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Identifier: 15678529

GI number: 15678529

Start: 446865

End: 448505

Strand: Direct

Name: Not Available

Synonym: MTH501

Alternate gene names: 15678529

Gene position: 446865-448505 (Clockwise)

Preceding gene: 15678527

Following gene: 15678530

Centisome position: 25.52

GC content: 49.97

Gene sequence:

>1641_bases
GTGAACTTGATCAGATACGTTAATCTCAGAATAATATCAGACAGGGATGAGATAGAATCTCAGCAGAAAAGGCTGGAAAA
TATTCTGAAGGAGAGAGCAGATAAGGTCGTTGAGGGGGGTGCCGGTTTTCAGGGGGGTGAGGAGAAGGGTAAGGTATACT
GGATGTCTGACCTTGGCATATGGTACATGACCCGATTCATAGAGGGGAGCAGGTACTGGAATGGCTTCGGGACAGAGGAG
CCAGAGGAGGGAGGTAACAGGACAATCGTGTGTGAGATAAACTTTCCCCCGGAGGGTATAAACCGTAGGGTTGGGGCTGC
TATAGCGCGTGATCCCACAGGAAACTACTATGTGGTGCACAGGGGCAAACTAGGTGGGAATTACAGTAAAAGAATATTTG
AGGAGAACTACCACGGTGAATGGACAACAGTCATTGACGGTGATCGGCAAGAAAAGGTTGTGGTCATAGGAAAAATTGAT
GAGACAATCCCTGAGAAAATAAGGAACTTTGTATATGAGGTCCAGAGGATAAAGGGCATGAAAGCCGATTCTAATCTTGA
AGAAAATTTTAAGAAAGAAAGTGGGACAGACATTTACCAGCATCTTGACAAAGGAACAGGAACAGACTTTTACCAGTACC
TGCAGATTCATGGTTATCACTTCAGACCGGAACTCGTTGAGAACTTCCTCCTCTCCCTCAAGGTCAAGCCCTTCGTGATA
CTGACCGGTAACTCGGGTACAGGTAAGACGAAGCTTGCACAGCTCTACGGCAGTTACATATCCACAGAGAATGACAAAAG
GTACCTGGTCGTCCCGGTGGGTGCCAACTGGACCGAGACGAGGCACATCTTCGGCTACCTCAACATAATGACGGGGGAAT
ACCAGAGCACCCCGGCCCTGGACTTCATCATGAGGGCCTCCAGGGACCCTGACAACCCCTACATCCTGATACTCGATGAG
ATGAACCTATCACACGTTGAACGCTACTTCTCTGACTTCCTCTCAGCCATGGAGAGCGGCGAACCAGTACCACTCCATGA
TGACCCCAACTCTGAGTTCCCATCCATGATAGAGATACCCGAGAACCTCAGGGTCGTGGGAACAGTCAACGTGGATGAGA
CCACCTACATGTTCTCACCGAAGGTCCTTGACCGGGCAAACACCATAGAATTCGAAACCCTCAGGCCAGGGGAGTATCTT
AACGGCACCCCCCACGACCAGGGCCCAGCAGGGGACACAGAATTCCTTGAAGACATCATGGAATACAGCAATGATAACAT
GAAGGACGACCTCCACATGGTATGGGATGAACTTGTGGCTGAACTTGACTTCTTCCATGAAACCCTCACAACCCCAGGAT
TCGACTTCGGCTTCAGGGTGACAGATGAGATCCTCAGATTCATGCATGCAGCCTGGATCTACGAGAAAAGACCCCGGGAA
TGGGAAAACTGGGAGCGCTACCTTGACGCCCAGATCAAACAGAAGATCCTCCCCAAGATCCACGGCCCCGAAAGACTCCT
CAGGGACACACTCGATAAACTCAAAGAACACTGCCAGGGCAGATTCCCTGAATCAGAGAAGAAGCTTGAGGAGATGCAGA
ACACCCTGAAAACCCAGCGCTACGCCTCCTTCATCAGGTAG

Upstream 100 bases:

>100_bases
ATCCCTGAGGCCAAAGGTGGAGTACCTGTCAATTCCATTTAACTTTCTGGCTCTCATCATAAACTAAATATTGAGATGGG
GATAAATAAGGCTGTGGGGT

Downstream 100 bases:

