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Identifier: 15646131

GI number: 15646131

Start: 1602088

End: 1603959

Strand: Reverse

Name: Not Available

Synonym: HP1523

Alternate gene names: 15646131

Gene position: 1603959-1602088 (Counterclockwise)

Preceding gene: 15646134

Following gene: 15646130

Centisome position: 96.17

GC content: 37.93

Gene sequence:

>1872_bases
TTGCAAGAAACAGATAATTTATTAAAAACATTGAATGTGAAATCGCTTTTAGAAGCCTTGCTTGTTTATACGCCCAAAGG
CTATAAAGATTTAAATTTATTAGAGCGTTTTGAAACGGGCTTGAGCGGCGTTTTAGAAGTGGGTATTTTAGAGAAAAGAA
ACTACGCCAAAGTTTTAAAGATTTTCGCCTATTCCAAACGATTTTACAAAAATTTAGAGCTTGTTTTTTTCAATTACAGC
GCGTTCCATCACAGCCAGTTTAAAACCGGCGAGAGTTTGTTTATTTATGGTAAATTAGAGCAAAGCTCTTTTAATCAAGC
TTATATCATTAACACGCCTAAAATCATTACCAAATTTGGTAAAATTTCTTTAATTTTTAAAAAAGTTAAAAATCATAAAA
AAATACAAGAAAATTTACAAAAACTCATTTCTTTAGAAAATTTAAAAAAGGAAGGCGTTAAAGAGAATATCGCGCATTTA
TTGTTAGAAATCTTTTTCCCCACGCCGCATTTTGTCAAGGATTTTGAAACGAATAAAAATTTTCCTTCACAACATTTAAA
TGCATTAAAATACATTGAAATGCTTTTTTATATGAAAAATTTAGAGCGCAAAAAATTGCAATTTGGCGCTAAAATCGCAT
GCCCCAATAATAACGAGCGCTTGAAAGCGTTTATCGCTTCTTTACCCTTTAAACTCACACGCGATCAACAAAACGCCATT
AAAGAAATCCAAAACGATCTCACTAGCTCCATAGCGTGCAAGCGTTTGATTATAGGCGATGTGGGGTGCGGGAAAACGAT
GGTGATTTTAGCGAGCATGGTATTAACTTACCCAAATAAAACCCTTTTAATGGCGCCCACTTCCATTCTCGCTAAACAGC
TTTATAACGAAGCCTTAAAATTTTTACCCCCTTATTTTGAAGTGGAATTGCTGCTCGGCGGGAGTTACAAGAAGCGATCC
AATCATTTGTTTGAAACAATCACGCATGTGGTTATCGGCACGCAAGCGTTGTTGTTTGATAAGCGCGATTTGAATGAATT
CGCTCTAGTGATCACTGATGAACAGCACCGATTTGGCACCAAGCAGCGCTACCAATTAGAAAAAATGGCAAGCAGTAAGG
GTAATAAACCCCATTCTTTGCAATTTTCCGCTACCCCCATTCCTCGCACGCTCGCCCTAGCCAAAAGCGCGTTTGTGAAA
ACGACCATGATTAGAGAAATCCCTTATCCTAAAGAGATTGAAACTCTAGTCTTGCATAAAAGAGATTTTAAAATAGTGAT
GGAGAAAATCAGCGAAGAAATCGCTAAAAACCATCAAGTCATTGTCGTCTATCCGCTGGTGAATGAGAGCGAAAAAATCC
CGTATTTATCGCTCAGTGAGGGGGCGAGTTTTTGGCAAAAACGCTTTAAAAAGGTTTATACCACTTCAGGGCAAGATAAA
AATAAAGAAGAAGTGATTGAAGAATTTAGAGAATCCGGGAGCATTCTTTTAGCGACTACGCTCATTGAGGTGGGCATTTC
TTTACCACGATTGAGCGTGATGGTGATTTTAGCGCCCGAAAGGTTAGGCTTAGCGACTTTACACCAGTTAAGGGGGCGCG
TTTCTCGTAACGGCTTGAAAGGCTATTGTTTTTTATGCACGATCCAAGAAGAAAACGAACGATTAGAAAAGTTTGCTGAT
GAATTGGACGGCTTTAAAATCGCTGAATTGGATTTAGAATACAGAAAAAGCGGGGATTTACTCCAGGGAGGGGAGCAGAG
CGGGAATAGTTTTGAATACATTGACTTAGCCAAAGATGAAAACATTATCGCTGAAGTGAAACGGGATTTTTTAAAGGCCG
CTAGCGTTTCACGGGGAACATTTGAAAATTGA

Upstream 100 bases:

