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Identifier: 15678291

GI number: 15678291

Start: 203298

End: 203828

Strand: Direct

Name: Not Available

Synonym: MTH263

Alternate gene names: 15678291

Gene position: 203298-203828 (Clockwise)

Preceding gene: 15678290

Following gene: 15678292

Centisome position: 11.61

GC content: 47.08

Gene sequence:

>531_bases
ATGAATCTGTGGAAGGATATTGAACCGGGACCATCAGTACCCGAGGTTGTCTATGCGGTTGTTGAAATACCAAAGGGTTC
AAGGAACAAGTACGAATACCACAAGGACCTTCAGGCATTCGCCCTTGACAGGGTACTCTACTCAGCAGTATTCTACCCTG
CAGAGTACGGTATAATACCAAGGACACTCTACGATGACGGAGACCCCATGGACATCCTCGTACTCATGGATGAACCAACA
TTCCCGGGCTGCATCATAGAATCAAGACCCATAGGCCTTTTAAGGATGATCGATGGTGGTGACCAGGACGACAAGATCCT
GGCGGTGCCTGTGGCAGACCCGCACTTCGCCGATGTAAAGGACATCTCAGACATACCAGAGCACAACCTTAAGGAGATAG
CAAACTTCTTTGAAACCTACAAGAAACTTGAAGGTAAAAAAACAGAGACACTCGGATGGGAGGGTGCTGAAAAGGCATTT
GAAGCAGTCAACCACTCCATAGAACTCTACAGGAAAAAATATATGGAGTAA

Upstream 100 bases:

>100_bases
TCAGAAGAAGGGCAAGGTCGAAGGGAATACCTGTTGTCTACCTGAGACAGAAAAGATATCTTGGAGTGGATGGGCATATA
TTGGAGTAGGAGGTTTACTC

Downstream 100 bases:

>100_bases
TTCTTTAATGGGGGATCCCATTGTATTATGTAACAAAGATTGTTGATACCGTCAGAATACCTCCAGACCGCTTTGAAGAG
CCACTGGAGGAGGTCGCCGT

Product: inorganic pyrophosphatase

Products: NA

Alternate protein names: Pyrophosphate phospho-hydrolase; PPase

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MNLWKDIEPGPSVPEVVYAVVEIPKGSRNKYEYHKDLQAFALDRVLYSAVFYPAEYGIIPRTLYDDGDPMDILVLMDEPT
FPGCIIESRPIGLLRMIDGGDQDDKILAVPVADPHFADVKDISDIPEHNLKEIANFFETYKKLEGKKTETLGWEGAEKAF
EAVNHSIELYRKKYME

Sequences:

>Translated_176_residues
MNLWKDIEPGPSVPEVVYAVVEIPKGSRNKYEYHKDLQAFALDRVLYSAVFYPAEYGIIPRTLYDDGDPMDILVLMDEPT
FPGCIIESRPIGLLRMIDGGDQDDKILAVPVADPHFADVKDISDIPEHNLKEIANFFETYKKLEGKKTETLGWEGAEKAF
EAVNHSIELYRKKYME
>Mature_176_residues
MNLWKDIEPGPSVPEVVYAVVEIPKGSRNKYEYHKDLQAFALDRVLYSAVFYPAEYGIIPRTLYDDGDPMDILVLMDEPT
FPGCIIESRPIGLLRMIDGGDQDDKILAVPVADPHFADVKDISDIPEHNLKEIANFFETYKKLEGKKTETLGWEGAEKAF
EAVNHSIELYRKKYME

Specific function: Unknown

COG id: COG0221

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PPase family

Homologues:

Organism=Escherichia coli, GI1790673, Length=172, Percent_Identity=41.2790697674419, Blast_Score=124, Evalue=4e-30,

Paralogues:

None

Copy number: 5480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): IPYR_METTH (O26363)

Other databases:

- EMBL:   AE000666
- PIR:   B69133
- RefSeq:   NP_275406.1
- ProteinModelPortal:   O26363
- SMR:   O26363
- STRING:   O26363
- GeneID:   1470224
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH263
- NMPDR:   fig|187420.1.peg.261
- eggNOG:   arNOG07782
- HOGENOM:   HBG529150
- OMA:   YRDEIEN
- PhylomeDB:   O26363
- ProtClustDB:   CLSK436228
- BioCyc:   MTHE187420:MTH263-MONOMER
- BRENDA:   3.6.1.1
- GO:   GO:0005737
- HAMAP:   MF_00209
- InterPro:   IPR008162
- Gene3D:   G3DSA:3.90.80.10
- PANTHER:   PTHR10286

Pfam domain/function: PF00719 Pyrophosphatase; SSF50324 Pyrophosphatase

EC number: =3.6.1.1

Molecular weight: Translated: 20084; Mature: 20084

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00387 PPASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLWKDIEPGPSVPEVVYAVVEIPKGSRNKYEYHKDLQAFALDRVLYSAVFYPAEYGIIP
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCC
RTLYDDGDPMDILVLMDEPTFPGCIIESRPIGLLRMIDGGDQDDKILAVPVADPHFADVK
CEECCCCCCEEEEEEECCCCCCCEEECCCCCCEEEEECCCCCCCCEEEEECCCCCCCCHH
DISDIPEHNLKEIANFFETYKKLEGKKTETLGWEGAEKAFEAVNHSIELYRKKYME
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLWKDIEPGPSVPEVVYAVVEIPKGSRNKYEYHKDLQAFALDRVLYSAVFYPAEYGIIP
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCC
RTLYDDGDPMDILVLMDEPTFPGCIIESRPIGLLRMIDGGDQDDKILAVPVADPHFADVK
CEECCCCCCEEEEEEECCCCCCCEEECCCCCCEEEEECCCCCCCCEEEEECCCCCCCCHH
DISDIPEHNLKEIANFFETYKKLEGKKTETLGWEGAEKAFEAVNHSIELYRKKYME
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463