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Identifier: 15645206

GI number: 15645206

Start: 611997

End: 613016

Strand: Reverse

Name: Not Available

Synonym: HP0581

Alternate gene names: 15645206

Gene position: 613016-611997 (Counterclockwise)

Preceding gene: 15645207

Following gene: 15645205

Centisome position: 36.75

GC content: 40.2

Gene sequence:

>1020_bases
ATGGAAATCACGCTTTTTGACCCCATAGACGCCCACTTGCATGTGCGAGAAAACGCACTTTTAAAAGCGGTGTTAGGATA
TTCTAGCGAGCCTTTTAGTGCTGCAGTGATCATGCCTAATCTCAGTAAGCCCTTGATTGACACTCCAACCACCCTTGAAT
ACGAAGAAGAAATTTTAAACCATTCTTCAAACTTCAAGCCTCTAATGAGTTTGTATTTCAATGATGGCTTGACTTTAGAA
GAATTGCAATGCGCAAAAGAAAAAGGCGTCAGGTTTTTAAAGCTCTACCCCAAAGGCATGACCACAAACGCGCAAAACGG
CACTTCGGATTTGTTGGGTGAAAAAACTTTAGAGGTTTTAGAAAACGCCCAAAAATTAGGCTTTATTTTATGCATCCATG
CAGAACAAACCGGGTTTTGTTTGGATAAAGAATTTTTATGCCATAGCGTTTTAGAAACTTTTGCCCTTTCATTCCCTAAA
CTCAAAATCATTATAGAGCATTTGAGCGACTGGCGCAGTATCGCTTTGATTGAAAAACATGACAATCTCTATGCGACTTT
GACTTTACACCATATCAGCATGACTTTAGATGATTTATTAGGGGGGAGTTTGAACCCGCATTGTTTTTGCAAACCCTTAA
TCAAAACCAAAAAAGACCAAGAAAGGCTTTTATCCCTTGCTTTAAAAGCCCACCCTAAAATCTCTTTTGGCTCTGATAGC
GCCCCGCATTTCATTTCTAAAAAGCATAGCGCTAACATCCCGGCGGGCATCTTTTCTGCCCCTATTTTATTGCCTGCGTT
GTGCGAACTTTTTGAAAAACACAACGCTTTAGAAAACTTGCAAGCCTTTATCAGCGATAACGCTAAAACAATCTATGGGC
TAGAAAATTTGCCCAGTAAAAAAGCGCGTTTGTCTAAAAAACCCTTTATGATCCCTACACACACGCTTTGCTTGAATGAA
AAAATCGCTATCTTAAGAGGGGGCGAAACGCTATCTTGGAACCTTCAAGAAATCGCCTAA

Upstream 100 bases:

>100_bases
CTTAAAGACCATTCAGATCGCTTATAAGGATTACCCACGCCCCAAAACTAAAACCCTCATTCGCATCAGAGTGCGTTATT
ACTTAGGGGGCAATTAAAAA

Downstream 100 bases:

>100_bases
AACATGCCGCCTTTTTTGTGGGGCTTTTTATCGTTTTATTTTTAATCATAATGAAGCGCCAAACCCCCCCCTATGCTTTT
ATGCGCAATCAAACCCTTGT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MEITLFDPIDAHLHVRENALLKAVLGYSSEPFSAAVIMPNLSKPLIDTPTTLEYEEEILNHSSNFKPLMSLYFNDGLTLE
ELQCAKEKGVRFLKLYPKGMTTNAQNGTSDLLGEKTLEVLENAQKLGFILCIHAEQTGFCLDKEFLCHSVLETFALSFPK
LKIIIEHLSDWRSIALIEKHDNLYATLTLHHISMTLDDLLGGSLNPHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDS
APHFISKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISDNAKTIYGLENLPSKKARLSKKPFMIPTHTLCLNE
KIAILRGGETLSWNLQEIA

