Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15645961

GI number: 15645961

Start: 1407878

End: 1408600

Strand: Reverse

Name: Not Available

Synonym: HP1348

Alternate gene names: 15645961

Gene position: 1408600-1407878 (Counterclockwise)

Preceding gene: 15645962

Following gene: 15645960

Centisome position: 84.46

GC content: 39.56

Gene sequence:

>723_bases
ATGAAGTCAAATAAAAAGTCCAATCGTTTAAGAGCGATTTATAGAGCTTTAGTGATCGCTATAGGACTAGCTGTTATCAT
CGTTTTCAATTACTTTAACCGCAAAAACAATAACGCCCGCTCCAGCCGTAGGGCTTGTTCGTGCTTTTTTTCCCTTACCG
GGGTTAATTTAGAAAAAATAGGCACTTTTGATACGGACGCTAAACTCATTGTCTTAAACCACCAAAGCTTACTAGACATC
ATTTATTTAGAAGCCTACCACCCTAGAAATATTTGCTGGATCGCTAAAAAAGAGCTGGGCGAAATCCCTTTTTATGGGCA
TGCCTTAACGGATACCGGAATGATTTTAATTGACAGAGAGGATAAAAAGGGGATTGTGAGCCTTTTGAAAGCGTGTAAAG
AAAAATTAGACCAAAACCGCCCTTTAGTGATTTTCCCTGAAGGCACTAGAGGCAAAGGAGGAGAAAAATTCCTCCCTTTC
AAGCAAGGGGCTAAAATCATCGCCGAAAAATTCCAGCTCAAAATCCAACCCATGGTGTTAATCAATTCCATTAAAATCTT
TAATTCCAAGCCTCTAGAAGCCTATAAAGCGCGCACCCGTTTAGTCATGCTAGAAAGCTATACGCCTGATTTTAACTCGC
CCACCTGGTATGAAGAATTACAAGAACGCATGCAAAAAGAGTATTTAAAACACTATCATGAATTAAACCCTAGCGAACAA
TGA

Upstream 100 bases:

>100_bases
GGGCTTTCTAAAAATGAAATGCCGATTAAAATCTTAGGCTCGCATGATGATTATTATAAAATCCTAACGCCGCATGAACA
AATAGGATGGGTCAAAAAAG

Downstream 100 bases:

>100_bases
AGCTTTTTGACTACGCTCCTTTGAGTTTGGCTTGGCGGGAGTTTTTGCAAAGCGAATTTAAAAAGCCTTATTTTTTAGAA
ATAGAAAAACGCTACCTAGA

Product: 1-acyl-glycerol-3-phosphate acyltransferase (plsC)

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MKSNKKSNRLRAIYRALVIAIGLAVIIVFNYFNRKNNNARSSRRACSCFFSLTGVNLEKIGTFDTDAKLIVLNHQSLLDI
IYLEAYHPRNICWIAKKELGEIPFYGHALTDTGMILIDREDKKGIVSLLKACKEKLDQNRPLVIFPEGTRGKGGEKFLPF
KQGAKIIAEKFQLKIQPMVLINSIKIFNSKPLEAYKARTRLVMLESYTPDFNSPTWYEELQERMQKEYLKHYHELNPSEQ

Sequences:

>Translated_240_residues
MKSNKKSNRLRAIYRALVIAIGLAVIIVFNYFNRKNNNARSSRRACSCFFSLTGVNLEKIGTFDTDAKLIVLNHQSLLDI
IYLEAYHPRNICWIAKKELGEIPFYGHALTDTGMILIDREDKKGIVSLLKACKEKLDQNRPLVIFPEGTRGKGGEKFLPF
KQGAKIIAEKFQLKIQPMVLINSIKIFNSKPLEAYKARTRLVMLESYTPDFNSPTWYEELQERMQKEYLKHYHELNPSEQ
>Mature_240_residues
MKSNKKSNRLRAIYRALVIAIGLAVIIVFNYFNRKNNNARSSRRACSCFFSLTGVNLEKIGTFDTDAKLIVLNHQSLLDI
IYLEAYHPRNICWIAKKELGEIPFYGHALTDTGMILIDREDKKGIVSLLKACKEKLDQNRPLVIFPEGTRGKGGEKFLPF
KQGAKIIAEKFQLKIQPMVLINSIKIFNSKPLEAYKARTRLVMLESYTPDFNSPTWYEELQERMQKEYLKHYHELNPSEQ

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

Homologues:

Organism=Homo sapiens, GI5453718, Length=229, Percent_Identity=25.764192139738, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI15100175, Length=229, Percent_Identity=25.764192139738, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17564032, Length=155, Percent_Identity=32.258064516129, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6320151, Length=151, Percent_Identity=31.7880794701987, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281364648, Length=168, Percent_Identity=30.952380952381, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24582856, Length=168, Percent_Identity=30.952380952381, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24582854, Length=168, Percent_Identity=30.952380952381, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PLSC_HELPY (O25903)

Other databases:

- EMBL:   AE000511
- PIR:   D64688
- RefSeq:   NP_208140.1
- ProteinModelPortal:   O25903
- GeneID:   900355
- GenomeReviews:   AE000511_GR
- KEGG:   hpy:HP1348
- NMPDR:   fig|85962.1.peg.1336
- TIGR:   HP_1348
- HOGENOM:   HBG321122
- OMA:   PFKSGAK
- ProtClustDB:   CLSK872541
- BRENDA:   2.3.1.51
- InterPro:   IPR002123
- InterPro:   IPR004552
- SMART:   SM00563
- TIGRFAMs:   TIGR00530

Pfam domain/function: PF01553 Acyltransferase

EC number: =2.3.1.51

Molecular weight: Translated: 27746; Mature: 27746

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSNKKSNRLRAIYRALVIAIGLAVIIVFNYFNRKNNNARSSRRACSCFFSLTGVNLEKI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHC
GTFDTDAKLIVLNHQSLLDIIYLEAYHPRNICWIAKKELGEIPFYGHALTDTGMILIDRE
CCCCCCCEEEEEECHHHHHHHEEECCCCCCEEEEEHHHHCCCCCCCEEECCCCEEEEECC
DKKGIVSLLKACKEKLDQNRPLVIFPEGTRGKGGEKFLPFKQGAKIIAEKFQLKIQPMVL
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHEECEEEE
INSIKIFNSKPLEAYKARTRLVMLESYTPDFNSPTWYEELQERMQKEYLKHYHELNPSEQ
EEEEEECCCCCHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKSNKKSNRLRAIYRALVIAIGLAVIIVFNYFNRKNNNARSSRRACSCFFSLTGVNLEKI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHC
GTFDTDAKLIVLNHQSLLDIIYLEAYHPRNICWIAKKELGEIPFYGHALTDTGMILIDRE
CCCCCCCEEEEEECHHHHHHHEEECCCCCCEEEEEHHHHCCCCCCCEEECCCCEEEEECC
DKKGIVSLLKACKEKLDQNRPLVIFPEGTRGKGGEKFLPFKQGAKIIAEKFQLKIQPMVL
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHEECEEEE
INSIKIFNSKPLEAYKARTRLVMLESYTPDFNSPTWYEELQERMQKEYLKHYHELNPSEQ
EEEEEECCCCCHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9252185