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Identifier: 15644763

GI number: 15644763

Start: 143594

End: 144835

Strand: Reverse

Name: Not Available

Synonym: HP0133

Alternate gene names: 15644763

Gene position: 144835-143594 (Counterclockwise)

Preceding gene: 15644766

Following gene: 15644762

Centisome position: 8.68

GC content: 38.73

Gene sequence:

>1242_bases
ATGGCACAAGAAAAAGCAGTTCCAAGAGATCCTAAAAAACTCAATGCGTTTGATTTGCGTTGGATGGTGTCCTTATTTGG
CACGGCGGTGGGGGCTGGGATTTTATTTTTGCCTATTAGAGCCGGTGGGCATGGGGTATGGGCTATTGTGGTAATGAGCG
CGATCATTTTCCCTTTAACTTATCTAGGGCATAGAGCTTTAGCTTATTTCATAGGATCTAAAGACAAAGAAGACATTACC
ATGGTCGTTCGCTCTCATTTTGGCGCTCAATGGGGTTTTCTTATCACTTTGCTTTATTTCTTAGCGATTTATCCTATTTG
CTTGGTTTATGGGGTGGGTATCACTAACGTGTTTGATCATTTTTTCACTAACCAGTTGCATTTAGCGCCTTTTCATCGGG
GATTATTGGCTGTAGCGTTAGTTTCTTTAATGATGTTGGTGATGGTTTTTAACGCTACGATTGTTACGCGCATTTGTAAC
GCTTTAGTGTATCCTTTATGCTTGATTTTATTGCTTTTTTCTTTGTATCTTATCCCTTATTGGCAAGGCGCTAATCTTTT
TGTGGTGCCGAGTTTTAAAGAATTTGTGTTAGCGATTTGGCTAACCTTACCGGTGCTTGTGTTTGCATTCGACCATAGCC
CCATCATTTCAACCTTCACTCAAAATGTGGGAAAAGAATACGGCGTTTTCAAAGAATACAAACTCAATCAAATTGAATTA
GGGACATCGCTGATGCTTTTAGGGTTTGTGATGTTTTTTGTGTTTTCGTGCGTCATGTGCTTGAATGCTGATGATTTTGT
GAAAGCAAGGGAACAAAATATCCCCATTTTAAGCTATTTGGCTAACACTTTAAACAACCCTTTAATCAATTATGCGGGGC
CTGTGGTGGCTTTTTTAGCGATTTTTTCATCTTTTTTTGGGCATTATTATGGGGCTAAGGAGGGTTTAGAAGGCATTATT
ATTCAAAGCTTAAAATTGAAAAAAGCTTCTAAACCCTTGAGCGTTAGCGTAACGATTTTTTTATGGCTGACTATCACGCT
TGTGGCTTATATTAACCCCAATATCTTGGATTTTATTGAAAATTTAGGCGGCCCCATTATCGCGCTCATTCTGTTTGTGA
TGCCCATGATAGCTTTTTATAGTGTTTCTAGTTTGAAGCGTTTTAGAAATTTCAAAGTGGATATTTTTGTGTTTGTCTTT
GGGAGCTTGACGGCTTTGAGCGTGTTTTTAGGACTATTTTAA

Upstream 100 bases:

>100_bases
CGTGCCCAAAACCACCCCTTAATCTCAAAAAACCCCAATCATAAAAAGCTTTATGCTACAATGAAAGCTCTTTAACACGA
TAAAAGGGCGGTTTAATAGC

Downstream 100 bases:

>100_bases
TGGCTAGTTTTTCTATTTTATCTATTTTTAAAATCGGCGTGGGGCCTAGCTCTTCACACACTATAGGGCCTATGGAAGCG
GGAGCGAGATTTTGCGAGTC

Product: serine transporter (sdaC)

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MAQEKAVPRDPKKLNAFDLRWMVSLFGTAVGAGILFLPIRAGGHGVWAIVVMSAIIFPLTYLGHRALAYFIGSKDKEDIT
MVVRSHFGAQWGFLITLLYFLAIYPICLVYGVGITNVFDHFFTNQLHLAPFHRGLLAVALVSLMMLVMVFNATIVTRICN
ALVYPLCLILLLFSLYLIPYWQGANLFVVPSFKEFVLAIWLTLPVLVFAFDHSPIISTFTQNVGKEYGVFKEYKLNQIEL
GTSLMLLGFVMFFVFSCVMCLNADDFVKAREQNIPILSYLANTLNNPLINYAGPVVAFLAIFSSFFGHYYGAKEGLEGII
IQSLKLKKASKPLSVSVTIFLWLTITLVAYINPNILDFIENLGGPIIALILFVMPMIAFYSVSSLKRFRNFKVDIFVFVF
GSLTALSVFLGLF

Sequences:

>Translated_413_residues
MAQEKAVPRDPKKLNAFDLRWMVSLFGTAVGAGILFLPIRAGGHGVWAIVVMSAIIFPLTYLGHRALAYFIGSKDKEDIT
MVVRSHFGAQWGFLITLLYFLAIYPICLVYGVGITNVFDHFFTNQLHLAPFHRGLLAVALVSLMMLVMVFNATIVTRICN
ALVYPLCLILLLFSLYLIPYWQGANLFVVPSFKEFVLAIWLTLPVLVFAFDHSPIISTFTQNVGKEYGVFKEYKLNQIEL
GTSLMLLGFVMFFVFSCVMCLNADDFVKAREQNIPILSYLANTLNNPLINYAGPVVAFLAIFSSFFGHYYGAKEGLEGII
IQSLKLKKASKPLSVSVTIFLWLTITLVAYINPNILDFIENLGGPIIALILFVMPMIAFYSVSSLKRFRNFKVDIFVFVF
GSLTALSVFLGLF
>Mature_412_residues
AQEKAVPRDPKKLNAFDLRWMVSLFGTAVGAGILFLPIRAGGHGVWAIVVMSAIIFPLTYLGHRALAYFIGSKDKEDITM
VVRSHFGAQWGFLITLLYFLAIYPICLVYGVGITNVFDHFFTNQLHLAPFHRGLLAVALVSLMMLVMVFNATIVTRICNA
LVYPLCLILLLFSLYLIPYWQGANLFVVPSFKEFVLAIWLTLPVLVFAFDHSPIISTFTQNVGKEYGVFKEYKLNQIELG
TSLMLLGFVMFFVFSCVMCLNADDFVKAREQNIPILSYLANTLNNPLINYAGPVVAFLAIFSSFFGHYYGAKEGLEGIII
QSLKLKKASKPLSVSVTIFLWLTITLVAYINPNILDFIENLGGPIIALILFVMPMIAFYSVSSLKRFRNFKVDIFVFVFG
SLTALSVFLGLF

Specific function: Involved in the import of serine into the cell [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=407, Percent_Identity=43.980343980344, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI1789504, Length=443, Percent_Identity=38.8261851015801, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1789211, Length=379, Percent_Identity=35.8839050131926, Blast_Score=211, Evalue=7e-56,
Organism=Escherichia coli, GI1789961, Length=412, Percent_Identity=24.7572815533981, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI145693183, Length=422, Percent_Identity=25.3554502369668, Blast_Score=114, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46244; Mature: 46113

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQEKAVPRDPKKLNAFDLRWMVSLFGTAVGAGILFLPIRAGGHGVWAIVVMSAIIFPLT
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
YLGHRALAYFIGSKDKEDITMVVRSHFGAQWGFLITLLYFLAIYPICLVYGVGITNVFDH
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FFTNQLHLAPFHRGLLAVALVSLMMLVMVFNATIVTRICNALVYPLCLILLLFSLYLIPY
HHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WQGANLFVVPSFKEFVLAIWLTLPVLVFAFDHSPIISTFTQNVGKEYGVFKEYKLNQIEL
CCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHCCCHHHH
GTSLMLLGFVMFFVFSCVMCLNADDFVKAREQNIPILSYLANTLNNPLINYAGPVVAFLA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
IFSSFFGHYYGAKEGLEGIIIQSLKLKKASKPLSVSVTIFLWLTITLVAYINPNILDFIE
HHHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCHHHHHHH
NLGGPIIALILFVMPMIAFYSVSSLKRFRNFKVDIFVFVFGSLTALSVFLGLF
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQEKAVPRDPKKLNAFDLRWMVSLFGTAVGAGILFLPIRAGGHGVWAIVVMSAIIFPLT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
YLGHRALAYFIGSKDKEDITMVVRSHFGAQWGFLITLLYFLAIYPICLVYGVGITNVFDH
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FFTNQLHLAPFHRGLLAVALVSLMMLVMVFNATIVTRICNALVYPLCLILLLFSLYLIPY
HHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WQGANLFVVPSFKEFVLAIWLTLPVLVFAFDHSPIISTFTQNVGKEYGVFKEYKLNQIEL
CCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHCCCHHHH
GTSLMLLGFVMFFVFSCVMCLNADDFVKAREQNIPILSYLANTLNNPLINYAGPVVAFLA
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
IFSSFFGHYYGAKEGLEGIIIQSLKLKKASKPLSVSVTIFLWLTITLVAYINPNILDFIE
HHHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCHHHHHHH
NLGGPIIALILFVMPMIAFYSVSSLKRFRNFKVDIFVFVFGSLTALSVFLGLF
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]