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Identifier: 15644686

GI number: 15644686

Start: 56224

End: 57714

Strand: Reverse

Name: Not Available

Synonym: HP0055

Alternate gene names: 15644686

Gene position: 57714-56224 (Counterclockwise)

Preceding gene: 15644687

Following gene: 15644685

Centisome position: 3.46

GC content: 42.59

Gene sequence:

>1491_bases
ATGGGACATGTTGTTTTAAGTACCCCTATTGTTACGATGTTTATCGTTTATTCGCTGTTAATGCTCTATATTGGTTTTTA
TTTTTACAAACAAAATGAAACGACTGAAGATTATTTCTTAGGCGATCGTTCCATGGGCCCTGTGATTAGCGCTTTGAGCG
CGGGGGCGAGCGATATGAGCGGGTGGCTTTTAATGGGATTGCCTGGAGCTTTATATGTGGGAGGGCTTATCAACTCACAT
ATCGCCATAGGGTTGAGTTTGGGCGCATTGATTAACTGGGTTTTTGTGGCCAAACGCTTACGCATTTATACGAGCGTGAT
CGCTAATTCCATCACCATTTCAGATTATTTTGAAACGCGCTTTAGCGATGACAAACACATCTTGCGCTTGATTTCAGCTT
TTGTGATTTTAATCTTTTTTATTTTTTACATTTCTTCAGGGCTAGTGAGTGGGGCCAAACTCTTTGAAGCGACCTTTGGC
ATTCAATACACCTACGCTTTAAGCATTGGCACGCTGATTATTGTTTCTTACACCTTTTTAGGGGGGTATAAGGCGGTGTG
TTGGACGGATTTGATTCAAGGGCTTTTGATGATGAGCGCTTTAATCGTGGTGCCGATCGTGATGATAATCCATCTTGGAG
GGATTGGAGAGGGGATTAAAATCATTAGAGAGATCAAGCCTGAAAACCTTTCTTTCTTGCAAGGCTCTAGCGTAGTCGCC
ATTATTTCAAGCCTTGCTTGGGGCTTAGGCTATTTTGGGCAACCCCATATTTTAGTGCGCTTCATGTCTATCCGCTCCAT
TAGAGATGTGCCTAAAGCGACCACTATTGGGATTTCTTGGATGGTTATTTCTTTGATTGGGGCATGCGTTATGGGGCTTT
TAGGCGTTGCGTATGTGCATAAATTTGATTTGAGTTTAGAAGACCCTGAAAAGATTTTCATTGTGATGAGTCAATTGCTC
TTTAACCCTTGGATCACAGGCATTTTATTGAGCGCGATTTTAGCGGCGGTGATGAGCACGGCCAGTTCGCAACTGCTTGT
AAGCTCTTCTACCATTGCTGAAGATTTCTATGCGACGATTTTCAATAAAGACGCCCCACAAAAATTAGTGATGGCTATTT
CTAGGCTTTCGGTTTTAGGGGTGGCTTGCATCGCTTTTTTCATTTCAACGGATAGAAACGCCAGCATTCTCAGCATCGTG
AGTTACGCATGGGCTGGCTTTGGCGCGAGTTTTGGATCTGTGATTTTATTCTCGCTTTTTTGGTCAAGAATGACGCGCAT
TGGAGCGATTGCTGGCATGCTTTCTGGGGCTAGCACGGTGATTTTATACGATAAATTTGGCAAAAGCTTTTTGGATATTT
ATGAAATCGTTCCGGGCTTTATTGTAGCGAGCGTAGCTATTGTGGTGTTTAGTTTGTTTTCTAGCGTACGAACAGGCACT
AAAGAGGCTTTTGAAACCATGCTTAAAGAAATTGAGAGCTTGAAACATTAA

Upstream 100 bases:

>100_bases
ACCGTTATGGGAATTTAGGCTCAAGGGTTTTAAGGCAACCCACTTGCCACAAATCATGCTGTGCTGAAAAATAAATATTG
TATTAAATAAGGAGATCAAA

Downstream 100 bases:

>100_bases
TGCTTCAAATGAATTTGGTTTAATCCTTAATCCCCTTATGCTCTTTGATCAAACCTTAACCTATATTTCTTTATTTTCTG
GGGCAGGAGTGGGGTGCTAT

Product: sodium/proline symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MGHVVLSTPIVTMFIVYSLLMLYIGFYFYKQNETTEDYFLGDRSMGPVISALSAGASDMSGWLLMGLPGALYVGGLINSH
IAIGLSLGALINWVFVAKRLRIYTSVIANSITISDYFETRFSDDKHILRLISAFVILIFFIFYISSGLVSGAKLFEATFG
IQYTYALSIGTLIIVSYTFLGGYKAVCWTDLIQGLLMMSALIVVPIVMIIHLGGIGEGIKIIREIKPENLSFLQGSSVVA
IISSLAWGLGYFGQPHILVRFMSIRSIRDVPKATTIGISWMVISLIGACVMGLLGVAYVHKFDLSLEDPEKIFIVMSQLL
FNPWITGILLSAILAAVMSTASSQLLVSSSTIAEDFYATIFNKDAPQKLVMAISRLSVLGVACIAFFISTDRNASILSIV
SYAWAGFGASFGSVILFSLFWSRMTRIGAIAGMLSGASTVILYDKFGKSFLDIYEIVPGFIVASVAIVVFSLFSSVRTGT
KEAFETMLKEIESLKH

Sequences:

>Translated_496_residues
MGHVVLSTPIVTMFIVYSLLMLYIGFYFYKQNETTEDYFLGDRSMGPVISALSAGASDMSGWLLMGLPGALYVGGLINSH
IAIGLSLGALINWVFVAKRLRIYTSVIANSITISDYFETRFSDDKHILRLISAFVILIFFIFYISSGLVSGAKLFEATFG
IQYTYALSIGTLIIVSYTFLGGYKAVCWTDLIQGLLMMSALIVVPIVMIIHLGGIGEGIKIIREIKPENLSFLQGSSVVA
IISSLAWGLGYFGQPHILVRFMSIRSIRDVPKATTIGISWMVISLIGACVMGLLGVAYVHKFDLSLEDPEKIFIVMSQLL
FNPWITGILLSAILAAVMSTASSQLLVSSSTIAEDFYATIFNKDAPQKLVMAISRLSVLGVACIAFFISTDRNASILSIV
SYAWAGFGASFGSVILFSLFWSRMTRIGAIAGMLSGASTVILYDKFGKSFLDIYEIVPGFIVASVAIVVFSLFSSVRTGT
KEAFETMLKEIESLKH
>Mature_495_residues
GHVVLSTPIVTMFIVYSLLMLYIGFYFYKQNETTEDYFLGDRSMGPVISALSAGASDMSGWLLMGLPGALYVGGLINSHI
AIGLSLGALINWVFVAKRLRIYTSVIANSITISDYFETRFSDDKHILRLISAFVILIFFIFYISSGLVSGAKLFEATFGI
QYTYALSIGTLIIVSYTFLGGYKAVCWTDLIQGLLMMSALIVVPIVMIIHLGGIGEGIKIIREIKPENLSFLQGSSVVAI
ISSLAWGLGYFGQPHILVRFMSIRSIRDVPKATTIGISWMVISLIGACVMGLLGVAYVHKFDLSLEDPEKIFIVMSQLLF
NPWITGILLSAILAAVMSTASSQLLVSSSTIAEDFYATIFNKDAPQKLVMAISRLSVLGVACIAFFISTDRNASILSIVS
YAWAGFGASFGSVILFSLFWSRMTRIGAIAGMLSGASTVILYDKFGKSFLDIYEIVPGFIVASVAIVVFSLFSSVRTGTK
EAFETMLKEIESLKH

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=494, Percent_Identity=47.165991902834, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI256985183, Length=428, Percent_Identity=22.6635514018692, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4507035, Length=394, Percent_Identity=23.8578680203046, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787251, Length=497, Percent_Identity=50.1006036217304, Blast_Score=475, Evalue=1e-135,
Organism=Escherichia coli, GI87082237, Length=485, Percent_Identity=27.2164948453608, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1790503, Length=441, Percent_Identity=22.6757369614512, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17539284, Length=368, Percent_Identity=25.2717391304348, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24645928, Length=373, Percent_Identity=28.1501340482574, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221459584, Length=356, Percent_Identity=25.561797752809, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221459588, Length=384, Percent_Identity=25.78125, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24651741, Length=461, Percent_Identity=25.1626898047722, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28573698, Length=396, Percent_Identity=25, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221459586, Length=385, Percent_Identity=25.1948051948052, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221459582, Length=359, Percent_Identity=28.133704735376, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281362918, Length=461, Percent_Identity=26.6811279826464, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24651739, Length=466, Percent_Identity=23.3905579399142, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 54082; Mature: 53951

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHVVLSTPIVTMFIVYSLLMLYIGFYFYKQNETTEDYFLGDRSMGPVISALSAGASDMS
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHCCCCCCC
GWLLMGLPGALYVGGLINSHIAIGLSLGALINWVFVAKRLRIYTSVIANSITISDYFETR
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FSDDKHILRLISAFVILIFFIFYISSGLVSGAKLFEATFGIQYTYALSIGTLIIVSYTFL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHH
GGYKAVCWTDLIQGLLMMSALIVVPIVMIIHLGGIGEGIKIIREIKPENLSFLQGSSVVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHH
IISSLAWGLGYFGQPHILVRFMSIRSIRDVPKATTIGISWMVISLIGACVMGLLGVAYVH
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFDLSLEDPEKIFIVMSQLLFNPWITGILLSAILAAVMSTASSQLLVSSSTIAEDFYATI
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEHHHHHHHHHHHH
FNKDAPQKLVMAISRLSVLGVACIAFFISTDRNASILSIVSYAWAGFGASFGSVILFSLF
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
WSRMTRIGAIAGMLSGASTVILYDKFGKSFLDIYEIVPGFIVASVAIVVFSLFSSVRTGT
HHHHHHHHHHHHHHCCCCEEEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
KEAFETMLKEIESLKH
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GHVVLSTPIVTMFIVYSLLMLYIGFYFYKQNETTEDYFLGDRSMGPVISALSAGASDMS
CCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHCCCCCCC
GWLLMGLPGALYVGGLINSHIAIGLSLGALINWVFVAKRLRIYTSVIANSITISDYFETR
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FSDDKHILRLISAFVILIFFIFYISSGLVSGAKLFEATFGIQYTYALSIGTLIIVSYTFL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHH
GGYKAVCWTDLIQGLLMMSALIVVPIVMIIHLGGIGEGIKIIREIKPENLSFLQGSSVVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHH
IISSLAWGLGYFGQPHILVRFMSIRSIRDVPKATTIGISWMVISLIGACVMGLLGVAYVH
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFDLSLEDPEKIFIVMSQLLFNPWITGILLSAILAAVMSTASSQLLVSSSTIAEDFYATI
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEHHHHHHHHHHHH
FNKDAPQKLVMAISRLSVLGVACIAFFISTDRNASILSIVSYAWAGFGASFGSVILFSLF
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
WSRMTRIGAIAGMLSGASTVILYDKFGKSFLDIYEIVPGFIVASVAIVVFSLFSSVRTGT
HHHHHHHHHHHHHHCCCCEEEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
KEAFETMLKEIESLKH
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]