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Identifier: 15678811

GI number: 15678811

Start: 715740

End: 717284

Strand: Direct

Name: Not Available

Synonym: MTH787

Alternate gene names: 15678811

Gene position: 715740-717284 (Clockwise)

Preceding gene: 15678808

Following gene: 15678814

Centisome position: 40.87

GC content: 52.94

Gene sequence:

>1545_bases
GTGGCATTGTCCACTGGATCAGGTGAGGCCATGAGTGCAAAGTGTATAATGGTTCAGGGCACATCATCGAGTGCAGGTAA
GAGCGTGATGGTCGCAGCTCTCTGCCGTATATTCTCACGGAGGGGATACAGGGTTGCGCCCTTCAAATCCCAGAACATGT
CACTGAACTCCTTCACAACAGCTGAGAACCGGGAGATAGCGGTGGCCCAGGTCCTCCAGGCAGAGGCCGCAGGGATAGAG
CCATCACACCACATGAACCCCGTCCTCCTCAAACCCAAGGAGGACTTCACATCCCAGGTAATAGTCCATGGGAGACCTGC
AGGAAACATGAACTTCCAGGACTACCAGACAGAATTCAGGGATACTGCCCTTGAGGCTATAAGGGAATCCCTTGAGTACC
TGAAGAGCAGGTATGAGCTTATAGTGATAGAGGGGGCAGGATCCCCCGCCGAGATAAACATGAGGGACAGGGACCTTGCC
AACATGGAGATCGCCCACCTTGCAGATGCCGACGTTATACTGGTGGCTGACATAGACCGTGGAGGTGTCTTCGCATCAAT
TGCAGGTACCCTGATGCTCCTTGATGAACGTGACAGGTCCCGGATAAAGGGTGTTGTCATAAACAAGTTTCGTGGTAACA
TTGACATACTGATGCCCGGCATTGAGAGGATCGAGGAGATCACAGGAGTCCCGGTGCTGGGTGTTCTGCCCTATGATGAA
GGCCTGAAACTCCCGGAGGAGGATTCAGCATCCCTCTCCCAGAGGAAGTACAGGGGAAGAGGGGATATACGGGTAGGAGT
TATGAGGCTGCCCAGGATATCAAACTTCACAGACATAGACCCCCTTGAGTACGAGGAGGACGTTGCTGTGAGGCTCATAG
AGACAGGTGACAGCCTTGATGACCTTGACGCCATCATAATCCCCGGGACCAGGAACACCATAAGCGACCTCATCCACCTT
GAGGAGAACGGCTTTGCTGACGAGATCCGGGACTTAAGCCGTGAGATACCTGTCTTTGGCATATGCGGTGGCTTTCAGAT
GCTGGGAAAGAGGATCCTTGATGATGCCCGGCAGGAGTCCAGTGAAGGCAGTGTTGATGGTCTCGGTCTTCTTGACTGTG
AGACCCACTTTACAGGTGAGGGTAAGATAATCTCCCAGAGTCAGGGAAGGGTCCTTGGTAACGGAATCTTCAGTGGTATG
AGGGGAGAGACCGTGGAGGGATATGAACTCCATGAGGGGACCACAGTCCTCGGTGATGTGAAACCCCTTCTGAGGGTTGA
CAGGGGCTTCGGGAACACCAGGAGCGGCGGATTCGATGGGGCGGTCGATGGAAACGTGGCCGGAACCTACTTCCATGGAA
TATTCCACAACTTCAGATTCAGGAGGTACTTCACAAATCTCCTCAGGGAGAGGAAGGGCATTGAACCACTGGAGTACTTG
GACGATAACTTCAGTGCATCAAGAAGGTTCTCAATCGACAGGCTGGCAGAGATCGTTGAGGAAAACATGGATCTCTCCAT
CATCGAGGAGATCCTTGAAGGATAG

Upstream 100 bases:

>100_bases
CACCAGCAATGTATTTAAGATTTTAGTGTTCAATATTGTTAGGACCAGACTCCAGTTCAGTCAGGATCAGCCTCAAGTTA
TAATAGAAAACCGTTAAGAG

Downstream 100 bases:

>100_bases
ATTTTAAGGACCCGGTCTTCATTTTCAATCTTAATTCTTTAGAGGATTAAAGGACGCCAGCATTTTAAAAGAGGCTGTTC
CATGCATTAACCAGAACAGA

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MALSTGSGEAMSAKCIMVQGTSSSAGKSVMVAALCRIFSRRGYRVAPFKSQNMSLNSFTTAENREIAVAQVLQAEAAGIE
PSHHMNPVLLKPKEDFTSQVIVHGRPAGNMNFQDYQTEFRDTALEAIRESLEYLKSRYELIVIEGAGSPAEINMRDRDLA
NMEIAHLADADVILVADIDRGGVFASIAGTLMLLDERDRSRIKGVVINKFRGNIDILMPGIERIEEITGVPVLGVLPYDE
GLKLPEEDSASLSQRKYRGRGDIRVGVMRLPRISNFTDIDPLEYEEDVAVRLIETGDSLDDLDAIIIPGTRNTISDLIHL
EENGFADEIRDLSREIPVFGICGGFQMLGKRILDDARQESSEGSVDGLGLLDCETHFTGEGKIISQSQGRVLGNGIFSGM
RGETVEGYELHEGTTVLGDVKPLLRVDRGFGNTRSGGFDGAVDGNVAGTYFHGIFHNFRFRRYFTNLLRERKGIEPLEYL
DDNFSASRRFSIDRLAEIVEENMDLSIIEEILEG

Sequences:

