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The map label for this gene is argJ

Identifier: 15678210

GI number: 15678210

Start: 128195

End: 129403

Strand: Direct

Name: argJ

Synonym: MTH182

Alternate gene names: 15678210

Gene position: 128195-129403 (Clockwise)

Preceding gene: 15678209

Following gene: 15678211

Centisome position: 7.32

GC content: 51.7

Gene sequence:

>1209_bases
GTGTATACAATGGAACTGAGATTTATAAGGGGTGGTGTCTGCGCTGTTGACGGAGTCCTCGCTGCCGGCTGCCGTGAGGG
CAAATATGGTGTTGGACTGATCATCAACAGGGGTTCAACCGCAGCCGCGGTCTTCACCTCAAACAGGGTTCGAGCAGAAC
CAGTTAAACTCACAGAGCGCGTAATTGCAGATGGAAGTATATCAGCCATCGTGGCAAACAGCGGGAACGCCAACTGCTTC
ACAGGCAGGGAAGGAATGGATGACGCCAGGAGGATGGCCAGAAAAGTGGCAGAGTCCCTCTCCATGGATGAAAGTGAGGT
TGCAGTGGCTTCAACAGGCGTTATAGGAAGAAGGATGCCCATTGATAAAATAGAGTTCCTCATCCAGAGTGCTGCAGCTC
AACTGGAAAACTCAGAGGCGGCATCGGGGGCTCTTGCAGAGGCGATAATGACCACCGACACCTTCCCCAAGGAGGTGGCA
GTTGAGTTTGAACTTGAAACAGGCGAAAAGGCGCGTATAGGTGCTGTTGCCAAGGGCTCCGGGATGATAGCCCCCAACAT
GGCCACAATGCTCTCATTCATAACAACCGATGTCGATGCATCGTCTTCTGAACTGACGGAGGCCCTCAGGGTGGCAGTTG
ATGAGAGCTTCAACATGCTCATAGTGGATGGTGATGAGAGCACCAATGACATGGTCATAATATCCTCAACCAGGACCTCA
GGAAGGATAGATTCAAACTTCAGGGAGGCTCTCGTTGCTGTGTGCAGGGAACTCGCCCGTATGATGGCCCGGGACGGTGA
GGGGGTCACCAAGTCCTTCCAGGTGGATGTTGTAAATGCAGGGACACATGAGGATGCAAAAATGGCTGCAAGGGCCATAG
CAGGTTCATCCCTTGTTAAAACAGCCATATTTGGAGCCGACCCCAACTGGGGGCGTATAGTTGCAGCTGCAGGCTACTCT
GGAGCAGAGTTTGACCCTGAGGAGATAAGCGTCACCCTTGAGTCTGATTCAGAATCCGTGGTAATAGTTGACCATGGTGA
TATCCTGGCATTTGAGGGTACAGAGGAACTTGAAACTGCTGAGAGGGTCATGACCAGCAAGGAGATAAGGATAATCGTTG
ACCTGGCTGCTGGAGATGAATCAGCCACTGCCTATGGCTGCGACCTCACCTATGATTATGTAAGGATAAATGCAGAGTAT
ACCACATGA

Upstream 100 bases:

>100_bases
GAACGGCAATGGGGAAGTCAACGTTGTTAACAACCAGGGGTCCTCCAACAACACCACCTACTGATGGGAGACGACCCCAG
CGAACTTTTTTTACGGGAGA

Downstream 100 bases:

>100_bases
CTGGCTGAAGGTGTTTTTATGAAAACAGTTAACATCCTCGTTGAGGCACTGCCCTACATAAAGAAGTTTCACAGAAAGAA
GATCATGATCAAGTATGGTG

Product: bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein

Products: NA

Alternate protein names: Glutamate N-acetyltransferase; Ornithine acetyltransferase; OATase; Ornithine transacetylase; Amino-acid acetyltransferase; N-acetylglutamate synthase; AGS

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MYTMELRFIRGGVCAVDGVLAAGCREGKYGVGLIINRGSTAAAVFTSNRVRAEPVKLTERVIADGSISAIVANSGNANCF
TGREGMDDARRMARKVAESLSMDESEVAVASTGVIGRRMPIDKIEFLIQSAAAQLENSEAASGALAEAIMTTDTFPKEVA
VEFELETGEKARIGAVAKGSGMIAPNMATMLSFITTDVDASSSELTEALRVAVDESFNMLIVDGDESTNDMVIISSTRTS
GRIDSNFREALVAVCRELARMMARDGEGVTKSFQVDVVNAGTHEDAKMAARAIAGSSLVKTAIFGADPNWGRIVAAAGYS
GAEFDPEEISVTLESDSESVVIVDHGDILAFEGTEELETAERVMTSKEIRIIVDLAAGDESATAYGCDLTYDYVRINAEY
TT

Sequences:

