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Identifier: 15645840

GI number: 15645840

Start: 1301547

End: 1302605

Strand: Reverse

Name: Not Available

Synonym: HP1226

Alternate gene names: 15645840

Gene position: 1302605-1301547 (Counterclockwise)

Preceding gene: 15645847

Following gene: 15645836

Centisome position: 78.1

GC content: 38.72

Gene sequence:

>1059_bases
GTGAAAATGAGAGAAATAAATATGATTTTATACATTCATATCCCCTTTTGTGAAAATAAATGCGGCTATTGCGCTTTCAA
TTCCTATGAAAACAAGCATGGGTTAAAAGAAGAATACACTCAAGCGTTATGCCTGGATTTAAAGCATGCGTTAAGTCAAA
CTGACGAACCAATTGAAAGCGTTTTTATTGGTGGCGGCACGCCTAACACTTTAAGCGTGAAGGCTTTTGAAAGGATTTTT
GAAAGCATTTATCAACATGCGAGCTTGAGCTTGGATTGTGAGATCACCACTGAAGCTAACCCCGAATTGATTACTAAAGC
TTGGTGTCAAGGCTTAAAAGGTTTAGGGATCAACCGCTTGAGTTTAGGGGTGCAAAGTTTTAGGGAAGATAAATTATTGT
TTTTAGAGCGCCAACATTCCAAAAATATCGCTCCTGCGATAGAAACTATTTTAAAAAGCGGGATTGAAAATATCAGCATT
GATTTGATTTATAACACCCCATTAGACAATGAAAACTCTCTAAAAGAAGAATTAAAACTCGCTAAAGAACTCCCTATCAA
CCACTTGAGCGCTTACGCTTTGAGCGTTGAAAAAAACACGAATTTAGAAAAAAACGCCAAAAAACCCTCATGCGCTCATT
TTGACAATGTGGTGAGAGAGATTTTAGAGGGCTTTTCTTTCAAGCAATACGAAGTGTCTAATTACGCTAGAAATTATCAA
GTCAAACACAACTTGGCTTACTGGGGGGCTAAAGATTATTTAGGGTGCGGGGCTGGGGCTGTGGGCTGCGTGGCGAATGA
GCGCTTTTTTGCAAAAAAACTCATAGAAAACTACATCAAAGACCCCCTACAACGCCAAGTTGAGACGCTTAATAAACAAG
ACAAACGCTTAGAAAAGCTGTTTTTAGGCTTGAGGTGCGTGCTTGGGGTTGAGCTTAGTTTCTTAGATGAAAATAAAGTA
AAGTTTTTGATTGAAGAGAACAAGGCTTTCATTAAAAATAACCGCTTGATAGCGAGCGATTTTTTCATGGCCGATGAAAT
GGCTTTGTGGCTGTTATGA

Upstream 100 bases:

>100_bases
GCCTAAAGCCATAATAACCTTTTTCATCGTTTGTCTCCTCTACTTATCAAAATGATCTTAAAATGATACAATTACAAGTT
TAAGTTTTGCTTAAAATGAA

Downstream 100 bases:

>100_bases
TTGTAGGCTTTGCTTCAATCAAGCGTTAATAAAACGCTAGAAAGCGTTTTTTAATGAATGCCTACAAAATTTTTAGCCAA
AAACCAACCAATGGCTACCC

Product: coproporphyrinogen III oxidase

Products: Protoporphyrinogen IX; CO2; H2O

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MKMREINMILYIHIPFCENKCGYCAFNSYENKHGLKEEYTQALCLDLKHALSQTDEPIESVFIGGGTPNTLSVKAFERIF
ESIYQHASLSLDCEITTEANPELITKAWCQGLKGLGINRLSLGVQSFREDKLLFLERQHSKNIAPAIETILKSGIENISI
DLIYNTPLDNENSLKEELKLAKELPINHLSAYALSVEKNTNLEKNAKKPSCAHFDNVVREILEGFSFKQYEVSNYARNYQ
VKHNLAYWGAKDYLGCGAGAVGCVANERFFAKKLIENYIKDPLQRQVETLNKQDKRLEKLFLGLRCVLGVELSFLDENKV
KFLIEENKAFIKNNRLIASDFFMADEMALWLL

Sequences:

>Translated_352_residues
MKMREINMILYIHIPFCENKCGYCAFNSYENKHGLKEEYTQALCLDLKHALSQTDEPIESVFIGGGTPNTLSVKAFERIF
ESIYQHASLSLDCEITTEANPELITKAWCQGLKGLGINRLSLGVQSFREDKLLFLERQHSKNIAPAIETILKSGIENISI
DLIYNTPLDNENSLKEELKLAKELPINHLSAYALSVEKNTNLEKNAKKPSCAHFDNVVREILEGFSFKQYEVSNYARNYQ
VKHNLAYWGAKDYLGCGAGAVGCVANERFFAKKLIENYIKDPLQRQVETLNKQDKRLEKLFLGLRCVLGVELSFLDENKV
KFLIEENKAFIKNNRLIASDFFMADEMALWLL
>Mature_352_residues
MKMREINMILYIHIPFCENKCGYCAFNSYENKHGLKEEYTQALCLDLKHALSQTDEPIESVFIGGGTPNTLSVKAFERIF
ESIYQHASLSLDCEITTEANPELITKAWCQGLKGLGINRLSLGVQSFREDKLLFLERQHSKNIAPAIETILKSGIENISI
DLIYNTPLDNENSLKEELKLAKELPINHLSAYALSVEKNTNLEKNAKKPSCAHFDNVVREILEGFSFKQYEVSNYARNYQ
VKHNLAYWGAKDYLGCGAGAVGCVANERFFAKKLIENYIKDPLQRQVETLNKQDKRLEKLFLGLRCVLGVELSFLDENKV
KFLIEENKAFIKNNRLIASDFFMADEMALWLL

Specific function: Unknown

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=267, Percent_Identity=33.7078651685393, Blast_Score=138, Evalue=8e-33,
Organism=Escherichia coli, GI1789325, Length=271, Percent_Identity=37.6383763837638, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI87082341, Length=288, Percent_Identity=25.3472222222222, Blast_Score=85, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: 1.3.3.3

Molecular weight: Translated: 40197; Mature: 40197

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMREINMILYIHIPFCENKCGYCAFNSYENKHGLKEEYTQALCLDLKHALSQTDEPIES
CCCEEEEEEEEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
VFIGGGTPNTLSVKAFERIFESIYQHASLSLDCEITTEANPELITKAWCQGLKGLGINRL
EEECCCCCCCEEHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCHHH
SLGVQSFREDKLLFLERQHSKNIAPAIETILKSGIENISIDLIYNTPLDNENSLKEELKL
HHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHH
AKELPINHLSAYALSVEKNTNLEKNAKKPSCAHFDNVVREILEGFSFKQYEVSNYARNYQ
HHHCCHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHCEE
VKHNLAYWGAKDYLGCGAGAVGCVANERFFAKKLIENYIKDPLQRQVETLNKQDKRLEKL
EEECEEECCCCHHCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGLRCVLGVELSFLDENKVKFLIEENKAFIKNNRLIASDFFMADEMALWLL
HHHHHHHHCCEEEEECCCCEEEEEECCCHHHHCCEEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MKMREINMILYIHIPFCENKCGYCAFNSYENKHGLKEEYTQALCLDLKHALSQTDEPIES
CCCEEEEEEEEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
VFIGGGTPNTLSVKAFERIFESIYQHASLSLDCEITTEANPELITKAWCQGLKGLGINRL
EEECCCCCCCEEHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCHHH
SLGVQSFREDKLLFLERQHSKNIAPAIETILKSGIENISIDLIYNTPLDNENSLKEELKL
HHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHH
AKELPINHLSAYALSVEKNTNLEKNAKKPSCAHFDNVVREILEGFSFKQYEVSNYARNYQ
HHHCCHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHCEE
VKHNLAYWGAKDYLGCGAGAVGCVANERFFAKKLIENYIKDPLQRQVETLNKQDKRLEKL
EEECEEECCCCHHCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGLRCVLGVELSFLDENKVKFLIEENKAFIKNNRLIASDFFMADEMALWLL
HHHHHHHHCCEEEEECCCCEEEEEECCCHHHHCCEEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coproporphyrinogen III; O2; H+

Specific reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]