>Translated_514_residues
MALSTGSGEAMSAKCIMVQGTSSSAGKSVMVAALCRIFSRRGYRVAPFKSQNMSLNSFTTAENREIAVAQVLQAEAAGIE
PSHHMNPVLLKPKEDFTSQVIVHGRPAGNMNFQDYQTEFRDTALEAIRESLEYLKSRYELIVIEGAGSPAEINMRDRDLA
NMEIAHLADADVILVADIDRGGVFASIAGTLMLLDERDRSRIKGVVINKFRGNIDILMPGIERIEEITGVPVLGVLPYDE
GLKLPEEDSASLSQRKYRGRGDIRVGVMRLPRISNFTDIDPLEYEEDVAVRLIETGDSLDDLDAIIIPGTRNTISDLIHL
EENGFADEIRDLSREIPVFGICGGFQMLGKRILDDARQESSEGSVDGLGLLDCETHFTGEGKIISQSQGRVLGNGIFSGM
RGETVEGYELHEGTTVLGDVKPLLRVDRGFGNTRSGGFDGAVDGNVAGTYFHGIFHNFRFRRYFTNLLRERKGIEPLEYL
DDNFSASRRFSIDRLAEIVEENMDLSIIEEILEG
>Mature_513_residues
ALSTGSGEAMSAKCIMVQGTSSSAGKSVMVAALCRIFSRRGYRVAPFKSQNMSLNSFTTAENREIAVAQVLQAEAAGIEP
SHHMNPVLLKPKEDFTSQVIVHGRPAGNMNFQDYQTEFRDTALEAIRESLEYLKSRYELIVIEGAGSPAEINMRDRDLAN
MEIAHLADADVILVADIDRGGVFASIAGTLMLLDERDRSRIKGVVINKFRGNIDILMPGIERIEEITGVPVLGVLPYDEG
LKLPEEDSASLSQRKYRGRGDIRVGVMRLPRISNFTDIDPLEYEEDVAVRLIETGDSLDDLDAIIIPGTRNTISDLIHLE
ENGFADEIRDLSREIPVFGICGGFQMLGKRILDDARQESSEGSVDGLGLLDCETHFTGEGKIISQSQGRVLGNGIFSGMR
GETVEGYELHEGTTVLGDVKPLLRVDRGFGNTRSGGFDGAVDGNVAGTYFHGIFHNFRFRRYFTNLLRERKGIEPLEYLD
DNFSASRRFSIDRLAEIVEENMDLSIIEEILEG

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 56737; Mature: 56606

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSTGSGEAMSAKCIMVQGTSSSAGKSVMVAALCRIFSRRGYRVAPFKSQNMSLNSFTT
CCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCEEC
AENREIAVAQVLQAEAAGIEPSHHMNPVLLKPKEDFTSQVIVHGRPAGNMNFQDYQTEFR
CCCCCHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHH
DTALEAIRESLEYLKSRYELIVIEGAGSPAEINMRDRDLANMEIAHLADADVILVADIDR
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCEECCCCCCCCCCEEEEECCCCEEEEEECCC
GGVFASIAGTLMLLDERDRSRIKGVVINKFRGNIDILMPGIERIEEITGVPVLGVLPYDE
CCEEHHHHCEEEEEECCCHHHHCEEEEEECCCCEEEEECCHHHHHHHCCCCEEEEECCCC
GLKLPEEDSASLSQRKYRGRGDIRVGVMRLPRISNFTDIDPLEYEEDVAVRLIETGDSLD
CCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
DLDAIIIPGTRNTISDLIHLEENGFADEIRDLSREIPVFGICGGFQMLGKRILDDARQES
CCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCC
SEGSVDGLGLLDCETHFTGEGKIISQSQGRVLGNGIFSGMRGETVEGYELHEGTTVLGDV
CCCCCCCEEEEECCCEECCCCEEEECCCCCEEEHHHHCCCCCCCCCCEEECCCCEEECCC
KPLLRVDRGFGNTRSGGFDGAVDGNVAGTYFHGIFHNFRFRRYFTNLLRERKGIEPLEYL
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
DDNFSASRRFSIDRLAEIVEENMDLSIIEEILEG
CCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure 
ALSTGSGEAMSAKCIMVQGTSSSAGKSVMVAALCRIFSRRGYRVAPFKSQNMSLNSFTT
CCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCEEC
AENREIAVAQVLQAEAAGIEPSHHMNPVLLKPKEDFTSQVIVHGRPAGNMNFQDYQTEFR
CCCCCHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHH
DTALEAIRESLEYLKSRYELIVIEGAGSPAEINMRDRDLANMEIAHLADADVILVADIDR
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCEECCCCCCCCCCEEEEECCCCEEEEEECCC
GGVFASIAGTLMLLDERDRSRIKGVVINKFRGNIDILMPGIERIEEITGVPVLGVLPYDE
CCEEHHHHCEEEEEECCCHHHHCEEEEEECCCCEEEEECCHHHHHHHCCCCEEEEECCCC
GLKLPEEDSASLSQRKYRGRGDIRVGVMRLPRISNFTDIDPLEYEEDVAVRLIETGDSLD
CCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
DLDAIIIPGTRNTISDLIHLEENGFADEIRDLSREIPVFGICGGFQMLGKRILDDARQES
CCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCC
SEGSVDGLGLLDCETHFTGEGKIISQSQGRVLGNGIFSGMRGETVEGYELHEGTTVLGDV
CCCCCCCEEEEECCCEECCCCEEEECCCCCEEEHHHHCCCCCCCCCCEEECCCCEEECCC
KPLLRVDRGFGNTRSGGFDGAVDGNVAGTYFHGIFHNFRFRRYFTNLLRERKGIEPLEYL
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
DDNFSASRRFSIDRLAEIVEENMDLSIIEEILEG
CCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]