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Identifier: 15646115

GI number: 15646115

Start: 1578968

End: 1580194

Strand: Reverse

Name: Not Available

Synonym: HP1506

Alternate gene names: 15646115

Gene position: 1580194-1578968 (Counterclockwise)

Preceding gene: 15646117

Following gene: 15646114

Centisome position: 94.74

GC content: 43.68

Gene sequence:

>1227_bases
TTGCAAGAAATTAAGTTGGATATTTATGCCACTTTGGTGTGCATGGTTTTAGTGCTGCTTTTGGGGCGTTATGTGATTTC
TAAAGTCAAGTTTTTGCGCGATTATGATATTCCAGAGCCTGTTGTGGGCGGGGTTTTAGTCGCTTTTGCTATCATGTTAG
CGCGTCAGTTTTACAATTTTGGCTTGCAATTTGATTCTTCTTTAAAAGATCCTTTAATGCTGACTTTTTTTATCACCATT
GGTTTGAGCGCGGATTTCAAATCTTTACAAAAAGGCGGGAAAATGCTTGCGGTTTTTTTGCTGGCTGTGGCGGGGTTTGT
GGTGTGTCAAAATGCAGTGGGGATTTCTACCGCTAGCCTTTTAGGGGTCAATCCTTTAATGGGGCTTTTAGGGGGGTCTA
TCGCTTTAGTGGGAGGGCATGGCACTAGCGCGGCATGGGCTAATTTTTTCACCCAACCACCTTATAATTTTAGCTCCAGC
TTAGAAGTGGGCATGGCGTGCGCGACTTTTGGCTTGGTGAGCGGGGGGATTATTGGAGGACCTGTCGCTAAATATTTGAT
CTCAAAATACAAACTAGAGCCTAAAGACACTAAAGAAAAAGACACTTTAGAGGGCGTGGTGTCTAAAGGCTTTGAAACCC
CTAAAGAGCAACGCCTAATCACCGAATCCAGTTTTGTAGAAACCTTAGCTCTAATTGCAATAGCTTTATTAGTGGGGACT
TTTTTATCGCATTTGGTGCCTAAAAGCTTCACCTTGCCGACTTTTGTGTGGTGCTTGTTTGTAGGGGTTATTTTAAGAAA
CACCTTGTCGTTTTTTAAAATCCATAGCGTGTTTGACAGAGAGGTTTCAGTCATAGGGAACGTGAGTTTGAGCCTGTTTT
TAGCCTACGCTTTGATGAGCGTGAATTTATTGGAATTGTTAAAACTCGCTGTGCCGTTAGCGGTTATTTTGAGCGTTCAA
GTGGTATTTATGATCCTTTATGTGGTGCTGGTAACCTTTAGGGTATGCGGGAAGGATTATGATGCGGCGGTGTTGTGCGC
GGGGCATTGCGGTTTTGGGCTTGGAGCGACTCCAACGGCTATGGTGAATATGCAAACCATCACCAACCACTACGGGCCAT
CGCATGTGGCGTTTATCGTCGTGCCTTTAGTGGGAGCGTTTTTTGTTGATATTATTAACGCTTTAGCGATTAAAGGCTTT
TTGCTCTTGCCTTTTTTCCCATCATGA

Upstream 100 bases:

>100_bases
TAATACTGTATGCAAGGAACACCTACTTTCTAACTGATCTCGTTCTTTTAGGGGGGTATTATATTATAATAAGATAAATT
TGATTAATAAGGATGCAAGT

Downstream 100 bases:

>100_bases
GACTTTATGAGAGTTTATTAGAAATGTGCTTGAATAAGGCATGGGAGCATCAAACCCTAGCCTTAGAAAACCCAAGCGTA
GCTTGCATGGTGTTGGATAA

Product: glutamate permease (gltS)

Products: Na (I) [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate permease [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MQEIKLDIYATLVCMVLVLLLGRYVISKVKFLRDYDIPEPVVGGVLVAFAIMLARQFYNFGLQFDSSLKDPLMLTFFITI
GLSADFKSLQKGGKMLAVFLLAVAGFVVCQNAVGISTASLLGVNPLMGLLGGSIALVGGHGTSAAWANFFTQPPYNFSSS
LEVGMACATFGLVSGGIIGGPVAKYLISKYKLEPKDTKEKDTLEGVVSKGFETPKEQRLITESSFVETLALIAIALLVGT
FLSHLVPKSFTLPTFVWCLFVGVILRNTLSFFKIHSVFDREVSVIGNVSLSLFLAYALMSVNLLELLKLAVPLAVILSVQ
VVFMILYVVLVTFRVCGKDYDAAVLCAGHCGFGLGATPTAMVNMQTITNHYGPSHVAFIVVPLVGAFFVDIINALAIKGF
LLLPFFPS

Sequences:

>Translated_408_residues
MQEIKLDIYATLVCMVLVLLLGRYVISKVKFLRDYDIPEPVVGGVLVAFAIMLARQFYNFGLQFDSSLKDPLMLTFFITI
GLSADFKSLQKGGKMLAVFLLAVAGFVVCQNAVGISTASLLGVNPLMGLLGGSIALVGGHGTSAAWANFFTQPPYNFSSS
LEVGMACATFGLVSGGIIGGPVAKYLISKYKLEPKDTKEKDTLEGVVSKGFETPKEQRLITESSFVETLALIAIALLVGT
FLSHLVPKSFTLPTFVWCLFVGVILRNTLSFFKIHSVFDREVSVIGNVSLSLFLAYALMSVNLLELLKLAVPLAVILSVQ
VVFMILYVVLVTFRVCGKDYDAAVLCAGHCGFGLGATPTAMVNMQTITNHYGPSHVAFIVVPLVGAFFVDIINALAIKGF
LLLPFFPS
>Mature_408_residues
MQEIKLDIYATLVCMVLVLLLGRYVISKVKFLRDYDIPEPVVGGVLVAFAIMLARQFYNFGLQFDSSLKDPLMLTFFITI
GLSADFKSLQKGGKMLAVFLLAVAGFVVCQNAVGISTASLLGVNPLMGLLGGSIALVGGHGTSAAWANFFTQPPYNFSSS
LEVGMACATFGLVSGGIIGGPVAKYLISKYKLEPKDTKEKDTLEGVVSKGFETPKEQRLITESSFVETLALIAIALLVGT
FLSHLVPKSFTLPTFVWCLFVGVILRNTLSFFKIHSVFDREVSVIGNVSLSLFLAYALMSVNLLELLKLAVPLAVILSVQ
VVFMILYVVLVTFRVCGKDYDAAVLCAGHCGFGLGATPTAMVNMQTITNHYGPSHVAFIVVPLVGAFFVDIINALAIKGF
LLLPFFPS

Specific function: Catalyzes the sodium-dependent uptake of extracellular glutamate [H]

COG id: COG0786

COG function: function code E; Na+/glutamate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gltS symporter family [H]

Homologues:

Organism=Escherichia coli, GI1790085, Length=386, Percent_Identity=56.4766839378238, Blast_Score=387, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004445 [H]

Pfam domain/function: PF03616 Glt_symporter [H]

EC number: NA

Molecular weight: Translated: 43958; Mature: 43958

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure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HEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + L-glutamate [Periplasm] = Na (I) [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2254324; 2017136; 7686882; 9278503; 1544582 [H]