>100_bases
GAGTGATTTTAGATTTCATCAATTAAATTTCCTTAAGTCAATGTATAATTTGACTATCTTATCATAAAAATGATTAAGGA
TTGGCTAGGGTAAGAACAAA

Downstream 100 bases:

>100_bases
AAATTAAGGCAGAATTGGGTAATTTAAATCATTTAAAAAAAGGATAGAGATGCAAAATAAAGAAATTGGTGAAGAAAAAA
GCGTTAATGAAAAAAATGTA

Product: ATP-dependent DNA helicase RecG

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 623; Mature: 623

Protein sequence:

>623_residues
MQETDNLLKTLNVKSLLEALLVYTPKGYKDLNLLERFETGLSGVLEVGILEKRNYAKVLKIFAYSKRFYKNLELVFFNYS
AFHHSQFKTGESLFIYGKLEQSSFNQAYIINTPKIITKFGKISLIFKKVKNHKKIQENLQKLISLENLKKEGVKENIAHL
LLEIFFPTPHFVKDFETNKNFPSQHLNALKYIEMLFYMKNLERKKLQFGAKIACPNNNERLKAFIASLPFKLTRDQQNAI
KEIQNDLTSSIACKRLIIGDVGCGKTMVILASMVLTYPNKTLLMAPTSILAKQLYNEALKFLPPYFEVELLLGGSYKKRS
NHLFETITHVVIGTQALLFDKRDLNEFALVITDEQHRFGTKQRYQLEKMASSKGNKPHSLQFSATPIPRTLALAKSAFVK
TTMIREIPYPKEIETLVLHKRDFKIVMEKISEEIAKNHQVIVVYPLVNESEKIPYLSLSEGASFWQKRFKKVYTTSGQDK
NKEEVIEEFRESGSILLATTLIEVGISLPRLSVMVILAPERLGLATLHQLRGRVSRNGLKGYCFLCTIQEENERLEKFAD
ELDGFKIAELDLEYRKSGDLLQGGEQSGNSFEYIDLAKDENIIAEVKRDFLKAASVSRGTFEN

Sequences:

>Translated_623_residues
MQETDNLLKTLNVKSLLEALLVYTPKGYKDLNLLERFETGLSGVLEVGILEKRNYAKVLKIFAYSKRFYKNLELVFFNYS
AFHHSQFKTGESLFIYGKLEQSSFNQAYIINTPKIITKFGKISLIFKKVKNHKKIQENLQKLISLENLKKEGVKENIAHL
LLEIFFPTPHFVKDFETNKNFPSQHLNALKYIEMLFYMKNLERKKLQFGAKIACPNNNERLKAFIASLPFKLTRDQQNAI
KEIQNDLTSSIACKRLIIGDVGCGKTMVILASMVLTYPNKTLLMAPTSILAKQLYNEALKFLPPYFEVELLLGGSYKKRS
NHLFETITHVVIGTQALLFDKRDLNEFALVITDEQHRFGTKQRYQLEKMASSKGNKPHSLQFSATPIPRTLALAKSAFVK
TTMIREIPYPKEIETLVLHKRDFKIVMEKISEEIAKNHQVIVVYPLVNESEKIPYLSLSEGASFWQKRFKKVYTTSGQDK
NKEEVIEEFRESGSILLATTLIEVGISLPRLSVMVILAPERLGLATLHQLRGRVSRNGLKGYCFLCTIQEENERLEKFAD
ELDGFKIAELDLEYRKSGDLLQGGEQSGNSFEYIDLAKDENIIAEVKRDFLKAASVSRGTFEN
>Mature_623_residues
MQETDNLLKTLNVKSLLEALLVYTPKGYKDLNLLERFETGLSGVLEVGILEKRNYAKVLKIFAYSKRFYKNLELVFFNYS
AFHHSQFKTGESLFIYGKLEQSSFNQAYIINTPKIITKFGKISLIFKKVKNHKKIQENLQKLISLENLKKEGVKENIAHL
LLEIFFPTPHFVKDFETNKNFPSQHLNALKYIEMLFYMKNLERKKLQFGAKIACPNNNERLKAFIASLPFKLTRDQQNAI
KEIQNDLTSSIACKRLIIGDVGCGKTMVILASMVLTYPNKTLLMAPTSILAKQLYNEALKFLPPYFEVELLLGGSYKKRS
NHLFETITHVVIGTQALLFDKRDLNEFALVITDEQHRFGTKQRYQLEKMASSKGNKPHSLQFSATPIPRTLALAKSAFVK
TTMIREIPYPKEIETLVLHKRDFKIVMEKISEEIAKNHQVIVVYPLVNESEKIPYLSLSEGASFWQKRFKKVYTTSGQDK
NKEEVIEEFRESGSILLATTLIEVGISLPRLSVMVILAPERLGLATLHQLRGRVSRNGLKGYCFLCTIQEENERLEKFAD
ELDGFKIAELDLEYRKSGDLLQGGEQSGNSFEYIDLAKDENIIAEVKRDFLKAASVSRGTFEN

Specific function: Critical role in recombination and DNA repair. Help process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3' to 5' polarity. RecG unwind branched dup

COG id: COG1200

COG function: function code LK; RecG-like helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367254, Length=587, Percent_Identity=32.1976149914821, Blast_Score=225, Evalue=8e-60,
Organism=Escherichia coli, GI1787357, Length=393, Percent_Identity=31.5521628498728, Blast_Score=164, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004609
- InterPro:   IPR001650
- InterPro:   IPR014021 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 71394; Mature: 71394

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQETDNLLKTLNVKSLLEALLVYTPKGYKDLNLLERFETGLSGVLEVGILEKRNYAKVLK
CCCHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IFAYSKRFYKNLELVFFNYSAFHHSQFKTGESLFIYGKLEQSSFNQAYIINTPKIITKFG
HHHHHHHHHCCEEEEEEECCHHCCCCCCCCCEEEEEEEECCCCCCCEEEEECHHHHHHHH
KISLIFKKVKNHKKIQENLQKLISLENLKKEGVKENIAHLLLEIFFPTPHFVKDFETNKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHCCCCCC
FPSQHLNALKYIEMLFYMKNLERKKLQFGAKIACPNNNERLKAFIASLPFKLTRDQQNAI
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHCCCCCCCCHHHHH
KEIQNDLTSSIACKRLIIGDVGCGKTMVILASMVLTYPNKTLLMAPTSILAKQLYNEALK
HHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHH
FLPPYFEVELLLGGSYKKRSNHLFETITHVVIGTQALLFDKRDLNEFALVITDEQHRFGT
HCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHEEECCCCCCCEEEEEECCHHHCCC
KQRYQLEKMASSKGNKPHSLQFSATPIPRTLALAKSAFVKTTMIREIPYPKEIETLVLHK
HHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RDFKIVMEKISEEIAKNHQVIVVYPLVNESEKIPYLSLSEGASFWQKRFKKVYTTSGQDK
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCC
NKEEVIEEFRESGSILLATTLIEVGISLPRLSVMVILAPERLGLATLHQLRGRVSRNGLK
CHHHHHHHHHHCCCEEEEHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCC
GYCFLCTIQEENERLEKFADELDGFKIAELDLEYRKSGDLLQGGEQSGNSFEYIDLAKDE
EEEEEEEEECHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCCCCCCCCCEEEEEECCCC
NIIAEVKRDFLKAASVSRGTFEN
HHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQETDNLLKTLNVKSLLEALLVYTPKGYKDLNLLERFETGLSGVLEVGILEKRNYAKVLK
CCCHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IFAYSKRFYKNLELVFFNYSAFHHSQFKTGESLFIYGKLEQSSFNQAYIINTPKIITKFG
HHHHHHHHHCCEEEEEEECCHHCCCCCCCCCEEEEEEEECCCCCCCEEEEECHHHHHHHH
KISLIFKKVKNHKKIQENLQKLISLENLKKEGVKENIAHLLLEIFFPTPHFVKDFETNKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHCCCCCC
FPSQHLNALKYIEMLFYMKNLERKKLQFGAKIACPNNNERLKAFIASLPFKLTRDQQNAI
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHCCCCCCCCHHHHH
KEIQNDLTSSIACKRLIIGDVGCGKTMVILASMVLTYPNKTLLMAPTSILAKQLYNEALK
HHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHH
FLPPYFEVELLLGGSYKKRSNHLFETITHVVIGTQALLFDKRDLNEFALVITDEQHRFGT
HCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHEEECCCCCCCEEEEEECCHHHCCC
KQRYQLEKMASSKGNKPHSLQFSATPIPRTLALAKSAFVKTTMIREIPYPKEIETLVLHK
HHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RDFKIVMEKISEEIAKNHQVIVVYPLVNESEKIPYLSLSEGASFWQKRFKKVYTTSGQDK
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCC
NKEEVIEEFRESGSILLATTLIEVGISLPRLSVMVILAPERLGLATLHQLRGRVSRNGLK
CHHHHHHHHHHCCCEEEEHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCC
GYCFLCTIQEENERLEKFADELDGFKIAELDLEYRKSGDLLQGGEQSGNSFEYIDLAKDE
EEEEEEEEECHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCCCCCCCCCEEEEEECCCC
NIIAEVKRDFLKAASVSRGTFEN
HHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]