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Identifier: 15645222

GI number: 15645222

Start: 630840

End: 632819

Strand: Reverse

Name: Not Available

Synonym: HP0597

Alternate gene names: 15645222

Gene position: 632819-630840 (Counterclockwise)

Preceding gene: 15645223

Following gene: 15645211

Centisome position: 37.94

GC content: 41.06

Gene sequence:

>1980_bases
ATGCTAAAAAAGATTTTTTATGGTTTTATCGTTTTATTTTTGATTGTCATGGGGTTATTAGCCATTCTTATCGCTCAAGT
TTGGGTAACTACGGATAAGGATATTGCTAAAATTAAAGATTATCGCCCAGGCGTCGCTTCACAGATTTTAGACCGAAAAG
GGCGTTTGATCGCTAATATCTATGATAAGGAATTTCGTTTTTATGCGCGTTTTGAAGAAATCCCCCCACGATTTATTGAA
AGCCTTTTAGCGGTAGAAGACACCCTCTTTTTTGAACATGGGGGGATCAATTTAGACGCTATCATGCGCGCTATGATTAA
AAACGCTAAAAGCGGTCGTTACACCGAGGGGGGTAGCACCCTAACCCAACAATTCGTTAAAAACATGGTGCTCACACGAG
AAAAAACCCTAACCAGAAAACTCAAAGAAGCGATCATTTCTATACGCATTGAAAAAGTCTTAAGCAAAGAAGAAATTTTA
GAGCGTTATTTGAACCAAACTTTTTTTGGGCATGGGTATTATGGCGTGAAAACCGCAAGTTTAGGGTATTTTAAAAAACC
CCTTGACAAACTCACGCTTAAAGAAATCACCATGCTAGTCGCCTTGCCTAGGGCTCCGAGTTTTTATGATCCTACCAAAA
ATTTAGAATTTTCACTCTCTAGGGCTAATGATATTTTAAGGCGGTTGTATTCTTTAGGCTGGATTTCTTCTAACGAGCTC
AAAGGCGCTCTCAATGAAGTGCCAATTGTTTATAACCAAACCTCCACGCAAAACATCGCCCCCTATGTCGTAGATGAAGT
GTTGAAGCAATTGGATCAATTAGACGGGTTAAAAACTCAAGGCTATACCATAAAGCTCACGATAGATTTGGATTACCAAC
GCTTAGCGTTAGAGTCCTTGCGTTTTGGGCATCAAAAAATCTTAGAAAAAATCGCTAAAGAAAAGCCAAAAACTAACGCG
TCTAATGAAGATGAAGACAACTTAAACGCTAGCATGATCGTTACAGACACGAGCACCGGTAAGATTTTAGCTTTAGTGGG
GGGGATTGATTATAAAAAAAGCGCTTTCAATCGCGCCACGCAAGCCAAACGGCAGTTTGGGAGCGCGATAAAGCCTTTTG
TGTATCAGATCGCTTTTGATAATGGCTATTCCACGACTTCTAAAATCCCTGATACCGCGCGAAACTTTGAAAATGGCAAT
TATAGTAAAAACAGTGAACAAAACCACGCATGGCACCCCAGCAATTATTCTCGCAAGTTTTTAGGGCTTGTAACCTTGCA
AGAAGCCTTGAGCCATTCGTTAAATCTAGCCACGATCAATTTAAGCGATCAGCTTGGCTTTGAAAAAATTTATCAATCTT
TAAGCGATATGGGGTTTAAAAACCTCCCTAAGGACTTGTCTATTGTGTTAGGGAGCTTTGCTATCTCACCCATTGATGCA
GCTGAAAAGTATTCTTTATTTTCTAATTACGGCACCATGCTCAAACCCATGCTCATTGAAAGCATCACTAACCAACAAAA
CGATGTCAAAACTTTCACGCCTATGGAAACCAAAAAGATCACCTCCAAAGAACAGGCTTTTTTAACCCTTTCAGTGCTGA
TGGATGCGGTAGAAAATGGCACAGGGAGTTTGGCTCGCATTAAAGGTTTAGAAATCGCCGGTAAAACCGGGACTTCTAAC
AACAATATTGACGCTTGGTTCATTGGCTTTACCCCCACCTTGCAAAGCGTGATCTGGTTTGGGAGGGACGATAACACGCC
TATTAGCAAAGGAGCGACAGGGGGTGTTGTGAGTGCGCCTGTGTATTCGTATTTCATGCGTAACATTTTAGCGATTGAAC
CTTCTTTAAAAAGAAAGTTTGATGTCCCCAAAGGCTTGCGTAAAGAAATCGTGGATAAAATCCCCTACTATTCAACCCCC
AATTCCATCACCCCCACCCCCAAAAGAACAGACGATAGCGAGGAACGCTTGTTGTTCTAA

Upstream 100 bases:

>100_bases
AGTCTCTTTATCCCTCAAAAACAGCTTAGAAGACACTAAAGAGCTTGCGAACACCCTTTTAAATTATTCTAAAATACAAT
CTTCTTTTAAGAGTGGTTAA

Downstream 100 bases:

>100_bases
GCCTACATGGCTATAGGGACTTTAACATCTCCGTAATTGACAGAATCTTTAAAGATTTCTTCCACTTTAGCCACAAGGAT
ACTCACCGCTTGATTGTCTA

Product: penicillin-binding protein 1A (PBP-1A)

Products: NA

Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MLKKIFYGFIVLFLIVMGLLAILIAQVWVTTDKDIAKIKDYRPGVASQILDRKGRLIANIYDKEFRFYARFEEIPPRFIE
SLLAVEDTLFFEHGGINLDAIMRAMIKNAKSGRYTEGGSTLTQQFVKNMVLTREKTLTRKLKEAIISIRIEKVLSKEEIL
ERYLNQTFFGHGYYGVKTASLGYFKKPLDKLTLKEITMLVALPRAPSFYDPTKNLEFSLSRANDILRRLYSLGWISSNEL
KGALNEVPIVYNQTSTQNIAPYVVDEVLKQLDQLDGLKTQGYTIKLTIDLDYQRLALESLRFGHQKILEKIAKEKPKTNA
SNEDEDNLNASMIVTDTSTGKILALVGGIDYKKSAFNRATQAKRQFGSAIKPFVYQIAFDNGYSTTSKIPDTARNFENGN
YSKNSEQNHAWHPSNYSRKFLGLVTLQEALSHSLNLATINLSDQLGFEKIYQSLSDMGFKNLPKDLSIVLGSFAISPIDA
AEKYSLFSNYGTMLKPMLIESITNQQNDVKTFTPMETKKITSKEQAFLTLSVLMDAVENGTGSLARIKGLEIAGKTGTSN
NNIDAWFIGFTPTLQSVIWFGRDDNTPISKGATGGVVSAPVYSYFMRNILAIEPSLKRKFDVPKGLRKEIVDKIPYYSTP
NSITPTPKRTDDSEERLLF

Sequences:

>Translated_659_residues
MLKKIFYGFIVLFLIVMGLLAILIAQVWVTTDKDIAKIKDYRPGVASQILDRKGRLIANIYDKEFRFYARFEEIPPRFIE
SLLAVEDTLFFEHGGINLDAIMRAMIKNAKSGRYTEGGSTLTQQFVKNMVLTREKTLTRKLKEAIISIRIEKVLSKEEIL
ERYLNQTFFGHGYYGVKTASLGYFKKPLDKLTLKEITMLVALPRAPSFYDPTKNLEFSLSRANDILRRLYSLGWISSNEL
KGALNEVPIVYNQTSTQNIAPYVVDEVLKQLDQLDGLKTQGYTIKLTIDLDYQRLALESLRFGHQKILEKIAKEKPKTNA
SNEDEDNLNASMIVTDTSTGKILALVGGIDYKKSAFNRATQAKRQFGSAIKPFVYQIAFDNGYSTTSKIPDTARNFENGN
YSKNSEQNHAWHPSNYSRKFLGLVTLQEALSHSLNLATINLSDQLGFEKIYQSLSDMGFKNLPKDLSIVLGSFAISPIDA
AEKYSLFSNYGTMLKPMLIESITNQQNDVKTFTPMETKKITSKEQAFLTLSVLMDAVENGTGSLARIKGLEIAGKTGTSN
NNIDAWFIGFTPTLQSVIWFGRDDNTPISKGATGGVVSAPVYSYFMRNILAIEPSLKRKFDVPKGLRKEIVDKIPYYSTP
NSITPTPKRTDDSEERLLF
>Mature_659_residues
MLKKIFYGFIVLFLIVMGLLAILIAQVWVTTDKDIAKIKDYRPGVASQILDRKGRLIANIYDKEFRFYARFEEIPPRFIE
SLLAVEDTLFFEHGGINLDAIMRAMIKNAKSGRYTEGGSTLTQQFVKNMVLTREKTLTRKLKEAIISIRIEKVLSKEEIL
ERYLNQTFFGHGYYGVKTASLGYFKKPLDKLTLKEITMLVALPRAPSFYDPTKNLEFSLSRANDILRRLYSLGWISSNEL
KGALNEVPIVYNQTSTQNIAPYVVDEVLKQLDQLDGLKTQGYTIKLTIDLDYQRLALESLRFGHQKILEKIAKEKPKTNA
SNEDEDNLNASMIVTDTSTGKILALVGGIDYKKSAFNRATQAKRQFGSAIKPFVYQIAFDNGYSTTSKIPDTARNFENGN
YSKNSEQNHAWHPSNYSRKFLGLVTLQEALSHSLNLATINLSDQLGFEKIYQSLSDMGFKNLPKDLSIVLGSFAISPIDA
AEKYSLFSNYGTMLKPMLIESITNQQNDVKTFTPMETKKITSKEQAFLTLSVLMDAVENGTGSLARIKGLEIAGKTGTSN
NNIDAWFIGFTPTLQSVIWFGRDDNTPISKGATGGVVSAPVYSYFMRNILAIEPSLKRKFDVPKGLRKEIVDKIPYYSTP
NSITPTPKRTDDSEERLLF

Specific function: Cell Wall Formation. Synthesis Of Cross-Linked Peptidoglycan From The Lipid Intermediates. The Enzyme Has A Penicillin-Insensitive Transglycosylase N-Terminal Domain (Formation Of Linear Glycan Strands) And A Penicillin-Sensitive Transpeptidase C-Terminal

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786343, Length=575, Percent_Identity=30.4347826086957, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1788867, Length=582, Percent_Identity=29.0378006872852, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI87082258, Length=271, Percent_Identity=35.4243542435424, Blast_Score=175, Evalue=1e-44,
Organism=Escherichia coli, GI1789601, Length=184, Percent_Identity=34.2391304347826, Blast_Score=102, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.1.129; 3.4.-.- [C]

Molecular weight: Translated: 74270; Mature: 74270

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKIFYGFIVLFLIVMGLLAILIAQVWVTTDKDIAKIKDYRPGVASQILDRKGRLIANI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHCCCEEEEH
YDKEFRFYARFEEIPPRFIESLLAVEDTLFFEHGGINLDAIMRAMIKNAKSGRYTEGGST
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCCCCCCCCHH
LTQQFVKNMVLTREKTLTRKLKEAIISIRIEKVLSKEEILERYLNQTFFGHGYYGVKTAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCEEECC
LGYFKKPLDKLTLKEITMLVALPRAPSFYDPTKNLEFSLSRANDILRRLYSLGWISSNEL
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCHHH
KGALNEVPIVYNQTSTQNIAPYVVDEVLKQLDQLDGLKTQGYTIKLTIDLDYQRLALESL
HHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHH
RFGHQKILEKIAKEKPKTNASNEDEDNLNASMIVTDTSTGKILALVGGIDYKKSAFNRAT
HCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHH
QAKRQFGSAIKPFVYQIAFDNGYSTTSKIPDTARNFENGNYSKNSEQNHAWHPSNYSRKF
HHHHHHCCHHCCCEEEEEECCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHH
LGLVTLQEALSHSLNLATINLSDQLGFEKIYQSLSDMGFKNLPKDLSIVLGSFAISPIDA
HHHHHHHHHHHCCCEEEEEECHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCH
AEKYSLFSNYGTMLKPMLIESITNQQNDVKTFTPMETKKITSKEQAFLTLSVLMDAVENG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCC
TGSLARIKGLEIAGKTGTSNNNIDAWFIGFTPTLQSVIWFGRDDNTPISKGATGGVVSAP
CCCEEEEECEEEECCCCCCCCCCEEEEEECCHHHHHHEEECCCCCCCCCCCCCCCCHHHH
VYSYFMRNILAIEPSLKRKFDVPKGLRKEIVDKIPYYSTPNSITPTPKRTDDSEERLLF
HHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLKKIFYGFIVLFLIVMGLLAILIAQVWVTTDKDIAKIKDYRPGVASQILDRKGRLIANI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHCCCEEEEH
YDKEFRFYARFEEIPPRFIESLLAVEDTLFFEHGGINLDAIMRAMIKNAKSGRYTEGGST
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCCCCCCCCHH
LTQQFVKNMVLTREKTLTRKLKEAIISIRIEKVLSKEEILERYLNQTFFGHGYYGVKTAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCEEECC
LGYFKKPLDKLTLKEITMLVALPRAPSFYDPTKNLEFSLSRANDILRRLYSLGWISSNEL
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCHHH
KGALNEVPIVYNQTSTQNIAPYVVDEVLKQLDQLDGLKTQGYTIKLTIDLDYQRLALESL
HHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHH
RFGHQKILEKIAKEKPKTNASNEDEDNLNASMIVTDTSTGKILALVGGIDYKKSAFNRAT
HCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHH
QAKRQFGSAIKPFVYQIAFDNGYSTTSKIPDTARNFENGNYSKNSEQNHAWHPSNYSRKF
HHHHHHCCHHCCCEEEEEECCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHH
LGLVTLQEALSHSLNLATINLSDQLGFEKIYQSLSDMGFKNLPKDLSIVLGSFAISPIDA
HHHHHHHHHHHCCCEEEEEECHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCH
AEKYSLFSNYGTMLKPMLIESITNQQNDVKTFTPMETKKITSKEQAFLTLSVLMDAVENG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCC
TGSLARIKGLEIAGKTGTSNNNIDAWFIGFTPTLQSVIWFGRDDNTPISKGATGGVVSAP
CCCEEEEECEEEECCCCCCCCCCEEEEEECCHHHHHHEEECCCCCCCCCCCCCCCCHHHH
VYSYFMRNILAIEPSLKRKFDVPKGLRKEIVDKIPYYSTPNSITPTPKRTDDSEERLLF
HHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]