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The map label for this gene is rpl4lp

Identifier: 15678034

GI number: 15678034

Start: 2023

End: 2787

Strand: Direct

Name: rpl4lp

Synonym: MTH3

Alternate gene names: 15678034

Gene position: 2023-2787 (Clockwise)

Preceding gene: 15678033

Following gene: 15678035

Centisome position: 0.12

GC content: 51.76

Gene sequence:

>765_bases
ATGAAGATTAAGGTTTATTCCCTAGAAGGTGAAGCCATAGATGAGATGGAACTTCCTGAAATTTTCAACGAAGAATTCAG
ACCCGACGTCATAAAGAGGGCTGTCCTGTCCGCACAGACAGCAAGGGTACAGCCATGGGGTCCAGATCCAATGGCAGGTA
AGAGGACCTCTGCACAGTCCTATGGTGCCGGACGCGGCGTTGCAATGGTTCCACGTATAAAGAATGGTTCAAGGGCCGCC
TTTGTTCCACAGGCAGTGGGCGGTAGAAGGGCTCACCCCCCAAGGCCCCAGAAGAACTACCATGAAAGGATAAACAGGAA
GGAGAGGCGACTTGCAATAAGGTCCGCAGTTGCAGCGACAGCCAGGAAGGACCTTGTGGAGGCAAGGGGTCACAGGATAG
AGAACGTACCCCAGCTGCCACTGGTGGTCGACGACGAACTCTCCATGATTAAAAGGACCGCCGATACAAGGGAAGTCTTC
AGGAAACTTGGAATCATGGACGACATTGTAAGGGCAAGGGAAGGCAAAAAGATACGAGCAGGAAAGGGAAAGATGAGGGG
TAGAAAGTACAGGACACCCAGGGGTCCCCTCATAGTCGTTGGAGACGATAAGGGGATAACAAGGGGTGCGAGGAACCACC
CGGGCGTTGACGTGGTAAGGGTGGAAAACCTCAACGCAGAGCTACTGGCCCCTGGAACACATCCTGGAAGACTGACCGTC
TTTACAAGATCAGCAATAGAAAAACTTGATGAACTATTCCAGTAA

Upstream 100 bases:

>100_bases
TCTCAGGAAGGCCATAAGGGCTGCAGGTAAACAGGAAGAAGCACCCCAGATAAACTACATCAGCACAGCATCAAAACAAG
GAGTATAAGAGTGGTTCAAA

Downstream 100 bases:

>100_bases
AGAAGGAGTGACGGTGTATATTATGGATCCATATGCTGTTATTATGAAGCCACATGTCACAGAGAAGAGCATGAACCTTA
TAGATCAGAACAATGAACTG

Product: 50S ribosomal protein L4P

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MKIKVYSLEGEAIDEMELPEIFNEEFRPDVIKRAVLSAQTARVQPWGPDPMAGKRTSAQSYGAGRGVAMVPRIKNGSRAA
FVPQAVGGRRAHPPRPQKNYHERINRKERRLAIRSAVAATARKDLVEARGHRIENVPQLPLVVDDELSMIKRTADTREVF
RKLGIMDDIVRAREGKKIRAGKGKMRGRKYRTPRGPLIVVGDDKGITRGARNHPGVDVVRVENLNAELLAPGTHPGRLTV
FTRSAIEKLDELFQ

Sequences:

>Translated_254_residues
MKIKVYSLEGEAIDEMELPEIFNEEFRPDVIKRAVLSAQTARVQPWGPDPMAGKRTSAQSYGAGRGVAMVPRIKNGSRAA
FVPQAVGGRRAHPPRPQKNYHERINRKERRLAIRSAVAATARKDLVEARGHRIENVPQLPLVVDDELSMIKRTADTREVF
RKLGIMDDIVRAREGKKIRAGKGKMRGRKYRTPRGPLIVVGDDKGITRGARNHPGVDVVRVENLNAELLAPGTHPGRLTV
FTRSAIEKLDELFQ
>Mature_254_residues
MKIKVYSLEGEAIDEMELPEIFNEEFRPDVIKRAVLSAQTARVQPWGPDPMAGKRTSAQSYGAGRGVAMVPRIKNGSRAA
FVPQAVGGRRAHPPRPQKNYHERINRKERRLAIRSAVAATARKDLVEARGHRIENVPQLPLVVDDELSMIKRTADTREVF
RKLGIMDDIVRAREGKKIRAGKGKMRGRKYRTPRGPLIVVGDDKGITRGARNHPGVDVVRVENLNAELLAPGTHPGRLTV
FTRSAIEKLDELFQ

Specific function: Forms part of the polypeptide exit tunnel

COG id: COG0088

COG function: function code J; Ribosomal protein L4

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribosomal protein L4P family

Homologues:

Organism=Homo sapiens, GI16579885, Length=257, Percent_Identity=40.4669260700389, Blast_Score=180, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17508669, Length=257, Percent_Identity=36.5758754863813, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6319505, Length=258, Percent_Identity=38.7596899224806, Blast_Score=173, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6320215, Length=258, Percent_Identity=38.7596899224806, Blast_Score=173, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24650747, Length=258, Percent_Identity=35.6589147286822, Blast_Score=167, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RL4_METTH (O26111)

Other databases:

- EMBL:   AE000666
- PIR:   B69138
- RefSeq:   NP_275148.1
- ProteinModelPortal:   O26111
- SMR:   O26111
- STRING:   O26111
- GeneID:   1469965
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH3
- NMPDR:   fig|187420.1.peg.3
- eggNOG:   arNOG06979
- HOGENOM:   HBG316531
- OMA:   KMRGRRY
- PhylomeDB:   O26111
- ProtClustDB:   PRK04042
- BioCyc:   MTHE187420:MTH3-MONOMER
- GO:   GO:0005840
- GO:   GO:0006412
- HAMAP:   MF_01328_A
- InterPro:   IPR002136
- InterPro:   IPR013000
- InterPro:   IPR019970
- TIGRFAMs:   TIGR03672

Pfam domain/function: PF00573 Ribosomal_L4; SSF52166 Ribosomal_L4/L1E

EC number: NA

Molecular weight: Translated: 28387; Mature: 28387

Theoretical pI: Translated: 11.25; Mature: 11.25

Prosite motif: PS00939 RIBOSOMAL_L1E

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKVYSLEGEAIDEMELPEIFNEEFRPDVIKRAVLSAQTARVQPWGPDPMAGKRTSAQS
CEEEEEECCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
YGAGRGVAMVPRIKNGSRAAFVPQAVGGRRAHPPRPQKNYHERINRKERRLAIRSAVAAT
CCCCCCEEEECCCCCCCCEEECCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ARKDLVEARGHRIENVPQLPLVVDDELSMIKRTADTREVFRKLGIMDDIVRAREGKKIRA
HHHHHHHHCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCEEEC
GKGKMRGRKYRTPRGPLIVVGDDKGITRGARNHPGVDVVRVENLNAELLAPGTHPGRLTV
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCCEEEE
FTRSAIEKLDELFQ
EEHHHHHHHHHHHC
>Mature Secondary Structure
MKIKVYSLEGEAIDEMELPEIFNEEFRPDVIKRAVLSAQTARVQPWGPDPMAGKRTSAQS
CEEEEEECCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
YGAGRGVAMVPRIKNGSRAAFVPQAVGGRRAHPPRPQKNYHERINRKERRLAIRSAVAAT
CCCCCCEEEECCCCCCCCEEECCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ARKDLVEARGHRIENVPQLPLVVDDELSMIKRTADTREVFRKLGIMDDIVRAREGKKIRA
HHHHHHHHCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCEEEC
GKGKMRGRKYRTPRGPLIVVGDDKGITRGARNHPGVDVVRVENLNAELLAPGTHPGRLTV
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCCEEEE
FTRSAIEKLDELFQ
EEHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463