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Identifier: 15645202

GI number: 15645202

Start: 607348

End: 608226

Strand: Reverse

Name: Not Available

Synonym: HP0577

Alternate gene names: 15645202

Gene position: 608226-607348 (Counterclockwise)

Preceding gene: 15645203

Following gene: 15645201

Centisome position: 36.47

GC content: 42.21

Gene sequence:

>879_bases
ATGGGCATGCCAAATAGGGGCGTTGTTTTATTAGACGGGCAAGCGCTAGCTGATAATATAGAAAAAGATTTGAAACATAA
AATCCAAATAATAACCGCACAAACGCATAAACGCCCCAAACTAGCCGTGATTTTAGTGGGGAAAGATCCCGCTAGTATCA
CTTATGTCAATATGAAGATCAAAGCATGCGAAAGGGTGGGCATGGATTTTGACTTAAAAACCCTCCAAGAAAATATTACT
GAAGCCAAATTGCTATCCTTGATTAAAGATTACAATACCGATCAAAACATTTCAGGCGTTTTAGTCCAGCTCCCTTTGCC
CAGACACATTGATACTAAAATGATTTTAGAAGCCATTGACCCAAACAAAGATGTGGATGGTTTCCACCCCCTTAATATCG
GTAAGCTCTGCACTCAAAAAGAATCGTTTCTGCCAGCCACCCCTATGGGCGTGATGCGGCTTTTAGAGCATTACCATATT
GAAATCAAGGGTAAGGATGTGGCGATTATTGGAGCGAGCAATATCATTGGCAAACCTTTAAGCATGCTCATGCTAAACGC
TGGGGCTAGCGTGAGCGTGTGCCATATTTTGACTAAAGACATTAGTTTTTACACCCAAAACGCTGATATTGTCTGCGTGG
GCGTGGGTAAACCTGATTTGATTAAAGCGAGCATGTTAAAAAAAGGGGCTGTAGTGGTGGATATTGGGATCAATCATTTG
AACGATGGGCGTATCGTGGGCGATGTGGATTTTAACAACGTGCAAAAAGTCGCCGGTTTTATCACCCCTGTGCCTAAAGG
CGTGGGGCCTATGACGATTGTCTCGCTTTTAGAAAACACTCTAATCGCTTTTGAAAAACAACAAAGGAAGGGATTTTAA

Upstream 100 bases:

>100_bases
TATCATGGGGCTAATCTTAAAGATTGACAAACTAGGTTTTTATTCCATTAAACGCATGATTTTTGCTACAATAATAGGAT
TTTAATTATATAAAGGACAA

Downstream 100 bases:

>100_bases
TGAAATTTTTACGCTCTGTTTATGCATTTTGCTCCAGTTGGGTAGGGACGATTGTTATTGTGCTGTTGGTTATCTTTTTT
ATCGCGCAAGCCTTTATCAT

Product: bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MGMPNRGVVLLDGQALADNIEKDLKHKIQIITAQTHKRPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENIT
EAKLLSLIKDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHI
EIKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHL
NDGRIVGDVDFNNVQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQRKGF

Sequences:

>Translated_292_residues
MGMPNRGVVLLDGQALADNIEKDLKHKIQIITAQTHKRPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENIT
EAKLLSLIKDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHI
EIKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHL
NDGRIVGDVDFNNVQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQRKGF
>Mature_291_residues
GMPNRGVVLLDGQALADNIEKDLKHKIQIITAQTHKRPKLAVILVGKDPASITYVNMKIKACERVGMDFDLKTLQENITE
AKLLSLIKDYNTDQNISGVLVQLPLPRHIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIE
IKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLN
DGRIVGDVDFNNVQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQRKGF

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate [H]

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family [H]

Homologues:

Organism=Homo sapiens, GI222418558, Length=293, Percent_Identity=41.6382252559727, Blast_Score=235, Evalue=3e-62,
Organism=Homo sapiens, GI94721354, Length=296, Percent_Identity=42.9054054054054, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI222136639, Length=283, Percent_Identity=36.0424028268551, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI36796743, Length=206, Percent_Identity=26.2135922330097, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786741, Length=274, Percent_Identity=48.1751824817518, Blast_Score=273, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17568735, Length=260, Percent_Identity=37.6923076923077, Blast_Score=170, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6319558, Length=287, Percent_Identity=43.5540069686411, Blast_Score=241, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6321643, Length=298, Percent_Identity=38.9261744966443, Blast_Score=210, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6322933, Length=280, Percent_Identity=23.2142857142857, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17136816, Length=293, Percent_Identity=43.3447098976109, Blast_Score=250, Evalue=9e-67,
Organism=Drosophila melanogaster, GI17136818, Length=293, Percent_Identity=43.3447098976109, Blast_Score=249, Evalue=1e-66,
Organism=Drosophila melanogaster, GI62472483, Length=285, Percent_Identity=39.2982456140351, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI45551871, Length=285, Percent_Identity=39.2982456140351, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24645718, Length=285, Percent_Identity=39.2982456140351, Blast_Score=204, Evalue=6e-53,
Organism=Drosophila melanogaster, GI17137370, Length=285, Percent_Identity=39.2982456140351, Blast_Score=204, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631 [H]

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C [H]

EC number: =1.5.1.5; =3.5.4.9 [H]

Molecular weight: Translated: 31875; Mature: 31744

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00766 THF_DHG_CYH_1 ; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMPNRGVVLLDGQALADNIEKDLKHKIQIITAQTHKRPKLAVILVGKDPASITYVNMKI
CCCCCCCEEEECCHHHHHHHHHHHHHEEEEEEECCCCCCCEEEEEECCCCCEEEEEEEEE
KACERVGMDFDLKTLQENITEAKLLSLIKDYNTDQNISGVLVQLPLPRHIDTKMILEAID
EEHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHCC
PNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIEIKGKDVAIIGASNIIGKPL
CCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHEEEEECCCEEEEEECCCCCCCCH
SMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHL
HHHEECCCCCEEEHHHHHHHHHEEECCCCEEEEECCCCCHHHHHHHHCCCEEEEECCCCC
NDGRIVGDVDFNNVQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQRKGF
CCCEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GMPNRGVVLLDGQALADNIEKDLKHKIQIITAQTHKRPKLAVILVGKDPASITYVNMKI
CCCCCCEEEECCHHHHHHHHHHHHHEEEEEEECCCCCCCEEEEEECCCCCEEEEEEEEE
KACERVGMDFDLKTLQENITEAKLLSLIKDYNTDQNISGVLVQLPLPRHIDTKMILEAID
EEHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHCC
PNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIEIKGKDVAIIGASNIIGKPL
CCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHEEEEECCCEEEEEECCCCCCCCH
SMLMLNAGASVSVCHILTKDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHL
HHHEECCCCCEEEHHHHHHHHHEEECCCCEEEEECCCCCHHHHHHHHCCCEEEEECCCCC
NDGRIVGDVDFNNVQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQRKGF
CCCEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA