Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15678642

GI number: 15678642

Start: 548351

End: 549112

Strand: Direct

Name: Not Available

Synonym: MTH614

Alternate gene names: 15678642

Gene position: 548351-549112 (Clockwise)

Preceding gene: 15678641

Following gene: 15678645

Centisome position: 31.31

GC content: 56.96

Gene sequence:

>762_bases
ATGCTGGCACTCTCAATCGCAGGCTTCGACCCATCAGGAGGGGCGGGTATACTTGCAGATATAAAGACCTTCTCTGCCCT
GGGGGTGTACGGTGCAGGTGTCATAACCGCATTGACAGCCCAGAACGTGGGGAGGGTCTCCGGTATAATGCCAGTACCCC
CTGGATTTGTGGAGGAACAGCTCGACCTTGTGATGGAGGACCTTCCAGTTGTGCATGCAAAGACAGGAATGCTCTACAGT
GCAGAGATAGTGGAGGCCGTTGCAGAGAAGGTGCGTGAGTACGGTCTGAGGGTGATTGTTGACCCGGTCATGGTGGCTGC
ATCCGGGGGTGAACTCTCAGAGGGGAACTTTGTGAGGGCACTGAGGAGGCACCTCCTCCCTGAGGCCCTGATCGTGACAC
CCAATGTCGCTGAGGCAGAGAGGCTCTCAGATATCCCCATAGGGACCGTGGATGATGCAATAAGGGCTGCCAGGGTCATA
GGTGAACTCTGCGATGTCATAATCACGGGGGGTCACCTCGGCGGGAGGAGTGTAATCCTGATCGACGGTGATGTGGAGGT
TCTTGAGGGGAAACTTCTTGATAGCCGGAACACCCATGGGAGTGGATGCTCCTTCTCAGCTGCAACGGCAGCATACCTTG
AGAGGGGGCTTGACCTGGGGGAAGCCCTGAGGATGGCCGACGACTTTGTGAGGGAGGCCATAAGGCACGGGCACCACGGT
ACCCTCAATCAGTTCTGGATGCACGGCAGGTACCCTGAATAG

Upstream 100 bases:

>100_bases
CACGCAAGGGAGTACCTCAGAAAACTCCGCTTCACAGTTAAACCCTCCCGGGGTTCGGACAGGCTGGAGGTTTCAAGGTC
ACCCTGAAGGAGGTGAAATC

Downstream 100 bases:

>100_bases
TCCATTAACTGAAAATAATTCGGATTTTTATTTCCGGCCCCTGACGGATCATGTCATGATGAATTTTTGTGTACTGTAAG
AGTCAGATGTTTGAGTTTGA

Product: transcriptional regulator

Products: NA

Alternate protein names: Thiamine-phosphate pyrophosphorylase; TMP pyrophosphorylase; TMP-PPase; Thiamine-phosphate synthase; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MLALSIAGFDPSGGAGILADIKTFSALGVYGAGVITALTAQNVGRVSGIMPVPPGFVEEQLDLVMEDLPVVHAKTGMLYS
AEIVEAVAEKVREYGLRVIVDPVMVAASGGELSEGNFVRALRRHLLPEALIVTPNVAEAERLSDIPIGTVDDAIRAARVI
GELCDVIITGGHLGGRSVILIDGDVEVLEGKLLDSRNTHGSGCSFSAATAAYLERGLDLGEALRMADDFVREAIRHGHHG
TLNQFWMHGRYPE

Sequences:

>Translated_253_residues
MLALSIAGFDPSGGAGILADIKTFSALGVYGAGVITALTAQNVGRVSGIMPVPPGFVEEQLDLVMEDLPVVHAKTGMLYS
AEIVEAVAEKVREYGLRVIVDPVMVAASGGELSEGNFVRALRRHLLPEALIVTPNVAEAERLSDIPIGTVDDAIRAARVI
GELCDVIITGGHLGGRSVILIDGDVEVLEGKLLDSRNTHGSGCSFSAATAAYLERGLDLGEALRMADDFVREAIRHGHHG
TLNQFWMHGRYPE
>Mature_253_residues
MLALSIAGFDPSGGAGILADIKTFSALGVYGAGVITALTAQNVGRVSGIMPVPPGFVEEQLDLVMEDLPVVHAKTGMLYS
AEIVEAVAEKVREYGLRVIVDPVMVAASGGELSEGNFVRALRRHLLPEALIVTPNVAEAERLSDIPIGTVDDAIRAARVI
GELCDVIITGGHLGGRSVILIDGDVEVLEGKLLDSRNTHGSGCSFSAATAAYLERGLDLGEALRMADDFVREAIRHGHHG
TLNQFWMHGRYPE

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=242, Percent_Identity=40.495867768595, Blast_Score=160, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6325378, Length=252, Percent_Identity=30.1587301587302, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324997, Length=252, Percent_Identity=33.7301587301587, Blast_Score=105, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6324517, Length=252, Percent_Identity=32.5396825396825, Blast_Score=105, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013749
- InterPro:   IPR004399
- InterPro:   IPR022998
- InterPro:   IPR003733 [H]

Pfam domain/function: PF08543 Phos_pyr_kin; PF02581 TMP-TENI [H]

EC number: =2.5.1.3; =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 26791; Mature: 26791

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLALSIAGFDPSGGAGILADIKTFSALGVYGAGVITALTAQNVGRVSGIMPVPPGFVEEQ
CEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHH
LDLVMEDLPVVHAKTGMLYSAEIVEAVAEKVREYGLRVIVDPVMVAASGGELSEGNFVRA
HHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCEEEECHHHEEECCCCCCCCHHHHH
LRRHLLPEALIVTPNVAEAERLSDIPIGTVDDAIRAARVIGELCDVIITGGHLGGRSVIL
HHHHCCCCEEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCEEEE
IDGDVEVLEGKLLDSRNTHGSGCSFSAATAAYLERGLDLGEALRMADDFVREAIRHGHHG
ECCCHHHHHCCHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
TLNQFWMHGRYPE
CHHHHHHCCCCCC
>Mature Secondary Structure
MLALSIAGFDPSGGAGILADIKTFSALGVYGAGVITALTAQNVGRVSGIMPVPPGFVEEQ
CEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHH
LDLVMEDLPVVHAKTGMLYSAEIVEAVAEKVREYGLRVIVDPVMVAASGGELSEGNFVRA
HHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCEEEECHHHEEECCCCCCCCHHHHH
LRRHLLPEALIVTPNVAEAERLSDIPIGTVDDAIRAARVIGELCDVIITGGHLGGRSVIL
HHHHCCCCEEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCEEEE
IDGDVEVLEGKLLDSRNTHGSGCSFSAATAAYLERGLDLGEALRMADDFVREAIRHGHHG
ECCCHHHHHCCHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
TLNQFWMHGRYPE
CHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA