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The map label for this gene is lpxK

Identifier: 15644956

GI number: 15644956

Start: 343588

End: 344526

Strand: Reverse

Name: lpxK

Synonym: HP0328

Alternate gene names: 15644956

Gene position: 344526-343588 (Counterclockwise)

Preceding gene: 15644957

Following gene: 15644952

Centisome position: 20.66

GC content: 37.49

Gene sequence:

>939_bases
ATGAAAAGCGATAAACCCTTTTTAGAACGCTATTTTTATGATCCCACTCTTTTGCAAAAGGGGTTGATTTTCGCACTCTA
TCCTTTTTCTTTAATCTATCAAGGCATCGCCACCCTTAAACGAAAAACCGCTAAAAAACATGATTTTAAAATCCCCATTA
TCAGTATAGGCAATTTGATCGCTGGGGGAAGCGGTAAAACGCCCTTTATTTTAGAGATCGCTCCAAGATACCAAGAAGTG
GCGGTTGTCTCTAGGGGGTATCAACGGGATTCTAAAGGCTTAGTGGTGGTGAGCGTTAAAGGAAACATTTTAGTTTCTCA
AAAAACAGCGGGCGATGAAGCCTATCTTTTAGCCTTGAATTTAAAACAAGCGAGCGTGATTGTGAGCGAAAAAAGAGAGC
TAGGCGTTTTAAAAGCCCTTGAATTAGGGGCAAAGATCGTGTTTTTAGACGATGGTTTTAGGTTTAATTTCAACCAATTC
AATTTGCTTTTAAAGCCTAAAGTCCCCCCCTACTACCCTTTTTGTTTGCCTAGCGGGTTGTATAGAGAAAGCATCAAAAG
CTATGAAGAAGCCCATTTGGTCGTTACAGAAGATAAGGATTATCAAAGAATAACCTCTATTTCTCGCCCCACCAAACGCA
TGCTTTTAGTAACGGCTATCGCTAATCCTAGCAGGCTTGATGCGTTTTTACCCAAAGAAGTGGTTAAAAAATTGTATTTT
AAAGACCATGCCCCTTTTAATTTGGAGCTTTTAGAAAAAGAATTTTATCAAAACAACGCCACTTCCTTATTGGTTACTTC
AAAAGATCTCGTCAAATTACAAGATTGCAACTTGCCCTTAAGCGTATTAAATTTAAAACTAGAAATTTGCCCTAAAGTTT
TAGAAGAGATTGATCATTATATCCTTTCTTATCCTTATAATACAAAAGAACGTCTATAA

Upstream 100 bases:

>100_bases
TAGGCTATGATGAAATTTTAGTGAAAAACATCACAAGCCGTATCCAAAAAAACGCTTTTAAATTAGAATTACCCGCCATC
GCCAAACGATTTAACCCTGA

Downstream 100 bases:

>100_bases
ACTCCTTATCTTTAGAAATAAAGCCTTTCAAACGCCCCTCTAACTCATAATGGTTTTTTTCATAAAAAGCGATCGCTTTG
AAATTGTTTTCCATCACTTC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKSDKPFLERYFYDPTLLQKGLIFALYPFSLIYQGIATLKRKTAKKHDFKIPIISIGNLIAGGSGKTPFILEIAPRYQEV
AVVSRGYQRDSKGLVVVSVKGNILVSQKTAGDEAYLLALNLKQASVIVSEKRELGVLKALELGAKIVFLDDGFRFNFNQF
NLLLKPKVPPYYPFCLPSGLYRESIKSYEEAHLVVTEDKDYQRITSISRPTKRMLLVTAIANPSRLDAFLPKEVVKKLYF
KDHAPFNLELLEKEFYQNNATSLLVTSKDLVKLQDCNLPLSVLNLKLEICPKVLEEIDHYILSYPYNTKERL

Sequences:

