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Identifier: 15678832

GI number: 15678832

Start: 736545

End: 738617

Strand: Direct

Name: Not Available

Synonym: MTH810

Alternate gene names: 15678832

Gene position: 736545-738617 (Clockwise)

Preceding gene: 15678831

Following gene: 15678833

Centisome position: 42.06

GC content: 51.52

Gene sequence:

>2073_bases
ATGAAGTCCCTCCCACCTGAAATGAGACAGATCCTCGGGGACTGCTACCCCCATATAAGGGAGCTGAACCCTGCCCAGAG
GAGTGCCATTGAAGCGGGTTACCTTGAATCAGAGGACAACTACATAATAGCCATACCCACAGCCAGCGGAAAGACCCTCC
TTGGTATCATTGCAGCCCTGAAAACGGTCATGGAAGGTGGGCGCGTGATCTACACAGTGCCCCTTCTATCAATCCAGAAC
GAAAAGATAAAGGAATTCCGCAAACTTGAAGAACACGGTATAAGGGTCGGTAAGGACCCGCGGACCTCTGACATCGCGGT
CATGGTCTTTGAATCCTTCGACAGCCTCACCAGGTTCTCATGGAATATCCTCCGGGAGGTTGACCTCCTCATCGTTGATG
AATTCCACATGATAGGGGAGTACACGAGGGGCCCGGTAATCGAGTCTGCAATTACAAGGGCAAGGACCCTGAATCCATCA
GTACGTATAGTTGCACTCTCTGCAACCCTCTCAAATATGGATGAAATAGCCGGATGGCTCGACGCAAGGGTTGTGGAGCA
CGACTACCGGCCTGTTCCCCTTCATCGGGAGGTCCTTGACACTGAGATGTTCGGGGTCAGGGAAAAGAACGATGTTGTCC
TCAAGGTTCTTGAGAGGTCCCTTGAGGATGGGAGCCAGACCCTCGCCTTCGTATCCACCAGGAGGTTCACAGAGTCCCTC
GCATCCCACCTTGCAGATAAGATATCAGGGAAGATACCTGATGACATGGTGGAGAGCTTCAGGGAGGTGGCCGGGAAGGT
TCTTGAGGTTCCAAAGTCCAGGGGATCCCCTCCAACCTCCACCTGCCTGAAACTTGCAGAATGCCTGGAGGCAGGGATCG
CATTCCACCATGCAGGACTCTTCAACAGGCAGCGGGAGATAATAGAGGACGAGTTCAGGGACGGGAATATACTGATGATA
ACCGCCACTCCCAGTCTCATGTACGGAGTCAACCTCCCATCAAGGACAGTTGTGATAAGGGACTACACCAGGTGGACGAG
TCAGGGCCCCAGGAGGATCCCTGTATTTGATTATGAGCAGATGTCTGGTAGGGCCGGGCGGCCCCAGTATGATGATGCCG
GCTACTCCTACCTCATAGCCAGGAGCCATGATGAGGCCATGGATCTGGAGGAGTACTACATCAGGGGTGAAGTCGAGAGG
ACGACCTCACGTATCATAGAGAACAGGGACGCCCTGTACAGACAGATAATTGCACAGGTCGCCTCCGGTCTCTCAGGAAC
CACGGAGGAGCTGGCAGATTTCTTCAGAAACACATTCTATGGGTACCAGATGGTTGAGGGTCCCTTCAGTGATTCATTCG
GGATGGACAGTATTCAGTATGAGGTCGAGAACGCCACAGAGTACCTTATGAGGAACAGGATCCTCTATCCTGGCCCTGAA
GGATTCTCCGCAACAGAGTTCGGTCTCCTCATAGCAAAATCCAATTACAGTGTGGAGACGGCCATCAAGCTCCACCAGTT
TGCATCAGAGATGGATGAGATGGACATATACCGCCTCATCTATGAGATAACAAGGACACCTGATATGCCCCTGATATCAT
TCAAGGGGAGGAAGAGCCGGGACCCTGTCCGTGATAAGCTGATGGAACATGGGCTCTTCCTAATGGACGTCGGGAACGAA
GAGGCGACGGCAGCTGCTCTGATTGAGTGGATCAATGAGAGAACAGAATATGAAATAGAGAATGCGTTTCATGTTTACGC
TGCTTCAACGAGGCGCTCGGCCTACGAAGCCTCAAAAATCGTTAAATTTTTTGGTAAGATCTGCGAGATAATGGGAGTAT
ACAGGCACTCCAGTCAACTCGAAATCCTTTCTGCAAGGCTCTATTATGGTGTGAAAGAGGATGCCATACCCCTTGTGGTT
GGTGTGAGAGGGCTTGGAAGAGTCCGGGCCCGTAAGATCATCAAAACCTTTGGTGAGGATCTGCGACATGTGCGGGAAGA
TGAACTTAAACGTATTGATGGAATCGGACCAAAAATGGCAGGGGCTATTAGAAGGTACTGTGAAAGGTTCTGA

Upstream 100 bases:

>100_bases
AAAGTGTTGAGAAGGACGATGATGGCCAGTACCCTGAAACGGCCATCAGCAACATAAGAGTCATTAAAAAGGAAAAGCTG
GAACTCTGAGGCGTGTTCAT

Downstream 100 bases:

>100_bases
TGCCCTCATAATGGCTCTGAGGAACATGGCAGCCACTCTAGGTGTGTATGATCTGATGGAGGTGCGTGTCTTCCTAGAAA
GGAGTTGCAGATTTGTTCAG

Product: DNA helicase related protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 690; Mature: 690

Protein sequence:

>690_residues
MKSLPPEMRQILGDCYPHIRELNPAQRSAIEAGYLESEDNYIIAIPTASGKTLLGIIAALKTVMEGGRVIYTVPLLSIQN
EKIKEFRKLEEHGIRVGKDPRTSDIAVMVFESFDSLTRFSWNILREVDLLIVDEFHMIGEYTRGPVIESAITRARTLNPS
VRIVALSATLSNMDEIAGWLDARVVEHDYRPVPLHREVLDTEMFGVREKNDVVLKVLERSLEDGSQTLAFVSTRRFTESL
ASHLADKISGKIPDDMVESFREVAGKVLEVPKSRGSPPTSTCLKLAECLEAGIAFHHAGLFNRQREIIEDEFRDGNILMI
TATPSLMYGVNLPSRTVVIRDYTRWTSQGPRRIPVFDYEQMSGRAGRPQYDDAGYSYLIARSHDEAMDLEEYYIRGEVER
TTSRIIENRDALYRQIIAQVASGLSGTTEELADFFRNTFYGYQMVEGPFSDSFGMDSIQYEVENATEYLMRNRILYPGPE
GFSATEFGLLIAKSNYSVETAIKLHQFASEMDEMDIYRLIYEITRTPDMPLISFKGRKSRDPVRDKLMEHGLFLMDVGNE
EATAAALIEWINERTEYEIENAFHVYAASTRRSAYEASKIVKFFGKICEIMGVYRHSSQLEILSARLYYGVKEDAIPLVV
GVRGLGRVRARKIIKTFGEDLRHVREDELKRIDGIGPKMAGAIRRYCERF

Sequences:

