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Identifier: 15678221

GI number: 15678221

Start: 136566

End: 137624

Strand: Direct

Name: Not Available

Synonym: MTH193

Alternate gene names: 15678221

Gene position: 136566-137624 (Clockwise)

Preceding gene: 15678220

Following gene: 15678222

Centisome position: 7.8

GC content: 51.46

Gene sequence:

>1059_bases
ATGACCAGAACCTATGCAATGGTTGGAACACCCTGCCAGATAACAGCAGCCACACTCATGGACAGATACACAGAGGACTT
TCCGGTTGAACTCAAACTCGGACTCTTCTGCATGGAAAACTTCTCCTACACATACCTCAAAAAACTCGCCGAGGAGGAGG
GCATTGACCTTGCAGATGTATCAGAGCTCAGGATAGAGAAGGGCAGGCTCTGGTTCCACCTTAACGATGGAAGCAAAGTT
TCAGTTTCCCTGGAAAGGGCGAGAGCCGCCATGAGGAAGAACTGCTCAGTGTGCATGGACTTCACATCAGAACAGTCCGA
CATATCCATAGGATCCGTGGGATCACCTGAAGGATGGTCAACGATCATAATAAGGACAGAGAGAGGCCATGAACTCATAG
AAAAGGCCAGGAAGGCAGGATACATTGAAACAAAACCCTTAACAGAGAGGGGAATCAGGATACTTGAGAAACTCGCATCA
GGTAAGAAGGAGGATAACCTCCAGGAGATAAAAAGAAGGGAGTCTGTTGCAAGGCCGGTCCTCTACTGGAGGGTGATGCC
AGATGAGGAATATCTCGAGGAGGTCACTGACTACCAGTTCGATGACCTGAGGTCTGATGTGATAGATGTGGGGGCCTGCG
TCCTCTGCGGGGCCTGCGTGGCCTCATGCCCGGAGGACATAGTCAGCATAAAGGATAGAAAGCCAGAGGTGGAGGGTACA
TGCCCGGAGGGCTGCAATGCCTGCTATGTGGCATGTCCCAGAACCTATGTACCCGACAGCATAATAGGTCATGACTCAGC
AATTACTCCCCTTGGGGAATACATTGAGATCCTGTCTGCGAGGGCACCCATGTTCAGGGGCCAGGATGGTGGTGTTGTAA
CAGCCCTCCTCACATACGCCCTCAGGGAGGGAATCATCGACGGGGCCCTGGTGGTTGACAGGGACCAGGAAAGGCCATGG
AAACCTTTACCTGTACTGGCAGAGGAGCCCCAGGACATTGTGAAGGCTGCAGGAACCAAATACTCGGCATGTCCATTACT
GAAGGTTTTAAAGGAATAA

Upstream 100 bases:

>100_bases
GTTACGGATTTAACCTTGATGATGAAGACTATCAGGCCTTCAGGAAGATCGTGCCAAGGAGTAAAAGACCATTTTATGGT
GAAGAATCGGAGGAAGGATA

Downstream 100 bases:

>100_bases
GAGGGGTTAAAAATGCCTTTTAAGGTTGAAAGAAAGGAAGAGGTATGTAAGAGGAACTTTGATCGTCCCGGCTGCTGCTG
GTACATGTGCGATAACAGGG

Product: coenzyme F420-reducing hydrogenase, beta subunit-like protein

Products: NA

Alternate protein names: 8-hydroxy-5-deazaflavin-reducing hydrogenase subunit beta; FRH [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MTRTYAMVGTPCQITAATLMDRYTEDFPVELKLGLFCMENFSYTYLKKLAEEEGIDLADVSELRIEKGRLWFHLNDGSKV
SVSLERARAAMRKNCSVCMDFTSEQSDISIGSVGSPEGWSTIIIRTERGHELIEKARKAGYIETKPLTERGIRILEKLAS
GKKEDNLQEIKRRESVARPVLYWRVMPDEEYLEEVTDYQFDDLRSDVIDVGACVLCGACVASCPEDIVSIKDRKPEVEGT
CPEGCNACYVACPRTYVPDSIIGHDSAITPLGEYIEILSARAPMFRGQDGGVVTALLTYALREGIIDGALVVDRDQERPW
KPLPVLAEEPQDIVKAAGTKYSACPLLKVLKE

Sequences:

>Translated_352_residues
MTRTYAMVGTPCQITAATLMDRYTEDFPVELKLGLFCMENFSYTYLKKLAEEEGIDLADVSELRIEKGRLWFHLNDGSKV
SVSLERARAAMRKNCSVCMDFTSEQSDISIGSVGSPEGWSTIIIRTERGHELIEKARKAGYIETKPLTERGIRILEKLAS
GKKEDNLQEIKRRESVARPVLYWRVMPDEEYLEEVTDYQFDDLRSDVIDVGACVLCGACVASCPEDIVSIKDRKPEVEGT
CPEGCNACYVACPRTYVPDSIIGHDSAITPLGEYIEILSARAPMFRGQDGGVVTALLTYALREGIIDGALVVDRDQERPW
KPLPVLAEEPQDIVKAAGTKYSACPLLKVLKE
>Mature_351_residues
TRTYAMVGTPCQITAATLMDRYTEDFPVELKLGLFCMENFSYTYLKKLAEEEGIDLADVSELRIEKGRLWFHLNDGSKVS
VSLERARAAMRKNCSVCMDFTSEQSDISIGSVGSPEGWSTIIIRTERGHELIEKARKAGYIETKPLTERGIRILEKLASG
KKEDNLQEIKRRESVARPVLYWRVMPDEEYLEEVTDYQFDDLRSDVIDVGACVLCGACVASCPEDIVSIKDRKPEVEGTC
PEGCNACYVACPRTYVPDSIIGHDSAITPLGEYIEILSARAPMFRGQDGGVVTALLTYALREGIIDGALVVDRDQERPWK
PLPVLAEEPQDIVKAAGTKYSACPLLKVLKE

Specific function: Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen [H]

COG id: COG1035

COG function: function code C; Coenzyme F420-reducing hydrogenase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the frhB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007516
- InterPro:   IPR017679
- InterPro:   IPR007525 [H]

Pfam domain/function: PF04432 FrhB_FdhB_C; PF04422 FrhB_FdhB_N [H]

EC number: =1.12.98.1 [H]

Molecular weight: Translated: 39249; Mature: 39118

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRTYAMVGTPCQITAATLMDRYTEDFPVELKLGLFCMENFSYTYLKKLAEEEGIDLADV
CCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEEEHHHCCCHHHHHHHHHHCCCCHHHH
SELRIEKGRLWFHLNDGSKVSVSLERARAAMRKNCSVCMDFTSEQSDISIGSVGSPEGWS
HHHHEECCEEEEEECCCCEEEEEHHHHHHHHHCCCCEEEECCCCCCCCEECCCCCCCCCE
TIIIRTERGHELIEKARKAGYIETKPLTERGIRILEKLASGKKEDNLQEIKRRESVARPV
EEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCE
LYWRVMPDEEYLEEVTDYQFDDLRSDVIDVGACVLCGACVASCPEDIVSIKDRKPEVEGT
EEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCC
CPEGCNACYVACPRTYVPDSIIGHDSAITPLGEYIEILSARAPMFRGQDGGVVTALLTYA
CCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LREGIIDGALVVDRDQERPWKPLPVLAEEPQDIVKAAGTKYSACPLLKVLKE
HHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
TRTYAMVGTPCQITAATLMDRYTEDFPVELKLGLFCMENFSYTYLKKLAEEEGIDLADV
CCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEEEHHHCCCHHHHHHHHHHCCCCHHHH
SELRIEKGRLWFHLNDGSKVSVSLERARAAMRKNCSVCMDFTSEQSDISIGSVGSPEGWS
HHHHEECCEEEEEECCCCEEEEEHHHHHHHHHCCCCEEEECCCCCCCCEECCCCCCCCCE
TIIIRTERGHELIEKARKAGYIETKPLTERGIRILEKLASGKKEDNLQEIKRRESVARPV
EEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCE
LYWRVMPDEEYLEEVTDYQFDDLRSDVIDVGACVLCGACVASCPEDIVSIKDRKPEVEGT
EEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCC
CPEGCNACYVACPRTYVPDSIIGHDSAITPLGEYIEILSARAPMFRGQDGGVVTALLTYA
CCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LREGIIDGALVVDRDQERPWKPLPVLAEEPQDIVKAAGTKYSACPLLKVLKE
HHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]