BacMap

Definition	Methanothermobacter thermautotrophicus str. Delta H chromosome, complete genome.
Accession	NC_000916
Length	1,751,377

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The map label for this gene is Not Available

Identifier: 15678574

GI number: 15678574

Start: 491431

End: 492705

Strand: Direct

Name: Not Available

Synonym: MTH546

Alternate gene names: 15678574

Gene position: 491431-492705 (Clockwise)

Preceding gene: 15678573

Following gene: 15678579

Centisome position: 28.06

GC content: 58.27

Gene sequence:

>1275_bases
ATGAAACCCAATCTGAGGAGGGAACTCGGTCTCTTCGACGCGGTGAACCTGGTGGTGGGGACCATCGTGGGGGCCGACAT
ATACATAGTGGCTGCCTATGGCGCCGGTAGCCTTGGCCCGGCATCGATACTCGCCTGGCTGCTCGCCGGACTCATGGCCC
TCATAATCGCCCTTGTATTCTCTGAGGCCTCAGCCATGCTCCCCAGGACAGGGGGCCCCTACGTCTATGCAGGCGAGGCC
CTCGGGAGGTTCACGGGTTTCATCACCGGCTGGTCCCTCTGGGTCTCATCATGGGTTGCCATAGCTGTTTTCCCCCTTGC
CTTCATCTACTACCTTGAATACTTCATCCCCCTTGACCCCCCTGCTGAGGCCGTGATAAAGGTCCTCTTCATCCTCTCAC
TCACCATCATAAACATTGCAGGGGTCGGGAGGGCCGGTAAGGTCAACGATATCCTCACAATCCTAAAGGTCGCCCCGGTG
CTCCTCTTCGCGGTCCTGGGCGCCATACACCTTGCACTGAACCCCGGGCTCCTGGTATCAAATTACACTCCAGCTGCACC
CATGGGCCTCGGGGCCCTGGGTACTGTGACTGTCCTGGTATTCTGGGCCTATGTTGGCTTTGAGCTTGTGACAGTCCCCG
CGGATGAGGTCAGGGACCCTGAGAGGACAATACCCCTCTCCATAACACTGGGGATGATCTTTGTCACCCTATTCTACATC
CTCACCAACGCTGTTATCCTTGGCCTTGTACCCTGGAGGGTCCTTGCATCCTCAACCGCGCCCCTCACGGTGGCCGGTTA
CAGCCTCATGGGGGGCATCGGGGCCCTCATACTCACAGCGGGTGCTGTGTTCTCCATTGCCGGTTCAGAGGAGGCAGGTA
TGCTCACAACTGCAAGGCTTCTCTTTGCCATGTCAGAGGATGGGTTCCTCCCGGGCTTCCTCTCCAGGGTCCACAGGAGG
TTCGGCACCCCACACATGAGCATCCTGGTCCAGAACCTCACAGCCCTCTTAGCGGCACTTACAGGCACCGTTTCGGGCCT
CATCGAGCTCTCTGTGGTTACCCTGCTCCTCCCCTACGCTGTGACATGCATCTCACTGGCCATCCTGAGGAGGAGGGATG
GTTCAGGCATCCCCCTTAAGAGTGTTCTGGGTGTACTGGTCTGCATCTACCTCCTCATGAACACCACACCATCCACCACT
GCCTGGGGACTCCTCCTGATCCTTTCAGGGGCACCCCTCTATCTGATATTCGGATTTAAAAGGCTGCGCCGCTGA

Upstream 100 bases:

>100_bases
TCTATAGACTATCTCAAATTCCTAAGCAGTTAGAGAGTAGATAATAATCACATCTAAATTGAGGGAAAGATTAAATCCAA
CCAACTAACTTATTAAATCC

Downstream 100 bases:

>100_bases
AGGGCCTCAGATTTTTTGGAACTTAACGAAGCACCAGCAATCATCATTATCCCGTGTGAAATGTCTTGGCCCACCTCCGC
TCCCGGCGCCGGATCATATG

Product: cationic amino acid transporter related protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MKPNLRRELGLFDAVNLVVGTIVGADIYIVAAYGAGSLGPASILAWLLAGLMALIIALVFSEASAMLPRTGGPYVYAGEA
LGRFTGFITGWSLWVSSWVAIAVFPLAFIYYLEYFIPLDPPAEAVIKVLFILSLTIINIAGVGRAGKVNDILTILKVAPV
LLFAVLGAIHLALNPGLLVSNYTPAAPMGLGALGTVTVLVFWAYVGFELVTVPADEVRDPERTIPLSITLGMIFVTLFYI
LTNAVILGLVPWRVLASSTAPLTVAGYSLMGGIGALILTAGAVFSIAGSEEAGMLTTARLLFAMSEDGFLPGFLSRVHRR
FGTPHMSILVQNLTALLAALTGTVSGLIELSVVTLLLPYAVTCISLAILRRRDGSGIPLKSVLGVLVCIYLLMNTTPSTT
AWGLLLILSGAPLYLIFGFKRLRR

