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Identifier: 15645393

GI number: 15645393

Start: 826470

End: 827678

Strand: Reverse

Name: Not Available

Synonym: HP0774

Alternate gene names: 15645393

Gene position: 827678-826470 (Counterclockwise)

Preceding gene: 15645394

Following gene: 15645392

Centisome position: 49.62

GC content: 39.62

Gene sequence:

>1209_bases
ATGGAACAAAAAATCGCTATCGCCTTAAAAGAGATCGCTAGAGGCACTAATGAAATCATTGGATTAGAATACATTGAAAA
GTTGGTGAGGAAATATTATGAAACCAATGAACGCTTTATCGTTAAAGCCGGGTTTGATCCTACCGCTCCAGATTTGCATT
TAGGGCATACGGTATTGATCCAAAAACTGGCTTTATTGCAGCAATATGGGGCTAGGGTTAAGTTTTTGATTGGGGATTTT
ACCGCTATGATAGGCGATCCTACAGGGAAAAATGAAACCAGAAAGCCCTTAAACCGGGAGCAAGTCTTAGAAAACGCTAA
AACTTATGAAGAGCAAATCTATAAAATTTTAGATGAAAAACACACCGAAGTGTGCTTTAATTCCACTTGGTTGGATGCTT
TAGGCGCAAAAGGCATGATAGAATTGTGCGCGAAGTTTTCAGTCGCTAGAATGCTAGAAAGGGACGATTTCACTAAACGC
TATAAAGAAAATCGCCCCATTAGCATCGTGGAATTTTTATACCCTTTGTTGCAGGGCTATGATTCAGTGGCGATGGATGC
GGACATTGAGCTTGGGGGCAATGATCAAAAGTTTAATTTGCTGGTGGGGCGTTTTTTGCAACGAGCTTATGGCTTGAATA
AAGAGCAGTCTGTCATCACCATGCCTTTATTAGAGGGGCTTGATGGGGTGCAAAAAATGAGTAAAAGCTTGGGGAATTAT
GTGGGGATCACTGAAGAGCCTAATGCGATGTTTGGGAAGATCATGAGCGTGAGCGATGATCTCATGTGGCGCTATTACAC
CCTTTTGAGCACTAAGACTTTAGAAGAAATTGAAGACTTAAAACATGGTATTTTAAACCAAACCTTGCACCCTAAAGCCG
TTAAAGAGGATCTCGCTAGTGAAATCGTGGCTCGTTATTATGACAATGATCAAGCCATCAAGGCTAAAGAGCAATTTTCT
AAAGTGTTTAGCGCAAACCTTTTGCCTGAAATTTTATCAGAGAGCGATTTTGATGAGGGGGTGGGGATTTTAGATGTTTT
AAAACAGATTGGCTTTTGCCCATCCACTTCACAAGCCAGGCGTGATATTCAAGGGGGAGGGGTAAAGATTAATCAAGAAG
TGATAAAAAATGAGAGTTATCGTTTTGTTAAAGGAAATTATGTTATACAGCTTGGTAAGAAAAGATTTATGAAATTAAAT
ATTAACTAA

Upstream 100 bases:

>100_bases
TCAGAGCCTTAATCAATCGCAAATATCAGGATAGGATTGTAGAATTATCCAGTCTGGATGACGCTTATGAATCATAATAA
GCCCTAATTAAGGAATGAAC

Downstream 100 bases:

>100_bases
TATTAAGGAAAGAGCTATGGTATCAACACTCAAACCGCTAAAAATCGGTAAGCACACCATAAAATTCCCTATCTTTCAAG
GGGGAATGGGTGTGGGGATT

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MEQKIAIALKEIARGTNEIIGLEYIEKLVRKYYETNERFIVKAGFDPTAPDLHLGHTVLIQKLALLQQYGARVKFLIGDF
TAMIGDPTGKNETRKPLNREQVLENAKTYEEQIYKILDEKHTEVCFNSTWLDALGAKGMIELCAKFSVARMLERDDFTKR
YKENRPISIVEFLYPLLQGYDSVAMDADIELGGNDQKFNLLVGRFLQRAYGLNKEQSVITMPLLEGLDGVQKMSKSLGNY
VGITEEPNAMFGKIMSVSDDLMWRYYTLLSTKTLEEIEDLKHGILNQTLHPKAVKEDLASEIVARYYDNDQAIKAKEQFS
KVFSANLLPEILSESDFDEGVGILDVLKQIGFCPSTSQARRDIQGGGVKINQEVIKNESYRFVKGNYVIQLGKKRFMKLN
IN

Sequences:

