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Identifier: 15644998

GI number: 15644998

Start: 378258

End: 379634

Strand: Reverse

Name: Not Available

Synonym: HP0370

Alternate gene names: 15644998

Gene position: 379634-378258 (Counterclockwise)

Preceding gene: 15644999

Following gene: 15644997

Centisome position: 22.76

GC content: 44.59

Gene sequence:

>1377_bases
ATGAATAAAGTGAATAAAGAAAATAAAAAGGTAGAAAAAAAAGAGCTTTCACGCATTTTGATCGCTAATAGAGGCGAGAT
CGCTTTAAGAGCGATCCAAACCATTCAAGAAATGGGTAAAGAATCCATAGCCATTTATTCTATCGCTGACAAGGACGCCC
ACTACCTCAATACGGCTAGCGCAAAAGTGTGTATAGGGGGGGCCAAATCCAGCGAGAGCTACTTGAATATCCCTGCGATC
ATTAGCGCGGCGGAATTGTTTGAAGCGGATGCGATTTTCCCCGGGTATGGGTTTTTGAGCGAGAATCAGAATTTTGTAGA
GATTTGCTCGCACCATTCTTTAGAATTTATTGGTCCAAGCGCGAAGGTCATGGCTTTAATGAGCGATAAATCCAAGGCCA
AAAGCGTGATGAAGGAAGCCGGCATGCCTGTGATTGAGGGCAGTGATGGGTTGCTTAAAAGCTATCAAGAAGCTGAAGAA
ATCGCTGATAAAATCGGCTACCCTGTCATCATTAAAGCAGCCGCTGGTGGGGGCGGGAGAGGCATGCGTGTCGTAGGAGA
TAAATCCAAGCTTAAAAACCTTTATTTAGCCGCAGAAACGGAAGCTTTGAGCGCGTTTGGCGATGGGAGCGTGTATTTAG
AAAAGTTCATCAACAAGCCCAAGCACATTGAAGTCCAAATTCTAGCCGATAAGCATGGCAATGTCATTCATGTGGGCGAA
AGGGATTGCTCGGTGCAAAGACGCCAACAAAAGCTCATTGAAGAAACCCCGGCAGTGGTTTTAGAAGAGGGCGTGCGTGA
GCGTTTGCTAGAAACAGCGATCAAGGCCGCTAAATATATCGGCTATGTGGGGGCGGGGACTTTTGAATTTTTGTTGGATT
CTAACATGAAAGATTTTTATTTCATGGAGATGAACACTCGTTTGCAAGTGGAACACACCATTAGCGAAATGGTGAGCGGG
TTAAACCTCATTGAGTGGATGATTAAAATCGCTCAAGGCGAAAAATTGCCCAAGCAAGAAAGCTTTTCTCTCAAAGGGCA
TGCGATAGAATGCCGAATCACGGCAGAAGATCCTAAAAAATTCTACCCAAGCCCGGGCAAAATTACCGAATGGATCGCTC
CTGGTGGGGTGAATGTGCGCCTTGATTCGCACGCGCATGCCAATTATGTCGTGCCTACGCACTATGATTCGATGATTGGC
AAGCTCATTGTGTGGGGTGAAAACAGAGAAAGAGCGATCGCTAAGATGAAAAGGGCTTTAAAGGAATTTAAAGTAGAAGG
CATTAAAACGACCATTCCTTTCCACCTTGAAATGCTTGAAAATGCGGATTTCAGGCAAGCAAAAATCCACACGAAGTATT
TAGAAGAAAATTTTTAA

Upstream 100 bases:

>100_bases
AAGTGGAATACCCTTGCAAGGTGGTTTCTGTTGAAGTGGGAGACGCTCAACCGGTAGAATACGGCACAAAACTCATCAAA
GTTGAAAAGCTTTAAAATCC

Downstream 100 bases:

>100_bases
GTTTTAAGGATTCTTTTAAGCATAGTTTAAGGGTTTTAAGCGATCAGAAAAAGTCAGCATTAAGTTTTATGGTTTTATAG
TAAAGTTTTTTCATGCAAAC

Product: biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MNKVNKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTASAKVCIGGAKSSESYLNIPAI
ISAAELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPSAKVMALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEE
IADKIGYPVIIKAAAGGGGRGMRVVGDKSKLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGE
RDCSVQRRQQKLIEETPAVVLEEGVRERLLETAIKAAKYIGYVGAGTFEFLLDSNMKDFYFMEMNTRLQVEHTISEMVSG
LNLIEWMIKIAQGEKLPKQESFSLKGHAIECRITAEDPKKFYPSPGKITEWIAPGGVNVRLDSHAHANYVVPTHYDSMIG
KLIVWGENRERAIAKMKRALKEFKVEGIKTTIPFHLEMLENADFRQAKIHTKYLEENF

Sequences:

>Translated_458_residues
MNKVNKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTASAKVCIGGAKSSESYLNIPAI
ISAAELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPSAKVMALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEE
IADKIGYPVIIKAAAGGGGRGMRVVGDKSKLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGE
RDCSVQRRQQKLIEETPAVVLEEGVRERLLETAIKAAKYIGYVGAGTFEFLLDSNMKDFYFMEMNTRLQVEHTISEMVSG
LNLIEWMIKIAQGEKLPKQESFSLKGHAIECRITAEDPKKFYPSPGKITEWIAPGGVNVRLDSHAHANYVVPTHYDSMIG
KLIVWGENRERAIAKMKRALKEFKVEGIKTTIPFHLEMLENADFRQAKIHTKYLEENF
>Mature_458_residues
MNKVNKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTASAKVCIGGAKSSESYLNIPAI
ISAAELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPSAKVMALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEE
IADKIGYPVIIKAAAGGGGRGMRVVGDKSKLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGE
RDCSVQRRQQKLIEETPAVVLEEGVRERLLETAIKAAKYIGYVGAGTFEFLLDSNMKDFYFMEMNTRLQVEHTISEMVSG
LNLIEWMIKIAQGEKLPKQESFSLKGHAIECRITAEDPKKFYPSPGKITEWIAPGGVNVRLDSHAHANYVVPTHYDSMIG
KLIVWGENRERAIAKMKRALKEFKVEGIKTTIPFHLEMLENADFRQAKIHTKYLEENF

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=447, Percent_Identity=43.6241610738255, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI106049528, Length=456, Percent_Identity=43.640350877193, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI106049295, Length=456, Percent_Identity=43.640350877193, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI106049292, Length=456, Percent_Identity=43.640350877193, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI189095269, Length=449, Percent_Identity=42.7616926503341, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI65506442, Length=450, Percent_Identity=42.6666666666667, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI295821183, Length=450, Percent_Identity=42.6666666666667, Blast_Score=371, Evalue=1e-102,
Organism=Homo sapiens, GI38679960, Length=516, Percent_Identity=31.9767441860465, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI38679977, Length=516, Percent_Identity=31.9767441860465, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI38679967, Length=516, Percent_Identity=31.9767441860465, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI38679971, Length=510, Percent_Identity=31.7647058823529, Blast_Score=256, Evalue=5e-68,
Organism=Homo sapiens, GI38679974, Length=510, Percent_Identity=31.7647058823529, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI134142062, Length=503, Percent_Identity=30.4174950298211, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI18105007, Length=238, Percent_Identity=24.3697478991597, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI21361331, Length=305, Percent_Identity=23.9344262295082, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI170295797, Length=305, Percent_Identity=23.9344262295082, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI169790915, Length=305, Percent_Identity=23.9344262295082, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=51.0112359550562, Blast_Score=434, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17562816, Length=460, Percent_Identity=44.3478260869565, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71987519, Length=447, Percent_Identity=43.6241610738255, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17567343, Length=448, Percent_Identity=41.7410714285714, Blast_Score=359, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI133931226, Length=508, Percent_Identity=29.5275590551181, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI71997168, Length=512, Percent_Identity=28.7109375, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71997163, Length=512, Percent_Identity=28.7109375, Blast_Score=215, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6321376, Length=452, Percent_Identity=43.8053097345133, Blast_Score=343, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6319685, Length=444, Percent_Identity=40.3153153153153, Blast_Score=342, Evalue=8e-95,
Organism=Saccharomyces cerevisiae, GI6319695, Length=452, Percent_Identity=43.3628318584071, Blast_Score=341, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6323863, Length=455, Percent_Identity=34.0659340659341, Blast_Score=246, Evalue=7e-66,
Organism=Saccharomyces cerevisiae, GI6324343, Length=510, Percent_Identity=31.3725490196078, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6322569, Length=321, Percent_Identity=22.7414330218069, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24651757, Length=448, Percent_Identity=44.1964285714286, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI281363050, Length=460, Percent_Identity=43.2608695652174, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652224, Length=460, Percent_Identity=43.2608695652174, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652222, Length=460, Percent_Identity=43.2608695652174, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652220, Length=460, Percent_Identity=43.2608695652174, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652218, Length=460, Percent_Identity=43.2608695652174, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652212, Length=460, Percent_Identity=43.2608695652174, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652210, Length=460, Percent_Identity=43.2608695652174, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652214, Length=460, Percent_Identity=43.2608695652174, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI19921944, Length=460, Percent_Identity=43.2608695652174, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652216, Length=460, Percent_Identity=43.2608695652174, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24651759, Length=397, Percent_Identity=45.3400503778337, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI161076407, Length=497, Percent_Identity=31.1871227364185, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24586460, Length=497, Percent_Identity=31.1871227364185, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI161076409, Length=497, Percent_Identity=31.1871227364185, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24586458, Length=497, Percent_Identity=31.1871227364185, Blast_Score=237, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 51002; Mature: 51002

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVNKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTAS
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHEECCC
AKVCIGGAKSSESYLNIPAIISAAELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPS
CEEEEECCCCCCCEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCC
AKVMALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEEIADKIGYPVIIKAAAGGGGR
HHEEEECCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
GMRVVGDKSKLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGE
CEEEECCHHHHCEEEEEECHHHHHHCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEECC
RDCSVQRRQQKLIEETPAVVLEEGVRERLLETAIKAAKYIGYVGAGTFEFLLDSNMKDFY
CCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHCCCCCCCEE
FMEMNTRLQVEHTISEMVSGLNLIEWMIKIAQGEKLPKQESFSLKGHAIECRITAEDPKK
EEEECCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCHH
FYPSPGKITEWIAPGGVNVRLDSHAHANYVVPTHYDSMIGKLIVWGENRERAIAKMKRAL
HCCCCCCEEEEECCCCEEEEECCCCCCCEEECCCHHHHHCEEEEECCCHHHHHHHHHHHH
KEFKVEGIKTTIPFHLEMLENADFRQAKIHTKYLEENF
HHHHHCCCEEECCCHHEECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKVNKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTAS
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHEECCC
AKVCIGGAKSSESYLNIPAIISAAELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPS
CEEEEECCCCCCCEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCC
AKVMALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEEIADKIGYPVIIKAAAGGGGR
HHEEEECCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
GMRVVGDKSKLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGE
CEEEECCHHHHCEEEEEECHHHHHHCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEECC
RDCSVQRRQQKLIEETPAVVLEEGVRERLLETAIKAAKYIGYVGAGTFEFLLDSNMKDFY
CCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHCCCCCCCEE
FMEMNTRLQVEHTISEMVSGLNLIEWMIKIAQGEKLPKQESFSLKGHAIECRITAEDPKK
EEEECCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCHH
FYPSPGKITEWIAPGGVNVRLDSHAHANYVVPTHYDSMIGKLIVWGENRERAIAKMKRAL
HCCCCCCEEEEECCCCEEEEECCCCCCCEEECCCHHHHHCEEEEECCCHHHHHHHHHHHH
KEFKVEGIKTTIPFHLEMLENADFRQAKIHTKYLEENF
HHHHHCCCEEECCCHHEECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]