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Identifier: 15678690

GI number: 15678690

Start: 590781

End: 592019

Strand: Direct

Name: Not Available

Synonym: MTH663

Alternate gene names: 15678690

Gene position: 590781-592019 (Clockwise)

Preceding gene: 15678689

Following gene: 15678691

Centisome position: 33.73

GC content: 53.75

Gene sequence:

>1239_bases
ATGGAGATGACTCTGATGGATGCGGTCTTAAACTCCGGTGACACTGCCTGGATGCTGGTATCAACAGCCCTGGTAATGCT
GATGACGGTTCCAGGCGTGGCACTATTCTACGGGGGTTTAACAAAAAAGGAAAACGTGCTGAACACCATGTTCCTATCCC
TGATAGCCTTCGCAGTGACGAGCATAATATGGGTACTCTACGGCTATCAGTTCGCCTTTGGAGCTGACATAATGGGGTTC
ATAGGAAGTCCAGTGAACCTGCTGATGAACGGGGTCGGTGTTAACACTGCTGCTGCACTGGCACCAACAATACCAGACTT
CCTCTACATAGCATTCCAGTTAACATTCGCAGCAATAACGGTTGCACTCATATCCGGTGCCGTCGTTGAAAGGATGAAGT
TCTCAGCCTGGCTGGCATTCATTGTGCTCTGGGTGAGCCTGGTCTACGTGCCGGTGGCCCACTGGGTATGGGGCGGAGGA
TTCCTGGCGCAGCTCGGTGCCCTGGACTTCGCAGGCGGTACTGTGGTTCACATCAACTCAGGTGTTGCAGCACTCGCACT
CGTCTACCTCCTCGGTAAGAGAAAGGACACGAGACTTCTGCCACACAACCTGGGATACTCAGTGATAGGTGCTTCACTGC
TCTGGTTCGGCTGGTTTGGATTCAACGCCGGTTCAGCACTCACGGCAGGTGGACTTGCAGCATCAGCCTTCCTGGTGACC
AACACTGCGGCGGCTGCTGGTATGGTATCATGGGTTATAATGGACTACCTCAAGGTGGGTAAACCCACAGTACTCGGCGG
AATATCCGGTGCAGTTGCTGGCCTCGTCGCCATAACACCTGCAGCAGGTTTCGTAACTGTACCTGCAGCCCTCATCATAG
GCCTTGTCACGAGCGTAATATCATACCTTGCAGTATCATACCTCAAACCAAGGCTTGGATACGACGATGCCCTGGACGTC
TTCGGAATACACGGCATGTCAGGTATATGGGGCTCAGTGGCAACAGGCCTCTTTGCAGCGCCATTCATCAACGAACTGGG
AACAGGCCTCATATACGGAAACCCTGGACAGCTGACAGCACAGGTGATAGCCGTGGCAGTTGTGGCTGCCTACTCCTTCG
TGGTGACACTGATCATCGGCAAACTCCTGGACTTCACCGTTGGTCTGAGGGTGAGCGGTAAGGAGGAGATGGAGGGCCTT
GACACCCACCTGCATGAGGAGACAGGCTACAGGATCTGA

Upstream 100 bases:

>100_bases
ATATATCAGCATCATCTTACTCTCATTGTCGGAAGTTACCTTCCTATTTCCGACTATGATATAAATTGTTGGAGAGAAAA
AATATAATTAAGAACAATAT

Downstream 100 bases:

>100_bases
GGTGATTTTCATGAAGGAAATAGTGGCCATAATAAGACCTGAAAAACTGGAGGAAGTTAAAAACGCCCTTGAAGCTGCAG
GGTGCCACGGTATGACTGTG

Product: ammonium transporter

Products: NH3 [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MEMTLMDAVLNSGDTAWMLVSTALVMLMTVPGVALFYGGLTKKENVLNTMFLSLIAFAVTSIIWVLYGYQFAFGADIMGF
IGSPVNLLMNGVGVNTAAALAPTIPDFLYIAFQLTFAAITVALISGAVVERMKFSAWLAFIVLWVSLVYVPVAHWVWGGG
FLAQLGALDFAGGTVVHINSGVAALALVYLLGKRKDTRLLPHNLGYSVIGASLLWFGWFGFNAGSALTAGGLAASAFLVT
NTAAAAGMVSWVIMDYLKVGKPTVLGGISGAVAGLVAITPAAGFVTVPAALIIGLVTSVISYLAVSYLKPRLGYDDALDV
FGIHGMSGIWGSVATGLFAAPFINELGTGLIYGNPGQLTAQVIAVAVVAAYSFVVTLIIGKLLDFTVGLRVSGKEEMEGL
DTHLHEETGYRI

Sequences:

>Translated_412_residues
MEMTLMDAVLNSGDTAWMLVSTALVMLMTVPGVALFYGGLTKKENVLNTMFLSLIAFAVTSIIWVLYGYQFAFGADIMGF
IGSPVNLLMNGVGVNTAAALAPTIPDFLYIAFQLTFAAITVALISGAVVERMKFSAWLAFIVLWVSLVYVPVAHWVWGGG
FLAQLGALDFAGGTVVHINSGVAALALVYLLGKRKDTRLLPHNLGYSVIGASLLWFGWFGFNAGSALTAGGLAASAFLVT
NTAAAAGMVSWVIMDYLKVGKPTVLGGISGAVAGLVAITPAAGFVTVPAALIIGLVTSVISYLAVSYLKPRLGYDDALDV
FGIHGMSGIWGSVATGLFAAPFINELGTGLIYGNPGQLTAQVIAVAVVAAYSFVVTLIIGKLLDFTVGLRVSGKEEMEGL
DTHLHEETGYRI
>Mature_412_residues
MEMTLMDAVLNSGDTAWMLVSTALVMLMTVPGVALFYGGLTKKENVLNTMFLSLIAFAVTSIIWVLYGYQFAFGADIMGF
IGSPVNLLMNGVGVNTAAALAPTIPDFLYIAFQLTFAAITVALISGAVVERMKFSAWLAFIVLWVSLVYVPVAHWVWGGG
FLAQLGALDFAGGTVVHINSGVAALALVYLLGKRKDTRLLPHNLGYSVIGASLLWFGWFGFNAGSALTAGGLAASAFLVT
NTAAAAGMVSWVIMDYLKVGKPTVLGGISGAVAGLVAITPAAGFVTVPAALIIGLVTSVISYLAVSYLKPRLGYDDALDV
FGIHGMSGIWGSVATGLFAAPFINELGTGLIYGNPGQLTAQVIAVAVVAAYSFVVTLIIGKLLDFTVGLRVSGKEEMEGL
DTHLHEETGYRI

Specific function: Involved In The Uptake Of Ammonia (Probable). [C]

COG id: COG0004

COG function: function code P; Ammonia permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ammonium transporter (TC 2.A.49) family

Homologues:

Organism=Escherichia coli, GI1786656, Length=409, Percent_Identity=46.6992665036675, Blast_Score=338, Evalue=5e-94,
Organism=Caenorhabditis elegans, GI17550182, Length=444, Percent_Identity=27.027027027027, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17550180, Length=443, Percent_Identity=26.410835214447, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI133931100, Length=434, Percent_Identity=27.1889400921659, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32564042, Length=315, Percent_Identity=33.6507936507937, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324187, Length=422, Percent_Identity=37.6777251184834, Blast_Score=240, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6325396, Length=421, Percent_Identity=34.2042755344418, Blast_Score=210, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6321559, Length=409, Percent_Identity=32.7628361858191, Blast_Score=200, Evalue=3e-52,
Organism=Drosophila melanogaster, GI161078314, Length=412, Percent_Identity=30.5825242718447, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y663_METTH (O26759)

Other databases:

- EMBL:   AE000666
- PIR:   C69188
- RefSeq:   NP_275805.1
- ProteinModelPortal:   O26759
- SMR:   O26759
- STRING:   O26759
- GeneID:   1470624
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH663
- NMPDR:   fig|187420.1.peg.660
- eggNOG:   arNOG05019
- HOGENOM:   HBG677626
- OMA:   KSYIAFI
- PhylomeDB:   O26759
- ProtClustDB:   CLSK878479
- BioCyc:   MTHE187420:MTH663-MONOMER
- InterPro:   IPR001905
- InterPro:   IPR018047
- PANTHER:   PTHR11730
- TIGRFAMs:   TIGR00836

Pfam domain/function: PF00909 Ammonium_transp; SSF111352 RH_like_transpt

EC number: NA

Molecular weight: Translated: 43138; Mature: 43138

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS01219 AMMONIUM_TRANSP

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10106cc4)-; HASH(0x101842b0)-; HASH(0xfdae47c)-; HASH(0xfa67f4c)-; HASH(0x1017e778)-; HASH(0xfe004a8)-; HASH(0x10216fc8)-; HASH(0xfbea3c4)-; HASH(0xfbe2240)-; HASH(0x10213dc4)-; HASH(0xf517e60)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NH3 [Periplasm] [C]

Specific reaction: NH3 [Periplasm] = NH3 [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9371463