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Identifier: 15645339

GI number: 15645339

Start: 770469

End: 772205

Strand: Reverse

Name: Not Available

Synonym: HP0717

Alternate gene names: 15645339

Gene position: 772205-770469 (Counterclockwise)

Preceding gene: 15645340

Following gene: 15645338

Centisome position: 46.3

GC content: 38.86

Gene sequence:

>1737_bases
ATGCAAGTTTTAGCGTTAAAATACCGCCCCAAACATTTTAGCGAGCTAGTCGGTCAAGAGAGCGTGGCTAAAACGCTTTC
TTTAGCCCTAGACAACCAGCGTTTGGCTAACGCTTATTTATTCAGCGGGTTAAGAGGCTCAGGGAAAACCAGCTCTTCTA
GGATTTTTGCTAGGGCTTTAATGTGTGAAGAAGGGCCAAAGGCTGTGCCTTGCGATACTTGCATCCAATGCCAGAGCGCT
TTAAACAACCACCACATAGATATTATAGAAATGGATGGGGCGTCTAATAGGGGGATTGATGATGTCCGTAATCTCATAGA
GCAAACGCGCTACAAACCAAGCTTTGGGCGCTATAAAATCTTTATCATTGATGAAGTGCATATGTTCACCACCGAAGCGT
TTAACGCGCTTTTAAAGACTTTAGAAGAGCCTCCTAGCCATGTGAAATTCCTTTTAGCGACAACAGACGCCTTGAAACTG
CCCGCTACCATACTCAGCCGCACCCAGCATTTCAGGTTTAAAAAAATCCCTGAAAATTCCGTTATTTCTCATTTAAAAAC
CATTTTAGAAAAAGAACAAGTGAGTTATGAAACAAGCGCGTTAGAAAAACTGGCTCACAGCGGGCAAGGGAGCCTAAGGG
ATACGATCACTCTTTTAGAACAAGCCATCAATTATTGCGATAACGCTATCACAGAAAGCAAGGTGGCTGAAATGTTAGGA
GCGATTGACAGAAGCGTTTTAGAAGATTTTTTCCAAAGCCTAATCAACCAAGATGAAGCGCGATTAAAAGAGCGTTATGC
CATTTTAGAAAATTATGAAACCGAGAGCGTTTTAGAAGAAATGATGCTTTTTTTGAAAGCGAAATTATTGAGCCCTGATT
TTTATTCTATCCTTTTGATAGAGCGCTTTTTTAAAATCATTATGAGCAGTTTGAGCCTTTTAAAAGAAGGGGCAAATGCC
AGTTTTGTGCTGTTGTTATTGAAAATGAAATTCAAAGAAGCTTTGAAATTCAAAGCCCTAGACGATGCGATTTTGGAATT
AGAGCAAACCCCTTTCAATCAAAACCCTAGCATAAGCTATAACGCCCCTAAACAAGAATCTAAAAATATAGAAAAAAGAG
AAAAAATAGAACAAATAGAAAGAATAGAGGGAACAGAAAAAAGAGAAAAACTAGAAAAAAAAGAGAACGCAGAAACCCCG
CAAACTCCCATGCTTTCAGCTAAAGATCGCATTTTTCACAACCTTTTCAAACAAGTTCAAACATTGGTTTATGAGCGCAA
TTATGAGTTAGGGGCGGTGTTTGAAAAAAATATCCGTTTCATTGATTTTGACAGCCAGACTAAAACCTTGACTTGGGAGT
CTTTAGCCACTGATAAGGATAAGGAGCTTTTAAGAGAACGATTTAAAATCGTGAAAAGTATCGTTGATGGGGTTTTTGGC
AAGGGCGAAAGTATCAAAATCGCTTTAAAAAATCATTCAGAAAATAAAAGCACTTTAGAAGTGGTTAAAGAGCTTAAATT
CCCTTATTCAAAGCCCAAACCAACCACTGAAACGACGGCTGAAACGAAAGAAAAAGAAACTAAAGAAAAAGAGATTCAAG
AAAACGACACTAAAGAGATTCAAGAAGTCCAACCAAAACAAGCCCCTACAGCGTTGCAAGAATTCATGGCTAACCACTCT
GAGCTGATTGAAGAGATTAAGAGCGAGTTTGAAATCAAAAGCGTGGAATTGTTATGA

Upstream 100 bases:

>100_bases
GGGATTTTTTAGCGCTATTGAGCAAAACCTAAAAAGGGGCTAGTTTTAAGTCATTTTGCATTACAATACTCCTAAATGAG
TTTTAAGGATTACAATCAAT

Downstream 100 bases:

>100_bases
GAGCGAATTTAGACGAGTTAGACAAAGTGGCGGCTGCAATTTTAAAAGATGATTTTAAAGGGGTGGTGCTTTTAAAAGGC
GTTGTGGGGAGCGGTAAAAC

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MQVLALKYRPKHFSELVGQESVAKTLSLALDNQRLANAYLFSGLRGSGKTSSSRIFARALMCEEGPKAVPCDTCIQCQSA
LNNHHIDIIEMDGASNRGIDDVRNLIEQTRYKPSFGRYKIFIIDEVHMFTTEAFNALLKTLEEPPSHVKFLLATTDALKL
PATILSRTQHFRFKKIPENSVISHLKTILEKEQVSYETSALEKLAHSGQGSLRDTITLLEQAINYCDNAITESKVAEMLG
AIDRSVLEDFFQSLINQDEARLKERYAILENYETESVLEEMMLFLKAKLLSPDFYSILLIERFFKIIMSSLSLLKEGANA
SFVLLLLKMKFKEALKFKALDDAILELEQTPFNQNPSISYNAPKQESKNIEKREKIEQIERIEGTEKREKLEKKENAETP
QTPMLSAKDRIFHNLFKQVQTLVYERNYELGAVFEKNIRFIDFDSQTKTLTWESLATDKDKELLRERFKIVKSIVDGVFG
KGESIKIALKNHSENKSTLEVVKELKFPYSKPKPTTETTAETKEKETKEKEIQENDTKEIQEVQPKQAPTALQEFMANHS
ELIEEIKSEFEIKSVELL

Sequences:

>Translated_578_residues
MQVLALKYRPKHFSELVGQESVAKTLSLALDNQRLANAYLFSGLRGSGKTSSSRIFARALMCEEGPKAVPCDTCIQCQSA
LNNHHIDIIEMDGASNRGIDDVRNLIEQTRYKPSFGRYKIFIIDEVHMFTTEAFNALLKTLEEPPSHVKFLLATTDALKL
PATILSRTQHFRFKKIPENSVISHLKTILEKEQVSYETSALEKLAHSGQGSLRDTITLLEQAINYCDNAITESKVAEMLG
AIDRSVLEDFFQSLINQDEARLKERYAILENYETESVLEEMMLFLKAKLLSPDFYSILLIERFFKIIMSSLSLLKEGANA
SFVLLLLKMKFKEALKFKALDDAILELEQTPFNQNPSISYNAPKQESKNIEKREKIEQIERIEGTEKREKLEKKENAETP
QTPMLSAKDRIFHNLFKQVQTLVYERNYELGAVFEKNIRFIDFDSQTKTLTWESLATDKDKELLRERFKIVKSIVDGVFG
KGESIKIALKNHSENKSTLEVVKELKFPYSKPKPTTETTAETKEKETKEKEIQENDTKEIQEVQPKQAPTALQEFMANHS
ELIEEIKSEFEIKSVELL
>Mature_578_residues
MQVLALKYRPKHFSELVGQESVAKTLSLALDNQRLANAYLFSGLRGSGKTSSSRIFARALMCEEGPKAVPCDTCIQCQSA
LNNHHIDIIEMDGASNRGIDDVRNLIEQTRYKPSFGRYKIFIIDEVHMFTTEAFNALLKTLEEPPSHVKFLLATTDALKL
PATILSRTQHFRFKKIPENSVISHLKTILEKEQVSYETSALEKLAHSGQGSLRDTITLLEQAINYCDNAITESKVAEMLG
AIDRSVLEDFFQSLINQDEARLKERYAILENYETESVLEEMMLFLKAKLLSPDFYSILLIERFFKIIMSSLSLLKEGANA
SFVLLLLKMKFKEALKFKALDDAILELEQTPFNQNPSISYNAPKQESKNIEKREKIEQIERIEGTEKREKLEKKENAETP
QTPMLSAKDRIFHNLFKQVQTLVYERNYELGAVFEKNIRFIDFDSQTKTLTWESLATDKDKELLRERFKIVKSIVDGVFG
KGESIKIALKNHSENKSTLEVVKELKFPYSKPKPTTETTAETKEKETKEKEIQENDTKEIQEVQPKQAPTALQEFMANHS
ELIEEIKSEFEIKSVELL

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI31563534, Length=217, Percent_Identity=31.3364055299539, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI4506491, Length=259, Percent_Identity=27.7992277992278, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI31881687, Length=259, Percent_Identity=27.7992277992278, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI6677723, Length=257, Percent_Identity=24.5136186770428, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI194306571, Length=287, Percent_Identity=24.0418118466899, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI194306567, Length=287, Percent_Identity=24.0418118466899, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1786676, Length=286, Percent_Identity=43.006993006993, Blast_Score=249, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17541988, Length=221, Percent_Identity=29.8642533936652, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17554730, Length=260, Percent_Identity=26.9230769230769, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71986063, Length=262, Percent_Identity=26.3358778625954, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6324039, Length=259, Percent_Identity=28.1853281853282, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322528, Length=346, Percent_Identity=25.7225433526012, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324478, Length=221, Percent_Identity=27.6018099547511, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17647857, Length=217, Percent_Identity=30.8755760368664, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI18859927, Length=294, Percent_Identity=27.2108843537415, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19921076, Length=288, Percent_Identity=23.9583333333333, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 66246; Mature: 66246

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVLALKYRPKHFSELVGQESVAKTLSLALDNQRLANAYLFSGLRGSGKTSSSRIFARAL
CCEEEEECCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
MCEEGPKAVPCDTCIQCQSALNNHHIDIIEMDGASNRGIDDVRNLIEQTRYKPSFGRYKI
HHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEE
FIIDEVHMFTTEAFNALLKTLEEPPSHVKFLLATTDALKLPATILSRTQHFRFKKIPENS
EEEECHHHHHHHHHHHHHHHHHCCHHHHEEHHEECHHHHHHHHHHHHHHHHHHHCCCCHH
VISHLKTILEKEQVSYETSALEKLAHSGQGSLRDTITLLEQAINYCDNAITESKVAEMLG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIDRSVLEDFFQSLINQDEARLKERYAILENYETESVLEEMMLFLKAKLLSPDFYSILLI
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
ERFFKIIMSSLSLLKEGANASFVLLLLKMKFKEALKFKALDDAILELEQTPFNQNPSISY
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
NAPKQESKNIEKREKIEQIERIEGTEKREKLEKKENAETPQTPMLSAKDRIFHNLFKQVQ
CCCCHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
TLVYERNYELGAVFEKNIRFIDFDSQTKTLTWESLATDKDKELLRERFKIVKSIVDGVFG
HHHHHCCCCCHHHHHCCCEEEEECCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
KGESIKIALKNHSENKSTLEVVKELKFPYSKPKPTTETTAETKEKETKEKEIQENDTKEI
CCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHH
QEVQPKQAPTALQEFMANHSELIEEIKSEFEIKSVELL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCC
>Mature Secondary Structure
MQVLALKYRPKHFSELVGQESVAKTLSLALDNQRLANAYLFSGLRGSGKTSSSRIFARAL
CCEEEEECCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
MCEEGPKAVPCDTCIQCQSALNNHHIDIIEMDGASNRGIDDVRNLIEQTRYKPSFGRYKI
HHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEE
FIIDEVHMFTTEAFNALLKTLEEPPSHVKFLLATTDALKLPATILSRTQHFRFKKIPENS
EEEECHHHHHHHHHHHHHHHHHCCHHHHEEHHEECHHHHHHHHHHHHHHHHHHHCCCCHH
VISHLKTILEKEQVSYETSALEKLAHSGQGSLRDTITLLEQAINYCDNAITESKVAEMLG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIDRSVLEDFFQSLINQDEARLKERYAILENYETESVLEEMMLFLKAKLLSPDFYSILLI
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
ERFFKIIMSSLSLLKEGANASFVLLLLKMKFKEALKFKALDDAILELEQTPFNQNPSISY
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
NAPKQESKNIEKREKIEQIERIEGTEKREKLEKKENAETPQTPMLSAKDRIFHNLFKQVQ
CCCCHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
TLVYERNYELGAVFEKNIRFIDFDSQTKTLTWESLATDKDKELLRERFKIVKSIVDGVFG
HHHHHCCCCCHHHHHCCCEEEEECCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
KGESIKIALKNHSENKSTLEVVKELKFPYSKPKPTTETTAETKEKETKEKEIQENDTKEI
CCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHH
QEVQPKQAPTALQEFMANHSELIEEIKSEFEIKSVELL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]