>Translated_312_residues
MKSDKPFLERYFYDPTLLQKGLIFALYPFSLIYQGIATLKRKTAKKHDFKIPIISIGNLIAGGSGKTPFILEIAPRYQEV
AVVSRGYQRDSKGLVVVSVKGNILVSQKTAGDEAYLLALNLKQASVIVSEKRELGVLKALELGAKIVFLDDGFRFNFNQF
NLLLKPKVPPYYPFCLPSGLYRESIKSYEEAHLVVTEDKDYQRITSISRPTKRMLLVTAIANPSRLDAFLPKEVVKKLYF
KDHAPFNLELLEKEFYQNNATSLLVTSKDLVKLQDCNLPLSVLNLKLEICPKVLEEIDHYILSYPYNTKERL
>Mature_312_residues
MKSDKPFLERYFYDPTLLQKGLIFALYPFSLIYQGIATLKRKTAKKHDFKIPIISIGNLIAGGSGKTPFILEIAPRYQEV
AVVSRGYQRDSKGLVVVSVKGNILVSQKTAGDEAYLLALNLKQASVIVSEKRELGVLKALELGAKIVFLDDGFRFNFNQF
NLLLKPKVPPYYPFCLPSGLYRESIKSYEEAHLVVTEDKDYQRITSISRPTKRMLLVTAIANPSRLDAFLPKEVVKKLYF
KDHAPFNLELLEKEFYQNNATSLLVTSKDLVKLQDCNLPLSVLNLKLEICPKVLEEIDHYILSYPYNTKERL

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 35531; Mature: 35531

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDKPFLERYFYDPTLLQKGLIFALYPFSLIYQGIATLKRKTAKKHDFKIPIISIGNLI
CCCCCCHHHHHCCCHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEE
AGGSGKTPFILEIAPRYQEVAVVSRGYQRDSKGLVVVSVKGNILVSQKTAGDEAYLLALN
ECCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCEEEEEECCCEEEEECCCCCCEEEEEEE
LKQASVIVSEKRELGVLKALELGAKIVFLDDGFRFNFNQFNLLLKPKVPPYYPFCLPSGL
CCHHEEEEHHHHHHHHHHHHHHCCEEEEEECCCEECCCEEEEEECCCCCCCCCCCCCCHH
YRESIKSYEEAHLVVTEDKDYQRITSISRPTKRMLLVTAIANPSRLDAFLPKEVVKKLYF
HHHHHHHHHHEEEEEECCCCHHHHHHCCCCCCEEEEEEEECCCHHHHHHCHHHHHHHHHH
KDHAPFNLELLEKEFYQNNATSLLVTSKDLVKLQDCNLPLSVLNLKLEICPKVLEEIDHY
CCCCCCCHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
ILSYPYNTKERL
EEECCCCHHCCC
>Mature Secondary Structure
MKSDKPFLERYFYDPTLLQKGLIFALYPFSLIYQGIATLKRKTAKKHDFKIPIISIGNLI
CCCCCCHHHHHCCCHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEE
AGGSGKTPFILEIAPRYQEVAVVSRGYQRDSKGLVVVSVKGNILVSQKTAGDEAYLLALN
ECCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCEEEEEECCCEEEEECCCCCCEEEEEEE
LKQASVIVSEKRELGVLKALELGAKIVFLDDGFRFNFNQFNLLLKPKVPPYYPFCLPSGL
CCHHEEEEHHHHHHHHHHHHHHCCEEEEEECCCEECCCEEEEEECCCCCCCCCCCCCCHH
YRESIKSYEEAHLVVTEDKDYQRITSISRPTKRMLLVTAIANPSRLDAFLPKEVVKKLYF
HHHHHHHHHHEEEEEECCCCHHHHHHCCCCCCEEEEEEEECCCHHHHHHCHHHHHHHHHH
KDHAPFNLELLEKEFYQNNATSLLVTSKDLVKLQDCNLPLSVLNLKLEICPKVLEEIDHY
CCCCCCCHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
ILSYPYNTKERL
EEECCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA