| Definition | Methanothermobacter thermautotrophicus str. Delta H chromosome, complete genome. |
|---|---|
| Accession | NC_000916 |
| Length | 1,751,377 |
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Identifier: 15678679
GI number: 15678679
Start: 576813
End: 578924
Strand: Direct
Name: Not Available
Synonym: MTH652
Alternate gene names: 15678679
Gene position: 576813-578924 (Clockwise)
Preceding gene: 15678678
Following gene: 15678681
Centisome position: 32.93
GC content: 54.02
Gene sequence:
>2112_bases ATGATCAGTTTAAGCACAACAGCCCTGAAGGTGCTTGAGGAGAGATACCTTCTCAGGGGTGAGGGTGGTGAGGTTGTAGA GACACCAGAGGAGATGTTCAGGAGGGTTGCGCGGGCCGTTGCATCTGCAGATGAGGCCTACGGTGATGACCCTGCAGTTG CGGAGGAGGCCTTCTACTCGGTTATGGGTAACCTTGAGTTCCTCCCAAATTCCCCGACCCTCATGAATGCAGGCACGCCC ATCAACCAGCTCTCCGCCTGTTTTGTACTCCCTGTTGAGGACTCAATTGATAGTATATTCAGCTCCCTGAGGGATATGGC CATCATCCACAAATCCGGTGGGGGTGTTGGCTTCTCATTTTCAAGGTTAAGACCCAGAGGGGACATCGTCGCGTCCACAA TGGGTGTTGCCTCGGGGCCGGTGTCCTTCATGAGGATATTCGATGTTGCGGTTGACGTTATAAAGCAGGGCGGGCGAAGA AGGGGCGCCAATATGGGTGTCCTCCATGTGAGCCACCCCGACATATTCAGCTTCATAGACGCCAAGTCAAGGGAGGGTCC CCTGCGGAACTTCAACCTCTCAGTCGCCGTACCTGATGAGTTCATGGATGACCGCCCGGTGGATCTGATAAACCCCAGGA ACGGTGAGGTGGTTGACTCGGTAGAATCCAGGGTGATACTTAAGAGGATCGTGGAGGCAGCCTGGAGGTCTGGAGATCCC GGGATCCTCTTTGAGGACCGTATAAACCGCTACAACCCCACTCCACAACTCGGGAGGATAGAGGCAACCAACCCCTGTGT ATCCGGTGACACCATTGTAATGACATCCGGGGGTCCGCGGACAGTGGCTGAACTGGAGGGCAAGCCCTTCACCGCACTTA TCAGGGGCTCAGGGTACCCCTGCCCCTCAGGTTTCTTCAGGACCTGTGAACGGGACGTATATGATCTTAGAACCAGGGAG GGTCATTGCTTAAGGTTGACCCATGATCACAGGGTCCTTGTAATGGATGGTGGTCTGGAATGGCGTGCCGCCGGTGAACT TGAAAGGGGAGACCGCCTTGTGATGGATGATGCTGCAGGGGAGTTTCCGGCACTTGCAACCTTCAGAGGCCTCAGGGGCG CCGGCCGCCAGGATGTCTATGACGCCACTGTCTACGGTGCCAGTGCATTCACAGCCAATGGATTCATAGTCCACAACTGT GGGGAGCAGCCACTCCTCACCCATGAATCATGCAATCTGGGGTCAGTTAATCTCAGCCTCATGGTAGGCCCCTCCGGTAT TAACTGGGAGAAGCTCCGGAGGACCATCCATGTGGCAGTGCACTTCCTTGACAATGTGATAGACGTTAACAGCTACCCCC TCCGTCCCGTGGAGGAGATGACACTGAGAACCCGTAAGATAGGGCTGGGTGTCATGGGCTTTGCTGATATGCTGATAAAA CTTGGAATACCCTACAATTCAGTGGCTGCCCTTGAGGTGGCCGGAAGGGTAATGTCATTCATATCATCTGAGGCCAGGAG GGCCTCCATGGAACTTGCCAGAGAGAGGGGATCATTCCCTGAATTTAAGGGCAGCATATGGGATATCCAGGGATTTGAGT GCATGAGGAACGCCACATTAACCACCATAGCCCCAACTGGTTCCCTGAGTATAATAGCAGGCACCAGCAGTGGAATTGAG CCCCTATTTGCCGTGTCCTTCACAAGGAACATCCTGGGAAGGAGCTTCCATGAGCTGCACCCCCTCTTTAAGACGATGGC GGGAAGACTTGATAAGAGATCCCTTGAGGCCATAGAATCCCGGGGGAGTCTGAGGGGTGTCCCCGGGGTGCCTGCGAGGA TAAGGAGGCTCTTTGTGACTGCACATGAAATAGACCCTGTATTCCATGTTAAAATGCAGGCCGCCTTCCAGCGGTACGTG GACAATGCTGTATCAAAAACAGTGAATCTGCCAGCTGATTCATCACCTGCTGACGTTGAAAGGGTGTTCAGGGCCGCCCA TGAGCTTGGCTGCAAAGGTGTTACTGTTTACAGGTATGGCAGTAAGGTGGATGAGGTCCTGAGGTTCCCTGAATATGCGG GTTCATGCCGTGATATGACCTGTCCTAATTAA
Upstream 100 bases:
>100_bases GACCCTGTTCTGGGCCAGAGAATACTTGATGATGCCGTTGAAAGTGTTATATCAGATGTGAAAGAGCTCCTGAAGATTAT ACAGGAATTTTAGCATAAAG
Downstream 100 bases:
>100_bases TAGAAGATTTAAAGCAGGTCCTTCATGATCACCAGTTTTTTCAAGAGCATTTCTAATTAAATTAATAGAAGATTTAAAGG TGATAAAATGGACACCAGAC
Product: ribonucleotide reductase, large subunit
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 703; Mature: 703
Protein sequence:
>703_residues MISLSTTALKVLEERYLLRGEGGEVVETPEEMFRRVARAVASADEAYGDDPAVAEEAFYSVMGNLEFLPNSPTLMNAGTP INQLSACFVLPVEDSIDSIFSSLRDMAIIHKSGGGVGFSFSRLRPRGDIVASTMGVASGPVSFMRIFDVAVDVIKQGGRR RGANMGVLHVSHPDIFSFIDAKSREGPLRNFNLSVAVPDEFMDDRPVDLINPRNGEVVDSVESRVILKRIVEAAWRSGDP GILFEDRINRYNPTPQLGRIEATNPCVSGDTIVMTSGGPRTVAELEGKPFTALIRGSGYPCPSGFFRTCERDVYDLRTRE GHCLRLTHDHRVLVMDGGLEWRAAGELERGDRLVMDDAAGEFPALATFRGLRGAGRQDVYDATVYGASAFTANGFIVHNC GEQPLLTHESCNLGSVNLSLMVGPSGINWEKLRRTIHVAVHFLDNVIDVNSYPLRPVEEMTLRTRKIGLGVMGFADMLIK LGIPYNSVAALEVAGRVMSFISSEARRASMELARERGSFPEFKGSIWDIQGFECMRNATLTTIAPTGSLSIIAGTSSGIE PLFAVSFTRNILGRSFHELHPLFKTMAGRLDKRSLEAIESRGSLRGVPGVPARIRRLFVTAHEIDPVFHVKMQAAFQRYV DNAVSKTVNLPADSSPADVERVFRAAHELGCKGVTVYRYGSKVDEVLRFPEYAGSCRDMTCPN
Sequences:
>Translated_703_residues MISLSTTALKVLEERYLLRGEGGEVVETPEEMFRRVARAVASADEAYGDDPAVAEEAFYSVMGNLEFLPNSPTLMNAGTP INQLSACFVLPVEDSIDSIFSSLRDMAIIHKSGGGVGFSFSRLRPRGDIVASTMGVASGPVSFMRIFDVAVDVIKQGGRR RGANMGVLHVSHPDIFSFIDAKSREGPLRNFNLSVAVPDEFMDDRPVDLINPRNGEVVDSVESRVILKRIVEAAWRSGDP GILFEDRINRYNPTPQLGRIEATNPCVSGDTIVMTSGGPRTVAELEGKPFTALIRGSGYPCPSGFFRTCERDVYDLRTRE GHCLRLTHDHRVLVMDGGLEWRAAGELERGDRLVMDDAAGEFPALATFRGLRGAGRQDVYDATVYGASAFTANGFIVHNC GEQPLLTHESCNLGSVNLSLMVGPSGINWEKLRRTIHVAVHFLDNVIDVNSYPLRPVEEMTLRTRKIGLGVMGFADMLIK LGIPYNSVAALEVAGRVMSFISSEARRASMELARERGSFPEFKGSIWDIQGFECMRNATLTTIAPTGSLSIIAGTSSGIE PLFAVSFTRNILGRSFHELHPLFKTMAGRLDKRSLEAIESRGSLRGVPGVPARIRRLFVTAHEIDPVFHVKMQAAFQRYV DNAVSKTVNLPADSSPADVERVFRAAHELGCKGVTVYRYGSKVDEVLRFPEYAGSCRDMTCPN >Mature_703_residues MISLSTTALKVLEERYLLRGEGGEVVETPEEMFRRVARAVASADEAYGDDPAVAEEAFYSVMGNLEFLPNSPTLMNAGTP INQLSACFVLPVEDSIDSIFSSLRDMAIIHKSGGGVGFSFSRLRPRGDIVASTMGVASGPVSFMRIFDVAVDVIKQGGRR RGANMGVLHVSHPDIFSFIDAKSREGPLRNFNLSVAVPDEFMDDRPVDLINPRNGEVVDSVESRVILKRIVEAAWRSGDP GILFEDRINRYNPTPQLGRIEATNPCVSGDTIVMTSGGPRTVAELEGKPFTALIRGSGYPCPSGFFRTCERDVYDLRTRE GHCLRLTHDHRVLVMDGGLEWRAAGELERGDRLVMDDAAGEFPALATFRGLRGAGRQDVYDATVYGASAFTANGFIVHNC GEQPLLTHESCNLGSVNLSLMVGPSGINWEKLRRTIHVAVHFLDNVIDVNSYPLRPVEEMTLRTRKIGLGVMGFADMLIK LGIPYNSVAALEVAGRVMSFISSEARRASMELARERGSFPEFKGSIWDIQGFECMRNATLTTIAPTGSLSIIAGTSSGIE PLFAVSFTRNILGRSFHELHPLFKTMAGRLDKRSLEAIESRGSLRGVPGVPARIRRLFVTAHEIDPVFHVKMQAAFQRYV DNAVSKTVNLPADSSPADVERVFRAAHELGCKGVTVYRYGSKVDEVLRFPEYAGSCRDMTCPN
Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]
COG id: COG0209
COG function: function code F; Ribonucleotide reductase, alpha subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ATP-cone domain [H]
Homologues:
Organism=Homo sapiens, GI4506749, Length=297, Percent_Identity=30.976430976431, Blast_Score=133, Evalue=6e-31, Organism=Escherichia coli, GI1789030, Length=234, Percent_Identity=29.0598290598291, Blast_Score=103, Evalue=5e-23, Organism=Caenorhabditis elegans, GI17555242, Length=313, Percent_Identity=30.6709265175719, Blast_Score=138, Evalue=1e-32, Organism=Saccharomyces cerevisiae, GI6322123, Length=289, Percent_Identity=30.7958477508651, Blast_Score=134, Evalue=6e-32, Organism=Saccharomyces cerevisiae, GI6320914, Length=289, Percent_Identity=30.7958477508651, Blast_Score=132, Evalue=1e-31, Organism=Drosophila melanogaster, GI17352481, Length=291, Percent_Identity=30.9278350515464, Blast_Score=124, Evalue=2e-28,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005144 - InterPro: IPR013344 - InterPro: IPR013509 - InterPro: IPR000788 - InterPro: IPR008926 [H]
Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]
EC number: =1.17.4.1 [H]
Molecular weight: Translated: 77036; Mature: 77036
Theoretical pI: Translated: 6.57; Mature: 6.57
Prosite motif: PS50817 INTEIN_N_TER ; PS50818 INTEIN_C_TER
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.6 %Cys (Translated Protein) 3.1 %Met (Translated Protein) 4.7 %Cys+Met (Translated Protein) 1.6 %Cys (Mature Protein) 3.1 %Met (Mature Protein) 4.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MISLSTTALKVLEERYLLRGEGGEVVETPEEMFRRVARAVASADEAYGDDPAVAEEAFYS CCCCHHHHHHHHHHHHHEECCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH VMGNLEFLPNSPTLMNAGTPINQLSACFVLPVEDSIDSIFSSLRDMAIIHKSGGGVGFSF HHCCCEECCCCCCEEECCCCHHHCCEEEEEECHHHHHHHHHHHHHEEEEEECCCCCCEEH SRLRPRGDIVASTMGVASGPVSFMRIFDVAVDVIKQGGRRRGANMGVLHVSHPDIFSFID HHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHC AKSREGPLRNFNLSVAVPDEFMDDRPVDLINPRNGEVVDSVESRVILKRIVEAAWRSGDP CCCCCCCCCCCEEEEECCHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCC GILFEDRINRYNPTPQLGRIEATNPCVSGDTIVMTSGGPRTVAELEGKPFTALIRGSGYP