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Identifier: 15678815

GI number: 15678815

Start: 721476

End: 722627

Strand: Direct

Name: Not Available

Synonym: MTH793

Alternate gene names: 15678815

Gene position: 721476-722627 (Clockwise)

Preceding gene: 15678814

Following gene: 15678817

Centisome position: 41.19

GC content: 54.6

Gene sequence:

>1152_bases
ATGAGGGATGTAGCAGTTATTGGAGTTTCACAGACAAAATTTGGAGAACTCTGGGATGTCTCCTTCAGGGACATGATAAC
CGAGGCCGGACTTGGGGCCATAGAGGACGCAGGAGTGGAGGGCGCAGACCTTGATGCGATGTACGTTGGTAACATGTCAG
CCGGTCTCTTCATAAAACAGGAGCATATATCCTCGCTCATCGCGGACCATGCTGGCCTGACACCCATACCCTCCACAAGG
GTTGAGGCCGCCTGTGCATCAGGGGGGCTCGCCCTCAGGAGCGGCATAATGGCGGTGGCATCAGGATACCATGACATCGT
GATAGCTGCAGGTGTTGAGAAGATGACCGACGTTGTTGACCCAACACCGGCAATTGCAACAGCATCCGACCAGGAGTGGG
AGGCCCAGCAGGGTGTCACATTCCCATCACTGTATGCCATGATGGCCAGGAGGCACATGTATGAGTACGGTACAACCAGG
GAGCAGCTCGCCATGGTCTCAGTGATAAACCATGAGAACGCCTCAAACAACCCCCGGGCCCAGTTTCCGATGAAGGTCAC
GGTTGAACAGGTCATGAACTCCACCATGGTAGCGGATCCCCTCAGGCTCCTCGACTGTTCACCGATATCTGATGGGGCCG
CAGCGGTTATACTATGCCCTGCAGACATGGCGAGGGAGTACACAGACACACCTGTCTATGTGAAGGCGTCTGCACAGGCC
TCAGGTACCATTGCACTTCATGACAGGAGGGACATAACAAGGATTGATGCAACCGTCAATGCAGCCAGAAATGCCTTCAA
GATGGCCAAGCTGACTCCAGGGGACATAGACCTTGTTGAGGTCCATGACTGTTTCAGTATAAACGGTATACTGGCTGTTG
AGGACCTTGGATTCGTCGAGAAGGGTGAAGGTGGAAGGGCCTTTGAGGATGGTATGACAAGGATTGATGGTGACATACCG
GTTAACCCATCAGGTGGGCTCAAGGCACGTGGCCATCCCCTTGGAGCCACCGGTATAGCCCAGGCAGCTGAGGTGGTATG
GCAGCTGCGTGGTGAAGCCGGTAAGAGACAGGTGGAAGGTGCTGAAATCGGCATGACCCACAACATCGGTGGAACCGGTG
GAACAGCGGCGGTCCACATATTTTCAAGGTGA

Upstream 100 bases:

>100_bases
ACCATCCGTGGCCGAGATCATCAAAAATAAGAGGTACGTCGACTATGCCTTATACGCCAAATTCAAGGGCAAACTCAGGA
TGGCTTAAGAGGGTGATAAT

Downstream 100 bases:

>100_bases
ATAATCCTTCAACCTTTTTTATTAATTTAAGAATGGCTCAGATCTGTTTGTTGATCTTTTCTTATTCCATGCGAGGGGAA
CCAAACTTTTTTTTGAACTG

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MRDVAVIGVSQTKFGELWDVSFRDMITEAGLGAIEDAGVEGADLDAMYVGNMSAGLFIKQEHISSLIADHAGLTPIPSTR
VEAACASGGLALRSGIMAVASGYHDIVIAAGVEKMTDVVDPTPAIATASDQEWEAQQGVTFPSLYAMMARRHMYEYGTTR
EQLAMVSVINHENASNNPRAQFPMKVTVEQVMNSTMVADPLRLLDCSPISDGAAAVILCPADMAREYTDTPVYVKASAQA
SGTIALHDRRDITRIDATVNAARNAFKMAKLTPGDIDLVEVHDCFSINGILAVEDLGFVEKGEGGRAFEDGMTRIDGDIP
VNPSGGLKARGHPLGATGIAQAAEVVWQLRGEAGKRQVEGAEIGMTHNIGGTGGTAAVHIFSR

Sequences:

>Translated_383_residues
MRDVAVIGVSQTKFGELWDVSFRDMITEAGLGAIEDAGVEGADLDAMYVGNMSAGLFIKQEHISSLIADHAGLTPIPSTR
VEAACASGGLALRSGIMAVASGYHDIVIAAGVEKMTDVVDPTPAIATASDQEWEAQQGVTFPSLYAMMARRHMYEYGTTR
EQLAMVSVINHENASNNPRAQFPMKVTVEQVMNSTMVADPLRLLDCSPISDGAAAVILCPADMAREYTDTPVYVKASAQA
SGTIALHDRRDITRIDATVNAARNAFKMAKLTPGDIDLVEVHDCFSINGILAVEDLGFVEKGEGGRAFEDGMTRIDGDIP
VNPSGGLKARGHPLGATGIAQAAEVVWQLRGEAGKRQVEGAEIGMTHNIGGTGGTAAVHIFSR
>Mature_383_residues
MRDVAVIGVSQTKFGELWDVSFRDMITEAGLGAIEDAGVEGADLDAMYVGNMSAGLFIKQEHISSLIADHAGLTPIPSTR
VEAACASGGLALRSGIMAVASGYHDIVIAAGVEKMTDVVDPTPAIATASDQEWEAQQGVTFPSLYAMMARRHMYEYGTTR
EQLAMVSVINHENASNNPRAQFPMKVTVEQVMNSTMVADPLRLLDCSPISDGAAAVILCPADMAREYTDTPVYVKASAQA
SGTIALHDRRDITRIDATVNAARNAFKMAKLTPGDIDLVEVHDCFSINGILAVEDLGFVEKGEGGRAFEDGMTRIDGDIP
VNPSGGLKARGHPLGATGIAQAAEVVWQLRGEAGKRQVEGAEIGMTHNIGGTGGTAAVHIFSR

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=399, Percent_Identity=35.0877192982456, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI302344760, Length=396, Percent_Identity=34.0909090909091, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI302344767, Length=324, Percent_Identity=36.4197530864198, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI302344762, Length=390, Percent_Identity=32.3076923076923, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI55956775, Length=346, Percent_Identity=29.4797687861272, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17537653, Length=392, Percent_Identity=31.6326530612245, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24585051, Length=396, Percent_Identity=34.0909090909091, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI19921506, Length=396, Percent_Identity=33.8383838383838, Blast_Score=202, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y793_METTH (O26884)

Other databases:

- EMBL:   AE000666
- PIR:   G69205
- RefSeq:   NP_275932.1
- ProteinModelPortal:   O26884
- IntAct:   O26884
- STRING:   O26884
- GeneID:   1471201
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH793
- NMPDR:   fig|187420.1.peg.787
- eggNOG:   arNOG04348
- HOGENOM:   HBG567272
- OMA:   FTIAEIC
- ProtClustDB:   PRK06064
- BioCyc:   MTHE187420:MTH793-MONOMER
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616
- Gene3D:   G3DSA:3.40.47.10
- PANTHER:   PTHR18919
- PIRSF:   PIRSF000429

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N; SSF53901 Thiolase-like

EC number: 2.3.1.16

Molecular weight: Translated: 40501; Mature: 40501

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDVAVIGVSQTKFGELWDVSFRDMITEAGLGAIEDAGVEGADLDAMYVGNMSAGLFIKQ
CCCEEEEECCCCCCCCEECCHHHHHHHHCCCCCHHHCCCCCCCCCEEEECCCCCCEEEEH
EHISSLIADHAGLTPIPSTRVEAACASGGLALRSGIMAVASGYHDIVIAAGVEKMTDVVD
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHCC
PTPAIATASDQEWEAQQGVTFPSLYAMMARRHMYEYGTTREQLAMVSVINHENASNNPRA
CCCCEECCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCC
QFPMKVTVEQVMNSTMVADPLRLLDCSPISDGAAAVILCPADMAREYTDTPVYVKASAQA
CCCCEEEHHHHHCCHHHCCCHHHEECCCCCCCCEEEEECCHHHHHHCCCCCEEEEECCCC
SGTIALHDRRDITRIDATVNAARNAFKMAKLTPGDIDLVEVHDCFSINGILAVEDLGFVE
CCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECCCCEE
KGEGGRAFEDGMTRIDGDIPVNPSGGLKARGHPLGATGIAQAAEVVWQLRGEAGKRQVEG
CCCCCCHHHHCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEECCC
AEIGMTHNIGGTGGTAAVHIFSR
CEECEEECCCCCCCCEEEEEECC
>Mature Secondary Structure
MRDVAVIGVSQTKFGELWDVSFRDMITEAGLGAIEDAGVEGADLDAMYVGNMSAGLFIKQ
CCCEEEEECCCCCCCCEECCHHHHHHHHCCCCCHHHCCCCCCCCCEEEECCCCCCEEEEH
EHISSLIADHAGLTPIPSTRVEAACASGGLALRSGIMAVASGYHDIVIAAGVEKMTDVVD
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHCC
PTPAIATASDQEWEAQQGVTFPSLYAMMARRHMYEYGTTREQLAMVSVINHENASNNPRA
CCCCEECCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCC
QFPMKVTVEQVMNSTMVADPLRLLDCSPISDGAAAVILCPADMAREYTDTPVYVKASAQA
CCCCEEEHHHHHCCHHHCCCHHHEECCCCCCCCEEEEECCHHHHHHCCCCCEEEEECCCC
SGTIALHDRRDITRIDATVNAARNAFKMAKLTPGDIDLVEVHDCFSINGILAVEDLGFVE
CCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECCCCEE
KGEGGRAFEDGMTRIDGDIPVNPSGGLKARGHPLGATGIAQAAEVVWQLRGEAGKRQVEG
CCCCCCHHHHCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEECCC
AEIGMTHNIGGTGGTAAVHIFSR
CEECEEECCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463