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The map label for this gene is trx [H]

Identifier: 13508002

GI number: 13508002

Start: 315874

End: 316182

Strand: Direct

Name: trx [H]

Synonym: MPN263

Alternate gene names: 13508002

Gene position: 315874-316182 (Clockwise)

Preceding gene: 13508001

Following gene: 13508003

Centisome position: 38.69

GC content: 39.48

Gene sequence:

>309_bases
ATGGTAACTGAAATTAAAAGTCTCAAACAACTCGGAGAGTTATTTGCTAGCAACAATAAGGTAATTATTGATTTTTGAGC
AGAATGGTGTGGGCCGTGCAAAATTACTGGACCAGAATTTGCTAAAGCTGCTAGTGAAGTGAGCACTGTAGCGTTTGCCA
AGGTAAATGTCGATGAACAAACTGACATTGCCGCTGCTTACAAAATTACCTCACTACCTACAATTGTTTTATTTGAAAAA
GGCCAGGAAAAGCACCGTGCTATTGGTTTTATGCCTAAAGCCAAGATCGTGCAACTTGTCAGCCAATAA

Upstream 100 bases:

>100_bases
GTTTATTTGTAAATACCCAAACACTCATGATCTAACACTTTAGATCATGGAAACAATTAGCGAACTTTTAGAATATAAAA
CAATTGAAAACAAATAGTTT

Downstream 100 bases:

>100_bases
AACTTCGTTTCATGATTGACTTGCTCGGGTTAGATCTTGATGGCACTTTGTTGTCTAGAACAAGGCAAATTAACGATCCT
ACTAAACAAGCTTTGGCTAA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 102; Mature: 102

Protein sequence:

>102_residues
MVTEIKSLKQLGELFASNNKVIIDFWAEWCGPCKITGPEFAKAASEVSTVAFAKVNVDEQTDIAAAYKITSLPTIVLFEK
GQEKHRAIGFMPKAKIVQLVSQ

Sequences:

>Translated_102_residues
MVTEIKSLKQLGELFASNNKVIIDF*AEWCGPCKITGPEFAKAASEVSTVAFAKVNVDEQTDIAAAYKITSLPTIVLFEK
GQEKHRAIGFMPKAKIVQLVSQ
>Mature_102_residues
MVTEIKSLKQLGELFASNNKVIIDF*AEWCGPCKITGPEFAKAASEVSTVAFAKVNVDEQTDIAAAYKITSLPTIVLFEK
GQEKHRAIGFMPKAKIVQLVSQ

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=75, Percent_Identity=38.6666666666667, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788936, Length=85, Percent_Identity=40, Blast_Score=63, Evalue=5e-12,
Organism=Escherichia coli, GI87082331, Length=90, Percent_Identity=30, Blast_Score=62, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17507705, Length=85, Percent_Identity=37.6470588235294, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=95, Percent_Identity=41.0526315789474, Blast_Score=82, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319925, Length=93, Percent_Identity=39.7849462365591, Blast_Score=75, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=94, Percent_Identity=35.1063829787234, Blast_Score=74, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24639826, Length=85, Percent_Identity=40, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 11011; Mature: 11011

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTEIKSLKQLGELFASNNKVIIDFAEWCGPCKITGPEFAKAASEVSTVAFAKVNVDEQT
CCCCHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCC
DIAAAYKITSLPTIVLFEKGQEKHRAIGFMPKAKIVQLVSQ
CHHHHEECCCCCEEEEEECCCCHHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure
MVTEIKSLKQLGELFASNNKVIIDFAEWCGPCKITGPEFAKAASEVSTVAFAKVNVDEQT
CCCCHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCC
DIAAAYKITSLPTIVLFEKGQEKHRAIGFMPKAKIVQLVSQ
CHHHHEECCCCCEEEEEECCCCHHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9202470; 8948633 [H]