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Identifier: 15678057

GI number: 15678057

Start: 12859

End: 14229

Strand: Direct

Name: Not Available

Synonym: MTH26

Alternate gene names: 15678057

Gene position: 12859-14229 (Clockwise)

Preceding gene: 15678056

Following gene: 15678058

Centisome position: 0.73

GC content: 51.71

Gene sequence:

>1371_bases
GTGGAGCAGTTGAAGGAAAAATTTGAACCCCTATTCTCAGTCCTGCCCCAGGTAAAGTCACCTGGTTACAGGGTTCCCTT
CAGGGAGAAACTCAAATGGACGGGCATAATCCTTGTCCTTTATTTCTTCCTGGCCCAGATACCCCTTTATGGTTTGAGTG
CAAATGCAGTGGACCAGTTTGCCCAGTTCAGGGCTGTGCTCGCAGGAAACTTTGGTTCAATACTCACCCTGGGTATAGGT
CCAATAGTATCAGCATCAATCATACTCCAGCTCCTGGTAGGGGGTAAGATCCTTAAACTTGACCTTTCGAGGCATGAGGA
TAAGGCGTTTTTCCAGGGACTGCAGAAGCTCCTTGCCATTGTATTCACATTCTTCGAGGCCCTGATATTCGTACTCACAG
GGTCACTGGCACCATCAGCTCCACAGTTTGTCTGGGTCCTCATACTCCAGCTCACCATCGGAGGGATACTGATAATATTC
CTTGATGAGGTGGTTTCCAAGTGGGGATTCGGTAGCGGTGTCGGACTATTCATCGCAGCGGGAGTATCCCAGGAGATAAT
CGTGGGTGCATTCAACCCGCTCTCAGCACCCACCCAGCCAGGGGTGCCTGCAGGTAGAATAACAGGTTTCCTCTACCTCC
TATTCACAGGGCAGTCACCGGACTTCCAGTACTATGTGCTCCCTGTACTGGCCCTCATAGCTGTGTTCCTTGTGGTTGTA
TACGCGGAGAGTATGCGTGTTGAGATACCCATATCCATGGGTGGGGGTAAGAGGCTCTCAAGGGGTGCTGTTGGAAAGTA
TCCCCTCAGGTTCATATACGCAAGTAACATGCCGGTTATACTCACAAGCGCCCTCCTCCTCAACGTCCAGCTCCTTGCCA
ATGTCTTCCAGAAACTGGGATACCCCATACTGGGTACCGTCAGCAATGGACAGGCAGTTGATGGGCTGGCATATCTCCTG
ACAGCCCCCAGGTCCATCGACGCCCTCATACTCGACCCCTTCAGGGTCGTCTTCTATGCGGTTGTATTCATCGGACTCTG
TGTCCTCTTTGCCTGGCTCTGGGTTGAGATAAGTAACATCGGCCCGAGGCATGTTGCGAGGCAGCTGTACCAGATGGGTA
TGCAGATACCTGGCTTCAGGAGCAGCAGGGGCCAGTTTGAGAAGATACTTAAACGCTACATACCCACCATAACCATACTT
GGTGGAGCATTTGTGGGGCTCCTTGCATTCGTGGCTGACCTCACAGGTTCACTCGGTGGAGGAACAGGTGTACTTCTCAC
CGTGGGTATAGTTTACAGACTCTATGAGGAGATAGCCCAGGAACAGCTCATGGACATGCACCCGATACTTCGAAGCTTCC
TGGGTGATTAG

Upstream 100 bases:

>100_bases
GTCCATCTCAAGGCATACGAGTTCTCCAGGAGCGCCACCGAGAAGATCGAAGAGGCCGGAGGAAAGGCTGAAGTCATAGA
GTGAAACCAGCTGACAAGGA

Downstream 100 bases:

>100_bases
AACTAAATTCGGAAGTGGTACCATGAAGGTTGTTGTAGTTGCGGGAATACCTGGTTCAGGAAGCACAACGGTCCTTGAGA
ACACCCTTAAGGAGCTTGAC

Product: preprotein translocase subunit SecY

Products: NA

Alternate protein names: Protein transport protein SEC61 subunit alpha homolog

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MEQLKEKFEPLFSVLPQVKSPGYRVPFREKLKWTGIILVLYFFLAQIPLYGLSANAVDQFAQFRAVLAGNFGSILTLGIG
PIVSASIILQLLVGGKILKLDLSRHEDKAFFQGLQKLLAIVFTFFEALIFVLTGSLAPSAPQFVWVLILQLTIGGILIIF
LDEVVSKWGFGSGVGLFIAAGVSQEIIVGAFNPLSAPTQPGVPAGRITGFLYLLFTGQSPDFQYYVLPVLALIAVFLVVV
YAESMRVEIPISMGGGKRLSRGAVGKYPLRFIYASNMPVILTSALLLNVQLLANVFQKLGYPILGTVSNGQAVDGLAYLL
TAPRSIDALILDPFRVVFYAVVFIGLCVLFAWLWVEISNIGPRHVARQLYQMGMQIPGFRSSRGQFEKILKRYIPTITIL
GGAFVGLLAFVADLTGSLGGGTGVLLTVGIVYRLYEEIAQEQLMDMHPILRSFLGD

Sequences:

>Translated_456_residues
MEQLKEKFEPLFSVLPQVKSPGYRVPFREKLKWTGIILVLYFFLAQIPLYGLSANAVDQFAQFRAVLAGNFGSILTLGIG
PIVSASIILQLLVGGKILKLDLSRHEDKAFFQGLQKLLAIVFTFFEALIFVLTGSLAPSAPQFVWVLILQLTIGGILIIF
LDEVVSKWGFGSGVGLFIAAGVSQEIIVGAFNPLSAPTQPGVPAGRITGFLYLLFTGQSPDFQYYVLPVLALIAVFLVVV
YAESMRVEIPISMGGGKRLSRGAVGKYPLRFIYASNMPVILTSALLLNVQLLANVFQKLGYPILGTVSNGQAVDGLAYLL
TAPRSIDALILDPFRVVFYAVVFIGLCVLFAWLWVEISNIGPRHVARQLYQMGMQIPGFRSSRGQFEKILKRYIPTITIL
GGAFVGLLAFVADLTGSLGGGTGVLLTVGIVYRLYEEIAQEQLMDMHPILRSFLGD
>Mature_456_residues
MEQLKEKFEPLFSVLPQVKSPGYRVPFREKLKWTGIILVLYFFLAQIPLYGLSANAVDQFAQFRAVLAGNFGSILTLGIG
PIVSASIILQLLVGGKILKLDLSRHEDKAFFQGLQKLLAIVFTFFEALIFVLTGSLAPSAPQFVWVLILQLTIGGILIIF
LDEVVSKWGFGSGVGLFIAAGVSQEIIVGAFNPLSAPTQPGVPAGRITGFLYLLFTGQSPDFQYYVLPVLALIAVFLVVV
YAESMRVEIPISMGGGKRLSRGAVGKYPLRFIYASNMPVILTSALLLNVQLLANVFQKLGYPILGTVSNGQAVDGLAYLL
TAPRSIDALILDPFRVVFYAVVFIGLCVLFAWLWVEISNIGPRHVARQLYQMGMQIPGFRSSRGQFEKILKRYIPTITIL
GGAFVGLLAFVADLTGSLGGGTGVLLTVGIVYRLYEEIAQEQLMDMHPILRSFLGD

Specific function: Involved in protein export. Interacts with secE to allow the translocation of proteins across the plasma membrane, by forming part of a channel

COG id: COG0201

COG function: function code U; Preprotein translocase subunit SecY

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secY/SEC61-alpha family

Homologues:

Organism=Homo sapiens, GI14589847, Length=466, Percent_Identity=34.549356223176, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI7019415, Length=466, Percent_Identity=34.9785407725322, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI217330618, Length=466, Percent_Identity=32.8326180257511, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI217330616, Length=406, Percent_Identity=33.2512315270936, Blast_Score=210, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17543770, Length=463, Percent_Identity=34.7732181425486, Blast_Score=246, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6323411, Length=464, Percent_Identity=35.5603448275862, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319760, Length=474, Percent_Identity=25.7383966244726, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI19920826, Length=466, Percent_Identity=34.9785407725322, Blast_Score=252, Evalue=4e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SECY_METTH (O26134)

Other databases:

- EMBL:   AE000666
- PIR:   F69132
- RefSeq:   NP_275171.1
- ProteinModelPortal:   O26134
- SMR:   O26134
- STRING:   O26134
- GeneID:   1469988
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH26
- NMPDR:   fig|187420.1.peg.26
- eggNOG:   arNOG04660
- HOGENOM:   HBG589438
- OMA:   WSDTSAG
- PhylomeDB:   O26134
- ProtClustDB:   PRK08568
- BioCyc:   MTHE187420:MTH26-MONOMER
- InterPro:   IPR002208
- InterPro:   IPR023201
- InterPro:   IPR019561
- PANTHER:   PTHR10906
- PIRSF:   PIRSF004557
- PRINTS:   PR00303
- TIGRFAMs:   TIGR00967

Pfam domain/function: PF10559 Plug_translocon; PF00344 SecY; SSF103491 SecY

EC number: NA

Molecular weight: Translated: 49791; Mature: 49791

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS00755 SECY_1; PS00756 SECY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x91f9ed4)-; HASH(0xbbed694)-; HASH(0xbbe89d0)-; HASH(0xbbbd8c0)-; HASH(0xbbf4f90)-; HASH(0xb020998)-; HASH(0xb15867c)-; HASH(0xbbeb380)-; HASH(0xbbf1294)-; HASH(0xbbf2ae0)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure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CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9371463