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Identifier: 15678608

GI number: 15678608

Start: 519188

End: 520324

Strand: Direct

Name: Not Available

Synonym: MTH580

Alternate gene names: NA

Gene position: 519188-520324 (Clockwise)

Preceding gene: 15678607

Following gene: 15678609

Centisome position: 29.64

GC content: 55.06

Gene sequence:

>1137_bases
GTGGCGAGTGAGATGAAGTTCGCATGGCTCCTGGCCCCCGACACCTACTGGGATGAGAAGAAGACCTTCATAACGGCGGC
CCTGGAATCAGGGATAGACCACATAGTGGACACCGCCGATTCCGGGAGGATAAAGAAGCTCGGTAACCTGACCCTCATCT
CCCCTGATGAGGACGCGGATATAGTACTTGTAGGTAGGGATGGTGAGGGTGACGGGACCCTTGAACTCCCGGAGACCCTT
GAGTACTCAAGGGACATTGAAATGGCATCAGAACTCAGTGAAAGTGGAAGACAGGTTGCAGCCTACGTGGAGATAAGGAG
CAAGGCCCATGAGGAGCTTGCCAGGAGGCTCGGGCGCGTCGTTGACTACCTCATACTGGTGGGTGAGGACTGGAAGATCA
TCCCCCTGGAGAACATAATCGCAGACCTGCAGGAAGAGGATGTTAAACTCATCGCCGCGGTGGCTGACGTGGACGAGGCC
CGGGTTGCCCTTGAAACCCTTGAACACGGAACCGACGGTGTCCTCATAGAACCGGCAGACATATCCCAGATAAAGGACAT
TGCAGCCCTCCTTGAGAATATTGAAAGCGAGACCTACGAACTTAAACCCGCCACCATAACCCGCATCGAGCCCATCGGAT
CAGGTGACAGGGTCTGCGTGGACACATGCTCCATAATGGGGATAGGCGAGGGCATGCTTGTGGGTAGCTACTCACAGGGA
CTGTTCCTGGTGCACAGTGAATCCCTTGAAAGTGAGTATGTGGCATCAAGGCCCTTCCGTGTCAATGCGGGTCCTGTACA
GGCCTACGTCATGGTGCCCGGTGGCAGGACCAGGTACCTCTCGGAACTTGAAACCGGCGACGAGGTCATCATAGTGGACA
GGGATGGCAGATCACGCTCCGCGATTGTGGGGAGGGTGAAGATCGAAAAGAGGCCCCTGATGCTCGTTGAGGCAGAGTAT
GAAGGCATGAAGGTCAGGACACTCCTCCAGAATGCCGAGACAATAAGGCTCGTGAATGATAAGGGTGAACCGGTATCTGT
AAGTGAACTGGGTGAGGGTGACAGGGTCCTGGTCTACTTCGACGAATCCGCCAGGCACTTCGGGATGGCCATAAAGGAGA
CCATAATCGAGAAATGA

Upstream 100 bases:

>100_bases
AACATATTCCAGGCCGATTCACCTGCAAACATGACAGGGGCCATAGCAGGCATAGTCCATGATGGCCTGAGTGTCGAGGA
GGCCGTCAGGATACTGAAGG

Downstream 100 bases:

>100_bases
TGGTGTGTGAAGGAAGCCATGCCCCGCTACAGAAAGGGATAAAATGTACCATGTGAAGTTGATAGGGCCCTCCGAGAAGG
ATGAAGTACTCGCTGAACTC

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: DHQ synthase [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MASEMKFAWLLAPDTYWDEKKTFITAALESGIDHIVDTADSGRIKKLGNLTLISPDEDADIVLVGRDGEGDGTLELPETL
EYSRDIEMASELSESGRQVAAYVEIRSKAHEELARRLGRVVDYLILVGEDWKIIPLENIIADLQEEDVKLIAAVADVDEA
RVALETLEHGTDGVLIEPADISQIKDIAALLENIESETYELKPATITRIEPIGSGDRVCVDTCSIMGIGEGMLVGSYSQG
LFLVHSESLESEYVASRPFRVNAGPVQAYVMVPGGRTRYLSELETGDEVIIVDRDGRSRSAIVGRVKIEKRPLMLVEAEY
EGMKVRTLLQNAETIRLVNDKGEPVSVSELGEGDRVLVYFDESARHFGMAIKETIIEK

Sequences:

