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Identifier: 16519757

GI number: 16519757

Start: 444539

End: 445642

Strand: Direct

Name: Not Available

Synonym: NGR_a03490

Alternate gene names: 16519757

Gene position: 444539-445642 (Clockwise)

Preceding gene: 16519758

Following gene: 16519755

Centisome position: 82.91

GC content: 55.98

Gene sequence:

>1104_bases
ATGAAATCAAGATTGCAGGTCAGGTCCGCACACGTCCCGCTGTGGTCTTGGATCATTCCGCTCTTCGGTTGTGTGATCGC
GGCTATGACATTGGCGCACGTGCTGCCGGAACGATCCGTCGTACTTCTGTTGATGTCGGCCGGCTTGCTAACAGGTGCGG
TCTTTGCTTCCGTACATCACGCCGAAATTCTTGCCGCTCGGGTGGGCCAACCTTCTGGAGCGATCCTCCTCGCCGTCTGC
GTGACAATCATCGAAGTGGCGATCATAGGTTCTTTGATGCTTTCCGGCGCGGAGGGAAACGAAGAAGTCGCGAGAGATAC
GGTCTTTGCCGCCGTGATGATCGTGCTCAATGGCGTCATCGGCCTCTGTCTCGTGCTTGGCGGCCGACGCCATCGCGAGC
AGTCGTTCCAGTTGAATGCCGCGTCGGCGGCACTGGCGGTACTAGGCACACTCGCGACACTGTCTCTCGTGCTGCCCAAT
TTCGTCACCGCGGGAAAACCACAGCAGTTTGCTGCAATACAGCTTGTCGTCATAGGACTTGTGTCTGTGGTCCTCTATGG
TGTGTTTCTGTTTGTGCAGACTGTTCGCCATCGCGACTATTTCATCGATGATGAAGACGCCGCTTCGCCTCCGGCTACCC
ATGAGACCCCGCGTAATCCGCTAGCGGCCGGAGCCTTGCTTGTGCTGGCCCTCATTGCAGTCATCCTATTGGCAATGCTA
CTTTCTTATCCGCTCGACAGCGCCGTCGAGGCGCTGGGACTGCCACAAGCCGTCGTGGGCGTAACTATCGCGGGAGTCGT
TCTGCTGCCAGAAGGGATAACCTCTGTCAAAGCGGCTTTAATGAATCGTCTTCAAAATAGCATAAACCTCGTACTCGGAT
CTGCGCTTGCGAGCATTGGGGTGACAATTCCAGTAGTAGCTGCCATATCGGTCGCTCTTGGACGAGATCTTGCTTTGGGT
CTCGCGCCACAGAACCTCATTATGCTGATCCTGACGCTGTTCGTCGGTACGATCACACTGGGAACGGGCAGAACGACCGT
ACTACAGGGCGCCGTTCATCTGGCGATATTCACGGTATTTCTCTTGCTTTCGGCCATTCCATGA

Upstream 100 bases:

>100_bases
ACTAGACTTGGCGAATCTCGCCCGACTTTCCGAAGCCTTAGTTTTGTTACGCCGATTACCGCGCAAGGAACCACGCATAC
TCATCACCAGGGGATGGAAA

Downstream 100 bases:

>100_bases
AAATTCAATAGCAGTGGTCTGCCGCATTTCAGCACGCGCCGTCTCCTAAAATGGTCGACCTCAGGAATGTGCACATCACT
TCGCTGCTGCGTGACTCCCA

Product: cation transporter

Products: Na (I) [Periplasm]; Ca (II) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MKSRLQVRSAHVPLWSWIIPLFGCVIAAMTLAHVLPERSVVLLLMSAGLLTGAVFASVHHAEILAARVGQPSGAILLAVC
VTIIEVAIIGSLMLSGAEGNEEVARDTVFAAVMIVLNGVIGLCLVLGGRRHREQSFQLNAASAALAVLGTLATLSLVLPN
FVTAGKPQQFAAIQLVVIGLVSVVLYGVFLFVQTVRHRDYFIDDEDAASPPATHETPRNPLAAGALLVLALIAVILLAML
LSYPLDSAVEALGLPQAVVGVTIAGVVLLPEGITSVKAALMNRLQNSINLVLGSALASIGVTIPVVAAISVALGRDLALG
LAPQNLIMLILTLFVGTITLGTGRTTVLQGAVHLAIFTVFLLLSAIP

Sequences:

