQLESDYMARIKRSKPSDA
HHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
SHLRREAFGRISSVIKRIEGDLDFLDFAKNKLRNMPTVDLDAFTVVIAGFPNVGKSTLLR
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHEECCCCCCHHHHHH
TLTGAEPEVADYPFTTKGIQIGHLERKWKRIQVIDTPGLLDRPVEDMNNIELQAMVALEN
HHCCCCCCCCCCCCCCCCEEECHHHHHHCEEEEECCCCCCCCCHHHHCCCHHHHHHHHHH
IADVIMFIFDASETCGYTLESQYSLYLGIRSVFDIPVVTVFNKMDLAENVKYLEEYINMV
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDPLKVSAFEGRGVSKIIKKLEGLYEKETREAHDNV
CCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]