>100_bases
TGATCACCGATGGACCAGGAGATAATCATAGAATTCAGGGCAGGGAGACTGAGGATAAATGGGGGTCCAGCGCCCATTGA
AGTACCTCCCAGGATGGTGA

Product: 5-methylcytosine-specific restriction enzyme McrB related protein

Products: NA

Alternate protein names: GTPase Subunit Of Restriction Endonuclease-Like Protein; 5-Methylcytosine-Specific Restriction McrB Related Protein; 5-Methylcytosine-Specific Restriction ; GTPase Subunit Of Restriction Endonuclease-Like; Site-Specific DNA-Methyltransferase Cytosine-Specific; 5-Methylcytosine-Specific Restriction-Like Protein; AAA Family ATPase; AAA ATPase; ATPase AAA Family

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MNLIRYVNLRIISDRDEIESQQKRLENILKERADKVVEGGAGFQGGEEKGKVYWMSDLGIWYMTRFIEGSRYWNGFGTEE
PEEGGNRTIVCEINFPPEGINRRVGAAIARDPTGNYYVVHRGKLGGNYSKRIFEENYHGEWTTVIDGDRQEKVVVIGKID
ETIPEKIRNFVYEVQRIKGMKADSNLEENFKKESGTDIYQHLDKGTGTDFYQYLQIHGYHFRPELVENFLLSLKVKPFVI
LTGNSGTGKTKLAQLYGSYISTENDKRYLVVPVGANWTETRHIFGYLNIMTGEYQSTPALDFIMRASRDPDNPYILILDE
MNLSHVERYFSDFLSAMESGEPVPLHDDPNSEFPSMIEIPENLRVVGTVNVDETTYMFSPKVLDRANTIEFETLRPGEYL
NGTPHDQGPAGDTEFLEDIMEYSNDNMKDDLHMVWDELVAELDFFHETLTTPGFDFGFRVTDEILRFMHAAWIYEKRPRE
WENWERYLDAQIKQKILPKIHGPERLLRDTLDKLKEHCQGRFPESEKKLEEMQNTLKTQRYASFIR

Sequences:

>Translated_546_residues
MNLIRYVNLRIISDRDEIESQQKRLENILKERADKVVEGGAGFQGGEEKGKVYWMSDLGIWYMTRFIEGSRYWNGFGTEE
PEEGGNRTIVCEINFPPEGINRRVGAAIARDPTGNYYVVHRGKLGGNYSKRIFEENYHGEWTTVIDGDRQEKVVVIGKID
ETIPEKIRNFVYEVQRIKGMKADSNLEENFKKESGTDIYQHLDKGTGTDFYQYLQIHGYHFRPELVENFLLSLKVKPFVI
LTGNSGTGKTKLAQLYGSYISTENDKRYLVVPVGANWTETRHIFGYLNIMTGEYQSTPALDFIMRASRDPDNPYILILDE
MNLSHVERYFSDFLSAMESGEPVPLHDDPNSEFPSMIEIPENLRVVGTVNVDETTYMFSPKVLDRANTIEFETLRPGEYL
NGTPHDQGPAGDTEFLEDIMEYSNDNMKDDLHMVWDELVAELDFFHETLTTPGFDFGFRVTDEILRFMHAAWIYEKRPRE
WENWERYLDAQIKQKILPKIHGPERLLRDTLDKLKEHCQGRFPESEKKLEEMQNTLKTQRYASFIR
>Mature_546_residues
MNLIRYVNLRIISDRDEIESQQKRLENILKERADKVVEGGAGFQGGEEKGKVYWMSDLGIWYMTRFIEGSRYWNGFGTEE
PEEGGNRTIVCEINFPPEGINRRVGAAIARDPTGNYYVVHRGKLGGNYSKRIFEENYHGEWTTVIDGDRQEKVVVIGKID
ETIPEKIRNFVYEVQRIKGMKADSNLEENFKKESGTDIYQHLDKGTGTDFYQYLQIHGYHFRPELVENFLLSLKVKPFVI
LTGNSGTGKTKLAQLYGSYISTENDKRYLVVPVGANWTETRHIFGYLNIMTGEYQSTPALDFIMRASRDPDNPYILILDE
MNLSHVERYFSDFLSAMESGEPVPLHDDPNSEFPSMIEIPENLRVVGTVNVDETTYMFSPKVLDRANTIEFETLRPGEYL
NGTPHDQGPAGDTEFLEDIMEYSNDNMKDDLHMVWDELVAELDFFHETLTTPGFDFGFRVTDEILRFMHAAWIYEKRPRE
WENWERYLDAQIKQKILPKIHGPERLLRDTLDKLKEHCQGRFPESEKKLEEMQNTLKTQRYASFIR