>Translated_690_residues
MKSLPPEMRQILGDCYPHIRELNPAQRSAIEAGYLESEDNYIIAIPTASGKTLLGIIAALKTVMEGGRVIYTVPLLSIQN
EKIKEFRKLEEHGIRVGKDPRTSDIAVMVFESFDSLTRFSWNILREVDLLIVDEFHMIGEYTRGPVIESAITRARTLNPS
VRIVALSATLSNMDEIAGWLDARVVEHDYRPVPLHREVLDTEMFGVREKNDVVLKVLERSLEDGSQTLAFVSTRRFTESL
ASHLADKISGKIPDDMVESFREVAGKVLEVPKSRGSPPTSTCLKLAECLEAGIAFHHAGLFNRQREIIEDEFRDGNILMI
TATPSLMYGVNLPSRTVVIRDYTRWTSQGPRRIPVFDYEQMSGRAGRPQYDDAGYSYLIARSHDEAMDLEEYYIRGEVER
TTSRIIENRDALYRQIIAQVASGLSGTTEELADFFRNTFYGYQMVEGPFSDSFGMDSIQYEVENATEYLMRNRILYPGPE
GFSATEFGLLIAKSNYSVETAIKLHQFASEMDEMDIYRLIYEITRTPDMPLISFKGRKSRDPVRDKLMEHGLFLMDVGNE
EATAAALIEWINERTEYEIENAFHVYAASTRRSAYEASKIVKFFGKICEIMGVYRHSSQLEILSARLYYGVKEDAIPLVV
GVRGLGRVRARKIIKTFGEDLRHVREDELKRIDGIGPKMAGAIRRYCERF
>Mature_690_residues
MKSLPPEMRQILGDCYPHIRELNPAQRSAIEAGYLESEDNYIIAIPTASGKTLLGIIAALKTVMEGGRVIYTVPLLSIQN
EKIKEFRKLEEHGIRVGKDPRTSDIAVMVFESFDSLTRFSWNILREVDLLIVDEFHMIGEYTRGPVIESAITRARTLNPS
VRIVALSATLSNMDEIAGWLDARVVEHDYRPVPLHREVLDTEMFGVREKNDVVLKVLERSLEDGSQTLAFVSTRRFTESL
ASHLADKISGKIPDDMVESFREVAGKVLEVPKSRGSPPTSTCLKLAECLEAGIAFHHAGLFNRQREIIEDEFRDGNILMI
TATPSLMYGVNLPSRTVVIRDYTRWTSQGPRRIPVFDYEQMSGRAGRPQYDDAGYSYLIARSHDEAMDLEEYYIRGEVER
TTSRIIENRDALYRQIIAQVASGLSGTTEELADFFRNTFYGYQMVEGPFSDSFGMDSIQYEVENATEYLMRNRILYPGPE
GFSATEFGLLIAKSNYSVETAIKLHQFASEMDEMDIYRLIYEITRTPDMPLISFKGRKSRDPVRDKLMEHGLFLMDVGNE
EATAAALIEWINERTEYEIENAFHVYAASTRRSAYEASKIVKFFGKICEIMGVYRHSSQLEILSARLYYGVKEDAIPLVV
GVRGLGRVRARKIIKTFGEDLRHVREDELKRIDGIGPKMAGAIRRYCERF

Specific function: Unknown

COG id: COG1204

COG function: function code R; Superfamily II helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain

Homologues:

Organism=Homo sapiens, GI139394648, Length=514, Percent_Identity=27.8210116731518, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI76880486, Length=469, Percent_Identity=28.1449893390192, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI40217847, Length=428, Percent_Identity=30.3738317757009, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI169218225, Length=426, Percent_Identity=29.81220657277, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI110556640, Length=490, Percent_Identity=25.3061224489796, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI130484567, Length=577, Percent_Identity=24.9566724436742, Blast_Score=133, Evalue=7e-31,
Organism=Homo sapiens, GI193211480, Length=424, Percent_Identity=27.8301886792453, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI67782311, Length=179, Percent_Identity=30.7262569832402, Blast_Score=68, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI86563272, Length=486, Percent_Identity=28.1893004115226, Blast_Score=158, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17537127, Length=497, Percent_Identity=29.1750503018109, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17537519, Length=495, Percent_Identity=27.0707070707071, Blast_Score=145, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17542826, Length=444, Percent_Identity=29.0540540540541, Blast_Score=126, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71995032, Length=395, Percent_Identity=26.3291139240506, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71995036, Length=101, Percent_Identity=37.6237623762376, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI133930973, Length=214, Percent_Identity=28.5046728971963, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321020, Length=483, Percent_Identity=28.7784679089027, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI9755332, Length=473, Percent_Identity=28.9640591966173, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321710, Length=478, Percent_Identity=27.6150627615063, Blast_Score=141, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6322411, Length=117, Percent_Identity=35.042735042735, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323430, Length=188, Percent_Identity=27.6595744680851, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17933644, Length=440, Percent_Identity=29.5454545454545, Blast_Score=157, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24647182, Length=468, Percent_Identity=26.9230769230769, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI28574898, Length=565, Percent_Identity=26.7256637168142, Blast_Score=149, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24660651, Length=437, Percent_Identity=27.2311212814645, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI17864608, Length=420, Percent_Identity=27.8571428571429, Blast_Score=119, Evalue=9e-27,
Organism=Drosophila melanogaster, GI17933658, Length=138, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HELS_METTH (O26901)

Other databases:

- EMBL:   AE000666
- PIR:   C69208
- RefSeq:   NP_275949.1
- ProteinModelPortal:   O26901
- STRING:   O26901
- GeneID:   1471218
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH810
- NMPDR:   fig|187420.1.peg.804
- eggNOG:   arNOG04277
- HOGENOM:   HBG551884
- ProtClustDB:   CLSK797999
- BioCyc:   MTHE187420:MTH810-MONOMER
- HAMAP:   MF_00442
- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR022965
- InterPro:   IPR003583
- InterPro:   IPR010994
- SMART:   SM00487
- SMART:   SM00490
- SMART:   SM00278

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; SSF47781 RuvA_2_like

EC number: 3.6.1.-

Molecular weight: Translated: 78511; Mature: 78511

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLPPEMRQILGDCYPHIRELNPAQRSAIEAGYLESEDNYIIAIPTASGKTLLGIIAAL
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEECCCCEEEEEECCCCHHHHHHHHHH
KTVMEGGRVIYTVPLLSIQNEKIKEFRKLEEHGIRVGKDPRTSDIAVMVFESFDSLTRFS
HHHHCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHH
WNILREVDLLIVDEFHMIGEYTRGPVIESAITRARTLNPSVRIVALSATLSNMDEIAGWL
HHHHHHHHHHEEHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHH
DARVVEHDYRPVPLHREVLDTEMFGVREKNDVVLKVLERSLEDGSQTLAFVSTRRFTESL
HHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ASHLADKISGKIPDDMVESFREVAGKVLEVPKSRGSPPTSTCLKLAECLEAGIAFHHAGL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FNRQREIIEDEFRDGNILMITATPSLMYGVNLPSRTVVIRDYTRWTSQGPRRIPVFDYEQ
HHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCCEEEEEECHHHHCCCCCCCCCCCHHH
MSGRAGRPQYDDAGYSYLIARSHDEAMDLEEYYIRGEVERTTSRIIENRDALYRQIIAQV
HCCCCCCCCCCCCCCEEEEEECCCCHHCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
ASGLSGTTEELADFFRNTFYGYQMVEGPFSDSFGMDSIQYEVENATEYLMRNRILYPGPE
HCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHEEEHHHHHHHHHHCCCCCCCCC
GFSATEFGLLIAKSNYSVETAIKLHQFASEMDEMDIYRLIYEITRTPDMPLISFKGRKSR
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
DPVRDKLMEHGLFLMDVGNEEATAAALIEWINERTEYEIENAFHVYAASTRRSAYEASKI
CHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCEECCCCEEEEEEHHHHHHHHHHHH
VKFFGKICEIMGVYRHSSQLEILSARLYYGVKEDAIPLVVGVRGLGRVRARKIIKTFGED
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHH
LRHVREDELKRIDGIGPKMAGAIRRYCERF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSLPPEMRQILGDCYPHIRELNPAQRSAIEAGYLESEDNYIIAIPTASGKTLLGIIAAL
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEECCCCEEEEEECCCCHHHHHHHHHH
KTVMEGGRVIYTVPLLSIQNEKIKEFRKLEEHGIRVGKDPRTSDIAVMVFESFDSLTRFS
HHHHCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHH
WNILREVDLLIVDEFHMIGEYTRGPVIESAITRARTLNPSVRIVALSATLSNMDEIAGWL
HHHHHHHHHHEEHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHH
DARVVEHDYRPVPLHREVLDTEMFGVREKNDVVLKVLERSLEDGSQTLAFVSTRRFTESL
HHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ASHLADKISGKIPDDMVESFREVAGKVLEVPKSRGSPPTSTCLKLAECLEAGIAFHHAGL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FNRQREIIEDEFRDGNILMITATPSLMYGVNLPSRTVVIRDYTRWTSQGPRRIPVFDYEQ
HHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCCEEEEEECHHHHCCCCCCCCCCCHHH
MSGRAGRPQYDDAGYSYLIARSHDEAMDLEEYYIRGEVERTTSRIIENRDALYRQIIAQV
HCCCCCCCCCCCCCCEEEEEECCCCHHCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
ASGLSGTTEELADFFRNTFYGYQMVEGPFSDSFGMDSIQYEVENATEYLMRNRILYPGPE
HCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHEEEHHHHHHHHHHCCCCCCCCC
GFSATEFGLLIAKSNYSVETAIKLHQFASEMDEMDIYRLIYEITRTPDMPLISFKGRKSR
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
DPVRDKLMEHGLFLMDVGNEEATAAALIEWINERTEYEIENAFHVYAASTRRSAYEASKI
CHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCEECCCCEEEEEEHHHHHHHHHHHH
VKFFGKICEIMGVYRHSSQLEILSARLYYGVKEDAIPLVVGVRGLGRVRARKIIKTFGED
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHH
LRHVREDELKRIDGIGPKMAGAIRRYCERF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463