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Identifier: 15678312

GI number: 15678312

Start: 218924

End: 220774

Strand: Direct

Name: Not Available

Synonym: MTH284

Alternate gene names: 15678312

Gene position: 218924-220774 (Clockwise)

Preceding gene: 15678311

Following gene: 15678313

Centisome position: 12.5

GC content: 47.38

Gene sequence:

>1851_bases
ATGGCAGTATGGCAGGATAACCTTAAAAGACTGCTGAATCAGAAAGAGGTACTCATAATCCACGGAAACATAAGGGACAC
CGCATACCTCACCGAGGAAGGAAACCTCGTCAGGGGCCTCACAGACCTTATCAACAGGACCGGCAGGGAACTTGGATACG
ATAAGACAGTGAGCTGGGGTTCATTCTTTGACCATGAAGGGAGGGGCCACTCCCCCATGTGGTCACTTGAAAGGATCACA
CCACTCAATGGGGACCAGCCAGAGATAAGGGAAACCGAAAGCCAGGACAGAGTCAGTGACGTACTCCACAGATGGCTGGA
GGACGAAATAACCTCCATTGATGAGAAAAAGATCTTTATTATAAATTACATCGACAAGATCACAGGCTACGCTCCAGATG
GAATGTACTCTGAACCCACAGCAGAACTTGTGACGCTCATACAGAAGATAATAGAGAACATATCTGAAAACAACCGCCTC
ATAATGATCGCCCTCAGGGACACGATGATCCCGGTTGAGTACTATACGAACTCGCCCCGTGTAGCAGTGATGGAGATACC
CCTCCCTGACAGAGCAGAGAGACACCTTTACTATTCCACAACACTGGCCTCAGCAAGCATCCCATCCGATCAGATAGACT
TACTCTCCAACATCACAGAGGGCCTCTACATGAAGGACCTCGAAAACATCCTCAGCGACGTCCTGGAAGAAATTGATGAG
AACCAGGAAGTCTCCTCTTCAATGCTGAGAAAAATAGTTAACAGGTACCGTATAGGTACCGAAGAGGATCCATGGAGCAG
GATACCACTCACAGGGCCTCCAAAGGGGCTTCTGGACTCGGCAGAGAACTGGTTTCTGGAGAGGGTTGTCGGACAGGATC
ATGCGGTCAGGGAGATAGTGAATGCAATAAAGAAGGCACGTTCAGGTGTCGTGGGCCTTTCATCGGGGGGACAGTCAAAA
CCAAAGGCAACGTTCTTCTTCGCAGGGCCTACAGGTGTTGGTAAAACATTCCTGGCCAAAAAACTGGCAGAGTACCTGTT
TGATACGGAGGAAGCATTTTTAAGGTTTGACATGAGTGAATTCAAGGAAGAGCACACAGTATCAAAGCTCATAGGTTCTC
CTCCAGGTTATGTTGGATATGAACAGGGAGGACAGCTCACCAACGCCATAAAGAACAGACCATTCTCGGTCATCCTCTTT
GATGAGATCGAAAAGGCTCACCCCAAGATAATGGATATATTCCTTCAGATCCTTGATGATGGACGCCTCACAGACAGCAG
GGGACAGACGGTCTTCTTCACAGAGAGCGTGATAATATTCACATCCAACATCGGGACCAGAACCGTGGACAGCAGGGGAA
ACACCACATCTGAACAGAGGAAACTTGATGAAATAATAAATGACAGCGATCTCTCTGACTCTGAAAGGGAGAGAAGGGTG
AGGGAACACTTCACGCGCAGTGTTAGAGAGTTCTTCATGCATGAGATATCAAGAAGAGAACTTCTTAACAGGATAGGCTC
ACATATAATAGCCTTCAACTACCTGAAAAAATCAGATTACCAGGTGAACATAATTGAAAACAAACTCAAGGACATTTCAG
AGAACTTCCGCGACAAATTCGCAGGCAGGGGGCACCGGCTCCACCTCTCCGGGGAATTAACTGGATATTTCCTTGAGAAG
TATGGAGATTCAATATCAGAGTTCGGGGGCAGAGGTCTTGTAAATGCCCTTGAAGATGAAATAGGGAACATAGTGGCTGA
CCAGCTGCTCCTTGCAGAGGAGAGGGGAATGTCAGATATAAATTTCGAAGTATATGTTGATGGGGATGTAATCAGATGCC
GGAGATCATGA

Upstream 100 bases:

>100_bases
GAACCAGGGAGGACCCAGGAATAAACCAGTCTTAAAGGAGAAGAAAGCAAAGAGGCTTCCAGAAAGTCGCATGAGAAGGA
TATGATGGAGATGTTGATCC

Downstream 100 bases:

>100_bases
ACCTTTACTGTGAGGTGAACCTGACAACGCCCCTGGTCCTTGTGCTTGAGCCATCACCGGTCCTCTGGGAGGATATAATG
AAGGTTTCAGCTGAAGTTAT

Product: ATP-dependent Clp protease regulatory subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MAVWQDNLKRLLNQKEVLIIHGNIRDTAYLTEEGNLVRGLTDLINRTGRELGYDKTVSWGSFFDHEGRGHSPMWSLERIT
PLNGDQPEIRETESQDRVSDVLHRWLEDEITSIDEKKIFIINYIDKITGYAPDGMYSEPTAELVTLIQKIIENISENNRL
IMIALRDTMIPVEYYTNSPRVAVMEIPLPDRAERHLYYSTTLASASIPSDQIDLLSNITEGLYMKDLENILSDVLEEIDE
NQEVSSSMLRKIVNRYRIGTEEDPWSRIPLTGPPKGLLDSAENWFLERVVGQDHAVREIVNAIKKARSGVVGLSSGGQSK
PKATFFFAGPTGVGKTFLAKKLAEYLFDTEEAFLRFDMSEFKEEHTVSKLIGSPPGYVGYEQGGQLTNAIKNRPFSVILF
DEIEKAHPKIMDIFLQILDDGRLTDSRGQTVFFTESVIIFTSNIGTRTVDSRGNTTSEQRKLDEIINDSDLSDSERERRV
REHFTRSVREFFMHEISRRELLNRIGSHIIAFNYLKKSDYQVNIIENKLKDISENFRDKFAGRGHRLHLSGELTGYFLEK
YGDSISEFGGRGLVNALEDEIGNIVADQLLLAEERGMSDINFEVYVDGDVIRCRRS

Sequences:

>Translated_616_residues
MAVWQDNLKRLLNQKEVLIIHGNIRDTAYLTEEGNLVRGLTDLINRTGRELGYDKTVSWGSFFDHEGRGHSPMWSLERIT
PLNGDQPEIRETESQDRVSDVLHRWLEDEITSIDEKKIFIINYIDKITGYAPDGMYSEPTAELVTLIQKIIENISENNRL
IMIALRDTMIPVEYYTNSPRVAVMEIPLPDRAERHLYYSTTLASASIPSDQIDLLSNITEGLYMKDLENILSDVLEEIDE
NQEVSSSMLRKIVNRYRIGTEEDPWSRIPLTGPPKGLLDSAENWFLERVVGQDHAVREIVNAIKKARSGVVGLSSGGQSK
PKATFFFAGPTGVGKTFLAKKLAEYLFDTEEAFLRFDMSEFKEEHTVSKLIGSPPGYVGYEQGGQLTNAIKNRPFSVILF
DEIEKAHPKIMDIFLQILDDGRLTDSRGQTVFFTESVIIFTSNIGTRTVDSRGNTTSEQRKLDEIINDSDLSDSERERRV
REHFTRSVREFFMHEISRRELLNRIGSHIIAFNYLKKSDYQVNIIENKLKDISENFRDKFAGRGHRLHLSGELTGYFLEK
YGDSISEFGGRGLVNALEDEIGNIVADQLLLAEERGMSDINFEVYVDGDVIRCRRS
>Mature_615_residues
AVWQDNLKRLLNQKEVLIIHGNIRDTAYLTEEGNLVRGLTDLINRTGRELGYDKTVSWGSFFDHEGRGHSPMWSLERITP
LNGDQPEIRETESQDRVSDVLHRWLEDEITSIDEKKIFIINYIDKITGYAPDGMYSEPTAELVTLIQKIIENISENNRLI
MIALRDTMIPVEYYTNSPRVAVMEIPLPDRAERHLYYSTTLASASIPSDQIDLLSNITEGLYMKDLENILSDVLEEIDEN
QEVSSSMLRKIVNRYRIGTEEDPWSRIPLTGPPKGLLDSAENWFLERVVGQDHAVREIVNAIKKARSGVVGLSSGGQSKP
KATFFFAGPTGVGKTFLAKKLAEYLFDTEEAFLRFDMSEFKEEHTVSKLIGSPPGYVGYEQGGQLTNAIKNRPFSVILFD
EIEKAHPKIMDIFLQILDDGRLTDSRGQTVFFTESVIIFTSNIGTRTVDSRGNTTSEQRKLDEIINDSDLSDSERERRVR
EHFTRSVREFFMHEISRRELLNRIGSHIIAFNYLKKSDYQVNIIENKLKDISENFRDKFAGRGHRLHLSGELTGYFLEKY
GDSISEFGGRGLVNALEDEIGNIVADQLLLAEERGMSDINFEVYVDGDVIRCRRS