>Translated_402_residues
MYTMELRFIRGGVCAVDGVLAAGCREGKYGVGLIINRGSTAAAVFTSNRVRAEPVKLTERVIADGSISAIVANSGNANCF
TGREGMDDARRMARKVAESLSMDESEVAVASTGVIGRRMPIDKIEFLIQSAAAQLENSEAASGALAEAIMTTDTFPKEVA
VEFELETGEKARIGAVAKGSGMIAPNMATMLSFITTDVDASSSELTEALRVAVDESFNMLIVDGDESTNDMVIISSTRTS
GRIDSNFREALVAVCRELARMMARDGEGVTKSFQVDVVNAGTHEDAKMAARAIAGSSLVKTAIFGADPNWGRIVAAAGYS
GAEFDPEEISVTLESDSESVVIVDHGDILAFEGTEELETAERVMTSKEIRIIVDLAAGDESATAYGCDLTYDYVRINAEY
TT
>Mature_402_residues
MYTMELRFIRGGVCAVDGVLAAGCREGKYGVGLIINRGSTAAAVFTSNRVRAEPVKLTERVIADGSISAIVANSGNANCF
TGREGMDDARRMARKVAESLSMDESEVAVASTGVIGRRMPIDKIEFLIQSAAAQLENSEAASGALAEAIMTTDTFPKEVA
VEFELETGEKARIGAVAKGSGMIAPNMATMLSFITTDVDASSSELTEALRVAVDESFNMLIVDGDESTNDMVIISSTRTS
GRIDSNFREALVAVCRELARMMARDGEGVTKSFQVDVVNAGTHEDAKMAARAIAGSSLVKTAIFGADPNWGRIVAAAGYS
GAEFDPEEISVTLESDSESVVIVDHGDILAFEGTEELETAERVMTSKEIRIIVDLAAGDESATAYGCDLTYDYVRINAEY
TT

Specific function: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis:the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate

COG id: COG1364

COG function: function code E; N-acetylglutamate synthase (N-acetylornithine aminotransferase)

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArgJ family

Homologues:

Organism=Saccharomyces cerevisiae, GI6323707, Length=416, Percent_Identity=38.9423076923077, Blast_Score=242, Evalue=6e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGJ_METTH (O26284)

Other databases:

- EMBL:   AE000666
- PIR:   C69110
- RefSeq:   NP_275325.1
- ProteinModelPortal:   O26284
- SMR:   O26284
- STRING:   O26284
- MEROPS:   T05.001
- GeneID:   1470143
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH182
- NMPDR:   fig|187420.1.peg.180
- eggNOG:   arNOG04939
- HOGENOM:   HBG284202
- OMA:   QNRFCAA
- PhylomeDB:   O26284
- ProtClustDB:   PRK05388
- BioCyc:   MTHE187420:MTH182-MONOMER
- BRENDA:   2.3.1.1
- BRENDA:   2.3.1.35
- GO:   GO:0005737
- HAMAP:   MF_01106
- InterPro:   IPR002813
- InterPro:   IPR016117
- PANTHER:   PTHR23100
- TIGRFAMs:   TIGR00120

Pfam domain/function: PF01960 ArgJ; SSF56266 Pept_S58_DmpA/Arg_biosyn_ArgJ

EC number: =2.3.1.35; =2.3.1.1

Molecular weight: Translated: 42650; Mature: 42650

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTMELRFIRGGVCAVDGVLAAGCREGKYGVGLIINRGSTAAAVFTSNRVRAEPVKLTER
CEEEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHH
VIADGSISAIVANSGNANCFTGREGMDDARRMARKVAESLSMDESEVAVASTGVIGRRMP
HHCCCCEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCHHEEEEECCCCCCCCC
IDKIEFLIQSAAAQLENSEAASGALAEAIMTTDTFPKEVAVEFELETGEKARIGAVAKGS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEEECCC
GMIAPNMATMLSFITTDVDASSSELTEALRVAVDESFNMLIVDGDESTNDMVIISSTRTS
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEECCCCC
GRIDSNFREALVAVCRELARMMARDGEGVTKSFQVDVVNAGTHEDAKMAARAIAGSSLVK
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCHHHH
TAIFGADPNWGRIVAAAGYSGAEFDPEEISVTLESDSESVVIVDHGDILAFEGTEELETA
HEEECCCCCCCEEEEECCCCCCCCCHHHEEEEEECCCCEEEEEECCCEEEECCCHHHHHH
ERVMTSKEIRIIVDLAAGDESATAYGCDLTYDYVRINAEYTT
HHHHCCCCEEEEEEEECCCCCCEEEECCEEEEEEEEEEEECC
>Mature Secondary Structure
MYTMELRFIRGGVCAVDGVLAAGCREGKYGVGLIINRGSTAAAVFTSNRVRAEPVKLTER
CEEEEEEEECCCHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHH
VIADGSISAIVANSGNANCFTGREGMDDARRMARKVAESLSMDESEVAVASTGVIGRRMP
HHCCCCEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCHHEEEEECCCCCCCCC
IDKIEFLIQSAAAQLENSEAASGALAEAIMTTDTFPKEVAVEFELETGEKARIGAVAKGS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEEEECCC
GMIAPNMATMLSFITTDVDASSSELTEALRVAVDESFNMLIVDGDESTNDMVIISSTRTS
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEECCCCC
GRIDSNFREALVAVCRELARMMARDGEGVTKSFQVDVVNAGTHEDAKMAARAIAGSSLVK
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCHHHH
TAIFGADPNWGRIVAAAGYSGAEFDPEEISVTLESDSESVVIVDHGDILAFEGTEELETA
HEEECCCCCCCEEEEECCCCCCCCCHHHEEEEEECCCCEEEEEECCCEEEECCCHHHHHH
ERVMTSKEIRIIVDLAAGDESATAYGCDLTYDYVRINAEYTT
HHHHCCCCEEEEEEEECCCCCCEEEECCEEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463