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Identifier: 15678211

GI number: 15678211

Start: 129422

End: 130303

Strand: Direct

Name: Not Available

Synonym: MTH183

Alternate gene names: 15678211

Gene position: 129422-130303 (Clockwise)

Preceding gene: 15678210

Following gene: 15678213

Centisome position: 7.39

GC content: 51.02

Gene sequence:

>882_bases
ATGAAAACAGTTAACATCCTCGTTGAGGCACTGCCCTACATAAAGAAGTTTCACAGAAAGAAGATCATGATCAAGTATGG
TGGCCATGCCATGATAGACGAGGCCGCCATGGACTCGACCGCCCGGGATACGGTCCTGCTCAAGTATGTGGGTATGGAAC
CCGTCGTGGTCCATGGAGGAGGACCCGAAATTTCCCGTGCAATGAACAAGATGGGTAAGGAGCCGAAGTTCATTGAGGGC
CTCAGGGTGACTGATGAGGAGACCATGGAGATAGTGAAGATGGTCCTCGTTGGTAAGATAAACACCAGCATAGTCTCAAA
GATATGCTACCATGGCGGGAGGGCCATAGGATTATCAGGTAAGGACAGCAACCTCCTCCTTGCAAGGAAGAGGGCGCCCC
ACGTTGTGAGGGACGATGAGACCGGTGAGAGGAGGGAGATAGACTTGGGCCTTGTGGGTGAGATAGAGTCCGTTGACCCC
GGCATAATCAACATGCTAACAGATAACAATTACATACCCGTTATATCACCCATAGGGGTTGACAGGGATGCAAATACACT
TAACCTCAACGCAGATACCGTTGCTGGTGAGGTTGCAGCGGGTATAGGGGCTGAAAAACTCATAGTACTGACAGACGTCC
CGGGGATACTCGAGGACCCTTCAGACCCTGATACCCTCATAAGGCGGATAAGTGTTGACGAGCTCAGTGACCTTGTAAAG
AGCGGCATAGTGGAGGGTGGCATGCTCCCCAAGACCCTCACCTGCATACAGGCAATCAATGATGGGGTGTCCTCTGCCCA
CATAATCGATGGAAGGGTTGAGCACTCACTGCTCCTTGAAATCTTCACAAAGAAGGGAATAGGGACCATGATAACAGAGT
GA

Upstream 100 bases:

>100_bases
TGCTGGAGATGAATCAGCCACTGCCTATGGCTGCGACCTCACCTATGATTATGTAAGGATAAATGCAGAGTATACCACAT
GACTGGCTGAAGGTGTTTTT

Downstream 100 bases:

>100_bases
ATGCCTGTTATACTGTTTCAGTGAATGGAGTAGTTAGCAGAGTTAATTGTTTTATGTCGCGGTGCTGATAGAAGCTGGCT
CTTGACCTGAAACTACTCCC

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKTVNILVEALPYIKKFHRKKIMIKYGGHAMIDEAAMDSTARDTVLLKYVGMEPVVVHGGGPEISRAMNKMGKEPKFIEG
LRVTDEETMEIVKMVLVGKINTSIVSKICYHGGRAIGLSGKDSNLLLARKRAPHVVRDDETGERREIDLGLVGEIESVDP
GIINMLTDNNYIPVISPIGVDRDANTLNLNADTVAGEVAAGIGAEKLIVLTDVPGILEDPSDPDTLIRRISVDELSDLVK
SGIVEGGMLPKTLTCIQAINDGVSSAHIIDGRVEHSLLLEIFTKKGIGTMITE

Sequences:

>Translated_293_residues
MKTVNILVEALPYIKKFHRKKIMIKYGGHAMIDEAAMDSTARDTVLLKYVGMEPVVVHGGGPEISRAMNKMGKEPKFIEG
LRVTDEETMEIVKMVLVGKINTSIVSKICYHGGRAIGLSGKDSNLLLARKRAPHVVRDDETGERREIDLGLVGEIESVDP
GIINMLTDNNYIPVISPIGVDRDANTLNLNADTVAGEVAAGIGAEKLIVLTDVPGILEDPSDPDTLIRRISVDELSDLVK
SGIVEGGMLPKTLTCIQAINDGVSSAHIIDGRVEHSLLLEIFTKKGIGTMITE
>Mature_293_residues
MKTVNILVEALPYIKKFHRKKIMIKYGGHAMIDEAAMDSTARDTVLLKYVGMEPVVVHGGGPEISRAMNKMGKEPKFIEG
LRVTDEETMEIVKMVLVGKINTSIVSKICYHGGRAIGLSGKDSNLLLARKRAPHVVRDDETGERREIDLGLVGEIESVDP
GIINMLTDNNYIPVISPIGVDRDANTLNLNADTVAGEVAAGIGAEKLIVLTDVPGILEDPSDPDTLIRRISVDELSDLVK
SGIVEGGMLPKTLTCIQAINDGVSSAHIIDGRVEHSLLLEIFTKKGIGTMITE

Specific function: Arginine biosynthesis; first step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetylglutamate kinase family

Homologues:

Organism=Escherichia coli, GI1789181, Length=295, Percent_Identity=26.7796610169492, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI145693208, Length=238, Percent_Identity=31.0924369747899, Blast_Score=79, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320913, Length=291, Percent_Identity=29.2096219931272, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ARGB_METTH (O26285)

Other databases:

- EMBL:   AE000666
- PIR:   F69111
- RefSeq:   NP_275326.1
- ProteinModelPortal:   O26285
- SMR:   O26285
- STRING:   O26285
- GeneID:   1470144
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH183
- NMPDR:   fig|187420.1.peg.181
- eggNOG:   arNOG04941
- HOGENOM:   HBG497643
- OMA:   MDIVEMV
- PhylomeDB:   O26285
- ProtClustDB:   PRK00942
- BioCyc:   MTHE187420:MTH183-MONOMER
- BRENDA:   2.7.2.8
- GO:   GO:0005737
- HAMAP:   MF_00082_A
- InterPro:   IPR004662
- InterPro:   IPR001048
- InterPro:   IPR001057
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF000728
- PRINTS:   PR00474
- TIGRFAMs:   TIGR00761

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.2.8

Molecular weight: Translated: 31700; Mature: 31700

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: BINDING 82-82 BINDING 188-188

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVNILVEALPYIKKFHRKKIMIKYGGHAMIDEAAMDSTARDTVLLKYVGMEPVVVHGG
CCHHHHHHHHHHHHHHHHHCEEEEEECCCEEEHHHHHCCCCCCEEEEEEECCCEEEEECC
GPEISRAMNKMGKEPKFIEGLRVTDEETMEIVKMVLVGKINTSIVSKICYHGGRAIGLSG
CHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCC
KDSNLLLARKRAPHVVRDDETGERREIDLGLVGEIESVDPGIINMLTDNNYIPVISPIGV
CCCCEEEEECCCCCCCCCCCCCCCEEECEEEECCCCCCCCCEEEEEECCCEEEEEECCCC
DRDANTLNLNADTVAGEVAAGIGAEKLIVLTDVPGILEDPSDPDTLIRRISVDELSDLVK
CCCCCEEECCCHHHHHHHHHCCCCCEEEEEECCCCHHCCCCCHHHHHHHCCHHHHHHHHH
SGIVEGGMLPKTLTCIQAINDGVSSAHIIDGRVEHSLLLEIFTKKGIGTMITE
HCCCCCCCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure
MKTVNILVEALPYIKKFHRKKIMIKYGGHAMIDEAAMDSTARDTVLLKYVGMEPVVVHGG
CCHHHHHHHHHHHHHHHHHCEEEEEECCCEEEHHHHHCCCCCCEEEEEEECCCEEEEECC
GPEISRAMNKMGKEPKFIEGLRVTDEETMEIVKMVLVGKINTSIVSKICYHGGRAIGLSG
CHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCC
KDSNLLLARKRAPHVVRDDETGERREIDLGLVGEIESVDPGIINMLTDNNYIPVISPIGV
CCCCEEEEECCCCCCCCCCCCCCCEEECEEEECCCCCCCCCEEEEEECCCEEEEEECCCC
DRDANTLNLNADTVAGEVAAGIGAEKLIVLTDVPGILEDPSDPDTLIRRISVDELSDLVK
CCCCCEEECCCHHHHHHHHHCCCCCEEEEEECCCCHHCCCCCHHHHHHHCCHHHHHHHHH
SGIVEGGMLPKTLTCIQAINDGVSSAHIIDGRVEHSLLLEIFTKKGIGTMITE
HCCCCCCCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463