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Identifier: 15678659

GI number: 15678659

Start: 561418

End: 562395

Strand: Direct

Name: Not Available

Synonym: MTH631

Alternate gene names: 15678659

Gene position: 561418-562395 (Clockwise)

Preceding gene: 15678657

Following gene: 15678660

Centisome position: 32.06

GC content: 52.76

Gene sequence:

>978_bases
ATGATACTAATCGTTGGCGGAGCAGGATACATCGGGTCACATGTCAATAAATTTCTATCAGAGAGGGGATACGAAACCCT
CATCCTTGATAACCTCACAAGGGGCCACAGGGATTTTGTTAAGTGGGGTGAATTCATAGAGGGTAACCTGGGTGATAGGA
GACTCCTTGACAGGACCTTTGAAACCCATGACGTGGATGCGGTCATGCACTTCGCAGCATTCACAGATGTCGGTGAATCG
GTCCTCAAACCAGGAAGGTACTACCATAACAACGTCGTGAACACCATAAACCTCCTGGATTCCATGGTGGACCATGGCGT
CAGGGACTTCATATTTTCATCCACCTGTGCAGTCTACGGGAACCCCATGGAGATACCAATAAGCGAGGAACACCCCCTCA
ACCCCATAAGCCCCTATGGCAGATCCAAACTCATGGTTGAGGAGATACTGGGGGACTACAGGGATGCCTATGGTCTCAAC
TATGTCTCGCTCCGCTACTTCAATGCAGCCGGAGCAGACCCTGAAGGAGAGGTGGGGGAGCTTCATAACCCTGAAACGCA
CCTCATACCCATCGTCCTGGATGTTGCCCTGGGTCTGCGGGACGCCGTGCGGATATTCGGCACAGATTACCCAACACCCG
ACGGAACATGTGTGAGGGACTACATCCACGTTATGGACCTGGCAGATGCCCACTGGAGGGCGCTCAGATACCTTGAGGGT
GGAGAAAGCGGGGTTTTCAACCTTGGAAACGGGAACGGCTTCTCAGTCATGGAGGTTATAGAGACCTGCAGGGAGGTCAC
AGGTGCCAGTATAAATGCTGTTGAGGATGACAGAAGACCAGGTGATCCACCGGAACTCGTGGGCAGTGCCGGTAGGGCCA
GGAGGGTCCTTGGCTGGAGGCCGGAATTCACAGAACTCGAGGATATAATAGAAACCGCATGGAACTGGCATTCAAGGATC
AGAGGGGGGATCTCATGA

Upstream 100 bases:

>100_bases
ATGCAAAGGCAGACCACAAAGACCTACCCACAAAAACAGGCCACCAAACCTTATTTACATGTTAACAGAAATATAGACAG
AATCATATCTGTGTGATAAA

Downstream 100 bases:

>100_bases
TAACCGTCACAGGAGATATAACCGTTGACTGGATACAGTGGTCCGTTAAGGGAGACTCTGATGTCTCAGAATTTAACTGG
AAGAACCACCTTGGATTCAA

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MILIVGGAGYIGSHVNKFLSERGYETLILDNLTRGHRDFVKWGEFIEGNLGDRRLLDRTFETHDVDAVMHFAAFTDVGES
VLKPGRYYHNNVVNTINLLDSMVDHGVRDFIFSSTCAVYGNPMEIPISEEHPLNPISPYGRSKLMVEEILGDYRDAYGLN
YVSLRYFNAAGADPEGEVGELHNPETHLIPIVLDVALGLRDAVRIFGTDYPTPDGTCVRDYIHVMDLADAHWRALRYLEG
GESGVFNLGNGNGFSVMEVIETCREVTGASINAVEDDRRPGDPPELVGSAGRARRVLGWRPEFTELEDIIETAWNWHSRI
RGGIS

Sequences:

>Translated_325_residues
MILIVGGAGYIGSHVNKFLSERGYETLILDNLTRGHRDFVKWGEFIEGNLGDRRLLDRTFETHDVDAVMHFAAFTDVGES
VLKPGRYYHNNVVNTINLLDSMVDHGVRDFIFSSTCAVYGNPMEIPISEEHPLNPISPYGRSKLMVEEILGDYRDAYGLN
YVSLRYFNAAGADPEGEVGELHNPETHLIPIVLDVALGLRDAVRIFGTDYPTPDGTCVRDYIHVMDLADAHWRALRYLEG
GESGVFNLGNGNGFSVMEVIETCREVTGASINAVEDDRRPGDPPELVGSAGRARRVLGWRPEFTELEDIIETAWNWHSRI
RGGIS
>Mature_325_residues
MILIVGGAGYIGSHVNKFLSERGYETLILDNLTRGHRDFVKWGEFIEGNLGDRRLLDRTFETHDVDAVMHFAAFTDVGES
VLKPGRYYHNNVVNTINLLDSMVDHGVRDFIFSSTCAVYGNPMEIPISEEHPLNPISPYGRSKLMVEEILGDYRDAYGLN
YVSLRYFNAAGADPEGEVGELHNPETHLIPIVLDVALGLRDAVRIFGTDYPTPDGTCVRDYIHVMDLADAHWRALRYLEG
GESGVFNLGNGNGFSVMEVIETCREVTGASINAVEDDRRPGDPPELVGSAGRARRVLGWRPEFTELEDIIETAWNWHSRI
RGGIS

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=341, Percent_Identity=39.8826979472141, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI56118217, Length=341, Percent_Identity=39.8826979472141, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI189083684, Length=341, Percent_Identity=39.8826979472141, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI7657641, Length=329, Percent_Identity=27.0516717325228, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI42516563, Length=307, Percent_Identity=23.7785016286645, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1786974, Length=333, Percent_Identity=43.2432432432432, Blast_Score=247, Evalue=8e-67,
Organism=Escherichia coli, GI1788353, Length=351, Percent_Identity=29.0598290598291, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI48994969, Length=336, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1790049, Length=275, Percent_Identity=28.7272727272727, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788366, Length=359, Percent_Identity=24.7910863509749, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788365, Length=345, Percent_Identity=24.6376811594203, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71982035, Length=347, Percent_Identity=37.7521613832853, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71982038, Length=349, Percent_Identity=37.2492836676218, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17568069, Length=326, Percent_Identity=29.4478527607362, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI133901786, Length=289, Percent_Identity=25.6055363321799, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17539422, Length=289, Percent_Identity=25.6055363321799, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI133901788, Length=289, Percent_Identity=25.6055363321799, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17539424, Length=289, Percent_Identity=25.6055363321799, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI133901790, Length=289, Percent_Identity=25.6055363321799, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319493, Length=339, Percent_Identity=41.2979351032448, Blast_Score=238, Evalue=1e-63,
Organism=Drosophila melanogaster, GI19923002, Length=338, Percent_Identity=39.6449704142012, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI21356223, Length=307, Percent_Identity=24.1042345276873, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 36269; Mature: 36269

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILIVGGAGYIGSHVNKFLSERGYETLILDNLTRGHRDFVKWGEFIEGNLGDRRLLDRTF
CEEEEECCCHHHHHHHHHHHHCCCEEEEEHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHC
ETHDVDAVMHFAAFTDVGESVLKPGRYYHNNVVNTINLLDSMVDHGVRDFIFSSTCAVYG
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCC
NPMEIPISEEHPLNPISPYGRSKLMVEEILGDYRDAYGLNYVSLRYFNAAGADPEGEVGE
CCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCC
LHNPETHLIPIVLDVALGLRDAVRIFGTDYPTPDGTCVRDYIHVMDLADAHWRALRYLEG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GESGVFNLGNGNGFSVMEVIETCREVTGASINAVEDDRRPGDPPELVGSAGRARRVLGWR
CCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHCCC
PEFTELEDIIETAWNWHSRIRGGIS
CCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MILIVGGAGYIGSHVNKFLSERGYETLILDNLTRGHRDFVKWGEFIEGNLGDRRLLDRTF
CEEEEECCCHHHHHHHHHHHHCCCEEEEEHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHC
ETHDVDAVMHFAAFTDVGESVLKPGRYYHNNVVNTINLLDSMVDHGVRDFIFSSTCAVYG
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCC
NPMEIPISEEHPLNPISPYGRSKLMVEEILGDYRDAYGLNYVSLRYFNAAGADPEGEVGE
CCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCC
LHNPETHLIPIVLDVALGLRDAVRIFGTDYPTPDGTCVRDYIHVMDLADAHWRALRYLEG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GESGVFNLGNGNGFSVMEVIETCREVTGASINAVEDDRRPGDPPELVGSAGRARRVLGWR
CCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHCCC
PEFTELEDIIETAWNWHSRIRGGIS
CCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]