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Identifier: 15678783

GI number: 15678783

Start: 686690

End: 687040

Strand: Direct

Name: Not Available

Synonym: MTH758

Alternate gene names: 15678783

Gene position: 686690-687040 (Clockwise)

Preceding gene: 15678782

Following gene: 15678784

Centisome position: 39.21

GC content: 49.29

Gene sequence:

>351_bases
GTGAAGATTAAGTATGCCACCATAATAGTTGATGAGATGGAGGAGTCTGTTAAATTCTACAGGGATGTGATGGGGTTCAC
TGTAGACAGCCATTACGATCTTGGAGCCAGCGGAGAGATAACAATCCTGAGGGGTGAAGGAGAAGCCATGGTGGAGCTGA
TCAAAAACCCCACCGATAAACCCGGATTCTTTTCAATAGGAATGGAGGTCGATGACCTCGAAGCCACCCTGAATGATCTG
AGATCGCGTGGAGCAAGGGTCCTTATGGAACCGACACCAATAACGGTGGGGCTCCTGGCATTCATTGAGGACCCGAATGG
AGTCCGTATAGCCCTGATTGAGCACCGTTAA

Upstream 100 bases:

>100_bases
TTGAGATGGCTTCAGACTTCATGGTGAGGATCTACTGCAATATACATGGTCTCTGGTACTGAGACACAGGATTACCTTTT
TTTAGCCAGGAGGTCCCGAT

Downstream 100 bases:

>100_bases
TCAATAAATAAATCGTCACTCTGAAACATCCTGAACCCCAAAACTTTTATTTTCCAGAATATAAAGAAATCCAACATGAA
GCGTATCCATTTTATCAGCC

Product: S-D-lactoylglutathione methylglyoxal lyase

Products: glutathione; methylglyoxal

Alternate protein names: Lactoylglutathione Lyase LglU; Glyoxalase Family Protein; S-D-Lactoylglutathione Methylglyoxal Lyase; Lactoylglutathione Lyase

Number of amino acids: Translated: 116; Mature: 116

Protein sequence:

>116_residues
MKIKYATIIVDEMEESVKFYRDVMGFTVDSHYDLGASGEITILRGEGEAMVELIKNPTDKPGFFSIGMEVDDLEATLNDL
RSRGARVLMEPTPITVGLLAFIEDPNGVRIALIEHR

Sequences:

>Translated_116_residues
MKIKYATIIVDEMEESVKFYRDVMGFTVDSHYDLGASGEITILRGEGEAMVELIKNPTDKPGFFSIGMEVDDLEATLNDL
RSRGARVLMEPTPITVGLLAFIEDPNGVRIALIEHR
>Mature_116_residues
MKIKYATIIVDEMEESVKFYRDVMGFTVDSHYDLGASGEITILRGEGEAMVELIKNPTDKPGFFSIGMEVDDLEATLNDL
RSRGARVLMEPTPITVGLLAFIEDPNGVRIALIEHR

Specific function: Catalyzes The Conversion Of Hemimercaptal, Formed From Methylglyoxal And Glutathione, To S-Lactoylglutathione. [C]

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.4.1.5

Molecular weight: Translated: 12932; Mature: 12932

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKYATIIVDEMEESVKFYRDVMGFTVDSHYDLGASGEITILRGEGEAMVELIKNPTDK
CEEEEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCC
PGFFSIGMEVDDLEATLNDLRSRGARVLMEPTPITVGLLAFIEDPNGVRIALIEHR
CCEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEECCCCEEEEEEECC
>Mature Secondary Structure
MKIKYATIIVDEMEESVKFYRDVMGFTVDSHYDLGASGEITILRGEGEAMVELIKNPTDK
CEEEEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCC
PGFFSIGMEVDDLEATLNDLRSRGARVLMEPTPITVGLLAFIEDPNGVRIALIEHR
CCEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): 20280 [C]

Specific activity: NA

Km value (mM): 0.0272 {methylglyoxal/glutathione} [C]

Substrates: (R)-S-lactoylglutathione

Specific reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal

General reaction: addition of RSH [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA