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Identifier: 15646146

GI number: 15646146

Start: 1616732

End: 1617970

Strand: Reverse

Name: Not Available

Synonym: HP1539

Alternate gene names: 15646146

Gene position: 1617970-1616732 (Counterclockwise)

Preceding gene: 15646147

Following gene: 15646204

Centisome position: 97.01

GC content: 42.94

Gene sequence:

>1239_bases
ATGGCAGAGATAAAAAAAGCGAAAAATTTAGGCGAATGGCTGGACATGCGTCTTGGCACTAACAAGCTTGTTAAAGTGCT
AATGACAGAATATTGGATCCCTAAAAACATCAATTTTTTATGGGCGATGGGGGTGATTTTATTAACCCTTTTTGGCGTGC
TTGTGGTCTCAGGGATTTTCTTGCTCATGTATTACAAGCCTGATGCGAAAATGGCGTTTGATAGCGTGAATTTCACCATC
ATGCAAGAAGTGGCTTATGGCTGGCTTTGGCGCCACATGCATGCCACGGCAGCGAGCATGATTTTTGTCATCATTTATAT
CCACATGTTTGTTGGCATCTATTATGGCTCTTACAAAAAGGGTCGTGAGATGATTTGGATTAGCGGGATGATTTTGTTTG
TGGTCTTTAGCGCGGAAGCCTTTAGCGGGTATATGCTGCCTTGGGGGCAGATGAGTTATTGGGCCGCAGCGGTTATCACG
AATTTATTTGGAGGCATTCCTTTCATTGGGGCTGATGTGGTGGAGTGGATTAGAGGCAATTATGTTGTGGCGGATTCCAC
TTTAACGCGCTTTTTCATGCTCCATGTGTTTTTACTGCCCATTGCGATCATTCTACTTGTTGGGGTGCATTTTTATTCTT
TACGCATCCCGCATGTCAATAACCAAGAAGGCGAAGAGATTGACTTTGAATTAGAAGAGAAGAAATTCATTGAAGGCAAG
AAAAAAGAATCCAAAGTCATTCCTTTTTGGCCGGTGTTCTTGTCTAAAGATATTTTTGTGGTTTGCGCGTTCATGGTCTT
TTTCTTTTACTTGGTGTGTTACCACTATGATTTTGCGATGGATCCTATCAACTTTGAAAGGGCTAACAGCCTTAAAACGC
CGCCTCACATTTACCCTGAATGGTATTTCTTATGGAGCTATGAAGTCTTAAGAGGCTTTTTCTTTAGCGCTGATTTAGGG
CTAATGGCCTTTGGCGTGGCGCAAGTGATTTTCTTTTTGCTACCCTTCTTGGATCGAAGTCCAGTGGTCGCTCCTGCGCA
CAAACGGCCGGCGTTTATGGTGTGGTTTTGGCTTGTAATCATTGATATGATTGTTTTAACGATCTATGGTAAATTGCCTC
CGCTTGGGATTGGTAAATACATTGGCTTAGCGGGTTCAATCACTTTTTTGGCCCTTTTCTTTGTGGTATTGCCCATCATC
ACTATCGCTGAGAGCAAGAAACAAGGGGGTGTTAGATGA

Upstream 100 bases:

>100_bases
TTTGATATCCCGCCTTTTAAAATTGAAGGCACTAAGATCACTTTTGGTGAAGCCGGGGCTGAATACAAGAAAATGATGGC
TAAAGCGTAAGGAGAGTTTA

Downstream 100 bases:

>100_bases
AAGAGTTTAAGATTCTAATCATCCTCATTGTGGTGGTAGGCGTGATTTATTATGGGGTTGAGCCTTATGCGCATTCGGTG
ATGCACCCTAAAGTCGCTCC

Product: ubiquinol cytochrome c oxidoreductase, cytochrome b subunit (fbcH)

Products: Q; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MAEIKKAKNLGEWLDMRLGTNKLVKVLMTEYWIPKNINFLWAMGVILLTLFGVLVVSGIFLLMYYKPDAKMAFDSVNFTI
MQEVAYGWLWRHMHATAASMIFVIIYIHMFVGIYYGSYKKGREMIWISGMILFVVFSAEAFSGYMLPWGQMSYWAAAVIT
NLFGGIPFIGADVVEWIRGNYVVADSTLTRFFMLHVFLLPIAIILLVGVHFYSLRIPHVNNQEGEEIDFELEEKKFIEGK
KKESKVIPFWPVFLSKDIFVVCAFMVFFFYLVCYHYDFAMDPINFERANSLKTPPHIYPEWYFLWSYEVLRGFFFSADLG
LMAFGVAQVIFFLLPFLDRSPVVAPAHKRPAFMVWFWLVIIDMIVLTIYGKLPPLGIGKYIGLAGSITFLALFFVVLPII
TIAESKKQGGVR

Sequences:

>Translated_412_residues
MAEIKKAKNLGEWLDMRLGTNKLVKVLMTEYWIPKNINFLWAMGVILLTLFGVLVVSGIFLLMYYKPDAKMAFDSVNFTI
MQEVAYGWLWRHMHATAASMIFVIIYIHMFVGIYYGSYKKGREMIWISGMILFVVFSAEAFSGYMLPWGQMSYWAAAVIT
NLFGGIPFIGADVVEWIRGNYVVADSTLTRFFMLHVFLLPIAIILLVGVHFYSLRIPHVNNQEGEEIDFELEEKKFIEGK
KKESKVIPFWPVFLSKDIFVVCAFMVFFFYLVCYHYDFAMDPINFERANSLKTPPHIYPEWYFLWSYEVLRGFFFSADLG
LMAFGVAQVIFFLLPFLDRSPVVAPAHKRPAFMVWFWLVIIDMIVLTIYGKLPPLGIGKYIGLAGSITFLALFFVVLPII
TIAESKKQGGVR
>Mature_411_residues
AEIKKAKNLGEWLDMRLGTNKLVKVLMTEYWIPKNINFLWAMGVILLTLFGVLVVSGIFLLMYYKPDAKMAFDSVNFTIM
QEVAYGWLWRHMHATAASMIFVIIYIHMFVGIYYGSYKKGREMIWISGMILFVVFSAEAFSGYMLPWGQMSYWAAAVITN
LFGGIPFIGADVVEWIRGNYVVADSTLTRFFMLHVFLLPIAIILLVGVHFYSLRIPHVNNQEGEEIDFELEEKKFIEGKK
KESKVIPFWPVFLSKDIFVVCAFMVFFFYLVCYHYDFAMDPINFERANSLKTPPHIYPEWYFLWSYEVLRGFFFSADLGL
MAFGVAQVIFFLLPFLDRSPVVAPAHKRPAFMVWFWLVIIDMIVLTIYGKLPPLGIGKYIGLAGSITFLALFFVVLPIIT
IAESKKQGGVR

Specific function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis [H]

COG id: COG1290

COG function: function code C; Cytochrome b subunit of the bc complex

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome b family [H]

Homologues:

Organism=Homo sapiens, GI251831119, Length=390, Percent_Identity=36.1538461538462, Blast_Score=216, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6226529, Length=321, Percent_Identity=37.3831775700935, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6226532, Length=241, Percent_Identity=38.5892116182573, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6226531, Length=152, Percent_Identity=43.421052631579, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6226530, Length=132, Percent_Identity=40.1515151515151, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016175
- InterPro:   IPR005798
- InterPro:   IPR005797
- InterPro:   IPR016174 [H]

Pfam domain/function: PF00032 Cytochrom_B_C; PF00033 Cytochrom_B_N [H]

EC number: 1.10.2.2

Molecular weight: Translated: 47511; Mature: 47380

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS51002 CYTB_NTER ; PS51003 CYTB_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AEIKKAKNLGEWLDMRLGTNKLVKVLMTEYWIPKNINFLWAMGVILLTLFGVLVVSGIF
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLMYYKPDAKMAFDSVNFTIMQEVAYGWLWRHMHATAASMIFVIIYIHMFVGIYYGSYKK
HHHEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GREMIWISGMILFVVFSAEAFSGYMLPWGQMSYWAAAVITNLFGGIPFIGADVVEWIRGN
CCEEEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
YVVADSTLTRFFMLHVFLLPIAIILLVGVHFYSLRIPHVNNQEGEEIDFELEEKKFIEGK
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCEEHHHHHHCCC
KKESKVIPFWPVFLSKDIFVVCAFMVFFFYLVCYHYDFAMDPINFERANSLKTPPHIYPE
CCCCCCCCEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCC
WYFLWSYEVLRGFFFSADLGLMAFGVAQVIFFLLPFLDRSPVVAPAHKRPAFMVWFWLVI
CEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
IDMIVLTIYGKLPPLGIGKYIGLAGSITFLALFFVVLPIITIAESKKQGGVR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: QH2; ferricytochrome c

Specific reaction: QH2 + 2 ferricytochrome c = Q + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2821268; 3004982; 2821272; 2556259; 2176897 [H]