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The map label for this gene is argI [H]

Identifier: 13508045

GI number: 13508045

Start: 360644

End: 361465

Strand: Direct

Name: argI [H]

Synonym: MPN306

Alternate gene names: 13508045

Gene position: 360644-361465 (Clockwise)

Preceding gene: 13508044

Following gene: 13508046

Centisome position: 44.18

GC content: 42.7

Gene sequence:

>822_bases
ATGGGTTGCACTTACATCGGCCCTTCTGGTTCCAATTTTGGTAAGAAGGAATCGATTGAAGACACTGCTAAAGTGTTGGG
TTCAATGTATGACGGAATTGAATTCCGTGGCTTTAAGCAAAGCGATGTTGATGCTTTGGTCAAGTACTCTGGTGTTCCTG
TTTGAAACGGTTTGACTGATGCGGAACACCCTACCCAAATGCTAGCGGATTACATGACGATTAAGGAGTTGAAGGGTGAT
TTGAAGGGGCGCAAAATTGTCTTTGCTGGTGATATTAAAAATAATGTGGCACGCTCGTTGATGATTGGGGCAGCTTTTGT
TGGTATGGACATAGTGCTAGTAGGTCCTAAAGCACAGCATGAATTAGTTCAAAATGGTGCTGGGTATAAAGAGGTCTTTG
AGCAGTGTCAAGCATTGTTTCAACTCAATGGTGGTAGTGTTAGCTTTAGCACTGATAAGCTGCAAGCGGCTAAGAATGCT
GATGTAATTTACACCGATGTGTGACTGTCGTTGGGTGAAGACTTTAGCTTATTTGAAGAACGGATTCAGGAGCTGGGTCA
ATTTCAAGTTGACATGGCTATGATCAAAGCAGCTAAGAGTGATGTGATCTTCTTGCACTGTCTCCCCGCTTTCCATGATG
ATCACACTAGCTTTTCACTGGAAATTAAACAAAAGTTAGGTAAAAAATATCCGGTGGTGAAAACGGGTGCGATGGAAGTG
ACTGATACGGTGTTTCAGTCCAAGCATAACATGGCCTTTATCCAAGCAGAAAACCGCTTGCACACGATTAAGGCCGTTAT
TTTAGCTACTTTAGGGTATTAA

Upstream 100 bases:

>100_bases
CCAGAACCGTCCCTTAGCGGGGAAGAACATTGTTTTACTGTTCCAAAAAGATTCTACCCGTACCCGTTGTGCCTTTGAAG
TGGCTGCCTTTGACTTGGGT

Downstream 100 bases:

>100_bases
AGATGCAAAAAATTGTCATAGCATTGGGTGGTAATGCATTAGGTAACAATCCCACCGAACAAAAGGACTTGGTACAACTA
CCAGCACGACAGGCGGTTGC

Product: less (fragment)

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MGCTYIGPSGSNFGKKESIEDTAKVLGSMYDGIEFRGFKQSDVDALVKYSGVPVWNGLTDAEHPTQMLADYMTIKELKGD
LKGRKIVFAGDIKNNVARSLMIGAAFVGMDIVLVGPKAQHELVQNGAGYKEVFEQCQALFQLNGGSVSFSTDKLQAAKNA
DVIYTDVWLSLGEDFSLFEERIQELGQFQVDMAMIKAAKSDVIFLHCLPAFHDDHTSFSLEIKQKLGKKYPVVKTGAMEV
TDTVFQSKHNMAFIQAENRLHTIKAVILATLGY

Sequences:

>Translated_273_residues
MGCTYIGPSGSNFGKKESIEDTAKVLGSMYDGIEFRGFKQSDVDALVKYSGVPV*NGLTDAEHPTQMLADYMTIKELKGD
LKGRKIVFAGDIKNNVARSLMIGAAFVGMDIVLVGPKAQHELVQNGAGYKEVFEQCQALFQLNGGSVSFSTDKLQAAKNA
DVIYTDV*LSLGEDFSLFEERIQELGQFQVDMAMIKAAKSDVIFLHCLPAFHDDHTSFSLEIKQKLGKKYPVVKTGAMEV
TDTVFQSKHNMAFIQAENRLHTIKAVILATLGY
>Mature_272_residues
GCTYIGPSGSNFGKKESIEDTAKVLGSMYDGIEFRGFKQSDVDALVKYSGVPV*NGLTDAEHPTQMLADYMTIKELKGDL
KGRKIVFAGDIKNNVARSLMIGAAFVGMDIVLVGPKAQHELVQNGAGYKEVFEQCQALFQLNGGSVSFSTDKLQAAKNAD
VIYTDV*LSLGEDFSLFEERIQELGQFQVDMAMIKAAKSDVIFLHCLPAFHDDHTSFSLEIKQKLGKKYPVVKTGAMEVT
DTVFQSKHNMAFIQAENRLHTIKAVILATLGY

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=260, Percent_Identity=35.7692307692308, Blast_Score=140, Evalue=9e-34,
Organism=Escherichia coli, GI1790703, Length=276, Percent_Identity=45.6521739130435, Blast_Score=232, Evalue=2e-62,
Organism=Escherichia coli, GI1786469, Length=275, Percent_Identity=46.1818181818182, Blast_Score=229, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6322373, Length=272, Percent_Identity=27.2058823529412, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 29670; Mature: 29539

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGCTYIGPSGSNFGKKESIEDTAKVLGSMYDGIEFRGFKQSDVDALVKYSGVPVNGLTDA
CCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHCCCCCCCCCCC
EHPTQMLADYMTIKELKGDLKGRKIVFAGDIKNNVARSLMIGAAFVGMDIVLVGPKAQHE
CCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCEEEEECCCHHHH
LVQNGAGYKEVFEQCQALFQLNGGSVSFSTDKLQAAKNADVIYTDVLSLGEDFSLFEERI
HHHCCCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHCCCCEEEHHHHHCCCCHHHHHHHH
QELGQFQVDMAMIKAAKSDVIFLHCLPAFHDDHTSFSLEIKQKLGKKYPVVKTGAMEVTD
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEHHHHCCCCCCEEECCCHHHHH
TVFQSKHNMAFIQAENRLHTIKAVILATLGY
HHHHCCCCEEEEEECCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GCTYIGPSGSNFGKKESIEDTAKVLGSMYDGIEFRGFKQSDVDALVKYSGVPVNGLTDA
CCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHCCCCCCCCCCC
EHPTQMLADYMTIKELKGDLKGRKIVFAGDIKNNVARSLMIGAAFVGMDIVLVGPKAQHE
CCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCEEEEECCCHHHH
LVQNGAGYKEVFEQCQALFQLNGGSVSFSTDKLQAAKNADVIYTDVLSLGEDFSLFEERI
HHHCCCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHCCCCEEEHHHHHCCCCHHHHHHHH
QELGQFQVDMAMIKAAKSDVIFLHCLPAFHDDHTSFSLEIKQKLGKKYPVVKTGAMEVTD
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEHHHHCCCCCCEEECCCHHHHH
TVFQSKHNMAFIQAENRLHTIKAVILATLGY
HHHHCCCCEEEEEECCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]