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Identifier: 15646188

GI number: 15646188

Start: 1659473

End: 1660483

Strand: Reverse

Name: Not Available

Synonym: HP1581

Alternate gene names: 15646188

Gene position: 1660483-1659473 (Counterclockwise)

Preceding gene: 15646194

Following gene: 15646187

Centisome position: 99.56

GC content: 39.27

Gene sequence:

>1011_bases
GTGTTGTGGGTGCTATATTTTTTAACCAGTTTATTTATTTGCTCTTTGATTGTTCTGTGGTCTAAAAAATCCATGCTTTT
TGTGGATAACGCTAATAAAATCCAAGGCTTTCATCATGCAAGAACCCCACGAGCCGGGGGGCTTGGGATCTTTCTTTCTT
TTGTGTTAGCTTATCTTTTTGAGCCTTTTGAAGCACCTTTTAAGGGGTTTTTTGTTTTTTTGGGGTTGTTGTTAGTCTTT
TTAAGCGGTTTTTTAGAAGACATTAACCTTTCATTAAGCCCCAAAATACGCCTTATTTTGCAAGCCGTAGGGGTTGTTTG
CATCATTTCATCAATGCCTTTAGTGGTGAGCGATTTTTCGCCCCTTTTTAGCTTGCCTTATTTTATCGCTTTTTTATTCG
CTATCTTTATGCTGGTGGGTATCAGTAACGCTATTAATATCATTGACGGGTTTAACGGGCTTGCATCAGGGATTTGCGCG
ATTACTCTTTTAGTCATTCATTATATAGAGCCTAGCAGTTTGGCGTGCCTATTAGCTTACATGGTGCTTGGGTTTATGGT
GTTAAATTTCCCTTTAGGAAAGATTTTTTTAGGCGATGGAGGGGCGTATTTTTTGGGTTTGGTGTGCGGGATTTCCCTTT
TACATTTGAGTTTGGAGCAAAAAATCAGCGTGTTTTTTGGGCTCAATTTAATGCTTTATCCGGTCATAGAGGTGCTTTTT
AGTATCCTTAGGCGCAAAATAAAACGCCAGAAAGCCACCATGCCGGATAACTTGCATTTGCACACCCTTTTATTCAAATA
CTTGCAACAGCGTTCTTTCAATTACCCTAACCCTTTATGCGCATTTATCCTTATTCTGTGCAACCTGCCTTTTATTTTAA
TCAGCGTCTTTTTCCGCTTAAATCCTTACGCGCTCATTGCCATTAGCCTAGTCTTTATCGCATGCTATTTAATGGGCTAT
GCTTATTTGAACAGGCAAGTTTGTGCTTTAGAAAAGCGAGCGTTTCAATGA

Upstream 100 bases:

>100_bases
TTTTTGGAATTGTAACATAAAACCCGCCTCTTACACCTATAAGATTTTATCATCAAGCTATCTTTTGCTATAATAGTGAA
AATACTAAATCCAATAAAAA

Downstream 100 bases:

>100_bases
AAAAGCTCAAAGGTCTTTTTTTGATCCTGCTCTTATGGGTCTATCCTTTAAGGAGTGAGCCAATCAATGAGGGAGCATAC
ATTTTAGAAGAGATTGGCGA

Product: methicillin resistance protein (llm)

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MLWVLYFLTSLFICSLIVLWSKKSMLFVDNANKIQGFHHARTPRAGGLGIFLSFVLAYLFEPFEAPFKGFFVFLGLLLVF
LSGFLEDINLSLSPKIRLILQAVGVVCIISSMPLVVSDFSPLFSLPYFIAFLFAIFMLVGISNAINIIDGFNGLASGICA
ITLLVIHYIEPSSLACLLAYMVLGFMVLNFPLGKIFLGDGGAYFLGLVCGISLLHLSLEQKISVFFGLNLMLYPVIEVLF
SILRRKIKRQKATMPDNLHLHTLLFKYLQQRSFNYPNPLCAFILILCNLPFILISVFFRLNPYALIAISLVFIACYLMGY
AYLNRQVCALEKRAFQ

Sequences:

>Translated_336_residues
MLWVLYFLTSLFICSLIVLWSKKSMLFVDNANKIQGFHHARTPRAGGLGIFLSFVLAYLFEPFEAPFKGFFVFLGLLLVF
LSGFLEDINLSLSPKIRLILQAVGVVCIISSMPLVVSDFSPLFSLPYFIAFLFAIFMLVGISNAINIIDGFNGLASGICA
ITLLVIHYIEPSSLACLLAYMVLGFMVLNFPLGKIFLGDGGAYFLGLVCGISLLHLSLEQKISVFFGLNLMLYPVIEVLF
SILRRKIKRQKATMPDNLHLHTLLFKYLQQRSFNYPNPLCAFILILCNLPFILISVFFRLNPYALIAISLVFIACYLMGY
AYLNRQVCALEKRAFQ
>Mature_336_residues
MLWVLYFLTSLFICSLIVLWSKKSMLFVDNANKIQGFHHARTPRAGGLGIFLSFVLAYLFEPFEAPFKGFFVFLGLLLVF
LSGFLEDINLSLSPKIRLILQAVGVVCIISSMPLVVSDFSPLFSLPYFIAFLFAIFMLVGISNAINIIDGFNGLASGICA
ITLLVIHYIEPSSLACLLAYMVLGFMVLNFPLGKIFLGDGGAYFLGLVCGISLLHLSLEQKISVFFGLNLMLYPVIEVLF
SILRRKIKRQKATMPDNLHLHTLLFKYLQQRSFNYPNPLCAFILILCNLPFILISVFFRLNPYALIAISLVFIACYLMGY
AYLNRQVCALEKRAFQ

Specific function: Catalyzes the formation of undecaprenyl-PP-N- acetylglucosamine. Involved in the synthesis of anionic cell-wall polymers as it mediates the initiation of the linkage unit formation that appears to be common to the two types of teichoic acids attached to t

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=266, Percent_Identity=25.5639097744361, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715
- InterPro:   IPR018480 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 37804; Mature: 37804

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLWVLYFLTSLFICSLIVLWSKKSMLFVDNANKIQGFHHARTPRAGGLGIFLSFVLAYLF
CCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHCCHHHCCCCCCCCHHHHHHHHHHHHH
EPFEAPFKGFFVFLGLLLVFLSGFLEDINLSLSPKIRLILQAVGVVCIISSMPLVVSDFS
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCC
PLFSLPYFIAFLFAIFMLVGISNAINIIDGFNGLASGICAITLLVIHYIEPSSLACLLAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
MVLGFMVLNFPLGKIFLGDGGAYFLGLVCGISLLHLSLEQKISVFFGLNLMLYPVIEVLF
HHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SILRRKIKRQKATMPDNLHLHTLLFKYLQQRSFNYPNPLCAFILILCNLPFILISVFFRL
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHC
NPYALIAISLVFIACYLMGYAYLNRQVCALEKRAFQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLWVLYFLTSLFICSLIVLWSKKSMLFVDNANKIQGFHHARTPRAGGLGIFLSFVLAYLF
CCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHCCHHHCCCCCCCCHHHHHHHHHHHHH
EPFEAPFKGFFVFLGLLLVFLSGFLEDINLSLSPKIRLILQAVGVVCIISSMPLVVSDFS
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCC
PLFSLPYFIAFLFAIFMLVGISNAINIIDGFNGLASGICAITLLVIHYIEPSSLACLLAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
MVLGFMVLNFPLGKIFLGDGGAYFLGLVCGISLLHLSLEQKISVFFGLNLMLYPVIEVLF
HHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SILRRKIKRQKATMPDNLHLHTLLFKYLQQRSFNYPNPLCAFILILCNLPFILISVFFRL
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHC
NPYALIAISLVFIACYLMGYAYLNRQVCALEKRAFQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12101296; 9384377 [H]