Sequences:

>Translated_339_residues
MEITLFDPIDAHLHVRENALLKAVLGYSSEPFSAAVIMPNLSKPLIDTPTTLEYEEEILNHSSNFKPLMSLYFNDGLTLE
ELQCAKEKGVRFLKLYPKGMTTNAQNGTSDLLGEKTLEVLENAQKLGFILCIHAEQTGFCLDKEFLCHSVLETFALSFPK
LKIIIEHLSDWRSIALIEKHDNLYATLTLHHISMTLDDLLGGSLNPHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDS
APHFISKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISDNAKTIYGLENLPSKKARLSKKPFMIPTHTLCLNE
KIAILRGGETLSWNLQEIA
>Mature_339_residues
MEITLFDPIDAHLHVRENALLKAVLGYSSEPFSAAVIMPNLSKPLIDTPTTLEYEEEILNHSSNFKPLMSLYFNDGLTLE
ELQCAKEKGVRFLKLYPKGMTTNAQNGTSDLLGEKTLEVLENAQKLGFILCIHAEQTGFCLDKEFLCHSVLETFALSFPK
LKIIIEHLSDWRSIALIEKHDNLYATLTLHHISMTLDDLLGGSLNPHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDS
APHFISKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISDNAKTIYGLENLPSKKARLSKKPFMIPTHTLCLNE
KIAILRGGETLSWNLQEIA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=339, Percent_Identity=30.3834808259587, Blast_Score=172, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6323452, Length=362, Percent_Identity=31.767955801105, Blast_Score=161, Evalue=1e-40,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006992
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF04909 Amidohydro_2 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 37883; Mature: 37883

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEITLFDPIDAHLHVRENALLKAVLGYSSEPFSAAVIMPNLSKPLIDTPTTLEYEEEILN
CEEEEECCCCCEEEEHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHC
HSSNFKPLMSLYFNDGLTLEELQCAKEKGVRFLKLYPKGMTTNAQNGTSDLLGEKTLEVL
CCCCCCHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
ENAQKLGFILCIHAEQTGFCLDKEFLCHSVLETFALSFPKLKIIIEHLSDWRSIALIEKH
HHHHHCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHEEEEEEC
DNLYATLTLHHISMTLDDLLGGSLNPHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDS
CCEEEEEEEEHHHHHHHHHHCCCCCCCCEECHHHHCCCHHHHHHHHHHHCCCCCCCCCCC
APHFISKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISDNAKTIYGLENLPSK
CCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCH
KARLSKKPFMIPTHTLCLNEKIAILRGGETLSWNLQEIA
HHHCCCCCCCCCCCEEEECCCEEEEECCCEEEECHHHCC
>Mature Secondary Structure
MEITLFDPIDAHLHVRENALLKAVLGYSSEPFSAAVIMPNLSKPLIDTPTTLEYEEEILN
CEEEEECCCCCEEEEHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHC
HSSNFKPLMSLYFNDGLTLEELQCAKEKGVRFLKLYPKGMTTNAQNGTSDLLGEKTLEVL
CCCCCCHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
ENAQKLGFILCIHAEQTGFCLDKEFLCHSVLETFALSFPKLKIIIEHLSDWRSIALIEKH
HHHHHCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHEEEEEEC
DNLYATLTLHHISMTLDDLLGGSLNPHCFCKPLIKTKKDQERLLSLALKAHPKISFGSDS
CCEEEEEEEEHHHHHHHHHHCCCCCCCCEECHHHHCCCHHHHHHHHHHHCCCCCCCCCCC
APHFISKKHSANIPAGIFSAPILLPALCELFEKHNALENLQAFISDNAKTIYGLENLPSK
CCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCH
KARLSKKPFMIPTHTLCLNEKIAILRGGETLSWNLQEIA
HHHCCCCCCCCCCCEEEECCCEEEEECCCEEEECHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA