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Identifier: 15678641

GI number: 15678641

Start: 547666

End: 548337

Strand: Direct

Name: Not Available

Synonym: MTH613

Alternate gene names: 15678641

Gene position: 547666-548337 (Clockwise)

Preceding gene: 15678640

Following gene: 15678642

Centisome position: 31.27

GC content: 54.91

Gene sequence:

>672_bases
ATGAAGACGTGCGCCATAATACCTGTCTCACGATTCACACATGCAAAGACCCGGCTCTCACCCACCCTTTCACCATCAGA
GAGGGAGGGGCTGCTGAAGGCCATGCTCATGGATGTATCGGGGGCCCTTGCCAGACACGTGGACAGGGTCCTGGTTATAA
GTGCAGATGAGGATGTCCTGGAATACGCATACAGCCTCGGACTTAAGATACTTGAGGAGGAGGGTGAGAGGGACCTCAAC
GGGGCCCTTGAGCAGGCAATGGACTTCTGCGCCCCGGAATTTGACAGGGTGATCATAACCCCCTCAGACATACCACTGAT
AGGGAAAGCAGATGTCAGCAACCTCCTGGACCATGCATCCCGCGCAGATGTTGTTATAGCGCCGGCGAATGGTGGCGGGA
CAAACACCCTCATATTAAGACCCTCTGCAATGAGCCTCAGGTTCGGTGACTGCAGCTTCTTTGAACACATACATGAGGCC
AGGGAGAGGGGACTCAGCGTATCGGTCTATGACTCATTCTACCTATCCCTCGATGTCAACACTGCGGAGGACCTCGGTGA
GATAATACTCCACGGTGAGGGGACCCACGCAAGGGAGTACCTCAGAAAACTCCGCTTCACAGTTAAACCCTCCCGGGGTT
CGGACAGGCTGGAGGTTTCAAGGTCACCCTGA

Upstream 100 bases:

>100_bases
GTGAGGTGAACATCAACAGTTCACTTCTTAACAGGAGCCAGAGCCCATTCAAGATTTTCTCCATGCTCGAGGGTCTTAAA
AATAGGTTTGGAGCGATACC

Downstream 100 bases:

>100_bases
AGGAGGTGAAATCATGCTGGCACTCTCAATCGCAGGCTTCGACCCATCAGGAGGGGCGGGTATACTTGCAGATATAAAGA
CCTTCTCTGCCCTGGGGGTG

Product: hypothetical protein

Products: NA

Alternate protein names: LP guanylyltransferase

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MKTCAIIPVSRFTHAKTRLSPTLSPSEREGLLKAMLMDVSGALARHVDRVLVISADEDVLEYAYSLGLKILEEEGERDLN
GALEQAMDFCAPEFDRVIITPSDIPLIGKADVSNLLDHASRADVVIAPANGGGTNTLILRPSAMSLRFGDCSFFEHIHEA
RERGLSVSVYDSFYLSLDVNTAEDLGEIILHGEGTHAREYLRKLRFTVKPSRGSDRLEVSRSP

Sequences:

>Translated_223_residues
MKTCAIIPVSRFTHAKTRLSPTLSPSEREGLLKAMLMDVSGALARHVDRVLVISADEDVLEYAYSLGLKILEEEGERDLN
GALEQAMDFCAPEFDRVIITPSDIPLIGKADVSNLLDHASRADVVIAPANGGGTNTLILRPSAMSLRFGDCSFFEHIHEA
RERGLSVSVYDSFYLSLDVNTAEDLGEIILHGEGTHAREYLRKLRFTVKPSRGSDRLEVSRSP
>Mature_223_residues
MKTCAIIPVSRFTHAKTRLSPTLSPSEREGLLKAMLMDVSGALARHVDRVLVISADEDVLEYAYSLGLKILEEEGERDLN
GALEQAMDFCAPEFDRVIITPSDIPLIGKADVSNLLDHASRADVVIAPANGGGTNTLILRPSAMSLRFGDCSFFEHIHEA
RERGLSVSVYDSFYLSLDVNTAEDLGEIILHGEGTHAREYLRKLRFTVKPSRGSDRLEVSRSP

Specific function: Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor

COG id: COG1920

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CofC family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COFC_METTH (O26710)

Other databases:

- EMBL:   AE000666
- PIR:   E69181
- RefSeq:   NP_275756.1
- ProteinModelPortal:   O26710
- SMR:   O26710
- STRING:   O26710
- GeneID:   1470574
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH613
- NMPDR:   fig|187420.1.peg.611
- eggNOG:   arNOG08928
- HOGENOM:   HBG699055
- OMA:   SSAGRFN
- ProtClustDB:   CLSK876373
- BioCyc:   MTHE187420:MTH613-MONOMER
- HAMAP:   MF_02114
- InterPro:   IPR002835
- TIGRFAMs:   TIGR03552

Pfam domain/function: PF01983 DUF121

EC number: =2.7.7.68

Molecular weight: Translated: 24540; Mature: 24540

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTCAIIPVSRFTHAKTRLSPTLSPSEREGLLKAMLMDVSGALARHVDRVLVISADEDVL
CCCEEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHH
EYAYSLGLKILEEEGERDLNGALEQAMDFCAPEFDRVIITPSDIPLIGKADVSNLLDHAS
HHHHHHCHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCEECCHHHHHHHHCCC
RADVVIAPANGGGTNTLILRPSAMSLRFGDCSFFEHIHEARERGLSVSVYDSFYLSLDVN
CCCEEEECCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHCCCEEEEEEEEEEEEECC
TAEDLGEIILHGEGTHAREYLRKLRFTVKPSRGSDRLEVSRSP
CHHHHHHEEEECCCCHHHHHHHHHHEEECCCCCCCCEEECCCC
>Mature Secondary Structure
MKTCAIIPVSRFTHAKTRLSPTLSPSEREGLLKAMLMDVSGALARHVDRVLVISADEDVL
CCCEEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHH
EYAYSLGLKILEEEGERDLNGALEQAMDFCAPEFDRVIITPSDIPLIGKADVSNLLDHAS
HHHHHHCHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCEECCHHHHHHHHCCC
RADVVIAPANGGGTNTLILRPSAMSLRFGDCSFFEHIHEARERGLSVSVYDSFYLSLDVN
CCCEEEECCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHCCCEEEEEEEEEEEEECC
TAEDLGEIILHGEGTHAREYLRKLRFTVKPSRGSDRLEVSRSP
CHHHHHHEEEECCCCHHHHHHHHHHEEECCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463