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Identifier: 15646172

GI number: 15646172

Start: 1647268

End: 1649034

Strand: Reverse

Name: Not Available

Synonym: HP1565

Alternate gene names: 15646172

Gene position: 1649034-1647268 (Counterclockwise)

Preceding gene: 15646173

Following gene: 15646169

Centisome position: 98.87

GC content: 40.8

Gene sequence:

>1767_bases
ATGAAAAATCTTCGCTATAAGCTTTTGCTCTTTGTTTTTATAGGGTTTTGGGGGTTACTAGCCTTAAATTTATTTATTTT
AAGCGTTAAAAATCAAGAATACTATGAAAAATTGGCTGAACGAAACATGACTAAAAAGGAATTTCTAGTCCCTACAAGGG
GAAATATTACAGACAGAAATGATGAGTTTTTGGCCACTAATGAATTGGTGTTTGGCGTGTTTTTGCCCAGCGGACTGAAA
CAAAAAGATCTTTTAGAAAAAATTGAAATCATCCAAAAGTTTTTCCCTAACTTTTCTAAAGAAACGCTTTTAAACAATTA
CCAAAAAGAAAATTCGCTTTATAACCATAACCTCATTAAAGTGGTTGGCTTCATTCCTTATGCCACCATGCAACCTCTTT
ATGCCAAACTCATCCAAACTCAAGGCATTTTTGCGCTTCCCTTAGACAAGCGTTACTACCCTAATAACGCTTTAGCTTCG
CATGTTTTAGGCTATGTGGGGGTGGCAAGCTTGCAAGATTTAAAAGACGATGAGGAGAATCAATACAGCCAGATTGTAGG
CAAAACCGGCATTGAAAAAGAATACAACAAGCTTTTACAAGGCAAGGTGGGTTATAAAATCATGCGTGTCAATGCGCTCA
ATCAAGAATTAGCCACCTTAGAAGTAGTGCTGCCAAGCACCAACAACCACTTGCAATTGAGTTTAGACAAACGCTTGCAA
AAAGAAGCGGACAAGCTCTTTGAAAATAAAAGGGGGGCTATTTTAGTGATGGATGCAGAAAATGGGGAATTGCTCGTTGC
AGGAAGTTACCCTGAATACAATTTGAACGATTTTGTAGGCGGGATCAGTCAAGACAAATGGCAAAAACTTCAAGATGATA
TTTATAACCCCTTATTAAACCGCTTCGCTAACGCCTTGTATCCGCCGGGATCTGTGGTTAAAATGGGCGTGGGCTTGAGC
TTTTTAGAAAACCTTCATATCACAGAAAACACCACCATACCCACCCCGCCTTTTATTGAAGTGGGCAAGCACAAATTCAG
AGACTGGAAAAAAACAGGGCATGGCAATTCTAATTTGTATAAAGCCATTAGGGAGTCCGTGGATGTGTATTTTTATAAGT
TTGGGCTTGAAATCTCTATAGAAAAACTCTCTAAAACCTTAAGGGAAGTGGGCTTTGGGGAAAAAACGGGCGTTGATTTG
CCGAATGAATTTGTGGGGATTGTGCCGGATAATTTGTGGAAACTCAAACGCTTCAATCAAGACTGGCGCGTTGGGGACAC
GCTCATTACCGCTATTGGGCAAGGCTCTTTTTTAGCCACGCCCTTGCAGGTTCTAGCCTACACGGGACTCATTGCTACGG
GCAAACTGGCAACGCCTCATTTCGCTATCAACAACAAACAACCGCTTAAAGATCCCCTAAATAGCTTTCAAAAAAAGAAG
CTCCAAGCCTTGAGAGTGGGCATGTATGAAGTGTGTAACCATAAAGACGGCACCGCTTATCATTCCACAAGGGGTTCTAA
GATTACTTTAGCGTGTAAAACCGGCACCGCACAAGTCGTGGAAATCGCTCAAAACATCGTCAATCGCATGAAAGAAAAGG
ATATGGAATATTTCCATCGATCCCATGCGTGGATTACCGCATTTTTGCCTTATGAAAAACCCAAATACGCTATCACTATT
TTAGTAGAACATGGGGAAGGGGGGTCAAAACTAGGGGGCCTGTTAGTGAAGATGAGTAATAAACTCTATGAGCTTGGCTA
TCTTTAA

Upstream 100 bases:

>100_bases
TACCTTTATTTATCGCGCTTTTTTTCGATGTCTTTGAGTTTGAAAATACTCGGCTTTCTCGCTCTTTTTGCTTTAATAGA
AAGCGCTTTGTGGGGTTTGT

Downstream 100 bases:

>100_bases
TAAAATTTTAAATCTTTTCAAAAACGCAACCTTTTAAACGCTAAAGACCATTAGCCAACCTGTTTCCAACTCATTCCACC
GCTCTATAACCCAGTCTAAC

Product: penicillin-binding protein 2 (pbp2)

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 588; Mature: 588

Protein sequence:

>588_residues
MKNLRYKLLLFVFIGFWGLLALNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGNITDRNDEFLATNELVFGVFLPSGLK
QKDLLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIKVVGFIPYATMQPLYAKLIQTQGIFALPLDKRYYPNNALAS
HVLGYVGVASLQDLKDDEENQYSQIVGKTGIEKEYNKLLQGKVGYKIMRVNALNQELATLEVVLPSTNNHLQLSLDKRLQ
KEADKLFENKRGAILVMDAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLNRFANALYPPGSVVKMGVGLS
FLENLHITENTTIPTPPFIEVGKHKFRDWKKTGHGNSNLYKAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDL
PNEFVGIVPDNLWKLKRFNQDWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKK
LQALRVGMYEVCNHKDGTAYHSTRGSKITLACKTGTAQVVEIAQNIVNRMKEKDMEYFHRSHAWITAFLPYEKPKYAITI
LVEHGEGGSKLGGLLVKMSNKLYELGYL

Sequences:

>Translated_588_residues
MKNLRYKLLLFVFIGFWGLLALNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGNITDRNDEFLATNELVFGVFLPSGLK
QKDLLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIKVVGFIPYATMQPLYAKLIQTQGIFALPLDKRYYPNNALAS
HVLGYVGVASLQDLKDDEENQYSQIVGKTGIEKEYNKLLQGKVGYKIMRVNALNQELATLEVVLPSTNNHLQLSLDKRLQ
KEADKLFENKRGAILVMDAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLNRFANALYPPGSVVKMGVGLS
FLENLHITENTTIPTPPFIEVGKHKFRDWKKTGHGNSNLYKAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDL
PNEFVGIVPDNLWKLKRFNQDWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKK
LQALRVGMYEVCNHKDGTAYHSTRGSKITLACKTGTAQVVEIAQNIVNRMKEKDMEYFHRSHAWITAFLPYEKPKYAITI
LVEHGEGGSKLGGLLVKMSNKLYELGYL
>Mature_588_residues
MKNLRYKLLLFVFIGFWGLLALNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGNITDRNDEFLATNELVFGVFLPSGLK
QKDLLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIKVVGFIPYATMQPLYAKLIQTQGIFALPLDKRYYPNNALAS
HVLGYVGVASLQDLKDDEENQYSQIVGKTGIEKEYNKLLQGKVGYKIMRVNALNQELATLEVVLPSTNNHLQLSLDKRLQ
KEADKLFENKRGAILVMDAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLNRFANALYPPGSVVKMGVGLS
FLENLHITENTTIPTPPFIEVGKHKFRDWKKTGHGNSNLYKAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDL
PNEFVGIVPDNLWKLKRFNQDWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKK
LQALRVGMYEVCNHKDGTAYHSTRGSKITLACKTGTAQVVEIAQNIVNRMKEKDMEYFHRSHAWITAFLPYEKPKYAITI
LVEHGEGGSKLGGLLVKMSNKLYELGYL

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=614, Percent_Identity=30.1302931596091, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1786272, Length=449, Percent_Identity=22.9398663697105, Blast_Score=107, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 66804; Mature: 66804

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLRYKLLLFVFIGFWGLLALNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGNITDRN
CCCCHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHCCCCHHHEECCCCCCCCCCC
DEFLATNELVFGVFLPSGLKQKDLLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIK
CCEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHH
VVGFIPYATMQPLYAKLIQTQGIFALPLDKRYYPNNALASHVLGYVGVASLQDLKDDEEN
HHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHH
QYSQIVGKTGIEKEYNKLLQGKVGYKIMRVNALNQELATLEVVLPSTNNHLQLSLDKRLQ
HHHHHHHCCCCHHHHHHHHCCCCCEEEEEEEHHCCCCEEEEEEECCCCCEEEEEHHHHHH
KEADKLFENKRGAILVMDAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLN
HHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHH
RFANALYPPGSVVKMGVGLSFLENLHITENTTIPTPPFIEVGKHKFRDWKKTGHGNSNLY
HHHHHCCCCCCCEECCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
KAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDLPNEFVGIVPDNLWKLKRFNQ
HHHHHHHHEEEEEECCEEEHHHHHHHHHHCCCCCCCCCCCCCHHEECCCCHHHHHHHCCC
DWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKK
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCHHHHHHHHHHH
LQALRVGMYEVCNHKDGTAYHSTRGSKITLACKTGTAQVVEIAQNIVNRMKEKDMEYFHR
HHHHHHHHHHHHCCCCCCCEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
SHAWITAFLPYEKPKYAITILVEHGEGGSKLGGLLVKMSNKLYELGYL
CCCEEEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHHCHHHHCCCC
>Mature Secondary Structure
MKNLRYKLLLFVFIGFWGLLALNLFILSVKNQEYYEKLAERNMTKKEFLVPTRGNITDRN
CCCCHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHCCCCHHHEECCCCCCCCCCC
DEFLATNELVFGVFLPSGLKQKDLLEKIEIIQKFFPNFSKETLLNNYQKENSLYNHNLIK
CCEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHH
VVGFIPYATMQPLYAKLIQTQGIFALPLDKRYYPNNALASHVLGYVGVASLQDLKDDEEN
HHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHH
QYSQIVGKTGIEKEYNKLLQGKVGYKIMRVNALNQELATLEVVLPSTNNHLQLSLDKRLQ
HHHHHHHCCCCHHHHHHHHCCCCCEEEEEEEHHCCCCEEEEEEECCCCCEEEEEHHHHHH
KEADKLFENKRGAILVMDAENGELLVAGSYPEYNLNDFVGGISQDKWQKLQDDIYNPLLN
HHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHH
RFANALYPPGSVVKMGVGLSFLENLHITENTTIPTPPFIEVGKHKFRDWKKTGHGNSNLY
HHHHHCCCCCCCEECCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
KAIRESVDVYFYKFGLEISIEKLSKTLREVGFGEKTGVDLPNEFVGIVPDNLWKLKRFNQ
HHHHHHHHEEEEEECCEEEHHHHHHHHHHCCCCCCCCCCCCCHHEECCCCHHHHHHHCCC
DWRVGDTLITAIGQGSFLATPLQVLAYTGLIATGKLATPHFAINNKQPLKDPLNSFQKKK
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCHHHHHHHHHHH
LQALRVGMYEVCNHKDGTAYHSTRGSKITLACKTGTAQVVEIAQNIVNRMKEKDMEYFHR
HHHHHHHHHHHHCCCCCCCEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
SHAWITAFLPYEKPKYAITILVEHGEGGSKLGGLLVKMSNKLYELGYL
CCCEEEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHHCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]