Sequences:

>Translated_424_residues
MKPNLRRELGLFDAVNLVVGTIVGADIYIVAAYGAGSLGPASILAWLLAGLMALIIALVFSEASAMLPRTGGPYVYAGEA
LGRFTGFITGWSLWVSSWVAIAVFPLAFIYYLEYFIPLDPPAEAVIKVLFILSLTIINIAGVGRAGKVNDILTILKVAPV
LLFAVLGAIHLALNPGLLVSNYTPAAPMGLGALGTVTVLVFWAYVGFELVTVPADEVRDPERTIPLSITLGMIFVTLFYI
LTNAVILGLVPWRVLASSTAPLTVAGYSLMGGIGALILTAGAVFSIAGSEEAGMLTTARLLFAMSEDGFLPGFLSRVHRR
FGTPHMSILVQNLTALLAALTGTVSGLIELSVVTLLLPYAVTCISLAILRRRDGSGIPLKSVLGVLVCIYLLMNTTPSTT
AWGLLLILSGAPLYLIFGFKRLRR
>Mature_424_residues
MKPNLRRELGLFDAVNLVVGTIVGADIYIVAAYGAGSLGPASILAWLLAGLMALIIALVFSEASAMLPRTGGPYVYAGEA
LGRFTGFITGWSLWVSSWVAIAVFPLAFIYYLEYFIPLDPPAEAVIKVLFILSLTIINIAGVGRAGKVNDILTILKVAPV
LLFAVLGAIHLALNPGLLVSNYTPAAPMGLGALGTVTVLVFWAYVGFELVTVPADEVRDPERTIPLSITLGMIFVTLFYI
LTNAVILGLVPWRVLASSTAPLTVAGYSLMGGIGALILTAGAVFSIAGSEEAGMLTTARLLFAMSEDGFLPGFLSRVHRR
FGTPHMSILVQNLTALLAALTGTVSGLIELSVVTLLLPYAVTCISLAILRRRDGSGIPLKSVLGVLVCIYLLMNTTPSTT
AWGLLLILSGAPLYLIFGFKRLRR

Specific function: Unknown

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI115648063, Length=360, Percent_Identity=28.8888888888889, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI115648022, Length=360, Percent_Identity=28.8888888888889, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI187423910, Length=433, Percent_Identity=27.2517321016166, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI7657591, Length=433, Percent_Identity=27.2517321016166, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI33286428, Length=440, Percent_Identity=27.9545454545455, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI186910308, Length=434, Percent_Identity=27.1889400921659, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI186910306, Length=434, Percent_Identity=27.1889400921659, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI186910304, Length=434, Percent_Identity=27.1889400921659, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI71979932, Length=445, Percent_Identity=27.1910112359551, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4507047, Length=411, Percent_Identity=26.5206812652068, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI258645169, Length=410, Percent_Identity=24.8780487804878, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI7657683, Length=399, Percent_Identity=26.3157894736842, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI258614003, Length=410, Percent_Identity=23.6585365853659, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI258614005, Length=410, Percent_Identity=23.9024390243902, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI110347453, Length=391, Percent_Identity=25.3196930946292, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI181337167, Length=405, Percent_Identity=24.1975308641975, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI9790235, Length=374, Percent_Identity=26.2032085561497, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI114326544, Length=228, Percent_Identity=25.4385964912281, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI114326550, Length=228, Percent_Identity=25.4385964912281, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI33286430, Length=226, Percent_Identity=27.8761061946903, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI2367353, Length=434, Percent_Identity=24.4239631336406, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI87082250, Length=381, Percent_Identity=24.6719160104987, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790575, Length=409, Percent_Identity=27.3838630806846, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1786789, Length=455, Percent_Identity=27.032967032967, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1786908, Length=346, Percent_Identity=27.1676300578035, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1789017, Length=386, Percent_Identity=26.4248704663212, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786302, Length=385, Percent_Identity=26.4935064935065, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788480, Length=466, Percent_Identity=24.0343347639485, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI48994972, Length=457, Percent_Identity=24.72647702407, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI87081708, Length=416, Percent_Identity=24.5192307692308, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790653, Length=331, Percent_Identity=24.773413897281, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1786602, Length=347, Percent_Identity=26.5129682997118, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI87081915, Length=342, Percent_Identity=22.8070175438596, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1787890, Length=435, Percent_Identity=23.6781609195402, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786694, Length=375, Percent_Identity=24.2666666666667, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081869, Length=454, Percent_Identity=24.0088105726872, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082023, Length=310, Percent_Identity=28.0645161290323, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=446, Percent_Identity=28.0269058295964, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17532491, Length=391, Percent_Identity=25.5754475703325, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17568033, Length=438, Percent_Identity=27.3972602739726, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17531343, Length=408, Percent_Identity=25.7352941176471, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17533459, Length=403, Percent_Identity=22.8287841191067, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI32566699, Length=413, Percent_Identity=27.3607748184019, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI193208714, Length=409, Percent_Identity=24.2053789731051, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI32566695, Length=409, Percent_Identity=24.2053789731051, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71982612, Length=447, Percent_Identity=22.5950782997763, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71982608, Length=447, Percent_Identity=22.5950782997763, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71993915, Length=458, Percent_Identity=24.6724890829694, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71995382, Length=450, Percent_Identity=22.6666666666667, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71995388, Length=453, Percent_Identity=22.7373068432671, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71990446, Length=456, Percent_Identity=22.3684210526316, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321629, Length=356, Percent_Identity=23.876404494382, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322892, Length=325, Percent_Identity=25.5384615384615, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221331183, Length=445, Percent_Identity=28.9887640449438, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17647653, Length=445, Percent_Identity=28.9887640449438, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24664379, Length=445, Percent_Identity=28.9887640449438, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24668806, Length=405, Percent_Identity=25.679012345679, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21356285, Length=405, Percent_Identity=25.679012345679, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24668802, Length=405, Percent_Identity=25.679012345679, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24641993, Length=375, Percent_Identity=28.5333333333333, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24641995, Length=375, Percent_Identity=28.5333333333333, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24666159, Length=406, Percent_Identity=23.3990147783251, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221512776, Length=406, Percent_Identity=23.3990147783251, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24651635, Length=435, Percent_Identity=26.2068965517241, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24651633, Length=435, Percent_Identity=26.2068965517241, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI45550968, Length=448, Percent_Identity=29.2410714285714, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19921172, Length=448, Percent_Identity=29.2410714285714, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24667468, Length=394, Percent_Identity=24.3654822335025, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI21357367, Length=441, Percent_Identity=25.6235827664399, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI281366235, Length=399, Percent_Identity=26.3157894736842, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI116007820, Length=399, Percent_Identity=26.3157894736842, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI116007818, Length=397, Percent_Identity=26.448362720403, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI85725152, Length=397, Percent_Identity=26.448362720403, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI161077963, Length=395, Percent_Identity=22.7848101265823, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004758
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 44909; Mature: 44909

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPNLRRELGLFDAVNLVVGTIVGADIYIVAAYGAGSLGPASILAWLLAGLMALIIALVF
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
SEASAMLPRTGGPYVYAGEALGRFTGFITGWSLWVSSWVAIAVFPLAFIYYLEYFIPLDP
HHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PAEAVIKVLFILSLTIINIAGVGRAGKVNDILTILKVAPVLLFAVLGAIHLALNPGLLVS
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
NYTPAAPMGLGALGTVTVLVFWAYVGFELVTVPADEVRDPERTIPLSITLGMIFVTLFYI
CCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECHHHCCCCCCCCCHHHHHHHHHHHHHHH
LTNAVILGLVPWRVLASSTAPLTVAGYSLMGGIGALILTAGAVFSIAGSEEAGMLTTARL
HHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHH
LFAMSEDGFLPGFLSRVHRRFGTPHMSILVQNLTALLAALTGTVSGLIELSVVTLLLPYA
HHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTCISLAILRRRDGSGIPLKSVLGVLVCIYLLMNTTPSTTAWGLLLILSGAPLYLIFGFK
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHH
RLRR
HHCC
>Mature Secondary Structure
MKPNLRRELGLFDAVNLVVGTIVGADIYIVAAYGAGSLGPASILAWLLAGLMALIIALVF
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
SEASAMLPRTGGPYVYAGEALGRFTGFITGWSLWVSSWVAIAVFPLAFIYYLEYFIPLDP
HHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PAEAVIKVLFILSLTIINIAGVGRAGKVNDILTILKVAPVLLFAVLGAIHLALNPGLLVS
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
NYTPAAPMGLGALGTVTVLVFWAYVGFELVTVPADEVRDPERTIPLSITLGMIFVTLFYI
CCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECHHHCCCCCCCCCHHHHHHHHHHHHHHH
LTNAVILGLVPWRVLASSTAPLTVAGYSLMGGIGALILTAGAVFSIAGSEEAGMLTTARL
HHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHH
LFAMSEDGFLPGFLSRVHRRFGTPHMSILVQNLTALLAALTGTVSGLIELSVVTLLLPYA
HHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTCISLAILRRRDGSGIPLKSVLGVLVCIYLLMNTTPSTTAWGLLLILSGAPLYLIFGFK
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHH
RLRR
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]