>Translated_367_residues
MKSRLQVRSAHVPLWSWIIPLFGCVIAAMTLAHVLPERSVVLLLMSAGLLTGAVFASVHHAEILAARVGQPSGAILLAVC
VTIIEVAIIGSLMLSGAEGNEEVARDTVFAAVMIVLNGVIGLCLVLGGRRHREQSFQLNAASAALAVLGTLATLSLVLPN
FVTAGKPQQFAAIQLVVIGLVSVVLYGVFLFVQTVRHRDYFIDDEDAASPPATHETPRNPLAAGALLVLALIAVILLAML
LSYPLDSAVEALGLPQAVVGVTIAGVVLLPEGITSVKAALMNRLQNSINLVLGSALASIGVTIPVVAAISVALGRDLALG
LAPQNLIMLILTLFVGTITLGTGRTTVLQGAVHLAIFTVFLLLSAIP
>Mature_367_residues
MKSRLQVRSAHVPLWSWIIPLFGCVIAAMTLAHVLPERSVVLLLMSAGLLTGAVFASVHHAEILAARVGQPSGAILLAVC
VTIIEVAIIGSLMLSGAEGNEEVARDTVFAAVMIVLNGVIGLCLVLGGRRHREQSFQLNAASAALAVLGTLATLSLVLPN
FVTAGKPQQFAAIQLVVIGLVSVVLYGVFLFVQTVRHRDYFIDDEDAASPPATHETPRNPLAAGALLVLALIAVILLAML
LSYPLDSAVEALGLPQAVVGVTIAGVVLLPEGITSVKAALMNRLQNSINLVLGSALASIGVTIPVVAAISVALGRDLALG
LAPQNLIMLILTLFVGTITLGTGRTTVLQGAVHLAIFTVFLLLSAIP

Specific function: Possible cation transporter

COG id: COG0387

COG function: function code P; Ca2+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family

Homologues:

Organism=Escherichia coli, GI1787468, Length=319, Percent_Identity=34.7962382445141, Blast_Score=186, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y4HA_RHISN (P55471)

Other databases:

- EMBL:   U00090
- RefSeq:   NP_443877.1
- GeneID:   962313
- GenomeReviews:   U00090_GR
- KEGG:   rhi:NGR_a03490
- HOGENOM:   HBG575576
- ProtClustDB:   CLSK808999
- InterPro:   IPR004713
- InterPro:   IPR004837
- TIGRFAMs:   TIGR00846

Pfam domain/function: PF01699 Na_Ca_ex

EC number: NA

Molecular weight: Translated: 38079; Mature: 38079

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xaf35d44)-; HASH(0xaf05fe4)-; HASH(0xbb1af58)-; HASH(0x9661b18)-; HASH(0xad65a00)-; HASH(0xcace6e0)-; HASH(0x403b4030)-; HASH(0xc74b19c)-; HASH(0x96e5308)-; HASH(0xcad7a7c)-; HASH(0xcace758)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRLQVRSAHVPLWSWIIPLFGCVIAAMTLAHVLPERSVVLLLMSAGLLTGAVFASVHH
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AEILAARVGQPSGAILLAVCVTIIEVAIIGSLMLSGAEGNEEVARDTVFAAVMIVLNGVI
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
GLCLVLGGRRHREQSFQLNAASAALAVLGTLATLSLVLPNFVTAGKPQQFAAIQLVVIGL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
VSVVLYGVFLFVQTVRHRDYFIDDEDAASPPATHETPRNPLAAGALLVLALIAVILLAML
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LSYPLDSAVEALGLPQAVVGVTIAGVVLLPEGITSVKAALMNRLQNSINLVLGSALASIG
HHCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VTIPVVAAISVALGRDLALGLAPQNLIMLILTLFVGTITLGTGRTTVLQGAVHLAIFTVF
HHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LLLSAIP
HHHHCCH
>Mature Secondary Structure
MKSRLQVRSAHVPLWSWIIPLFGCVIAAMTLAHVLPERSVVLLLMSAGLLTGAVFASVHH
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AEILAARVGQPSGAILLAVCVTIIEVAIIGSLMLSGAEGNEEVARDTVFAAVMIVLNGVI
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
GLCLVLGGRRHREQSFQLNAASAALAVLGTLATLSLVLPNFVTAGKPQQFAAIQLVVIGL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
VSVVLYGVFLFVQTVRHRDYFIDDEDAASPPATHETPRNPLAAGALLVLALIAVILLAML
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LSYPLDSAVEALGLPQAVVGVTIAGVVLLPEGITSVKAALMNRLQNSINLVLGSALASIG
HHCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VTIPVVAAISVALGRDLALGLAPQNLIMLILTLFVGTITLGTGRTTVLQGAVHLAIFTVF
HHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LLLSAIP
HHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm]; Ca (II) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + Proton [Periplasm] = Proton [Cytoplasm] + Na (I) [Periplasm] Ca (II) [Cytoplasm] + Proton [Periplasm] = Ca (II) [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9163424