CEEEHHHHCCCCCCCCCCEEECCCCCCCCCEEEEECCCCCCCEECCCCCEEEEEECCCCC CPSGFFRTCERDVYDLRTREGHCLRLTHDHRVLVMDGGLEWRAAGELERGDRLVMDDAAG CCCHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCEEECCCCCCCCEEEEECCCC EFPALATFRGLRGAGRQDVYDATVYGASAFTANGFIVHNCGEQPLLTHESCNLGSVNLSL CCCHHHHHHHHCCCCCCCCCHHEEECCCEEECCCEEEECCCCCCCEECCCCCCCCEEEEE MVGPSGINWEKLRRTIHVAVHFLDNVIDVNSYPLRPVEEMTLRTRKIGLGVMGFADMLIK EECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH LGIPYNSVAALEVAGRVMSFISSEARRASMELARERGSFPEFKGSIWDIQGFECMRNATL HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHCCCEE TTIAPTGSLSIIAGTSSGIEPLFAVSFTRNILGRSFHELHPLFKTMAGRLDKRSLEAIES EEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH RGSLRGVPGVPARIRRLFVTAHEIDPVFHVKMQAAFQRYVDNAVSKTVNLPADSSPADVE CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHH RVFRAAHELGCKGVTVYRYGSKVDEVLRFPEYAGSCRDMTCPN HHHHHHHHCCCCCEEEEECCCHHHHHHHCHHHCCCCCCCCCCC >Mature Secondary Structure MISLSTTALKVLEERYLLRGEGGEVVETPEEMFRRVARAVASADEAYGDDPAVAEEAFYS CCCCHHHHHHHHHHHHHEECCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH VMGNLEFLPNSPTLMNAGTPINQLSACFVLPVEDSIDSIFSSLRDMAIIHKSGGGVGFSF HHCCCEECCCCCCEEECCCCHHHCCEEEEEECHHHHHHHHHHHHHEEEEEECCCCCCEEH SRLRPRGDIVASTMGVASGPVSFMRIFDVAVDVIKQGGRRRGANMGVLHVSHPDIFSFID HHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHC AKSREGPLRNFNLSVAVPDEFMDDRPVDLINPRNGEVVDSVESRVILKRIVEAAWRSGDP CCCCCCCCCCCEEEEECCHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCC GILFEDRINRYNPTPQLGRIEATNPCVSGDTIVMTSGGPRTVAELEGKPFTALIRGSGYP CEEEHHHHCCCCCCCCCCEEECCCCCCCCCEEEEECCCCCCCEECCCCCEEEEEECCCCC CPSGFFRTCERDVYDLRTREGHCLRLTHDHRVLVMDGGLEWRAAGELERGDRLVMDDAAG CCCHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCEEECCCCCCCCEEEEECCCC EFPALATFRGLRGAGRQDVYDATVYGASAFTANGFIVHNCGEQPLLTHESCNLGSVNLSL CCCHHHHHHHHCCCCCCCCCHHEEECCCEEECCCEEEECCCCCCCEECCCCCCCCEEEEE MVGPSGINWEKLRRTIHVAVHFLDNVIDVNSYPLRPVEEMTLRTRKIGLGVMGFADMLIK EECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH LGIPYNSVAALEVAGRVMSFISSEARRASMELARERGSFPEFKGSIWDIQGFECMRNATL HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHCCCEE TTIAPTGSLSIIAGTSSGIEPLFAVSFTRNILGRSFHELHPLFKTMAGRLDKRSLEAIES EEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH RGSLRGVPGVPARIRRLFVTAHEIDPVFHVKMQAAFQRYVDNAVSKTVNLPADSSPADVE CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHH RVFRAAHELGCKGVTVYRYGSKVDEVLRFPEYAGSCRDMTCPN HHHHHHHHCCCCCEEEEECCCHHHHHHHCHHHCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9634230; 12218036 [H]