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The map label for this gene is fumC

Identifier: 15645938

GI number: 15645938

Start: 1384217

End: 1385608

Strand: Reverse

Name: fumC

Synonym: HP1325

Alternate gene names: 15645938

Gene position: 1385608-1384217 (Counterclockwise)

Preceding gene: 15645943

Following gene: 15645937

Centisome position: 83.08

GC content: 44.76

Gene sequence:

>1392_bases
ATGCAATTTAGAATTGAACATGACACGATGGGCGAAATCAAAGTAAATGATAGCCAATATTGGGGGGCTCAAACGCAACG
CAGTCTTGAAAACTTTAAGATCGGCACTGAAAAAATGCCTAAAGAACTCATTGGCGCGTTTGCCAAACTCAAAAGGAGTC
TGGCGGTAGTTAACCACAAGTTAGGGAAATTAAGCCTGGAAAAATCCCAAGCCATTATCAAGGCGTGCGATTGCATTTTA
AAAGGCGAGCTGTGCGGCGAGTTTCCCTTAGCGATATGGCAAACAGGGAGCGGGACTCAAACGAACATGAATCTCAATGA
AGTCATTGCCAATAAGGCTACCGAAATTTTAGGGGGTAATTTCAGAGAGAAAAAACTCATCCACCCTAACGATGACGTGA
ACATGTCTCAAAGCTCCAACGACACTTTCCCTACCGCAATGCACATTGTGAGCGTGCTAGAAATCACGCACAGACTGCTC
CCTAGTTTGGAGAATCTGTTAAAAACCTTTAAAGAAAAAAGCCAACAATTTAAAGAGATTGTCAAGATCGGACGCACGCA
TTTACAAGACGCTACGCCTTTAACTTTGGGGCAAGAATTTAGCGGGTATGCGAGCATGCTAGAGCATTCTAAACAACAAA
TTTTAGAGAGTTTGGAGCATTTAAGAGAATTAGCCATAGGCGGGACGGCCGTAGGCACAGGGCTAAACGCTCATAAAGAA
TTGAGCGAAAAAGTGGCTGAAGAATTGAGCCAGTTTAGCGGCGTGAAATTCGTCTCTGCGCCCAATAAGTTCCATGCGCT
CACTAGCCATGACGCTATCGCTTATGCGCATGGGGCTTTTAAAGCTTTAGCGGCGAATTTAATGAAAATCGCTAACGATA
TTAGATGGCTTGCGAGCGGGCCGCGCTGTGGTTTGGGCGAGCTTAATATCCCTGAAAACGAGCCGGGCAGTTCTATTATG
CCCGGTAAAGTCAATCCCACGCAATGCGAAGCGATGACAATGGTGGCCGTGCAAGTGATGGGGAATGATACCGCTATTGG
CATTGCGGCCAGTCAGGGTAATTTTGAATTGAACGTGTTCAAGCCGGTGATCATTTATAATTTCTTGCAAAGTTTAAGGC
TATTGAGCGATAGCATGGAAAGTTTTAATATCCATTGCGCGAGCGGCATTGAGCCTAATAGAGAAAAGATTGATTATTAC
TTGCACCATTCTTTGATGTTAGTAACCGCCCTAAACCCGCATGTGGGCTATGAAAACGCCGCTAAAATCGCTAAAAACGC
CCACAAAAAAGGCATTTCTTTAAAAGAAAGCGCGCTGGAACTGAAACTCTTGAGCGCTGAAGATTTTGACAAATTCGTGG
TGCCTGAAAAGATGATCGGGCCTAAGGCTTGA

Upstream 100 bases:

>100_bases
TTGTGGAAATGGTGTTTAAAAAATTAGGGTTTTTAAGTAGAAGGTATAAGAGTTTATGCTATTTTTTTAAGGTTTTAAAA
TCAAATTTCAAAGGATTAGC

Downstream 100 bases:

>100_bases
AACCTTGGGTGGGCGCGTGAGATGAATCCTGAAAAAGCCACTCATTGCAAAGAGATTCGTAAGATCTTAAAAGAGGCGTT
GCATGACAATAAAGATTTGA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MQFRIEHDTMGEIKVNDSQYWGAQTQRSLENFKIGTEKMPKELIGAFAKLKRSLAVVNHKLGKLSLEKSQAIIKACDCIL
KGELCGEFPLAIWQTGSGTQTNMNLNEVIANKATEILGGNFREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITHRLL
PSLENLLKTFKEKSQQFKEIVKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
LSEKVAEELSQFSGVKFVSAPNKFHALTSHDAIAYAHGAFKALAANLMKIANDIRWLASGPRCGLGELNIPENEPGSSIM
PGKVNPTQCEAMTMVAVQVMGNDTAIGIAASQGNFELNVFKPVIIYNFLQSLRLLSDSMESFNIHCASGIEPNREKIDYY
LHHSLMLVTALNPHVGYENAAKIAKNAHKKGISLKESALELKLLSAEDFDKFVVPEKMIGPKA

Sequences:

>Translated_463_residues
MQFRIEHDTMGEIKVNDSQYWGAQTQRSLENFKIGTEKMPKELIGAFAKLKRSLAVVNHKLGKLSLEKSQAIIKACDCIL
KGELCGEFPLAIWQTGSGTQTNMNLNEVIANKATEILGGNFREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITHRLL
PSLENLLKTFKEKSQQFKEIVKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
LSEKVAEELSQFSGVKFVSAPNKFHALTSHDAIAYAHGAFKALAANLMKIANDIRWLASGPRCGLGELNIPENEPGSSIM
PGKVNPTQCEAMTMVAVQVMGNDTAIGIAASQGNFELNVFKPVIIYNFLQSLRLLSDSMESFNIHCASGIEPNREKIDYY
LHHSLMLVTALNPHVGYENAAKIAKNAHKKGISLKESALELKLLSAEDFDKFVVPEKMIGPKA
>Mature_463_residues
MQFRIEHDTMGEIKVNDSQYWGAQTQRSLENFKIGTEKMPKELIGAFAKLKRSLAVVNHKLGKLSLEKSQAIIKACDCIL
KGELCGEFPLAIWQTGSGTQTNMNLNEVIANKATEILGGNFREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITHRLL
PSLENLLKTFKEKSQQFKEIVKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
LSEKVAEELSQFSGVKFVSAPNKFHALTSHDAIAYAHGAFKALAANLMKIANDIRWLASGPRCGLGELNIPENEPGSSIM
PGKVNPTQCEAMTMVAVQVMGNDTAIGIAASQGNFELNVFKPVIIYNFLQSLRLLSDSMESFNIHCASGIEPNREKIDYY
LHHSLMLVTALNPHVGYENAAKIAKNAHKKGISLKESALELKLLSAEDFDKFVVPEKMIGPKA

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=58.6580086580087, Blast_Score=542, Evalue=1e-154,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=53.968253968254, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1787896, Length=458, Percent_Identity=63.5371179039301, Blast_Score=601, Evalue=1e-173,
Organism=Escherichia coli, GI87082375, Length=462, Percent_Identity=37.8787878787879, Blast_Score=321, Evalue=6e-89,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=58.0993520518359, Blast_Score=556, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=60.3658536585366, Blast_Score=423, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6324993, Length=462, Percent_Identity=59.7402597402597, Blast_Score=553, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=56.6810344827586, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=56.6810344827586, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=56.0344827586207, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=54.6236559139785, Blast_Score=515, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=48.5961123110151, Blast_Score=454, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50975; Mature: 50975

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFRIEHDTMGEIKVNDSQYWGAQTQRSLENFKIGTEKMPKELIGAFAKLKRSLAVVNHK
CCEEECCCCCCCEEECCCHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGKLSLEKSQAIIKACDCILKGELCGEFPLAIWQTGSGTQTNMNLNEVIANKATEILGGN
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
FREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITHRLLPSLENLLKTFKEKSQQFKEI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHH
LSEKVAEELSQFSGVKFVSAPNKFHALTSHDAIAYAHGAFKALAANLMKIANDIRWLASG
HHHHHHHHHHHHCCCEEEECCCHHCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRCGLGELNIPENEPGSSIMPGKVNPTQCEAMTMVAVQVMGNDTAIGIAASQGNFELNVF
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCCEEEEEECCCCEEEEEH
KPVIIYNFLQSLRLLSDSMESFNIHCASGIEPNREKIDYYLHHSLMLVTALNPHVGYENA
HHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHEEEECCCCCCCHHH
AKIAKNAHKKGISLKESALELKLLSAEDFDKFVVPEKMIGPKA
HHHHHHHHHCCCCHHHHHHHEEEECCCCCCHHCCCHHHCCCCC
>Mature Secondary Structure
MQFRIEHDTMGEIKVNDSQYWGAQTQRSLENFKIGTEKMPKELIGAFAKLKRSLAVVNHK
CCEEECCCCCCCEEECCCHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGKLSLEKSQAIIKACDCILKGELCGEFPLAIWQTGSGTQTNMNLNEVIANKATEILGGN
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
FREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITHRLLPSLENLLKTFKEKSQQFKEI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHH
LSEKVAEELSQFSGVKFVSAPNKFHALTSHDAIAYAHGAFKALAANLMKIANDIRWLASG
HHHHHHHHHHHHCCCEEEECCCHHCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRCGLGELNIPENEPGSSIMPGKVNPTQCEAMTMVAVQVMGNDTAIGIAASQGNFELNVF
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCCEEEEEECCCCEEEEEH
KPVIIYNFLQSLRLLSDSMESFNIHCASGIEPNREKIDYYLHHSLMLVTALNPHVGYENA
HHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHEEEECCCCCCCHHH
AKIAKNAHKKGISLKESALELKLLSAEDFDKFVVPEKMIGPKA
HHHHHHHHHCCCCHHHHHHHEEEECCCCCCHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]