>Translated_402_residues
MEQKIAIALKEIARGTNEIIGLEYIEKLVRKYYETNERFIVKAGFDPTAPDLHLGHTVLIQKLALLQQYGARVKFLIGDF
TAMIGDPTGKNETRKPLNREQVLENAKTYEEQIYKILDEKHTEVCFNSTWLDALGAKGMIELCAKFSVARMLERDDFTKR
YKENRPISIVEFLYPLLQGYDSVAMDADIELGGNDQKFNLLVGRFLQRAYGLNKEQSVITMPLLEGLDGVQKMSKSLGNY
VGITEEPNAMFGKIMSVSDDLMWRYYTLLSTKTLEEIEDLKHGILNQTLHPKAVKEDLASEIVARYYDNDQAIKAKEQFS
KVFSANLLPEILSESDFDEGVGILDVLKQIGFCPSTSQARRDIQGGGVKINQEVIKNESYRFVKGNYVIQLGKKRFMKLN
IN
>Mature_402_residues
MEQKIAIALKEIARGTNEIIGLEYIEKLVRKYYETNERFIVKAGFDPTAPDLHLGHTVLIQKLALLQQYGARVKFLIGDF
TAMIGDPTGKNETRKPLNREQVLENAKTYEEQIYKILDEKHTEVCFNSTWLDALGAKGMIELCAKFSVARMLERDDFTKR
YKENRPISIVEFLYPLLQGYDSVAMDADIELGGNDQKFNLLVGRFLQRAYGLNKEQSVITMPLLEGLDGVQKMSKSLGNY
VGITEEPNAMFGKIMSVSDDLMWRYYTLLSTKTLEEIEDLKHGILNQTLHPKAVKEDLASEIVARYYDNDQAIKAKEQFS
KVFSANLLPEILSESDFDEGVGILDVLKQIGFCPSTSQARRDIQGGGVKINQEVIKNESYRFVKGNYVIQLGKKRFMKLN
IN

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=398, Percent_Identity=27.1356783919598, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1787925, Length=368, Percent_Identity=29.0760869565217, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25145802, Length=277, Percent_Identity=28.8808664259928, Blast_Score=96, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6325160, Length=406, Percent_Identity=24.384236453202, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI20130383, Length=399, Percent_Identity=26.0651629072682, Blast_Score=111, Evalue=7e-25,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 45739; Mature: 45739

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQKIAIALKEIARGTNEIIGLEYIEKLVRKYYETNERFIVKAGFDPTAPDLHLGHTVLI
CCCHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHH
QKLALLQQYGARVKFLIGDFTAMIGDPTGKNETRKPLNREQVLENAKTYEEQIYKILDEK
HHHHHHHHHCCCEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
HTEVCFNSTWLDALGAKGMIELCAKFSVARMLERDDFTKRYKENRPISIVEFLYPLLQGY
HHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
DSVAMDADIELGGNDQKFNLLVGRFLQRAYGLNKEQSVITMPLLEGLDGVQKMSKSLGNY
CCCEECCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHCCHHHHHHHHHHCCE
VGITEEPNAMFGKIMSVSDDLMWRYYTLLSTKTLEEIEDLKHGILNQTLHPKAVKEDLAS
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
EIVARYYDNDQAIKAKEQFSKVFSANLLPEILSESDFDEGVGILDVLKQIGFCPSTSQAR
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCHHHH
RDIQGGGVKINQEVIKNESYRFVKGNYVIQLGKKRFMKLNIN
HHHCCCCEEECHHHHCCCCCEEEECCEEEEECCCEEEEECCC
>Mature Secondary Structure
MEQKIAIALKEIARGTNEIIGLEYIEKLVRKYYETNERFIVKAGFDPTAPDLHLGHTVLI
CCCHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHH
QKLALLQQYGARVKFLIGDFTAMIGDPTGKNETRKPLNREQVLENAKTYEEQIYKILDEK
HHHHHHHHHCCCEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
HTEVCFNSTWLDALGAKGMIELCAKFSVARMLERDDFTKRYKENRPISIVEFLYPLLQGY
HHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
DSVAMDADIELGGNDQKFNLLVGRFLQRAYGLNKEQSVITMPLLEGLDGVQKMSKSLGNY
CCCEECCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHCCHHHHHHHHHHCCE
VGITEEPNAMFGKIMSVSDDLMWRYYTLLSTKTLEEIEDLKHGILNQTLHPKAVKEDLAS
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
EIVARYYDNDQAIKAKEQFSKVFSANLLPEILSESDFDEGVGILDVLKQIGFCPSTSQAR
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCHHHH
RDIQGGGVKINQEVIKNESYRFVKGNYVIQLGKKRFMKLNIN
HHHCCCCEEECHHHHCCCCCEEEECCEEEEECCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]