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The map label for this gene is moaA

Identifier: 15645387

GI number: 15645387

Start: 820477

End: 821442

Strand: Reverse

Name: moaA

Synonym: HP0768

Alternate gene names: 15645387

Gene position: 821442-820477 (Counterclockwise)

Preceding gene: 15645390

Following gene: 15645386

Centisome position: 49.25

GC content: 35.51

Gene sequence:

>966_bases
GTGTTAGTAGATAGTTTTAATAGGGTTATTGACTATATTAGGGTTTCTGTAACCAAACAGTGCAATTTCAGGTGTCAGTA
TTGCATGCCTGCTACGCCATTAAATTTTTTTGATAATGAAGAATTATTGCCTTTGGATAATGTTTTAGAATTTCTCAAAA
TCGCCATTGATGAGGGCGTTAAAAAAATTAGAATCACGGGTGGGGAGCCGCTATTACGCAAAGGCTTAGATGAATTTATC
GCTAAATTGCACGCTTACAATAAAGAAGTGGAGTTAGTTTTAAGCACTAATGGTTTTTTACTCAAAAAAATGGCTAAGGA
TTTAAAAAATGCCGGGTTAGCGCAAGTGAATGTTTCATTGGATTCTTTAAAAAGCGATAGGGTTTTAAAAATCTCTCAAA
AAGACGCTCTTAAAAACACGCTAGAAGGGATTGAAGAGTCTTTGAAAGTGGGTTTAAAACTCAAATTAAACACGGTTGTG
ATAAAAAGCGTTAATGATGATGAAATCTTAGAGCTTTTAGAATACGCAAAAAATAGGCATATACAAATCCGCTACATTGA
ATTTATGGAAAACACGCATGCTAAAAGTTTGGTTAAAGGCTTGAAAGAGCGAGAAATTTTAGATTTGATCGCTCAAAAAT
ATCAAATCATTGAGGCAGAAAAACCCAAACAAGGGTCTTCTAAAATCTACACGCTAGAAAATGGCTATCAATTTGGCATT
ATCGCTCCGCATAGCGATGATTTTTGCCAATCTTGCAATCGTATCCGTTTGGCTTCTGATGGTAAGATTTGCCCATGTTT
ATACTATCAAGACGCCATAGACGCTAAAGAGGCGATCATCAATAAGGATACAAAAAATATAAAAAGGCTTTTAAAGCAAT
CTGTCATCAATAAACCAGAAAAAAACATGTGGAATGATAAAAACAGCGAAACTCCCACAAGGGCGTTTTACTACACAGGG
GGGTAG

Upstream 100 bases:

>100_bases
TAGGGTTTTTCAAAAGTTCTATCCATGTTTGATGTTGTTAAGTCGTTGTTTATTATGTTACACTAAAAGCTTAAATAAAA
GGGCATAAGGGATAAAGGGA

Downstream 100 bases:

>100_bases
GGGAGTAAAATATTTATTATTTTAAACCTTTTTATTAAAAATAAGGCGGTTTGTTTAGGATTTTTGGTTATAGTGGCTAG
GATCAAACAATAAGGAGTTC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MLVDSFNRVIDYIRVSVTKQCNFRCQYCMPATPLNFFDNEELLPLDNVLEFLKIAIDEGVKKIRITGGEPLLRKGLDEFI
AKLHAYNKEVELVLSTNGFLLKKMAKDLKNAGLAQVNVSLDSLKSDRVLKISQKDALKNTLEGIEESLKVGLKLKLNTVV
IKSVNDDEILELLEYAKNRHIQIRYIEFMENTHAKSLVKGLKEREILDLIAQKYQIIEAEKPKQGSSKIYTLENGYQFGI
IAPHSDDFCQSCNRIRLASDGKICPCLYYQDAIDAKEAIINKDTKNIKRLLKQSVINKPEKNMWNDKNSETPTRAFYYTG
G

Sequences:

>Translated_321_residues
MLVDSFNRVIDYIRVSVTKQCNFRCQYCMPATPLNFFDNEELLPLDNVLEFLKIAIDEGVKKIRITGGEPLLRKGLDEFI
AKLHAYNKEVELVLSTNGFLLKKMAKDLKNAGLAQVNVSLDSLKSDRVLKISQKDALKNTLEGIEESLKVGLKLKLNTVV
IKSVNDDEILELLEYAKNRHIQIRYIEFMENTHAKSLVKGLKEREILDLIAQKYQIIEAEKPKQGSSKIYTLENGYQFGI
IAPHSDDFCQSCNRIRLASDGKICPCLYYQDAIDAKEAIINKDTKNIKRLLKQSVINKPEKNMWNDKNSETPTRAFYYTG
G
>Mature_321_residues
MLVDSFNRVIDYIRVSVTKQCNFRCQYCMPATPLNFFDNEELLPLDNVLEFLKIAIDEGVKKIRITGGEPLLRKGLDEFI
AKLHAYNKEVELVLSTNGFLLKKMAKDLKNAGLAQVNVSLDSLKSDRVLKISQKDALKNTLEGIEESLKVGLKLKLNTVV
IKSVNDDEILELLEYAKNRHIQIRYIEFMENTHAKSLVKGLKEREILDLIAQKYQIIEAEKPKQGSSKIYTLENGYQFGI
IAPHSDDFCQSCNRIRLASDGKICPCLYYQDAIDAKEAIINKDTKNIKRLLKQSVINKPEKNMWNDKNSETPTRAFYYTG
G

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=327, Percent_Identity=29.0519877675841, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI116734668, Length=327, Percent_Identity=29.0519877675841, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1786999, Length=325, Percent_Identity=27.3846153846154, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI32566329, Length=328, Percent_Identity=32.0121951219512, Blast_Score=188, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17561210, Length=328, Percent_Identity=32.6219512195122, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI32566331, Length=323, Percent_Identity=31.8885448916409, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI28574488, Length=282, Percent_Identity=34.3971631205674, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI28574490, Length=285, Percent_Identity=34.0350877192982, Blast_Score=187, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36658; Mature: 36658

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVDSFNRVIDYIRVSVTKQCNFRCQYCMPATPLNFFDNEELLPLDNVLEFLKIAIDEGV
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
KKIRITGGEPLLRKGLDEFIAKLHAYNKEVELVLSTNGFLLKKMAKDLKNAGLAQVNVSL
EEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEH
DSLKSDRVLKISQKDALKNTLEGIEESLKVGLKLKLNTVVIKSVNDDEILELLEYAKNRH
HHCCCCCEEEECHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEECCHHHHHHHHHHHCCCC
IQIRYIEFMENTHAKSLVKGLKEREILDLIAQKYQIIEAEKPKQGSSKIYTLENGYQFGI
EEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEEEE
IAPHSDDFCQSCNRIRLASDGKICPCLYYQDAIDAKEAIINKDTKNIKRLLKQSVINKPE
ECCCCCHHHHCCCCEEECCCCCEEEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
KNMWNDKNSETPTRAFYYTGG
HHCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MLVDSFNRVIDYIRVSVTKQCNFRCQYCMPATPLNFFDNEELLPLDNVLEFLKIAIDEGV
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
KKIRITGGEPLLRKGLDEFIAKLHAYNKEVELVLSTNGFLLKKMAKDLKNAGLAQVNVSL
EEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEH
DSLKSDRVLKISQKDALKNTLEGIEESLKVGLKLKLNTVVIKSVNDDEILELLEYAKNRH
HHCCCCCEEEECHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEECCHHHHHHHHHHHCCCC
IQIRYIEFMENTHAKSLVKGLKEREILDLIAQKYQIIEAEKPKQGSSKIYTLENGYQFGI
EEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEEEE
IAPHSDDFCQSCNRIRLASDGKICPCLYYQDAIDAKEAIINKDTKNIKRLLKQSVINKPE
ECCCCCHHHHCCCCEEECCCCCEEEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
KNMWNDKNSETPTRAFYYTGG
HHCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA