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Identifier: 15678155

GI number: 15678155

Start: 82058

End: 82981

Strand: Direct

Name: Not Available

Synonym: MTH127

Alternate gene names: 15678155

Gene position: 82058-82981 (Clockwise)

Preceding gene: 15678154

Following gene: 15678156

Centisome position: 4.69

GC content: 52.92

Gene sequence:

>924_bases
GTGTTAATTTTGAATGTGAATCACATGAATATAACCCAGGGTATGGGTGTGGCAGAGCTCATAGAGGAGATGGGACGTTC
AGGGGTCCTGGGAGCTGGCAGGGTCCACAGGGCAACGAAGCTCCTGCGTGGGATGATTGATGACCTGGAAATGGCCATCT
TCATGAGCGTGGCCGGGCCCCTGGTTCCAGGCGGCATGAGGAGGATAATAAGGGACCTCATAGATGATGGAACCATAAGC
GCCCTGATAACAAGTGGCGCAAACCTTACCCATGACCTCCTGGAGGCCTTCGGGGGCGCCCATTACAGGGACTATGGCTT
TGACGATGAGAAACTGCACCAGGAGGGTATAGGCCGTATTGGTGATGTCTATACAAGGTCAGAGGACTTTGAGGTATTTG
AATCAGAGAACCAGGAAATATTTTCATCCATATTCTCAGCAAAACCCCACATATCCATCCAGGAACTCATACATGAGATA
GGAGGCCATCTGGATGATGATATGTCAATAATAAGAACAGCACATCTTCGCGGAGTCCCCATATACGCCCCTGGACTCAT
TGACAGCATGCTGGGCCTCCAGCTATGGATGTACACCCAGGATAACAGGATCTGCCTGGATGCTGTGAAGGATATGCACA
GTCTCTCGGACCTTGTTTTCAGCCATGAGCGCATAGGCGCCATAATACTTGGAGGAGGACTCCCCAAACACTACACCCTC
GCATCAACCCTCCTCAGGGGAGGGGTGGATGCCGCGGTCCAGATAACCATGGACCGTAGTGAGACCGGGAGCCTCAGCGG
GGCACCCCTGGAGGAGGCAAAGTCATGGGCGAAGGCCCAGGCAGGTTCAAACCTTGTAACTGTGGTGGGTGATGCAACAG
CACTCTTCCCGGTCATACTGGCGGGGGCATTATCTGAGCTTTAG

Upstream 100 bases:

>100_bases
TATAATTGCACCAGCTTAACAGGATCCAGTACATACCGGCTAAGGCATGCACTCGAGATCTGTTATTTAATTAAATCTTT
ACAGTTATCAATCCAGGGAA

Downstream 100 bases:

>100_bases
GGCGAGGTTGGAGATTAGACGGGATTATCATTACTGAGGGTCTGTATGATTGAGTTTCTATACCCTGTTTCAGGTTTTCT
CATGAAGATTGCCGATGAGT

Product: deoxyhypusine synthase

Products: NA

Alternate protein names: DHS

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MLILNVNHMNITQGMGVAELIEEMGRSGVLGAGRVHRATKLLRGMIDDLEMAIFMSVAGPLVPGGMRRIIRDLIDDGTIS
ALITSGANLTHDLLEAFGGAHYRDYGFDDEKLHQEGIGRIGDVYTRSEDFEVFESENQEIFSSIFSAKPHISIQELIHEI
GGHLDDDMSIIRTAHLRGVPIYAPGLIDSMLGLQLWMYTQDNRICLDAVKDMHSLSDLVFSHERIGAIILGGGLPKHYTL
ASTLLRGGVDAAVQITMDRSETGSLSGAPLEEAKSWAKAQAGSNLVTVVGDATALFPVILAGALSEL

Sequences:

>Translated_307_residues
MLILNVNHMNITQGMGVAELIEEMGRSGVLGAGRVHRATKLLRGMIDDLEMAIFMSVAGPLVPGGMRRIIRDLIDDGTIS
ALITSGANLTHDLLEAFGGAHYRDYGFDDEKLHQEGIGRIGDVYTRSEDFEVFESENQEIFSSIFSAKPHISIQELIHEI
GGHLDDDMSIIRTAHLRGVPIYAPGLIDSMLGLQLWMYTQDNRICLDAVKDMHSLSDLVFSHERIGAIILGGGLPKHYTL
ASTLLRGGVDAAVQITMDRSETGSLSGAPLEEAKSWAKAQAGSNLVTVVGDATALFPVILAGALSEL
>Mature_307_residues
MLILNVNHMNITQGMGVAELIEEMGRSGVLGAGRVHRATKLLRGMIDDLEMAIFMSVAGPLVPGGMRRIIRDLIDDGTIS
ALITSGANLTHDLLEAFGGAHYRDYGFDDEKLHQEGIGRIGDVYTRSEDFEVFESENQEIFSSIFSAKPHISIQELIHEI
GGHLDDDMSIIRTAHLRGVPIYAPGLIDSMLGLQLWMYTQDNRICLDAVKDMHSLSDLVFSHERIGAIILGGGLPKHYTL
ASTLLRGGVDAAVQITMDRSETGSLSGAPLEEAKSWAKAQAGSNLVTVVGDATALFPVILAGALSEL

Specific function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine

COG id: COG1899

COG function: function code O; Deoxyhypusine synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoxyhypusine synthase family

Homologues:

Organism=Homo sapiens, GI4503325, Length=328, Percent_Identity=25.3048780487805, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17536927, Length=262, Percent_Identity=27.0992366412214, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321859, Length=279, Percent_Identity=26.8817204301075, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45550569, Length=268, Percent_Identity=25.7462686567164, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHYS_METTH (O26230)

Other databases:

- EMBL:   AE000666
- PIR:   E69036
- RefSeq:   NP_275270.1
- ProteinModelPortal:   O26230
- SMR:   O26230
- STRING:   O26230
- GeneID:   1470088
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH127
- NMPDR:   fig|187420.1.peg.125
- eggNOG:   arNOG05744
- HOGENOM:   HBG716221
- OMA:   YINTGQE
- PhylomeDB:   O26230
- ProtClustDB:   CLSK797831
- BioCyc:   MTHE187420:MTH127-MONOMER
- BRENDA:   2.5.1.46
- HAMAP:   MF_00153
- InterPro:   IPR002773
- InterPro:   IPR022899
- Gene3D:   G3DSA:3.40.910.10
- PANTHER:   PTHR11703
- TIGRFAMs:   TIGR00321

Pfam domain/function: PF01916 DS

EC number: =2.5.1.46

Molecular weight: Translated: 33178; Mature: 33178

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: ACT_SITE 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLILNVNHMNITQGMGVAELIEEMGRSGVLGAGRVHRATKLLRGMIDDLEMAIFMSVAGP
CEEEEECCCCHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LVPGGMRRIIRDLIDDGTISALITSGANLTHDLLEAFGGAHYRDYGFDDEKLHQEGIGRI
CCCHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHH
GDVYTRSEDFEVFESENQEIFSSIFSAKPHISIQELIHEIGGHLDDDMSIIRTAHLRGVP
HHHHCCCCCHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCC
IYAPGLIDSMLGLQLWMYTQDNRICLDAVKDMHSLSDLVFSHERIGAIILGGGLPKHYTL
EECCHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHH
ASTLLRGGVDAAVQITMDRSETGSLSGAPLEEAKSWAKAQAGSNLVTVVGDATALFPVIL
HHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHH
AGALSEL
HHHHHCC
>Mature Secondary Structure
MLILNVNHMNITQGMGVAELIEEMGRSGVLGAGRVHRATKLLRGMIDDLEMAIFMSVAGP
CEEEEECCCCHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LVPGGMRRIIRDLIDDGTISALITSGANLTHDLLEAFGGAHYRDYGFDDEKLHQEGIGRI
CCCHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHH
GDVYTRSEDFEVFESENQEIFSSIFSAKPHISIQELIHEIGGHLDDDMSIIRTAHLRGVP
HHHHCCCCCHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCC
IYAPGLIDSMLGLQLWMYTQDNRICLDAVKDMHSLSDLVFSHERIGAIILGGGLPKHYTL
EECCHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHH
ASTLLRGGVDAAVQITMDRSETGSLSGAPLEEAKSWAKAQAGSNLVTVVGDATALFPVIL
HHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHH
AGALSEL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463