>Translated_378_residues
MASEMKFAWLLAPDTYWDEKKTFITAALESGIDHIVDTADSGRIKKLGNLTLISPDEDADIVLVGRDGEGDGTLELPETL
EYSRDIEMASELSESGRQVAAYVEIRSKAHEELARRLGRVVDYLILVGEDWKIIPLENIIADLQEEDVKLIAAVADVDEA
RVALETLEHGTDGVLIEPADISQIKDIAALLENIESETYELKPATITRIEPIGSGDRVCVDTCSIMGIGEGMLVGSYSQG
LFLVHSESLESEYVASRPFRVNAGPVQAYVMVPGGRTRYLSELETGDEVIIVDRDGRSRSAIVGRVKIEKRPLMLVEAEY
EGMKVRTLLQNAETIRLVNDKGEPVSVSELGEGDRVLVYFDESARHFGMAIKETIIEK
>Mature_377_residues
ASEMKFAWLLAPDTYWDEKKTFITAALESGIDHIVDTADSGRIKKLGNLTLISPDEDADIVLVGRDGEGDGTLELPETLE
YSRDIEMASELSESGRQVAAYVEIRSKAHEELARRLGRVVDYLILVGEDWKIIPLENIIADLQEEDVKLIAAVADVDEAR
VALETLEHGTDGVLIEPADISQIKDIAALLENIESETYELKPATITRIEPIGSGDRVCVDTCSIMGIGEGMLVGSYSQGL
FLVHSESLESEYVASRPFRVNAGPVQAYVMVPGGRTRYLSELETGDEVIIVDRDGRSRSAIVGRVKIEKRPLMLVEAEYE
GMKVRTLLQNAETIRLVNDKGEPVSVSELGEGDRVLVYFDESARHFGMAIKETIIEK

Specific function: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis [H]

COG id: COG1465

COG function: function code E; Predicted alternative 3-dehydroquinate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal-type DHQ synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002812
- ProDom:   PD017907 [H]

Pfam domain/function: PF01959 DHQS [H]

EC number: NA

Molecular weight: Translated: 41699; Mature: 41568

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASEMKFAWLLAPDTYWDEKKTFITAALESGIDHIVDTADSGRIKKLGNLTLISPDEDAD
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHCHHHHHCCCCCCCEEECCCEEEECCCCCCC
IVLVGRDGEGDGTLELPETLEYSRDIEMASELSESGRQVAAYVEIRSKAHEELARRLGRV
EEEEECCCCCCCEEECCHHHHHHCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHH
VDYLILVGEDWKIIPLENIIADLQEEDVKLIAAVADVDEARVALETLEHGTDGVLIEPAD
HEEEEEECCCCEEEEHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHCCCCCEEECCCC
ISQIKDIAALLENIESETYELKPATITRIEPIGSGDRVCVDTCSIMGIGEGMLVGSYSQG
HHHHHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCEEEEEEEEEEECCCCEEEECCCCC
LFLVHSESLESEYVASRPFRVNAGPVQAYVMVPGGRTRYLSELETGDEVIIVDRDGRSRS
EEEEECCCCCCHHHHCCCEEECCCCEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCCC
AIVGRVKIEKRPLMLVEAEYEGMKVRTLLQNAETIRLVNDKGEPVSVSELGEGDRVLVYF
EEEEEEEECCCCEEEEEECCCCEEHHHHHCCCCEEEEECCCCCEEEHHHCCCCCEEEEEE
DESARHFGMAIKETIIEK
CCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
ASEMKFAWLLAPDTYWDEKKTFITAALESGIDHIVDTADSGRIKKLGNLTLISPDEDAD
CCCCEEEEEECCCCCCCCCHHHHHHHHHHCHHHHHCCCCCCCEEECCCEEEECCCCCCC
IVLVGRDGEGDGTLELPETLEYSRDIEMASELSESGRQVAAYVEIRSKAHEELARRLGRV
EEEEECCCCCCCEEECCHHHHHHCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHH
VDYLILVGEDWKIIPLENIIADLQEEDVKLIAAVADVDEARVALETLEHGTDGVLIEPAD
HEEEEEECCCCEEEEHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHCCCCCEEECCCC
ISQIKDIAALLENIESETYELKPATITRIEPIGSGDRVCVDTCSIMGIGEGMLVGSYSQG
HHHHHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCEEEEEEEEEEECCCCEEEECCCCC
LFLVHSESLESEYVASRPFRVNAGPVQAYVMVPGGRTRYLSELETGDEVIIVDRDGRSRS
EEEEECCCCCCHHHHCCCEEECCCCEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCCC
AIVGRVKIEKRPLMLVEAEYEGMKVRTLLQNAETIRLVNDKGEPVSVSELGEGDRVLVYF
EEEEEEEECCCCEEEEEECCCCEEHHHHHCCCCEEEEECCCCCEEEHHHCCCCCEEEEEE
DESARHFGMAIKETIIEK
CCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]