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Identifier: 15678814

GI number: 15678814

Start: 720414

End: 721463

Strand: Direct

Name: Not Available

Synonym: MTH792

Alternate gene names: 15678814

Gene position: 720414-721463 (Clockwise)

Preceding gene: 15678811

Following gene: 15678815

Centisome position: 41.13

GC content: 53.52

Gene sequence:

>1050_bases
GTGATACTCATGGCTGGAATAGTCGGATATGGAGTTTACATTCCATCATACAGAATAAAGGTTGAAGAAATCGCGAGGGT
CTGGGGAGACGACCCCCAGGCCATATCAAGGGGGCTGGTTGTGGAGGAAAAATCGGTCCCTGGTCCTGATGAGGACACAG
CAACAATCTCAGTTGAAGCTGCCCGTAATGCCCTCAGAAGGAGCCAGATAGATCCCTCAGAGATAGGAGCTGTCTATGTG
GGATCAGAATCCCACCCCTACGCTGTTAAGCCAACAGCAACAATCGTTGCAGAGGCTGTTGAGGCAACACCCGAGATGAC
AGCAGCTGACCTTGAGTTCGCATGTAAGGCAGGTACCGCAGGTATACAGGCCTGCATGGGACTTGTTGACTCAGGCATAA
TCAAGTACGGCCTTGCAGTCGGTGCTGACACAGCCCAGGGAGCCCCCGGTGACGCCCTTGAGTACACTGCATCAGCAGGA
GGGGCAGCCTATGTTATAGGTGGAAAGAACTGCCTTGCAGATATAAAGGAAACCTACAGCTTCACAACAGACACCCCCGA
CTTCTACAGGAGGGAGGGAATGCCCTACCCCCGGCACGGGGGAAGATTCACCGGTGAACCCGCCTACTTCAAGCATGTCC
TGGGAGCCGCGAGGGGTATGATGGAGAAGACCGGTCTCAGCGCAGATGACTTCGACTACGCGGTCTTCCACCAGCCAAAC
GGGAAGTTCTACCTGAAGGCCGCTCGCAAACTGGGATTTGAAAGCGAACAGGTTAAACCGGGACTTTTGACGCCTGTGAT
AGGGAACACCTACTCAGGTGCAACACCAGTAGGCCTTGCAGCAACCCTTGACGTTGCAGAACCAGGCGCAAGGATACTGG
CAGTGTCCTATGGTTCAGGTGCCGGGAGCGACGCCTTCATAATAGAGGTGAATGATCTCATAGAGGAGAGGCGTGACCTT
GCACCATCCGTGGCCGAGATCATCAAAAATAAGAGGTACGTCGACTATGCCTTATACGCCAAATTCAAGGGCAAACTCAG
GATGGCTTAA

Upstream 100 bases:

>100_bases
TGCCATATATCATCTATATATATCAGAAGCCATGATAGTAGAGCAAGGAATAAATACTTTAATTTTAGAATAATAACAGG
ATCCAGACTAATATTATGGT

Downstream 100 bases:

>100_bases
GAGGGTGATAATATGAGGGATGTAGCAGTTATTGGAGTTTCACAGACAAAATTTGGAGAACTCTGGGATGTCTCCTTCAG
GGACATGATAACCGAGGCCG

Product: hypothetical protein

Products: 3-oxoacyl-[acyl-carrier protein]; CO2; [acyl-carrier protein]

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MILMAGIVGYGVYIPSYRIKVEEIARVWGDDPQAISRGLVVEEKSVPGPDEDTATISVEAARNALRRSQIDPSEIGAVYV
GSESHPYAVKPTATIVAEAVEATPEMTAADLEFACKAGTAGIQACMGLVDSGIIKYGLAVGADTAQGAPGDALEYTASAG
GAAYVIGGKNCLADIKETYSFTTDTPDFYRREGMPYPRHGGRFTGEPAYFKHVLGAARGMMEKTGLSADDFDYAVFHQPN
GKFYLKAARKLGFESEQVKPGLLTPVIGNTYSGATPVGLAATLDVAEPGARILAVSYGSGAGSDAFIIEVNDLIEERRDL
APSVAEIIKNKRYVDYALYAKFKGKLRMA

Sequences:

>Translated_349_residues
MILMAGIVGYGVYIPSYRIKVEEIARVWGDDPQAISRGLVVEEKSVPGPDEDTATISVEAARNALRRSQIDPSEIGAVYV
GSESHPYAVKPTATIVAEAVEATPEMTAADLEFACKAGTAGIQACMGLVDSGIIKYGLAVGADTAQGAPGDALEYTASAG
GAAYVIGGKNCLADIKETYSFTTDTPDFYRREGMPYPRHGGRFTGEPAYFKHVLGAARGMMEKTGLSADDFDYAVFHQPN
GKFYLKAARKLGFESEQVKPGLLTPVIGNTYSGATPVGLAATLDVAEPGARILAVSYGSGAGSDAFIIEVNDLIEERRDL
APSVAEIIKNKRYVDYALYAKFKGKLRMA
>Mature_349_residues
MILMAGIVGYGVYIPSYRIKVEEIARVWGDDPQAISRGLVVEEKSVPGPDEDTATISVEAARNALRRSQIDPSEIGAVYV
GSESHPYAVKPTATIVAEAVEATPEMTAADLEFACKAGTAGIQACMGLVDSGIIKYGLAVGADTAQGAPGDALEYTASAG
GAAYVIGGKNCLADIKETYSFTTDTPDFYRREGMPYPRHGGRFTGEPAYFKHVLGAARGMMEKTGLSADDFDYAVFHQPN
GKFYLKAARKLGFESEQVKPGLLTPVIGNTYSGATPVGLAATLDVAEPGARILAVSYGSGAGSDAFIIEVNDLIEERRDL
APSVAEIIKNKRYVDYALYAKFKGKLRMA

Specific function: Catalyzes The Condensation Reaction Of Fatty Acid Synthesis By The Addition To An Acyl Acceptor Of Two Carbons From Malonyl-Acp. Catalyzes The First Condensation Reaction Which Initiates Fatty Acid Synthesis And May Therefore Play A Role In Governing The

COG id: COG3425

COG function: function code I; 3-hydroxy-3-methylglutaryl CoA synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPF0219 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013747
- InterPro:   IPR004656
- InterPro:   IPR013528
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08541 ACP_syn_III_C; PF01154 HMG_CoA_synt_N [H]

EC number: 2.3.1.41

Molecular weight: Translated: 37075; Mature: 37075

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILMAGIVGYGVYIPSYRIKVEEIARVWGDDPQAISRGLVVEEKSVPGPDEDTATISVEA
CEEEEEEHHHHEECCCEEEEHHHHHHHHCCCHHHHHCCCEEECCCCCCCCCCCEEEEHHH
ARNALRRSQIDPSEIGAVYVGSESHPYAVKPTATIVAEAVEATPEMTAADLEFACKAGTA
HHHHHHHCCCCHHHCCEEEECCCCCCEEECCHHHHHHHHHHCCCCCCHHHHHHHHCCCCH
GIQACMGLVDSGIIKYGLAVGADTAQGAPGDALEYTASAGGAAYVIGGKNCLADIKETYS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEECCCCCEEEEEECHHHHHHHHHHHC
FTTDTPDFYRREGMPYPRHGGRFTGEPAYFKHVLGAARGMMEKTGLSADDFDYAVFHQPN
CCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCC
GKFYLKAARKLGFESEQVKPGLLTPVIGNTYSGATPVGLAATLDVAEPGARILAVSYGSG
CCEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCC
AGSDAFIIEVNDLIEERRDLAPSVAEIIKNKRYVDYALYAKFKGKLRMA
CCCCEEEEEHHHHHHHHHCCCHHHHHHHCCCCEEEEEEEEEECCCEECC
>Mature Secondary Structure
MILMAGIVGYGVYIPSYRIKVEEIARVWGDDPQAISRGLVVEEKSVPGPDEDTATISVEA
CEEEEEEHHHHEECCCEEEEHHHHHHHHCCCHHHHHCCCEEECCCCCCCCCCCEEEEHHH
ARNALRRSQIDPSEIGAVYVGSESHPYAVKPTATIVAEAVEATPEMTAADLEFACKAGTA
HHHHHHHCCCCHHHCCEEEECCCCCCEEECCHHHHHHHHHHCCCCCCHHHHHHHHCCCCH
GIQACMGLVDSGIIKYGLAVGADTAQGAPGDALEYTASAGGAAYVIGGKNCLADIKETYS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEECCCCCEEEEEECHHHHHHHHHHHC
FTTDTPDFYRREGMPYPRHGGRFTGEPAYFKHVLGAARGMMEKTGLSADDFDYAVFHQPN
CCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCC
GKFYLKAARKLGFESEQVKPGLLTPVIGNTYSGATPVGLAATLDVAEPGARILAVSYGSG
CCEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCC
AGSDAFIIEVNDLIEERRDLAPSVAEIIKNKRYVDYALYAKFKGKLRMA
CCCCEEEEEHHHHHHHHHCCCHHHHHHHCCCCEEEEEEEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: 2-Mercaptoethanol; DTT; EDTA [C]

Metal ions: Phosphate [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.04 {acetyl-ACP}} 0.031 {acetyl-ACP}} 0.138 {cis-9-hexadecenoyl-ACP}} 0.017 {cis-9-hexadecenoyl-ACP}} 0.012 {cis-3-decenoyl-ACP}} [C]

Substrates: acyl-[acyl-carrier protein]; malonyl-[acyl-carrier protein]

Specific reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

General reaction: Acyl group transfer [C]

Inhibitor: Acetyl-CoA; Acyl-CoA; Iodoacetamide; N-Ethyl maleimide acyl -ACP-derivatives protect, malonyl -ACP-decarboxyl ation, [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]