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=315, Percent_Identity=32.3809523809524, Blast_Score=160, Evalue=5e-39,
Organism=Escherichia coli, GI1788943, Length=382, Percent_Identity=36.1256544502618, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI1787109, Length=303, Percent_Identity=35.6435643564356, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6320464, Length=319, Percent_Identity=39.1849529780564, Blast_Score=207, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6323002, Length=385, Percent_Identity=34.8051948051948, Blast_Score=197, Evalue=5e-51,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 70287; Mature: 70156

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVWQDNLKRLLNQKEVLIIHGNIRDTAYLTEEGNLVRGLTDLINRTGRELGYDKTVSWG
CCCCHHHHHHHCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCC
SFFDHEGRGHSPMWSLERITPLNGDQPEIRETESQDRVSDVLHRWLEDEITSIDEKKIFI
CCCCCCCCCCCCCCCHHHCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
INYIDKITGYAPDGMYSEPTAELVTLIQKIIENISENNRLIMIALRDTMIPVEYYTNSPR
EEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEEEECCCCC
VAVMEIPLPDRAERHLYYSTTLASASIPSDQIDLLSNITEGLYMKDLENILSDVLEEIDE
EEEEECCCCCCCCCEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NQEVSSSMLRKIVNRYRIGTEEDPWSRIPLTGPPKGLLDSAENWFLERVVGQDHAVREIV
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
NAIKKARSGVVGLSSGGQSKPKATFFFAGPTGVGKTFLAKKLAEYLFDTEEAFLRFDMSE
HHHHHHHCCEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHCHHH
FKEEHTVSKLIGSPPGYVGYEQGGQLTNAIKNRPFSVILFDEIEKAHPKIMDIFLQILDD
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHCHHHHHHHHHHHCC
GRLTDSRGQTVFFTESVIIFTSNIGTRTVDSRGNTTSEQRKLDEIINDSDLSDSERERRV
CCEECCCCCEEEEEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHH
REHFTRSVREFFMHEISRRELLNRIGSHIIAFNYLKKSDYQVNIIENKLKDISENFRDKF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHECCCCCEEEHHHHHHHHHHHHHHHHH
AGRGHRLHLSGELTGYFLEKYGDSISEFGGRGLVNALEDEIGNIVADQLLLAEERGMSDI
CCCCCEEEECCCHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NFEVYVDGDVIRCRRS
CEEEEECCCEEEEECC
>Mature Secondary Structure 
AVWQDNLKRLLNQKEVLIIHGNIRDTAYLTEEGNLVRGLTDLINRTGRELGYDKTVSWG
CCCHHHHHHHCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCC
SFFDHEGRGHSPMWSLERITPLNGDQPEIRETESQDRVSDVLHRWLEDEITSIDEKKIFI
CCCCCCCCCCCCCCCHHHCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
INYIDKITGYAPDGMYSEPTAELVTLIQKIIENISENNRLIMIALRDTMIPVEYYTNSPR
EEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEEEECCCCC
VAVMEIPLPDRAERHLYYSTTLASASIPSDQIDLLSNITEGLYMKDLENILSDVLEEIDE
EEEEECCCCCCCCCEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NQEVSSSMLRKIVNRYRIGTEEDPWSRIPLTGPPKGLLDSAENWFLERVVGQDHAVREIV
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
NAIKKARSGVVGLSSGGQSKPKATFFFAGPTGVGKTFLAKKLAEYLFDTEEAFLRFDMSE
HHHHHHHCCEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHCHHH
FKEEHTVSKLIGSPPGYVGYEQGGQLTNAIKNRPFSVILFDEIEKAHPKIMDIFLQILDD
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHCHHHHHHHHHHHCC
GRLTDSRGQTVFFTESVIIFTSNIGTRTVDSRGNTTSEQRKLDEIINDSDLSDSERERRV
CCEECCCCCEEEEEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHH
REHFTRSVREFFMHEISRRELLNRIGSHIIAFNYLKKSDYQVNIIENKLKDISENFRDKF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHECCCCCEEEHHHHHHHHHHHHHHHHH
AGRGHRLHLSGELTGYFLEKYGDSISEFGGRGLVNALEDEIGNIVADQLLLAEERGMSDI
CCCCCEEEECCCHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NFEVYVDGDVIRCRRS
CEEEEECCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]