Specific function: Recognizes N4- And C5-Methylcytosine (And 5-Hydroxy- Methylcytosines) Produced By A Broad Range Of DNA Methylases And Appears To Act Against 5-Methylcytosine Preceded By A Purine Residue. Binds To DNA Containing Methylated Cytosines; Also Binds To GTP. [

COG id: COG1401

COG function: function code V; GTPase subunit of restriction endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.1.21.- [C]

Molecular weight: Translated: 63504; Mature: 63504

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIRYVNLRIISDRDEIESQQKRLENILKERADKVVEGGAGFQGGEEKGKVYWMSDLGI
CCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCH
WYMTRFIEGSRYWNGFGTEEPEEGGNRTIVCEINFPPEGINRRVGAAIARDPTGNYYVVH
HHHHHHHCCCCEECCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHEECCCCCEEEEE
RGKLGGNYSKRIFEENYHGEWTTVIDGDRQEKVVVIGKIDETIPEKIRNFVYEVQRIKGM
CCCCCCCHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCC
KADSNLEENFKKESGTDIYQHLDKGTGTDFYQYLQIHGYHFRPELVENFLLSLKVKPFVI
CCCCCHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHEECCEEEE
LTGNSGTGKTKLAQLYGSYISTENDKRYLVVPVGANWTETRHIFGYLNIMTGEYQSTPAL
EECCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHEEEEEEEEECCCCCCCHH
DFIMRASRDPDNPYILILDEMNLSHVERYFSDFLSAMESGEPVPLHDDPNSEFPSMIEIP
HHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCC
ENLRVVGTVNVDETTYMFSPKVLDRANTIEFETLRPGEYLNGTPHDQGPAGDTEFLEDIM
CCCEEEEEECCCCEEEEECCHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHH
EYSNDNMKDDLHMVWDELVAELDFFHETLTTPGFDFGFRVTDEILRFMHAAWIYEKRPRE
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
WENWERYLDAQIKQKILPKIHGPERLLRDTLDKLKEHCQGRFPESEKKLEEMQNTLKTQR
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
YASFIR
HHHHCC
>Mature Secondary Structure
MNLIRYVNLRIISDRDEIESQQKRLENILKERADKVVEGGAGFQGGEEKGKVYWMSDLGI
CCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCH
WYMTRFIEGSRYWNGFGTEEPEEGGNRTIVCEINFPPEGINRRVGAAIARDPTGNYYVVH
HHHHHHHCCCCEECCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHEECCCCCEEEEE
RGKLGGNYSKRIFEENYHGEWTTVIDGDRQEKVVVIGKIDETIPEKIRNFVYEVQRIKGM
CCCCCCCHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCC
KADSNLEENFKKESGTDIYQHLDKGTGTDFYQYLQIHGYHFRPELVENFLLSLKVKPFVI
CCCCCHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHEECCEEEE
LTGNSGTGKTKLAQLYGSYISTENDKRYLVVPVGANWTETRHIFGYLNIMTGEYQSTPAL
EECCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHEEEEEEEEECCCCCCCHH
DFIMRASRDPDNPYILILDEMNLSHVERYFSDFLSAMESGEPVPLHDDPNSEFPSMIEIP
HHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCC
ENLRVVGTVNVDETTYMFSPKVLDRANTIEFETLRPGEYLNGTPHDQGPAGDTEFLEDIM
CCCEEEEEECCCCEEEEECCHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHH
EYSNDNMKDDLHMVWDELVAELDFFHETLTTPGFDFGFRVTDEILRFMHAAWIYEKRPRE
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
WENWERYLDAQIKQKILPKIHGPERLLRDTLDKLKEHCQGRFPESEKKLEEMQNTLKTQR
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
YASFIR
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds; Endodeoxyribonucleases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA